Publication Cover
Drying Technology
An International Journal
Volume 25, 2007 - Issue 5
253
Views
21
CrossRef citations to date
0
Altmetric
Original Articles

Sublimation Kinetics during Freeze-Drying of Pharmaceutical Protein Formulation

, &
Pages 753-758 | Published online: 06 Jun 2007

REFERENCES

  • Millman , M.J. ; Liapis , A.I. ; Marchello , J.M. An analysis of the lyophilization process using a sorption sublimation model and various operational policies . AIChE Journal 1985 , 31 , 1594 – 1604 .
  • Sadikoglu , H. ; Liapis , A.I. Mathematical modelling of primary and secondary drying stages of bulk solution freeze-drying in trays: Parameter estimation and model discrimination by comparison of theoretical results with experimental data . Drying Technology 1997 , 15 , 791 – 810 .
  • Liapis , A.I. ; Bruttini , R. A theory for the primary and secondary drying stages of freeze-drying of pharmaceutical crystalline and amorphous solutes: Comparison between experimental data and theory . Separation Technology 1994 , 4 , 144 – 155 .
  • Milton , N. ; Pikal , M.J. ; Roy , M.L. ; Nail , S.L. Evaluation of manometric temperature measurement as a method of monitoring product temperature during freeze-drying . PDA Journal of Pharmaceutical Science Technology 1997 , 51 ( 1 ), 7 – 16 .
  • Cannon , A. ; Shemeley , K. Statistical evaluation of vial design features that influence sublimation rates during primary drying . Pharmaceutical Research 2004 , 31 ( 3 ), 536 – 542 .
  • Brülls , M. ; Rasmusson , A. Heat transfer in vial lyophilization . International Journal of Pharmaceutics 2002 , 246 , 1 – 16 .
  • Hottot , A. ; Peczalski , T. ; Vessot , S. ; Andrieu , J. Freeze-drying of pharmaceutical proteins in vials . Modelling of freezing and sublimation steps. Drying Technology 2006 , 24 , 1 – 10 .
  • Hottot , A. ; Vessot , S. ; Andrieu , J. A direct characterization method of the ice morphology . Relationship between mean crystals size and primary drying times of freeze-drying processes. Drying Technology 2004 , 22 ( 8 ), 1 – 13 .
  • Hottot , A. ; Vessot , S. ; Andrieu , J. Determination of mass and heat transfer parameters during freeze-drying cycle of pharmaceutical products . PDA Journal of Pharmaceutical Science Technology 2005 , 59 , 138 – 153 .
  • Caillet , A. ; Cogné , C. ; Andrieu , J. ; Laurent , P. ; Rivoire , A. Characterization of the structure of ice cream by optical microscopy . Influence of freezing parameters on ice crystal structure. Lebensmittel-Wissenschaft-Technologie Journal 2003 , 36 , 743 – 749 .
  • Navarri , P. ; Andrieu , J. High intensity infra-red drying . Part I Case of capillary-porous material. Chemical Engineering and Processing 1993 , 32 , 311 – 318 .
  • Navarri , P. ; Andrieu , J. High intensity infra-red drying . Part II Case of coated films. Chemical Engineering and Processing 1993 , 32 , 319 – 325 .
  • Genin , N. ; René , F. ; Corrieu , G. A method for on line determination of residual water content and sublimation end point during freeze drying . Chemical Engineering and Processing 1996 , 255 – 263 .
  • Roth , C. ; Winter , G. ; Lee , G. Continuous measurement of drying rate of crystalline and amorphous systems during freeze-drying using an in situ microbalance technique . Journal of Pharmaceutical Sciences 2001 , 90 ( 9 ), 1345 – 1355 .
  • Jun , X. ; Jeffery , H. ; Volker , L. ; Wang , D.Q. Investigation of freeze-drying sublimation rates using a freeze-drying microbalance technique . International Journal of Pharmaceutics 2004 , 279 ( 1–2 ), 95 – 105 .
  • Kuu ; Hardwick ; Akers . Correlation of laboratory and production freeze drying cycles . International Journal of Pharmaceutics 2005 , 302 , 56 – 67 .
  • Trappler , E. Scale-up strategy for a lyophilization process . American Pharmaceutical Review 2001 , 4 ( 3 ), 55 – 60 .
  • Rambhatla , S. ; Pikal , M.J. Heat and mass transfer scale-up issues during freeze-drying, I: A typical radiation and the edge vial effect . AAPS PharmSciTech 2003 , 4 ( 2 ), 1 – 10 .
  • Rambhatla , S. ; Ramot , R. ; Bhugra , C. ; Pikal , M.J. Heat and mass transfer scale up issues during freeze-drying, I: Control and characterization of the degree of supercooling . AAPS PharmSciTech 2004 , 5 ( 4 ), 1 – 9 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.