DNA-modifying enzyme reaction-based biosensors for disease diagnostics: recent biotechnological advances and future perspectives

References

• Abolhasan R, Mehdizadeh A, Rashidi MR, et al. Application of hairpin DNA-based biosensors with various signal amplification strategies in clinical diagnosis. Biosens Bioelectron. 2019;129:164–174.
   PubMed Web of Science ®Google Scholar
• Sawyers CL. The cancer biomarker problem. Nature. 2008;452(7187):548–552.
   PubMed Web of Science ®Google Scholar
• McManus DD, Freedman JE. MicroRNAs in platelet function and cardiovascular disease. Nat Rev Cardiol. 2015;12(12):711–717.
   PubMed Web of Science ®Google Scholar
• Yoo SM, Lee SY. Optical biosensors for the detection of pathogenic microorganisms. Trends Biotechnol. 2016;34(1):7–25.
   PubMed Web of Science ®Google Scholar
• Chamorro-Garcia A, Merkoçi A. Nanobiosensors in diagnostics. Nanobiomedicine (Rij. 2016;3:184954351666357.
   Google Scholar
• Sharifi M, Avadi MR, Attar F, et al. Cancer diagnosis using nanomaterials based electrochemical nanobiosensors. Biosens Bioelectron. 2019;126:773–784.
   PubMed Web of Science ®Google Scholar
• Vikrant K, Bhardwaj N, Bhardwaj SK, et al. Nanomaterials as efficient platforms for sensing DNA. Biomaterials. 2019;214:119215.
   PubMed Web of Science ®Google Scholar
• Kim YS, Raston NH, Gu MB. Aptamer-based nanobiosensors. Biosens Bioelectron. 2016;76:2–19.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Chen F, Li Q, et al. Isothermal amplification of nucleic acids. Chem Rev. 2015;115(22):12491–12545.
   PubMed Web of Science ®Google Scholar
• Tian L, Weizmann Y. Real-time detection of telomerase activity using the exponential isothermal amplification of telomere repeat assay. J Am Chem Soc. 2013;135(5):1661–1664.
   PubMed Web of Science ®Google Scholar
• Bi S, Cui Y, Dong Y, et al. Target-induced self-assembly of DNA nanomachine on magnetic particle for multi-amplified biosensing of nucleic acid, protein, and cancer cell. Biosens Bioelectron. 2014;53:207–213.
   PubMed Web of Science ®Google Scholar
• Bi S, Ye J, Dong Y, et al. Target-triggered cascade recycling amplification for label-free detection of microRNA and molecular logic operations. Chem Commun. 2016;52(2):402–405.
   PubMed Web of Science ®Google Scholar
• Asal M, Özen Ö, Şahinler M, et al. An overview of biomolecules, immobilization methods and support materials of biosensors. Sensor Review. 2019;39(3):377–386.
   Web of Science ®Google Scholar
• Vigneshvar S, Sudhakumari CC, Senthilkumaran B, et al. Recent advances in biosensor technology for potential applications - An overview. Front Bioeng Biotechnol. 2016;4:11.
   PubMed Web of Science ®Google Scholar
• Yoo SM, Kang T, Kim B, et al. Detection of single nucleotide polymorphisms by a gold nanowire-on-film SERS sensor coupled with S1 nuclease treatment. Chem Eur J. 2011;17(31):8657–8662.
   PubMed Web of Science ®Google Scholar
• Yoo SM, Kim DM, Lee SY. Multispot array combined with S1 nuclease-mediated elimination of unpaired nucleotides. BioChip J. 2015;9(2):156–163.
   Web of Science ®Google Scholar
• Bao B, Zhu J, Gong L, et al. Sensitive DNA detection using cascade amplification strategy based on conjugated polyelectrolytes and hybridization chain reaction. RSC Adv. 2017;7(6):3528–3533.
   Web of Science ®Google Scholar
• Wang J, Wang X, Wu S, et al. Fluorescent trimethyl-substituted naphthyridine as a label-free signal reporter for one-step and highly sensitive fluorescent detection of DNA in serum samples. Biosens Bioelectron. 2017;87:984–990.
   PubMed Web of Science ®Google Scholar
• Chen X, Lin C, Chen Y, et al. A label-free fluorescence strategy for selective detection of nicotinamide adenine dinucleotide based on a dumbbell-like probe with low background noise. Biosens Bioelectron. 2016;77:486–490.
   PubMed Web of Science ®Google Scholar
• Li H, Wang S, Wu Z, et al. New function of exonuclease and highly sensitive label-free colorimetric DNA detection. Biosens Bioelectron. 2016;77:879–885.
   PubMed Web of Science ®Google Scholar
• Chen HG, Ren W, Jia J, et al. Fluorometric detection of mutant DNA oligonucleotide based on toehold strand displacement-driving target recycling strategy and exonuclease III-assisted suppression. Biosens Bioelectron. 2016;77:40–45.
   PubMed Web of Science ®Google Scholar
• Zou P, Liu Y, Wang H, et al. G-quadruplex DNAzyme-based chemiluminescence biosensing platform based on dual signal amplification for label-free and sensitive detection of protein. Biosens Bioelectron. 2016;79:29–33.
   PubMed Web of Science ®Google Scholar
• Wu X, Chen J, Zhao JX. Ultrasensitive detection of 3'-5' exonuclease enzymatic activity using molecular beacons. Analyst. 2014;139(5):1081–1087.
   PubMed Web of Science ®Google Scholar
• Xiong E, Yan X, Zhang X, et al. Exonuclease III-assisted cascade signal amplification strategy for label-free and ultrasensitive electrochemical detection of nucleic acids. Biosens Bioelectron. 2017;87:732–736.
   PubMed Web of Science ®Google Scholar
• Feng Q, Zhao X, Guo Y, et al. Stochastic DNA walker for electrochemical biosensing sensitized with gold nanocages@graphene nanoribbons. Biosens Bioelectron. 2018;108:97–102.
   PubMed Web of Science ®Google Scholar
• Ren W, Zhang Y, Chen HG, et al. Ultrasensitive label-free resonance Rayleigh scattering aptasensor for Hg(2+) Using Hg(2+)-triggered exonuclease III-assisted target recycling and growth of G-wires for signal amplification. Anal Chem. 2016;88(2):1385–1390.
   PubMed Web of Science ®Google Scholar
• Liu Q, Li L, Zhao Y, et al. Colorimetric detection of DNA at the nanomolar level based on enzyme-induced gold nanoparticle de-aggregation. Mikrochim Acta. 2018;185(6):301.
   PubMed Web of Science ®Google Scholar
• Xu L, Shen X, Li B, et al. G-quadruplex based Exo III-assisted signal amplification aptasensor for the colorimetric detection of adenosine. Anal Chim Acta. 2017;980:58–64.
   PubMed Web of Science ®Google Scholar
• Zhang J, Huang J, He F. The construction of Mycobacterium tuberculosis 16S rDNA MSPQC sensor based on exonuclease III-assisted cyclic signal amplification. Biosens Bioelectron. 2019;138:111322.
   PubMed Web of Science ®Google Scholar
• Xu H, Wu D, Li CQ, et al. Label-free colorimetric detection of cancer related gene based on two-step amplification of molecular machine. Biosens Bioelectron. 2017;90:314–320.
   PubMed Web of Science ®Google Scholar
• Ou S, Xu T, Liu X, et al. Rapid and ultrasensitive detection of microRNA based on strand displacement amplification-mediated entropy-driven circuit reaction. Sens Actuators B-Chem. 2018;255:3057–3063.
   Web of Science ®Google Scholar
• Liu HY, Tian T, Zhang YH, et al. Sensitive and rapid detection of microRNAs using hairpin probes-mediated exponential isothermal amplification. Biosens Bioelectron. 2017;89:710–714.
   PubMed Web of Science ®Google Scholar
• Liu M, Ma F, Zhang Q, et al. Label-free and ultrasensitive detection of polynucleotide kinase activity at the single-cell level. Chem Commun. 2018;54(13):1583–1586.
   PubMed Web of Science ®Google Scholar
• Cheng R, Tao M, Shi Z, et al. Label-free and sensitive detection of T4 polynucleotide kinase activity via coupling DNA strand displacement reaction with enzymatic-aided amplification. Biosens Bioelectron. 2015;73:138–145.
   PubMed Web of Science ®Google Scholar
• Xu H, Xue C, Zhang R, et al. Exponential rolling circle amplification and its sensing application for highly sensitive DNA detection of tumor suppressor gene. Sens Actuators B-Chem. 2017;243:1240–1247.
   Web of Science ®Google Scholar
• Yin HS, Li BC, Zhou YL, et al. Signal-on fluorescence biosensor for microRNA-21 detection based on DNA strand displacement reaction and Mg2+-dependent DNAzyme cleavage. Biosens Bioelectron. 2017;96:106–112.
   PubMed Web of Science ®Google Scholar
• Yue S, Zhao T, Bi S, et al. Programmable strand displacement-based magnetic separation for simultaneous amplified detection of multiplex microRNAs by chemiluminescence imaging array. Biosens Bioelectron. 2017;98:234–239.
   PubMed Web of Science ®Google Scholar
• Cao J, Yao Y, Fan K, et al. Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Sci Adv. 2018;4(11):eaau4602.
   PubMed Web of Science ®Google Scholar
• Wu D, Xu H, Shi H, et al. A label-free colorimetric isothermal cascade amplification for the detection of disease-related nucleic acids based on double-hairpin molecular beacon. Anal Chim Acta. 2017;957:55–62.
   PubMed Web of Science ®Google Scholar
• Xu J, Qian J, Li H, et al. Intelligent DNA machine for the ultrasensitive colorimetric detection of nucleic acids. Biosens Bioelectron. 2016;75:41–47.
   PubMed Web of Science ®Google Scholar
• Yan YR, Shen B, Wang H, et al. A novel and versatile nanomachine for ultrasensitive and specific detection of microRNAs based on molecular beacon initiated strand displacement amplification coupled with catalytic hairpin assembly with DNAzyme formation. Analyst. 2015;140(16):5469–5474.
   PubMed Web of Science ®Google Scholar
• Zheng XJ, Niu L, Wei D, et al. Label-free detection of microRNA based on coupling multiple isothermal amplification techniques. Sci Rep. 2016;6(1):35982.
   PubMedGoogle Scholar
• Wang K, Fan D, Liu Y, et al. Cascaded multiple amplification strategy for ultrasensitive detection of HIV/HCV virus DNA. Biosens Bioelectron. 2017;87:116–121.
   PubMed Web of Science ®Google Scholar
• Chen J, Zhou XQ, Ma YJ, et al. Asymmetric exponential amplification reaction on a toehold/biotin featured template: an ultrasensitive and specific strategy for isothermal microRNAs analysis. Nucleic Acids Res. 2016;44(15):e130–19.
   PubMed Web of Science ®Google Scholar
• Zhang DY, Turberfield AJ, Yurke B, et al. Engineering entropy-driven reactions and networks catalyzed by DNA. Science. 2007;318(5853):1121–1125.
   PubMed Web of Science ®Google Scholar
• Lv YF, Cui L, Peng RZ, et al. Entropy beacon: a hairpin-free DNA amplification strategy for efficient detection of nucleic acids. Anal Chem. 2015;87(23):11714–11720.
   PubMed Web of Science ®Google Scholar
• Shi K, Dou BT, Yang CY, et al. DNA-fueled molecular machine enables enzyme-free target recycling amplification for electronic detection of microRNA from cancer cells with highly minimized background noise. Anal Chem. 2015;87(16):8578–8583.
   PubMed Web of Science ®Google Scholar
• He XW, Zeng T, Li Z, et al. Catalytic molecular imaging of microRNA in living cells by DNA-programmed nanoparticle disassembly. Angew Chem Int Ed. 2016;55(9):3073–3076.
   PubMed Web of Science ®Google Scholar
• Liu SF, Fang L, Tian YS, et al. Label-free, non-enzymatic and ultrasensitive electrochemical nucleic acid biosensing by tandem DNA-fueled target recycling and hybridization chain reaction. Sens Actuators B-Chem. 2017;244:450–457.
   Web of Science ®Google Scholar
• Zhang DY, Winfree E. Control of DNA strand displacement kinetics using toehold exchange. J Am Chem Soc. 2009;131(47):17303–17314.
   PubMed Web of Science ®Google Scholar
• Genot AJ, Zhang DY, Bath J, et al. Remote toehold: a mechanism for flexible control of DNA hybridization kinetics. J Am Chem Soc. 2011;133(7):2177–2182.
   PubMed Web of Science ®Google Scholar
• Wang M, Zhou Y, Yin H, et al. Signal-on electrochemiluminescence biosensor for microRNA-319a detection based on two-stage isothermal strand-displacement polymerase reaction. Biosens Bioelectron. 2018;107:34–39.
   PubMed Web of Science ®Google Scholar
• Yoo SM, Kang T, Kang H, et al. Combining a nanowire SERRS sensor and a target recycling reaction for ultrasensitive and multiplex identification of pathogenic fungi. Small. 2011;7(23):3371–3376.
   PubMed Web of Science ®Google Scholar
• Luo C, Tang H, Cheng W, et al. A sensitive electrochemical DNA biosensor for specific detection of Enterobacteriaceae bacteria by Exonuclease III-assisted signal amplification. Biosens Bioelectron. 2013;48:132–137.
   PubMed Web of Science ®Google Scholar
• Pei Q, Song X, Liu S, et al. A facile signal-on electrochemical DNA sensing platform for ultrasensitive detection of pathogenic bacteria based on Exo III-assisted autonomous multiple-cycle amplification. Analyst. 2019;144(9):3023–3029.
   PubMed Web of Science ®Google Scholar
• Pan J, Li Q, Zhou D, et al. Label-free and highly sensitive fluorescence detection of lead(ii) based on DNAzyme and exonuclease III-assisted cascade signal amplification. New J Chem. 2019;43(15):5857–5862.
   Web of Science ®Google Scholar
• Wang K, Zhai FH, He MQ, et al. A simple enzyme-assisted cascade amplification strategy for ultrasensitive and label-free detection of DNA. Anal Bioanal Chem. 2019;411(19):4569–4576.
   PubMed Web of Science ®Google Scholar
• Miao P, Han K, Wang B, et al. Electrochemical detection of aqueous Ag + based on Ag+-assisted ligation reaction. Sci Rep. 2015;5(1):9161.
   PubMedGoogle Scholar
• Jeong J, Kim H, Lee DJ, et al. RCA-based biosensor for electrical and colorimetric detection of pathogen DNA. Nanoscale Res Lett. 2016;11(1):242.
   PubMedGoogle Scholar
• Wu J, de Paz A, Zamft BM, et al. DNA binding strength increases the processivity and activity of a Y-Family DNA polymerase. Sci Rep. 2017;7(1):4756.
   PubMedGoogle Scholar
• Yan J, Beattie TR, Rojas AL, et al. Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme. Nat Commun. 2017;8(1):15075.
   PubMedGoogle Scholar
• Wang Y, Prosen DE, Mei L, et al. A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro. Nucleic Acids Res. 2004;32(3):1197–1207.
   PubMed Web of Science ®Google Scholar
• Sirin S, Pearlman DA, Sherman W. Physics-based enzyme design: predicting binding affinity and catalytic activity. Proteins. 2014;82(12):3397–3409.
   PubMed Web of Science ®Google Scholar
• Barrozo A, Borstnar R, Marloie G, et al. Computational protein engineering: bridging the gap between rational design and laboratory evolution. IJMS. 2012;13(12):12428–12460.
   Google Scholar
• Mailloux S, Gerasimova YV, Guz N, et al. Bridging the two worlds: A universal interface between enzymatic and DNA computing systems. Angew Chem Int Ed. 2015;54(22):6562–6566.
   PubMed Web of Science ®Google Scholar
• Katz E, Poghossian A, Schöning MJ. Enzyme-based logic gates and circuits-analytical applications and interfacing with electronics. Anal Bioanal Chem. 2017;409(1):81–94.
   PubMed Web of Science ®Google Scholar
• Arata H, Komatsu H, Han A, et al. Rapid microRNA detection using power-free microfluidic chip: coaxial stacking effect enhances the sandwich hybridization. Analyst. 2012;137(14):3234–3237.
   PubMed Web of Science ®Google Scholar
• Liu W, Zhu M, Liu H, et al. Invading stacking primer: a trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants. Biosens Bioelectron. 2016;81:309–316.
   PubMed Web of Science ®Google Scholar
• Wang L, Han Y, Xiao S, et al. Reverse strand-displacement amplification strategy for rapid detection of p53 gene. Talanta. 2018;187:365–369.
   PubMed Web of Science ®Google Scholar
• Srinivas N, Ouldridge TE, Šulc P, et al. On the biophysics and kinetics of toehold-mediated DNA strand displacement. Nucleic Acids Res. 2013;41(22):10641–10658.
   PubMed Web of Science ®Google Scholar
• Yang C, Dou B, Shi K, et al. Multiplexed and amplified electronic sensor for the detection of microRNAs from cancer cells. Anal Chem. 2014;86(23):11913–11918.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang LX, Luo F, et al. An electrochemiluminescence biosensor for Kras mutations based on locked nucleic acid functionalized DNA walkers and hyperbranched rolling circle amplification. Chem Commun. 2017;53(20):2910–2913.
   PubMed Web of Science ®Google Scholar
• Wang H-Q, Liu W-Y, Wu Z, et al. Homogeneous label-free genotyping of single nucleotide polymorphism using ligation-mediated strand displacement amplification with DNAzyme-based chemiluminescence detection. Anal Chem. 2011;83(6):1883–1889.
   PubMed Web of Science ®Google Scholar
• Tan E, Wong J, Nguyen D, et al. Isothermal DNA amplification coupled with DNA nanosphere-based colorimetric detection. Anal Chem. 2005;77(24):7984–7992.
   PubMed Web of Science ®Google Scholar
• Weizmann Y, Beissenhirtz MK, Cheglakov Z, et al. A virus spotlighted by an autonomous DNA machine. Angew Chem Int Ed. 2006;45(44):7384–7388.
   PubMed Web of Science ®Google Scholar
• Ding C, Li X, Ge Y, et al. Fluorescence detection of telomerase activity in cancer cells based on isothermal circular strand-displacement polymerization reaction. Anal Chem. 2010;82(7):2850–2855.
   PubMed Web of Science ®Google Scholar
• Yang L, Fung CW, Cho EJ, et al. Real-time rolling circle amplification for protein detection. Anal Chem. 2007;79(9):3320–3329.
   PubMed Web of Science ®Google Scholar
• Zhang YP, Cui YX, Li XY, et al. A modified exponential amplification reaction (EXPAR) with an improved signal-to-noise ratio for ultrasensitive detection of polynucleotide kinase. Chem Commun. 2019;55(53):7611–7614.
   PubMed Web of Science ®Google Scholar
• Jia HX, Li ZP, Liu CH, et al. Ultrasensitive detection of microRNAs by exponential isothermal amplification. Angew Chem Int Ed. 2010;49(32):5498–5501.
   PubMed Web of Science ®Google Scholar
• Huang M, Zhou X, Wang H, et al. Clustered regularly interspaced short palindromic repeats/Cas9 triggered isothermal amplification for site-specific nucleic acid detection. Anal Chem. 2018;90(3):2193–2200.
   PubMed Web of Science ®Google Scholar
• Reid MS, Le XC, Zhang H. Exponential isothermal amplification of nucleic acids and assays for proteins, cells, small molecules, and enzyme activities: An EXPAR example. Angew Chem Int Ed. 2018;57(37):11856–11866.
   PubMed Web of Science ®Google Scholar
• Xu Y, Wang Y, Liu S, et al. Ultrasensitive and rapid detection of miRNA with three-way junction structure-based trigger-assisted exponential enzymatic amplification. Biosens Bioelectron. 2016;81:236–241.
   PubMed Web of Science ®Google Scholar
• Esteban-Fernandez de Avila B, Araque E, Campuzano S, et al. Dual functional graphene derivative-based electrochemical platforms for detection of the TP53 gene with single nucleotide polymorphism selectivity in biological samples. Anal Chem. 2015;87(4):2290–2298.
   PubMed Web of Science ®Google Scholar
• Li X, Li DX, Zhou WJ, et al. A microRNA-activated molecular machine for non-enzymatic target recycling amplification detection of microRNA from cancer cells. Chem Commun. 2015;51(55):11084–11087.
   PubMed Web of Science ®Google Scholar
• Deng HM, Ren YQ, Shen W, et al. An ultrasensitive homogeneous chemiluminescent assay for microRNAs. Chem Commun. 2013;49(82):9401–9403.
   PubMed Web of Science ®Google Scholar
• Persano S, Valentini P, Kim JH, et al. Colorimetric detection of human papilloma virus by double isothermal amplification. Chem Commun. 2013;49(90):10605–10607.
   PubMed Web of Science ®Google Scholar
• Hong C, Kim DM, Baek A, et al. Fluorescence-based detection of single-nucleotide changes in RNA using graphene oxide and DNAzyme. Chem Commun. 2015;51(26):5641–5644.
   PubMed Web of Science ®Google Scholar
• Zhu DB, Zhang L, Ma WG, et al. Detection of microRNA in clinical tumor samples by isothermal enzyme-free amplification and label-free graphene oxide-based SYBR Green I fluorescence platform. Biosens Bioelectron. 2015;65:152–158.
   PubMed Web of Science ®Google Scholar
• Shi M, Chen J, Huang Y, et al. A multicolor nano-immunosensor for the detection of multiple targets. RSC Adv. 2013;3(33):13884–13890.
   Web of Science ®Google Scholar
• Qiang WB, Wang X, Li W, et al. A fluorescent biosensing platform based on the polydopamine nanospheres intergrating with exonuclease III-assisted target recycling amplification. Biosens Bioelectron. 2015;71:143–149.
   PubMed Web of Science ®Google Scholar
• Torabi SF, Lu Y. Functional DNA nanomaterials for sensing and imaging in living cells. Curr Opin Chem Biol. 2014;28:88–95.
   Google Scholar
• Wei Y, Zhang J, Wang X, et al. Amplified fluorescent aptasensor through catalytic recycling for highly sensitive detection of ochratoxin A. Biosens Bioelectron. 2015;65:16–22.
   PubMed Web of Science ®Google Scholar
• Wang P, Han P, Dong L, et al. Direct potential resolution and simultaneous detection of cytosine and 5-methylcytosine based on the construction of polypyrrole functionalized graphene nanowall interface. Electrochem Commun. 2015;61:36–39.
   Web of Science ®Google Scholar
• Cai SX, Chen M, Liu MM, et al. A signal amplification electrochemical aptasensor for the detection of breast cancer cell via free-running DNA walker. Biosens Bioelectron. 2016;85:184–189.
   PubMed Web of Science ®Google Scholar
• Ji YH, Zhang L, Zhu LY, et al. Binding-induced DNA walker for signal amplification in highly selective electrochemical detection of protein. Biosens Bioelectron. 2017;96:201–205.
   PubMed Web of Science ®Google Scholar
• Jung C, Allen PB, Ellington AD. A simple, cleated DNA walker that hangs on to surfaces. ACS Nano. 2017;11(8):8047–8054.
   PubMed Web of Science ®Google Scholar
• Pu QL, Li JL, Qiu JH, et al. Universal ratiometric electrochemical biosensing platform based on mesoporous platinum nanocomposite and nicking endonuclease assisted DNA walking strategy. Biosens Bioelectron. 2017;94:719–727.
   PubMed Web of Science ®Google Scholar
• Liu C, Hu Y, Pan Q, et al. A microRNA-triggered self-powered DNAzyme walker operating in living cells. Biosens. Bioelectron. 2019;136:31–37.
   PubMed Web of Science ®Google Scholar
• Yang L, Zhang Y, Li R, et al. Electrochemiluminescence biosensor for ultrasensitive determination of ochratoxin A in corn samples based on aptamer and hyperbranched rolling circle amplification. Biosens Bioelectron. 2015;70:268–274.
   PubMed Web of Science ®Google Scholar
• Yang L, Tao Y, Yue G, et al. Highly selective and sensitive electrochemiluminescence biosensor for p53 DNA sequence based on nicking endonuclease assisted target recycling and hyperbranched rolling circle amplification. Anal Chem. 2016;88(10):5097–5103.
   PubMed Web of Science ®Google Scholar
• Liao H, Zhou Y, Chai Y, et al. An ultrasensitive electrochemiluminescence biosensor for detection of MicroRNA by in-situ electrochemically generated copper nanoclusters as luminophore and TiO2 as coreaction accelerator. Biosens Bioelectron. 2018;114:10–14.
   PubMed Web of Science ®Google Scholar
• Xu H, Jiang Y, Liu D, et al. Twin target self-amplification-based DNA machine for highly sensitive detection of cancer-related gene. Anal Chim Acta. 2018;1011:86–93.
   PubMed Web of Science ®Google Scholar
• Deng RJ, Tang LH, Tian Q, et al. Toehold-initiated rolling circle amplification for visualizing individual microRNAs in situ in single cells. Angew Chem Int Ed. 2014;53(9):2389–2393.
   PubMed Web of Science ®Google Scholar
• Li H, Ren J, Liu Y, et al. Application of DNA machine in amplified DNA detection. Chem Commun. 2014;50(6):704–706.
   PubMed Web of Science ®Google Scholar
• Wang K, Ren J, Fan D, et al. Integration of graphene oxide and DNA as a universal platform for multiple arithmetic logic units. Chem Commun. 2014;50(92):14390–14393.
   PubMed Web of Science ®Google Scholar
• Li J, Jia Y, Zheng J, et al. Aptamer degradation inhibition combined with DNAzyme cascade-based signal amplification for colorimetric detection of proteins. Chem Commun. 2013;49(55):6137–6139.
   PubMed Web of Science ®Google Scholar
• Zhang S, Wang K, Huang C, et al. Reconfigurable and resettable arithmetic logic units based on magnetic beads and DNA. Nanoscale. 2015;7(48):20749–20756.
   PubMed Web of Science ®Google Scholar
• Zhou W, Gong X, Xiang Y, et al. Quadratic recycling amplification for label-free and sensitive visual detection of HIV DNA. Biosens Bioelectron. 2014;55:220–224.
   PubMed Web of Science ®Google Scholar
• Shen ZF, Li F, Jiang YF, et al. Palindromic molecule beacon-based cascade amplification for colorimetric detection of cancer genes. Anal Chem. 2018;90(5):3335–3340.
   PubMed Web of Science ®Google Scholar
• Yang ZH, Zhuo Y, Yuan R, et al. An amplified electrochemical immunosensor based on in situ-produced 1-naphthol as electroactive substance and graphene oxide and Pt nanoparticles functionalized CeO2 nanocomposites as signal enhancer. Biosens Bioelectron. 2015;69:321–327.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhao Z, Lei Z, et al. Sensitive detection of polynucleotide kinase activity by paper-based fluorescence assay with λ exonuclease assistance. Anal Chem. 2016;88(23):11358–11363.
   PubMed Web of Science ®Google Scholar