AQP8 Modulates Mitochondrial H₂O₂ Transport to Influence Glioma Proliferation

References

• Turrens JF. Mitochondrial formation of reactive oxygen species. J Physiol. 2003;552(2):335–344. doi:10.1111/j.1469-7793.2003.00335.x.
   PubMed Web of Science ®Google Scholar
• Rhee SG. Cell signaling. H2O2, a necessary evil for cell signaling. Science. 2006;312(5782):1882–1883. doi:10.1126/science.1130481.
   PubMed Web of Science ®Google Scholar
• Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Curr Biol. 2014;24(10):R453–62. doi:10.1016/j.cub.2014.03.034.
   PubMed Web of Science ®Google Scholar
• Yang Y, Karakhanova S, Hartwig W, D'Haese JG, Philippov PP, Werner J, et al. Mitochondria and mitochondrial ROS in cancer: novel targets for anticancer therapy. J Cell Physiol. 2016;231(12):2570–2581. doi:10.1002/jcp.25349.
   PubMed Web of Science ®Google Scholar
• Zhang J, Wang X, Vikash V, Ye Q, Wu D, Liu Y, et al. ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev. 2016; 2016:4350965. doi:10.1155/2016/4350965.
   PubMed Web of Science ®Google Scholar
• Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Saavedra E, Moreno-Sánchez R. The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy. Mol Aspects Med. 2010;31(2):145–170. doi:10.1016/j.mam.2010.02.008.
   PubMed Web of Science ®Google Scholar
• Giorgio M, Trinei M, Migliaccio E, Pelicci PG. Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol. 2007;8(9):722–728. doi:10.1038/nrm2240.
   PubMed Web of Science ®Google Scholar
• López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–1217. doi:10.1016/j.cell.2013.05.039.
   PubMed Web of Science ®Google Scholar
• Ostrom QT, Cioffi G, Gittleman H, Patil N, Waite K, Kruchko C, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2012–2016. Neuro Oncol. 2019;21(5):v1–v100. doi:10.1093/neuonc/noz150.
   PubMedGoogle Scholar
• Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol. 2006;2(9):494–503; quiz 1 p following 516. doi:10.1038/ncpneuro0289.
   PubMedGoogle Scholar
• Śledzińska P, Bebyn MG, Furtak J, et al. Prognostic and predictive biomarkers in gliomas. Int J Mol Sci. 2021;22:10373. doi:10.3390/ijms221910373.
   PubMed Web of Science ®Google Scholar
• Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455:1061–1068. doi:10.1038/nature07385.
   PubMed Web of Science ®Google Scholar
• Ludwig K, Kornblum HI. Molecular markers in glioma. J Neurooncol. 2017;134(3):505–512. doi:10.1007/s11060-017-2379-y.
   PubMed Web of Science ®Google Scholar
• Weller M, van den Bent M, Tonn JC, Stupp R, Preusser M, Cohen-Jonathan-Moyal E, et al. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol. 2017;18(6):e315–e329. doi:10.1016/S1470-2045(17)30194-8.
   PubMed Web of Science ®Google Scholar
• Zhu SJ, Wang KJ, Gan SW, Xu J, Xu SY, Sun SQ, et al. Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade. Biochem Biophys Res Commun. 2013;440(1):168–172. doi:10.1016/j.bbrc.2013.09.057.
   PubMed Web of Science ®Google Scholar
• Hao Z, Huajun S, Zhen G, Yu X, Qian L, Ziling C, et al. AQP8 promotes glioma proliferation and growth, possibly through the ROS/PTEN/AKT signaling pathway. Bmc Cancer. 2023;23(1):516. doi:10.1186/s12885-023-11025-8.
   PubMed Web of Science ®Google Scholar
• Calamita G, Ferri D, Gena P, Liquori GE, Cavalier A, Thomas D, et al. The inner mitochondrial membrane has aquaporin-8 water channels and is highly permeable to water. J Biol Chem. 2005;280(17):17149–17153. doi:10.1074/jbc.C400595200.
   PubMed Web of Science ®Google Scholar
• Ikaga R, Namekata I, Kotiadis VN, Ogawa H, Duchen MR, Tanaka H, et al. Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep. 2015;4:187–195. doi:10.1016/j.bbrep.2015.09.009.
   PubMedGoogle Scholar
• Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K. Characterization of aquaporin-driven hydrogen peroxide transport. Biochim Biophys Acta Biomembr. 2020;1862(2):183065. doi:10.1016/j.bbamem.2019.183065.
   PubMed Web of Science ®Google Scholar
• Bienert GP, Chaumont F. Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide. Biochim Biophys Acta. 2014;1840(5):1596–1604. doi:10.1016/j.bbagen.2013.09.017.
   PubMed Web of Science ®Google Scholar
• Krüger C, Waldeck-Weiermair M, Kaynert J, Pokrant T, Komaragiri Y, Otto O, et al. AQP8 is a crucial H(2)O(2) transporter in insulin-producing RINm5F cells. Redox Biol. 2021;43:101962. doi:10.1016/j.redox.2021.101962.
   PubMed Web of Science ®Google Scholar
• Cai Z, Shen Z, Zhao J, Zhang H, Guo Z, Xia Q, et al. AQP8 may affect glioma proliferation and growth by regulating GSK-3β phosphorylation and nuclear transport of β-catenin. Int J Dev Neurosci. 2023;83(4):333–345. doi:10.1002/jdn.10261.
   PubMed Web of Science ®Google Scholar
• Angelova PR, Abramov AY. Functional role of mitochondrial reactive oxygen species in physiology. Free Radic Biol Med. 2016;100:81–85. doi:10.1016/j.freeradbiomed.2016.06.005.
   PubMed Web of Science ®Google Scholar
• Mailloux RJ, McBride SL, Harper ME. Unearthing the secrets of mitochondrial ROS and glutathione in bioenergetics. Trends Biochem Sci. 2013;38(12):592–602. doi:10.1016/j.tibs.2013.09.001.
   PubMed Web of Science ®Google Scholar
• Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. ROS and the DNA damage response in cancer. Redox Biol. 2019;25:101084. doi:10.1016/j.redox.2018.101084.
   PubMed Web of Science ®Google Scholar
• Vigneron A, Vousden KH. p53, ROS and senescence in the control of aging. Aging (Albany NY). 2010;2(8):471–474. doi:10.18632/aging.100189.
   PubMedGoogle Scholar
• Jiang P, Du W, Mancuso A, Wellen KE, Yang X. Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature. 2013;493(7434):689–693. doi:10.1038/nature11776.
   PubMed Web of Science ®Google Scholar
• Sies H. Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol. 2017;11:613–619. doi:10.1016/j.redox.2016.12.035.
   PubMed Web of Science ®Google Scholar
• Ježek P, Holendová B, Plecitá-Hlavatá L. Redox signaling from mitochondria: signal propagation and its targets. Biomolecules. 2020;10(1):93. doi:10.3390/biom10010093.
   PubMed Web of Science ®Google Scholar
• Moloney JN, Cotter TG. ROS signalling in the biology of cancer. Semin Cell Dev Biol. 2018;80:50–64. doi:10.1016/j.semcdb.2017.05.023.
   PubMed Web of Science ®Google Scholar
• Bertolotti M, Bestetti S, García-Manteiga JM, Medraño-Fernandez I, Dal Mas A, Malosio ML, et al. Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability? Antioxid Redox Signal. 2013;19(13):1447–1451. doi:10.1089/ars.2013.5330.
   PubMed Web of Science ®Google Scholar
• Marchissio MJ, Francés DEA, Carnovale CE, Marinelli RA. Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability. Toxicol Appl Pharmacol. 2012;264(2):246–254. doi:10.1016/j.taap.2012.08.005.
   PubMed Web of Science ®Google Scholar
• Bienert GP, Schjoerring JK, Jahn TP. Membrane transport of hydrogen peroxide. Biochim Biophys Acta. 2006;1758(8):994–1003. doi:10.1016/j.bbamem.2006.02.015.
   PubMed Web of Science ®Google Scholar
• Bienert GP, Møller ALB, Kristiansen KA, Schulz A, Møller IM, Schjoerring JK, et al. Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes*. J Biol Chem. 2007;282(2):1183–1192. doi:10.1074/jbc.M603761200.
   PubMed Web of Science ®Google Scholar
• Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. Biochem J. 2011;435(2):297–312. doi:10.1042/BJ20110162.
   PubMed Web of Science ®Google Scholar
• Liu B, Chen Y, St CD. ROS and p53: a versatile partnership. Free Radic Biol Med. 2008;44(8):1529–1535. doi:10.1016/j.freeradbiomed.2008.01.011.
   PubMed Web of Science ®Google Scholar
• Ben-Porath I, Weinberg RA. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol. 2005;37(5):961–976. doi:10.1016/j.biocel.2004.10.013.
   PubMed Web of Science ®Google Scholar
• van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509(7501):439–446. doi:10.1038/nature13193.
   PubMed Web of Science ®Google Scholar
• Rigoulet M, Yoboue ED, Devin A. Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling. Antioxid Redox Signal. 2011;14(3):459–468. doi:10.1089/ars.2010.3363.
   PubMed Web of Science ®Google Scholar
• Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA. 2005;102(50):17993–17998. doi:10.1073/pnas.0508886102.
   PubMed Web of Science ®Google Scholar
• Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science. 2005;309(5733):481–484. doi:10.1126/science.1112125.
   PubMed Web of Science ®Google Scholar
• Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, et al. Mitochondrial dysfunction induces senescence with a distinct secretory phenotype. Cell Metab. 2016;23(2):303–314. doi:10.1016/j.cmet.2015.11.011.
   PubMed Web of Science ®Google Scholar
• Turkez H, Tozlu OO, Arslan ME, Mardinoglu A. Safety and efficacy assessments to take antioxidants in glioblastoma therapy: from in vitro experiences to animal and clinical studies. Neurochem Int. 2021;150:105168. doi:10.1016/j.neuint.2021.105168.
   PubMed Web of Science ®Google Scholar