Does Aspirin Use Reduce the Risk for Ovarian Cancer?

References

• Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49. doi:10.3322/caac.21820.
   PubMed Web of Science ®Google Scholar
• Alvarez Secord A, O'Malley DM, Sood AK, Westin SN, Liu JF. Rationale for combination PARP inhibitor and antiangiogenic treatment in advanced epithelial ovarian cancer: a review. Gynecol Oncol. 2021;162(2):482–495. doi:10.1016/j.ygyno.2021.05.018.
   PubMed Web of Science ®Google Scholar
• Loomans-Kropp HA, Pinsky P, Umar A. Evaluation of aspirin use with cancer incidence and survival among older adults in the prostate, lung, colorectal, and ovarian cancer screening trial. JAMA Netw Open. 2021;4(1):e2032072. doi:10.1001/jamanetworkopen.2020.32072.
   PubMed Web of Science ®Google Scholar
• Rothwell PM, Fowkes FGR, Belch JFF, Ogawa H, Warlow CP, Meade TW, et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet. 2011;377(9759):31–41. doi:10.1016/S0140-6736(10)62110-1.
   PubMed Web of Science ®Google Scholar
• McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, et al. Effect of aspirin on cancer incidence and mortality in older adults. N Engl J Med. 2018;379(16):1519–1528. doi:10.1056/NEJMoa1803955.
   PubMed Web of Science ®Google Scholar
• La Vecchia C. Ovarian cancer: epidemiology and risk factors. Eur J Cancer Prev. 2017;26(1):55–62. doi:10.1097/CEJ.0000000000000217.
   PubMed Web of Science ®Google Scholar
• Trabert B, Poole EM, White E, Visvanathan K, Adami H-O, Anderson GL, et al. Analgesic use and ovarian cancer risk: an analysis in the ovarian cancer cohort consortium. J Natl Cancer Inst. 2019;111(2):137–145. doi:10.1093/jnci/djy100.
   PubMedGoogle Scholar
• Zhang H, Lu J, Jiao Y, Chen Q, Li M, Wang Z, et al. Aspirin inhibits natural killer/T-cell lymphoma by modulation of VEGF expression and mitochondrial function. Front Oncol. 2019;8:679. doi:10.3389/fonc.2018.00679.
   PubMed Web of Science ®Google Scholar
• Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell. 1998;93(5):705–716. doi:10.1016/s0092-8674(00)81433-6.
   PubMed Web of Science ®Google Scholar
• Ai G, Dachineni R, Kumar DR, Marimuthu S, Alfonso LF, Bhat GJ. Aspirin acetylates wild type and mutant p53 in colon cancer cells: identification of aspirin acetylated sites on recombinant p53. Tumour Biol. 2016;37(5):6007–6016. doi:10.1007/s13277-015-4438-3.
   PubMedGoogle Scholar
• Choi BH, Chakraborty G, Baek K, Yoon HS. Aspirin-induced Bcl-2 translocation and its phosphorylation in the nucleus trigger apoptosis in breast cancer cells. Exp Mol Med. 2013;45(10):e47–e47. doi:10.1038/emm.2013.91.
   PubMedGoogle Scholar
• Deng L, Hu S, Baydoun AR, Chen J, Chen X, Cong X, et al. Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway. Cell Prolif. 2009;2(6):721–730. doi:10.1111/j.1365-2184.2009.00639.x.
   Google Scholar
• Hurwitz LM, Pinsky PF, Huang W-Y, Freedman ND, Trabert B. Aspirin use and ovarian cancer risk using extended follow-up of the PLCO Cancer Screening Trial. Gynecol Oncol. 2020;159(2):522–526. doi:10.1016/j.ygyno.2020.08.038.
   PubMed Web of Science ®Google Scholar
• Hurwitz LM, Townsend MK, Jordan SJ, Patel AV, Teras LR, Lacey JV, et al. Modification of the association between frequent aspirin use and ovarian cancer risk: a meta-analysis using individual-level data from two ovarian cancer consortia. J Clin Oncol. 2022;40(36):4207–4217. doi:10.1200/JCO.21.01900.
   PubMed Web of Science ®Google Scholar
• Trabert B, Ness RB, Lo-Ciganic W-H, Murphy MA, Goode EL, Poole EM, et al. Aspirin, nonaspirin nonsteroidal anti-inflammatory drug, and acetaminophen use and risk of invasive epithelial ovarian cancer: a pooled analysis in the Ovarian Cancer Association Consortium. J Natl Cancer Inst. 2014;106(2):djt431–djt431. doi:10.1093/jnci/djt431.
   PubMedGoogle Scholar
• Baandrup L, Faber MT, Christensen J, Jensen A, Andersen KK, Friis S, et al. Nonsteroidal anti-inflammatory drugs and risk of ovarian cancer: systematic review and meta-analysis of observational studies. Acta Obstet Gynecol Scand. 2013;92(3):245–255. doi:10.1111/aogs.12069.
   PubMed Web of Science ®Google Scholar
• Pinheiro SP, Tworoger SS, Cramer DW, Rosner BA, Hankinson SE. Use of nonsteroidal anti-inflammatory agents and incidence of ovarian cancer in 2 large prospective cohorts. Am J Epidemiol. 2009;169(11):1378–1387. doi:10.1093/aje/kwp062.
   PubMed Web of Science ®Google Scholar
• Barnard ME, Poole EM, Curhan GC, Eliassen AH, Rosner BA, Terry KL, et al. Association of analgesic use with risk of ovarian cancer in the nurses’ health studies. JAMA Oncol. 2018;4(12):1675–1682. doi:10.1001/jamaoncol.2018.4149.
   PubMed Web of Science ®Google Scholar
• McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, et al. Effect of aspirin on cancer incidence and mortality in older adults. J Natl Cancer Inst. 2021;113(3):258–265. doi:10.1093/jnci/djaa114.
   PubMedGoogle Scholar
• Hussain M, Javeed A, Ashraf M, Zhao Y, Mukhtar MM, Rehman MU. Aspirin and immune system. Int Immunopharmacol. 2012;12(1):10–20. doi:10.1016/j.intimp.2011.11.021.
   PubMed Web of Science ®Google Scholar
• Lacey JV, Sherman ME, Hartge P, Schatzkin A, Schairer C. Medication use and risk of ovarian carcinoma: a prospective study. Int J Cancer. 2004;108(2):281–286. doi:10.1002/ijc.11538.
   PubMed Web of Science ®Google Scholar
• Setiawan VW, Matsuno RK, Lurie G, Wilkens LR, Carney ME, Henderson BE, et al. Use of nonsteroidal anti-inflammatory drugs and risk of ovarian and endometrial cancer: the Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev. 2012;21(9):1441–1449. doi:10.1158/1055-9965.EPI-12-0390-T.
   PubMed Web of Science ®Google Scholar
• Hwang D, Scollard D, Byrne J, Levine E. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst. 1998;90(6):455–460. doi:10.1093/jnci/90.6.455.
   PubMedGoogle Scholar
• Concato J, Shah N, Horwitz RI. Randomized, controlled trials, observational studies, and the hierarchy of research designs. N Engl J Med. 2000;342(25):1887–1892. doi:10.1056/NEJM200006223422507.
   PubMed Web of Science ®Google Scholar
• Lavie CJ, Howden CW, Scheiman JS, Tursi JT. Upper gastrointestinal toxicity with long-term aspirin therapy: consequences and prevention. Curr Probl Cardiol. 2017;42(5):146–164. doi:10.1016/j.cpcardiol.2017.01.006.
   PubMed Web of Science ®Google Scholar