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Articles

Protease activated receptor-2 (PAR2): possible target of phytochemicals

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Pages 2003-2022 | Received 18 Aug 2014, Accepted 06 Nov 2014, Published online: 13 Dec 2014

References

  • Alex, A., Millan, D. S., Perez, M., Wakenhut, F., & Whitlock, G. A. (2011). Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space. Medicinal Chemistry Communication, 2, 669–674. doi:10.1039/C1MD00093D.
  • Anna, R. M., Rayhana, R. B., Andrew, B. F., Charles, D. C., Rachael, L. H., & Jeannine, S. S. (2004). Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochemical Pharmacology, 68, 1729–1738.
  • Aqil, F.1., Munagala, R., Jeyabalan, J., & Vadhanam, M. V. (2013, February 19). Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Letters, 13, 00158–00164, S0304–3835. doi:10.1016/j.canlet.2013.02.032
  • Aravindan, S., Natarajan, M., Herman, T. S., Awasthi, V., & Aravindan, N. (2013, March 4). Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization, phytochemicals converge on radiation induced rel signaling. Radiation Oncology, 8, 46. doi:10.1186/1748-717X-8-4610.1186/1748-717X-8-46
  • Ballesteros, J. A., Weinstein, H., & Stuart, C. S. (1995). Integrated methods for the construction of three-dimensional models and computational probing of structure–function relations in G protein coupled receptors. Methods in Neurosciences, 25, 366–428.
  • Bao, G. Q., Shen, B. Y., Pan, C. P., Zhang, Y. J., Shi, M. M., & Peng, C. H. (2013). Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology Letters, 12222, 23–35.
  • Barreiro, G., Guimarães, C. R., Tubert-Brohman, I., Lyons, T. M., Tirado-Rives, J., & Jorgensen, W. L. J. (2007). Search for non-nucleoside inhibitors of HIV-1 reverse transcriptase using chemical similarity molecular docking and MMGB/SA scoring. Chemical Information and Modeling, 47, 2416–2428.
  • Barry, G. D., Le, G. T., & Fairlie, D. P. (2006). Agonists and antagonists of protease activated receptors (PARs). Current Medicinal Chemistry, 13, 243–265.
  • Barry, G. D., Suen, J. Y., Le, G. T., Cotterell, A., Reid, R. C., & Fairlie, D. P. (2010). Novel agonists and antagonists for human protease activated receptor 2. Journal of Medicinal Chemistry, 53, 7428–7440.
  • Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., … Bunnett, N. W. (1996). Molecular cloning expression and potential functions of the human proteinase-activated receptor 2. Biochemical Journal, 314, 1009–1016.
  • Bouquet, J., Rivaud, M., Chevalley, S., Deharo, E., Jullian, V., & Valentin, A. (2012). Biological activities of nitidine a potential anti-malarial lead compound. Malaria Journal, 11, 67.10.1186/1475-2875-11-67
  • Bowers, K. J., Chow, E., Xu, H., Dror, R. O., Eastwood, M. P., Gregersen, B. A., … Shaw, D. E. (2006, November 11–17). Scalable Algorithms for Molecular Dynamics Simulations on Commodity Clusters. In SC Conference Proceedings of the ACM/IEEE (pp. 4311–4317).
  • Bulotta, S., Corradino, R., Celano, M., Maiuolo, J., D’Agostino, M., Oliverio, M., … Russo, D. (2013). Antioxidant and antigrowth action of per acetylated oleuropein in thyroid cancer cells. Journal of Molecular Endocrinology, 5, 181–189.
  • Cárdeno, A., Sánchez-Hidalgo, M., & Alarcón-de-la-Lastra, C. (2013). An up-date of olive oil phenols in inflammation and cancer, molecular mechanisms and clinical implications. Current Medicinal Chemistry, 20, 4758–4776.
  • Catania, A., Barrajón-Catalán, E., Nicolosi, S., Cicirata, F., & Micol, V. (2013). Immunoliposome encapsulation increases cytotoxic activity and selectivity of curcumin and resveratrol against HER2 over expressing human breast cancer cells. Breast Cancer Research and Treatment, 141, 55–65.
  • Chadwick, M., Trewin, H., Gawthrop, F., & Wagstaff, C. (2013). Sesquiterpenoids lactones, benefits to plants and people. International Journal of Molecular Sciences, 14, 12780–12805.
  • Chen, J. (2014). Editorial: Phytochemicals, intracellular signalling pathways and anti-cancer effects. Anti-Cancer Agents in Medicinal Chemistry, 14, 777–778.
  • Chen, X. W., Di, Y. M., Zhang, J., Zhou, Z. W., Li, C. G., & Zhou, S. F. (2012). Interaction of herbal compounds with biological targets, a case study with berberine. Scientific World Journal. Article ID 708292, 31 pages. doi:10.1100/2012/708292
  • Coughlin, S. R., & Camerer, E. (2003). Participation in inflammation. Journal of Clinical Investigation, 111, 25–27.
  • Dai, G. F., Zhao, J., Jiang, Z. W., Zhu, L. P., Xu, H. W., Ma, W. Y., … Liu, H. M. (2011). Anti-inflammatory effect of novel andrographolide derivatives through inhibition of NO and PGE2 production. International Immunopharmacology, 11, 2144–2149.
  • Deng, Z., Chuaqui, C., & Singh, J. (2004). Structural interaction fingerprint (SIFt). A novel method for analyzing threedimensional proteinligand binding interactions. Journal of Medicinal Chemistry, 47, 337–344.
  • Du, J., Sun, H., Xi, L., Li, J., Yang, Y., Liu, H., & Yao, X. (2011). Molecular modeling study of checkpoint kinase 1 inhibitors by multiple docking strategies and Prime/MMGBSA. Journal of Computational Chemistry, 32, 2800–2808.
  • Elamin, M. H., Daghestani, M. H., Omer, S. A., Elobeid, M. A., Virk, P., Al-Olayan, E. M., … Aboussekhra, A. (2013). Olive oil oleuropein has anti-breast cancer properties with higher efficiency on ER-negative cells. Food and Chemical Toxicology, 53, 310–316.
  • Farid, R., Day, T., Friesner, R. A., & Pearlstein, R. A. (2006). New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies. Bioorganic & Medicinal Chemistry, 14, 3160–3173.
  • Friesner, R. A., Banks, J. L., Murphy, R. B., Halgren, T. A., Klicic, J. J., Mainz, D. T., … Shenkin, P. S. (2004). Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. Journal of Medicinal Chemistry, 47, 1739–1749.
  • Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., … Mainz, D. T. (2006). Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein−ligand complexes. Journal of Medicinal Chemistry, 49, 6177–6196.
  • Gieseler, F., Ungefroren, H., Settmacher, U., Hollenberg, M. D., & Kaufmann, R. (2013). Proteinase-activated receptors (PARs) – Focus on receptor–receptor-interactions and their physiological and pathophysiological impact. Cell Communication and Signaling, 11, 86.10.1186/1478-811X-11-86
  • Halgren, T. A., Murphy, R. B., Friesner, R. A., Beard, H. S., Frye, L. L., Pollard, W. T., & Banks, J. L. (2004). Glide: A new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. Journal of Medicinal Chemistry, 47, 1750–1759.
  • Han, S. S., Keum, Y. S., Chun, K. S., & Surh, Y. J. (2002). Suppression of phorbol ester-induced nf-κB activation by capsaicin in cultured human promyelocytic leukemia cells. Archives of Pharmacal Research, 25, 475–479.10.1007/BF02976605
  • Hassan, Z. K., Elamin, M. H., Omer, S. A., Daghestani, M. H., Al-Olayan, E. S., Elobeid, M. A., & Virk, P. (2013). Oleuropein induces apoptosis via the p53 pathway in breast cancer cells. Asian Pacific Journal of Cancer Prevention, 14, 6739–6742.
  • Hjortoe, G. M., Petersen, L. C., Albrektsen, T., Sorensen, B. B., Norby, P. L., Mandal, S. K., … Rao, L. V. (2004). Tissue factor–factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration. Blood, 103, 3029–3037.
  • Hou, T., Wang, J., Li, Y., & Wang, W. (2011). Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking. Journal of Computational Chemistry, 32, 866–877.10.1002/jcc.v32.5
  • Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., … Kuo, P. L. (2011). Glabridin an isoflavan from licorice root inhibits migration invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/rho signaling pathway. Molecular Nutrition & Food Research, 55, 318–327.
  • Hussain, A., Mohsin, J., Prabhu, S. A., Begum, S., Nusri, Qel-A, … Sharma, C. (2013). Sulforaphane inhibits growth of human breast cancer cells and augments the therapeutic index of the chemotherapeutic drug, gemcitabine. Asian Pacific Journal of Cancer Prevention, 14, 5855–5860.
  • Inoue, M., Tajima, K., Mizutani, M., Iwata, H., Iwase, T., Miura, S., … Tominaga, S. (2001). Regular consumption of green tea and the risk of breast cancer recurrence follow-up study from the hospitalbased epidemiologic research program at aichi cancer center (HERPACC). Japan Cancer Letters, 167, 175–182; Journal of Natural Products, 70, 461–477.
  • Jaber, M., Maoz, M., Kancharla, A., Agranovich, D., Peretz, T., Grisaru-Granovsky, S., … Bar-Shavit, R. (2013). Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer. Cellular and Molecular Life Sciences, 71, 2517–2533.
  • Jacobson, M. P., Kaminski, G. A., Friesner, R. A., & Rapp, C. S. (2002). Force field validation using protein side chain prediction. Journal of Physical Chemistry, 106, 11673–11680.
  • Jacobson, M. P., Pincus, D. L., Rapp, C. S., Day, T. J. F., Honig, B., Shaw, D. E., & Friesner, R. A. (2004). A hierarchical approach to all-atom protein loop prediction. Proteins: Structure, Function and Bioinformatics, 55, 351–367.
  • Jorgensen, W. L., & Duffy, E. (2002). Prediction of drug solubility from structure. Advanced Drug Delivery Reviews, 54, 355–366.
  • Joseph, M., & Hayes, G. A. (2012). MM-GB(PB)sa calculations of protein–ligand binding free energies molecular dynamics. In L. Wang (Ed.), Studies of synthetic and biological macromolecules. InTech. ISBN: 978-953-51-0444-5. Retrieved from http://www.intechopen.com/books/moleculardynamics-studies-of-synthetic-and-biological-macromolecules/mm-gb-pb-sa-calculations-of-protein-ligandbinding-free-energies
  • Kakarala, K. K., Jamil, K., & Devaraji, V. (2014). Structure and putative signaling mechanism of Protease activated receptor (PAR2) – A promising target for breast cancer. Journal of Molecular Graphics and Modelling, 53, 179–199. doi:10.1016/j.jmgm.2014.07.012
  • Kang, Y., Park, M. A., Heo, S. W., Park, S. Y., Kang, K. W., Park, P. H., & Kim, J. A. (2013). The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells. Biochimica et Biophysica Acta, 1830, 2638–2648.
  • Kanke, T., Kabeya, M., Kubo, S., Kondo, S., Yasuoka, K., Tagashira, J., … Ishiwata, H. (2009, September). Novel antagonists for proteinase-activated receptor 2: Inhibition of cellular and vascular responses in vitro and in vivo. British Journal of Pharmacology, 158, 361–371. doi:10.1111/j.1476-5381.2009.00342.x10.1111/bph.2009.158.issue-1
  • Kapadia, G. J., Rao, G. S., Ramachandran, C., Iida, A., Suzuki, N., & Tokuda, H. J. (2013). Synergistic cytotoxicity of red beetroot (Beta vulgaris L) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. Journal of Complementary and Integrative Medicine, 10.
  • Khag, M. K., Ansari, I. A., & Khan, M. S. (2013). Dietary phytochemicals as potent chemotherapeutic agents against breast cancer, Inhibition of NF-κB pathway via molecular interactions in rel homology domain of its precursor protein p105. Pharmacognosy Magazine, 33, 51–57.
  • Kim, M. B., O’Brien, T. E., Moore, J. T., Anderson, D. E., Foss, M. H., Weibel, D. L., … Shaw, J. T. (2012). The synthesis and antimicrobial activity of heterocyclic derivatives of totarol. ACS Medicinal, Chemistry Letters, 3, 818–822.
  • Kim, S. Y., Lee, I. S., & Moon, A. (2013). 2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells. Chemico-Biological Interactions, 203, 565–572.
  • Klinski, E., Semov, A., Yan, X., Alakhov, V., Muyzhnek, E., Kiselev, V. (2013). Block copolymer based composition of epigallocatechin-3-gallate with improved oral bioavailability as a way to increase its therapeutic activity. Journal of Nanomedicine & Biotherapeutic Discovery, 3, 117.
  • Kollman, P. A., Massova, I., Reyes, C., Kuhn, B., Huo, S., Chong, L., … Lee, M. (2000). Calculating structures and free energies of complex molecules: Combining molecular mechanics and continuum models. Accounts of Chemical Research, 33, 889–897.10.1021/ar000033j
  • Lee, K. W., Bode, A. M., & Dong, Z. (2011). Molecular targets of phytochemicals for cancer prevention. Nature Reviews Cancer, 11, 211–218. Epub: 2011, February 10. doi:10.1038/nrc301710.1038/nrc3017
  • Liu, D., & Chen, Z. (2013). The effect of curcumin on breast cancer cells. Journal of Breast Cancer, 16, 133–137.
  • Liu, Y., & Mueller, B. M. (2006). Protease-activated receptor-2 regulates vascular endothelial growth factor expression in MDA-MB-231 cells via MAPK pathways. Biochemical and Biophysical Research Communications, 344, 1263–1270.
  • Luo, W., Liu, Y., Zhang, J., Luo, X., Lin, C., & Guo, J. (2013). Andrographolide inhibits the activation of NF-κB and MMP-9 activity in H3255 lung cancer cells. Experimental and Therapeutic Medicine, 6, 743–746.
  • Lyne, P. D., Lamb, M. L., & Saeh, J. C. (2006). Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring. Journal of Medicinal Chemistry, 49, 4805–4808.
  • MacFarlane, S. R., Seatter, M. J., Kanke, T., Hunter, G. D., & Plevin, R. (2001). Proteinase-activated receptors. Pharmacological Reviews, 53, 245–282.
  • Matej, R., Mandáková, P., Netíková, I., Poucková, P., & Olejár, T. (2007). Proteinase-activated receptor-2 expression in breast cancer and the role of trypsin on growth and metabolism of breast cancer cell line MDA MB-231. Physiological Research, 56, 475–484.
  • Menendez, J. A., Vazquez-Martin, A., Garcia-Villalba, R., Carrasco-Pancorbo, A., Oliveras-Ferraros, C., Fernandez-Gutierrez, A., & Segura-Carretero, A. (2008). Anti-HER2 (erbB-2) oncogene effects of phenolic compounds directly isolated from commercial extra-virgin olive oil (EVOO). BMC Cancer, 8, 377.
  • Mirza, R. H., Chi, N., & Chi, Y. (2013). Therapeutic potential of the natural product mangiferin in metabolic syndrome. Journal of Nutritional Therapeutics, 2, 74–79.
  • Morris, D. R., Ding, Y., Ricks, T. K., Gullapalli, A., Wolfe, B. L., & Trejo, J. (2006). Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling migration and invasion of breast cancer cells. Cancer Research, 66, 307–314.
  • Ouhtit, A., Gaur, R. L., Abdraboh, M., Ireland, S. K., & Rao, P. N. (2013). Simultaneous inhibition of cell-cycle, proliferation, survival, metastatic pathways and induction of apoptosis in breast cancer cells by a phytochemical super-cocktail, genes that underpin its mode of action. Journal of Cancer, 144, 703–715.
  • Parisis, N., Metodieva, G., & Metodiev, M. V. (2013). Pseudopodial and β-arrestin-interacting proteomes from migrating breast cancer cells upon PAR2 activation. Journal of Proteomics, 980, 91–106.
  • Schaffner, F., Versteeg, H. H., Schillert, A., Yokota, N., Petersen, L. C., Mueller, B. M., & Ruf, W. (2010). Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development. Blood, 23116, 6106–6113.
  • Schmidt, B. M., Ribnicky, D. M., Lipsky, P. E., & Raskin, I. (2007). Revisiting the ancient concept of botanical therapeutics. Nature Chemical Biology, 3, 360–366.
  • Shehzad, A., & Lee, Y. S. (2013). Molecular mechanisms of curcumin action: Signal transduction. BioFactors, 1, 27–36.
  • Sherman, W., Beard, H. S., & Farid, R. (2006). Use of an induced fit receptor structure in virtual screening. Chemical Biology & Drug Design, 67, 83–84.
  • Sherman, W., Day, T., Jacobson, M. P., Friesner, R. A., & Farid, R. (2006). Novel procedure for modeling ligand/receptor induced fit effects. Journal of Medicinal Chemistry, 49, 534–553.
  • Shivakumar, D., Williams, J., Wu, Y., Damm, W., Shelley, J., & Sherman, W. (2010). Prediction of absolute solvation free energies using molecular dynamics free energy perturbation and the OPLS force field. Journal of Chemical Theory and Computation, 6, 1509–1519.
  • Singh, A. K., Manoharan, S., Vasudevan, K., Rajasekaran, D., Manimaran, A., & Suresh, K. (2013). Anti-cell proliferative and anti-angiogenic potential of andrographolide during 7, 12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis. Asian Pacific Journal of Cancer Prevention: APJCP, 14, 6001–6005.
  • Singh, B. N., Shankar, S., & Srivastava, R. K. (2011). Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochemical Pharmacology, 82, 1807–1821. Epub: 2011, July 30. doi:10.1016/j.bcp.2011.07.09310.1016/j.bcp.2011.07.093
  • Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., … Hollenberg, M. D. (2005). Proteinase-activated receptors, transducers of proteinase-mediated signaling in inflammation and immune response. Endocrine Reviews, 26, 1–43.
  • Su, S., Li, Y., Luo, Y., Sheng, Y., Su, Y., Padia, R. N., … Huang, S. (2009). Proteinase-activated receptor 2 expression in breast cancer and its role in breast cancer cell migration. Oncogene, 28, 3047–3057.
  • Suen, J. Y., Barry, G. D., Lohman, R. J., Halili, M. A., Cotterell, A. J., Le, G. T., & Fairlie, D. P. (2012). Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110). British Journal of Pharmacology, 165, 1413–1423.10.1111/j.1476-5381.2011.01610.x
  • Surh, Y. J., Han, S. S., Keum, Y. S., Seo, H. J., & Lee, S. S. (2002). Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1. BioFactors, 12, 112–107.
  • Tamir, S., Eizenberg, M., Somjen, D., Stern, N., Shelach, R., Kaye, A., & Vaya, J. (2000). Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Research, 60, 5704–5709.
  • Trivedi, N. P., Rawal, U. M., & Patel, B. P. (2007). Hepatoprotective effect of andrographolide against hexachlorocyclohexane-induced oxidative injury. Integrative Cancer Therapies, 6, 271–280.
  • Vadodkar, A. S., Suman, S., Lakshmanaswamy, R., & Damodaran, C. (2012). Chemoprevention of breast cancer by dietary compounds. Anti-Cancer Agents in Medicinal Chemistry, 10, 1185–1202.
  • Venugopal, R., & Liu, R. H. (2012). Phytochemicals in diets for breast cancer prevention, the importance of resveratrol and ursolic acid. Food Science and Human Wellness, 1, 1–13.10.1016/j.fshw.2012.12.001
  • Versteeg, H. H., Schaffner, F., Kerver, M., Ellies, L. G., Andrade-Gordon, P., Mueller, B. M., & Ruf, W. (2008). Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Research, 168, 7219–7227.
  • Wang, L. J., Zhou, X., Wang, W., Tang, F., Qi, C. L., Yang, X., … Geng, J. G. (2013). Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation. Journal of Dental Research, 90, 1246–1252.
  • Yang, C. S., & Wang, X. (2010). Green tea and cancer prevention. Nutrition and Cancer, 62, 931–937.
  • Yiannakopoulou, E. C. (2013). Green tea catechins, proposed mechanisms of action in breast cancer focusing on the interplay between survival and apoptosis. Anti-Cancer Agents in Medicinal Chemistry, 14, 290–295.
  • Zhang, C., Srinivasan, Y., Arlow, D. H., Fung, J. J., Palmer, D., Zheng, Y., … Kobilka, B. K. (2012). High-resolution crystal structure of human protease-activated receptor. Nature, 492, 387–392.

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