Withanone and caffeic acid phenethyl ester are predicted to interact with main protease (M^pro) of SARS-CoV-2 and inhibit its activity

References

• Aanouz, I., Belhassan, A., El Khatabi, K., Lakhlifi, T., El Idrissi, M., & Bouachrine, M. (2020). Moroccan medicinal plants as inhibitors against SARS-CoV-2 main protease: Computational investigations. Journal of Biomolecular Structure and Dynamics, 1–9. https://doi.org/10.1080/07391102.2020.1758790
   PubMed Web of Science ®Google Scholar
• Abdelli, I., Hassani, F., Bekkel Brikci, S., & Ghalem, S. (2020). In silico study the inhibition of Angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from western Algeria. Journal of Biomolecular Structure and Dynamics, 1–17. https://doi.org/10.1080/07391102.2020.1763199
   PubMed Web of Science ®Google Scholar
• Akyol, S., Ozturk, G., Ginis, Z., Armutcu, F., Yigitoglu, M. R., & Akyol, O. (2013). In vivo and in vitro antineoplastic actions of caffeic acid phenethyl ester (CAPE): therapeutic perspectives. Nutrition and Cancer, 65(4), 515–526. https://doi.org/10.1080/01635581.2013.776693
   PubMed Web of Science ®Google Scholar
• Al-Khafaji, K., Al-DuhaidahawiL, D., & Taskin Tok, T. (2020). Using integrated computational approaches to identify safe and rapid treatment for SARS -CoV- 2. Journal of Biomolecular Structure and Dynamics, 1–11. https://doi.org/10.1080/07391102.2020.1764392
   Web of Science ®Google Scholar
• Amoros, M., Lurton, E., Boustie, J., Girre, L., Sauvager, F., & Cormier, M. (1994). Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate. Journal of Natural Products, 57(5), 644–647. https://doi.org/10.1021/np50107a013
   PubMed Web of Science ®Google Scholar
• Anjaly, K., & Tiku, A. B. (2018). Radio-modulatory potential of caffeic acid phenethyl ester: A therapeutic perspective. Anti-Cancer Agents in Medicinal Chemistry, 18(4), 468–475. https://doi.org/10.2174/1871520617666171113143945
   PubMed Web of Science ®Google Scholar
• Balkrishna, A., Pokhrel, S., Singh, J., & Varshney, A. (2020). Withanone from Withania somnifera may inhibit novel Coronavirus (COVID-19) entry by disrupting interactions between viral S-protein receptor binding domain and host ACE2 receptor. Virology Journal, 1–26. https://doi.org/10.21203/rs.3.rs-17806/v1
   PubMed Web of Science ®Google Scholar
• Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., & Ciccozzi, M. (2020). The 2019-new coronavirus epidemic: Evidence for virus evolution. Journal of Medical Virology, 92(4), 455–459. https://doi.org/10.1002/jmv.25688
   PubMed Web of Science ®Google Scholar
• Boopathi, S., Poma, A. B., & Kolandaivel, P. (2020). Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/10.1080/07391102.2020.1758788
   PubMed Web of Science ®Google Scholar
• Bowers, K. J., Chow, D. E., Xu, H., Dror, R. O., Eastwood, M. P., Gregersen, B. A., Klepeis, J. L., Kolossvary, I., Moraes, M. A., Sacerdoti, F. D., & Salmon, J. K. (2006). Scalable algorithms for molecular dynamics simulations on commodity clusters [Paper presentation]. SC ‘06: Proceedings of the 2006 ACM/IEEE Conference on Supercomputing, Tampa, Florida (pp. 43–44). Association for Computing Machinery. https://doi.org/10.1109/SC.2006.54
   Google Scholar
• Cai, Z., Zhang, G., Tang, B., Liu, Y., Fu, X., & Zhang, X. (2015). Promising anti-influenza properties of active constituent of withania somnifera ayurvedic herb in targeting neuraminidase of H1N1 influenza: Computational study. Cell Biochemistry and Biophysics, 72(3), 727–739. https://doi.org/10.1007/s12013-015-0524-9
   PubMed Web of Science ®Google Scholar
• Ceraolo, C., & Giorgi, F. M. (2020). Genomic variance of the 2019-nCoV coronavirus. Journal of Medical Virology, 92(5), 522–528. https://doi.org/10.1002/jmv.25700
   PubMed Web of Science ®Google Scholar
• Chang, Y. C., Tung, Y. A., Lee, K. H., Chen, T. F., Hsiao, Y. C., Chang, H. C., Hsieh, T. T., Su, C. H., Wang, S. S., Yu, J. Y., & Shih, S. S. (2020). Potential therapeutic agents for COVID-19 based on the analysis of protease and RNA polymerase potential therapeutic agents for COVID-19 based on the analysis of protease and RNA polymerase docking. Preprints, 1–11. https://doi.org/10.20944/preprints202002.0242.v1
   Google Scholar
• Coleman, J. J., Komura, T., Munro, J., Wu, M. P., Busanelli, R. R., Koehler, A. N., Thomas, M., Wagner, F. F., Holson, E. B., & Mylonakis, E. (2016). Activity of caffeic acid phenethyl ester in Caenorhabditis elegans. Future Medicinal Chemistry, 8(17), 2033–2046. https://doi.org/10.4155/fmc-2016-0085
   PubMed Web of Science ®Google Scholar
• Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. (2020). The species severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2. Nature Microbiology, 5(4), 536–544. https://doi.org/10.1038/s41564-020-0695-z
   PubMed Web of Science ®Google Scholar
• Costi, R., Di Santo, R., Artico, M., Massa, S., Ragno, R., Loddo, R., La Colla, M., Tramontano, E., La Colla, P., & Pani, A. (2004). 2,6-Bis(3,4,5-trihydroxybenzylydene) derivatives of cyclohexanone: Novel potent HIV-1 integrase inhibitors that prevent HIV-1 multiplication in cell-based assays. Bioorganic & Medicinal Chemistry, 12(1), 199–215. https://doi.org/10.1016/j.bmc.2003.10.005
   PubMed Web of Science ®Google Scholar
• Das, S., Sarmah, S., Lyndem, S., & Singha Roy, A. (2020). An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study. Journal of Biomolecular Structure and Dynamics, 1–18. https://doi.org/10.1080/07391102.2020.1763201
   PubMed Web of Science ®Google Scholar
• De Clercq, E. (2002). Strategies in the design of antiviral drugs. Nature Reviews. Drug Discovery, 1(1), 13–25. https://doi.org/10.1038/nrd703
   PubMed Web of Science ®Google Scholar
• Demestre, M., Messerli, S. M., Celli, N., Shahhossini, M., Kluwe, L., Mautner, V., & Maruta, H. (2009). CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytotherapy Research: PTR, 23(2), 226–230. https://doi.org/10.1002/ptr.2594
   PubMed Web of Science ®Google Scholar
• Elfiky, A. A. (2020). SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: An in silico perspective. Journal of Biomolecular Structure and Dynamics, 1–9. https://doi.org/10.1080/07391102.2020.1761882
   PubMed Web of Science ®Google Scholar
• Elmezayen, A. D., Al-Obaidi, A., Şahin, A. T., & Yelekçi, K. (2020). Drug repurposing for coronavirus (COVID-19): In silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes. Journal of Biomolecular Structure and Dynamics, 1–13. https://doi.org/10.1080/07391102.2020.1758791
   PubMed Web of Science ®Google Scholar
• Enmozhi, S. K., Raja, K., Sebastine, I., & Joseph, J. (2020). Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: An in silico approach. Journal of Biomolecular Structure and Dynamics, 1–7. https://doi.org/10.1080/07391102.2020.1760136
   PubMed Web of Science ®Google Scholar
• Erdemli, H. K., Akyol, S., Armutcu, F., & Akyol, O. (2015). Antiviral properties of caffeic acid phenethyl ester and its potential application. Journal of Intercultural Ethnopharmacology, 4(4), 344–347. https://doi.org/10.5455/jice.20151012013034
   PubMedGoogle Scholar
• FDA News Release. (2020). Coronavirus (COVID-19) update: FDA Issues emergency use authorization for potential COVID-19 treatment. Retrieved May 01, 2020, from https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment.
   Google Scholar
• Fesen, M. R., Kohn, K. W., Leteurtre, F., & Pommier, Y. (1993). Inhibitors of human immunodeficiency virus integrase. Proceedings of the National Academy of Sciences, 90(6), 2399–2403. https://doi.org/10.1073/pnas.90.6.2399
   PubMed Web of Science ®Google Scholar
• Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., Sanschagrin, P. C., & Mainz, D. T. (2006). Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. Journal of Medicinal Chemistry, 49(21), 6177–6196. https://doi.org/10.1021/jm051256o
   PubMed Web of Science ®Google Scholar
• Friesner, R. A., Banks, J. L., Murphy, R. B., Halgren, T. A., Klicic, J. J., Mainz, D. T., Repasky, M. P., Knoll, E. H., Shelley, M., Perry, J. K., Shaw, D. E., Francis, P., & Shenkin, P. S. (2004). Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. Journal of Medicinal Chemistry, 47(7), 1739–1749. https://doi.org/10.1021/jm0306430
   PubMed Web of Science ®Google Scholar
• Graham, R. L., Donaldson, E. F., & Baric, R. S. (2013). A decade after SARS: Strategies for controlling emerging coronaviruses. Nature Reviews. Microbiology, 11(12), 836–848. https://doi.org/10.1038/nrmicro3143
   PubMed Web of Science ®Google Scholar
• Greenwood, J. R., Calkins, D., Sullivan, A. P., & Shelley, J. C. (2010). Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution. Journal of Computer-Aided Molecular Design, 24(6–7), 591–604. https://doi.org/10.1007/s10822-010-9349-1
   PubMed Web of Science ®Google Scholar
• Gupta, M. K., & Vadde, R. (2020). Insights into the structure-function relationship of both wild and mutant zinc transporter ZnT8 in human: A computational structural biology approach. Journal of Biomolecular Structure & Dynamics, 38(1), 137–151. https://doi.org/10.1080/07391102.2019.1567391
   PubMed Web of Science ®Google Scholar
• Gupta, M. K., Vemula, S., Donde, R., Gouda, G., Behera, L., & Vadde, R. (2020). In-silico approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel. Journal of Biomolecular Structure and Dynamics, 1–11. https://doi.org/10.1080/07391102.2020.1751300
   PubMed Web of Science ®Google Scholar
• Gyebi, G. A., Ogunro, O. B., Adegunloye, A. P., Ogunyemi, O. M., & Afolabi, S. O. (2020). Potential inhibitors of Coronavirus 3-Chymotrypsin-like protease (3CLpro): An in silico screening of alkaloids and terpenoids from African medicinal plants. Journal of Biomolecular Structure and Dynamics, 1–19. https://doi.org/10.1080/07391102.2020.1764868
   PubMed Web of Science ®Google Scholar
• Harder, E., Damm, W., Maple, J., Wu, C., Reboul, M., Xiang, J. Y., Wang, L., Lupyan, D., Dahlgren, M. K., Knight, J. L., Kaus, J. W., Cerutti, D. S., Krilov, G., Jorgensen, W. L., Abel, R., & Friesner, R. A. (2016). OPLS3: A force field providing broad coverage of drug-like small molecules and proteins. Journal of Chemical Theory and Computation, 12(1), 281–296. https://doi.org/10.1021/acs.jctc.5b00864
   PubMed Web of Science ®Google Scholar
• Hasan, A., Paray, B. A., Hussain, A., Qadir, F. A., Attar, F., Aziz, F. M., Sharifi, M., Derakhshankhah, H., Rasti, B., Mehrabi, M., & Shahpasand, K. (2020). A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin. Journal of Biomolecular Structure and Dynamics, 1–9. https://doi.org/10.1080/07391102.2020.1754293
   PubMed Web of Science ®Google Scholar
• Ho, C. C., Lin, S. S., Chou, M. Y., Chen, F. L., Hu, C. C., Chen, C. S., Lu, G. Y., & Yang, C. C. (2005). Effects of CAPE-like compounds on HIV replication in vitro and modulation of cytokines in vivo. The Journal of Antimicrobial Chemotherapy, 56(2), 372–379. https://doi.org/10.1093/jac/dki244
   PubMed Web of Science ®Google Scholar
• Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., Müller, M. A., Drosten, C., & Pöhlmann, S. (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181(2), 271–280. https://doi.org/10.1016/j.cell.2020.02.052
   PubMed Web of Science ®Google Scholar
• Islam, R., Parves, R., Paul, A. S., Uddin, N., Rahman, M. S., Mamun, A. A., Hossain, M. N., Ali, M. A., & Halim, M. A. (2020). A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics, 1–20. https://doi.org/10.1080/07391102.2020.1761883
   PubMed Web of Science ®Google Scholar
• Jacobson, M. P., Pincus, D. L., Rapp, C. S., Day, T. J., Honig, B., Shaw, D. E., & Friesner, R. A. (2004). A hierarchical approach to all-atom protein loop prediction. Proteins, 55(2), 351–367. https://doi.org/10.1002/prot.10613
   PubMed Web of Science ®Google Scholar
• Jin, Z., Du, X., Xu, Y., Deng, Y., Liu, M., Zhao, Y., Zhang, B., Li, X., Zhang, L., Peng, C., Duan, Y., Yu, J., Wang, L., Yang, K., Liu, F., Jiang, R., Yang, X., You, T., Liu, X., … Yang, H. (2020). Structure of Mpro from COVID-19 virus and discovery of its inhibitors. Nature, 1–33. https://doi.org/10.1038/s41586-020-2223-y
   Web of Science ®Google Scholar
• Joshi, R. S., Jagdale, S. S., Bansode, S. B., Shankar, S. S., Tellis, M. B., Pandya, V. K., Chugh, A., Giri, A. P., & Kulkarni, M. J. (2020). Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease. Journal of Biomolecular Structure and Dynamics, 1–16. https://doi.org/10.1080/07391102.2020.1760137
   Web of Science ®Google Scholar
• Kaul, S. C., & Wadhwa, R. (Eds.). (2017). Science of ashwagandha: Preventive and therapeutic potentials. Springer International Publishing.
   Google Scholar
• Khan, R. J., Jha, R. K., Amera, G., Jain, M., Singh, E., Pathak, A., Singh, R. P., Muthukumaran, J., & Singh, A. K. (2020). Targeting SARS-CoV-2: A systematic drug repurposing approach to identify promising inhibitors against 3C-like proteinase and 2’-O-ribose methyltransferase. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/10.1080/07391102.2020.1753577
   Web of Science ®Google Scholar
• Khan, S. A., Zia, K., Ashraf, S., Uddin, R., & Ul-Haq, Z. (2020). Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach. Journal of Biomolecular Structure and Dynamics, 1–10. https://doi.org/10.1080/07391102.2020.1751298
   Web of Science ®Google Scholar
• Kishimoto, N., Kakino, Y., Iwai, K., Mochida, K., & Fujita, T. (2005). In vitro antibacterial, antimutagenic and anti-influenza virus activity of caffeic acid phenethyl esters. Biocontrol Science, 10(4), 155–161. https://doi.org/10.4265/bio.10.155
   Google Scholar
• Kumar, D., Kumari, K., Jayaraj, A., Kumar, V., Kumar, R. V., Dass, S. K., Chandra, R., & Singh, P. (2020). Understanding the binding affinity of noscapines with protease of SARS-CoV-2 for COVID-19 using MD simulations at different temperatures. Journal of Biomolecular Structure and Dynamics, 1–14. https://doi.org/10.1080/07391102.2020.1752310
   PubMed Web of Science ®Google Scholar
• Kwon, M. J., Shin, H. M., Perumalsamy, H., Wang, X., & Ahn, Y. J. (2019). Antiviral effects and possible mechanisms of action of constituents from Brazilian propolis and related compounds. Journal of Apicultural Research, 1–13. https://doi.org/10.1080/00218839.2019.1695715
   Web of Science ®Google Scholar
• Latheef, S. K., Dhama, K., Samad, H. A., Wani, M. Y., Kumar, M. A., Palanivelu, M., Malik, Y. S., Singh, S. D., & Singh, R. (2017). Immunomodulatory and prophylactic efficacy of herbal extracts against experimentally induced chicken infectious anaemia in chicks: Assessing the viral load and cell mediated immunity. VirusDisease, 28(1), 115–120. https://doi.org/10.1007/s13337-016-0355-3
   PubMedGoogle Scholar
• Lefkovits, I. V. A. N., Su, Z., Fisher, P., & Grunberger, D. (1997). Caffeic acid phenethyl ester profoundly modifies protein synthesis profile in type 5 adenovirus-transformed cloned rat embryo fibroblast cells. International Journal of Oncology, 11(1), 59–67. https://doi.org/10.3892/ijo.11.1.59
   PubMed Web of Science ®Google Scholar
• Li, X., Wang, W., Zhao, X., Zai, J., Zhao, Q., Li, Y., & Chaillon, A. (2020). Transmission dynamics and evolutionary history of 2019-nCoV. Journal of Medical Virology, 92(5), 501–511. https://doi.org/10.1002/jmv.25701
   PubMed Web of Science ®Google Scholar
• Li, X., Zai, J., Wang, X., & Li, Y. (2020). Potential of large “first generation” human-to-human transmission of 2019-nCoV. Journal of Medical Virology, 92(4), 448–454. https://doi.org/10.1002/jmv.25693
   PubMed Web of Science ®Google Scholar
• Lobo-Galo, N., Terrazas-López, M., Martínez-Martínez, A., & Díaz-Sánchez, Á. G. (2020). FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication. Journal of Biomolecular Structure and Dynamics, 1–12. https://doi.org/10.1080/07391102.2020.1764393
   PubMed Web of Science ®Google Scholar
• Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., Bi, Y., Ma, X., Zhan, F., Wang, L., Hu, T., Zhou, H., Hu, Z., Zhou, W., Zhao, L., … Tan, W. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet, 395(10224), 565–574. https://doi.org/10.1016/S0140-6736(20)30251-8
   PubMed Web of Science ®Google Scholar
• Lyu, S. Y., Rhim, J. Y., & Park, W. B. (2005). Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. Archives of Pharmacal Research, 28(11), 1293–1301. https://doi.org/10.1007/BF02978215
   PubMed Web of Science ®Google Scholar
• Maruta, H. (2020). Tackling the Coronaviral infection: Blocking either the “pathogenic” kinase PAK1 or polymerase RdRP. Journal of Infectious Diseases and Therapy, 8(2), 418.
   Google Scholar
• Munagala, R., Kausar, H., Munjal, C., & Gupta, R. C. (2011). Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells. Carcinogenesis, 32(11), 1697–1705. https://doi.org/10.1093/carcin/bgr192
   PubMed Web of Science ®Google Scholar
• Muralidharan, N., Sakthivel, R., Velmurugan, D., & Gromiha, M. M. (2020). Computational studies of drug repurposing and synergism of lopinavir, oseltamivir and ritonavir binding with SARS-CoV-2 protease against COVID-19. Journal of Biomolecular Structure and Dynamics, 1–6. https://doi.org/10.1080/07391102.2020.1752802
   PubMed Web of Science ®Google Scholar
• Murtaza, G., Sajjad, A., Mehmood, Z., Shah, S. H., & Siddiqi, A. R. (2015). Possible molecular targets for therapeutic applications of caffeic acid phenethyl ester in inflammation and cancer. Journal of Food and Drug Analysis, 23(1), 11–18. https://doi.org/10.1016/j.jfda.2014.06.001
   PubMed Web of Science ®Google Scholar
• Norris, P. J., Hirschkorn, D. F., DeVita, D. A., Lee, T. H., & Murphy, E. L. (2010). Human T cell leukemia virus type 1 infection drives spontaneous proliferation of natural killer cells. Virulence, 1(1), 19–28. https://doi.org/10.4161/viru.1.1.9868
   PubMed Web of Science ®Google Scholar
• Pant, S., Singh, M., Ravichandiran, V., Murty, U. S. N., & Srivastava, H. K. (2020). Peptide-like and small-molecule inhibitors against Covid-19. Journal of Biomolecular Structure and Dynamics, 1–10. https://doi.org/10.1080/07391102.2020.1757510
   PubMed Web of Science ®Google Scholar
• Paraskevis, D., Kostaki, E. G., Magiorkinis, G., Panayiotakopoulos, G., Sourvinos, G., & Tsiodras, S. (2020). Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 79, 104212. https://doi.org/10.1016/j.meegid.2020.104212
   PubMed Web of Science ®Google Scholar
• Sarma, P., Sekhar, N., Prajapat, M., Avti, P., Kaur, H., Kumar, S., Singh, S., Kumar, H., Prakash, A., Dhibar, D. P., & Medhi, B. (2020). In-silico homology assisted identification of inhibitor of RNA binding against 2019-nCoV N-protein (N terminal domain). Journal of Biomolecular Structure and Dynamics, 1–11. https://doi.org/10.1080/07391102.2020.1753580
   PubMed Web of Science ®Google Scholar
• Sastry, G. M., Adzhigirey, M., Day, T., Annabhimoju, R., & Sherman, W. (2013). Protein and ligand preparation: Parameters, protocols, and influence on virtual screening enrichments. Journal of Computer-Aided Molecular Design, 27(3), 221–234. https://doi.org/10.1007/s10822-013-9644-8
   PubMed Web of Science ®Google Scholar
• Schrodinger Release 2020-1. (2020). Maestro 019-3 SR, glide, ligprep, protein preparation wizard, prime, Desmond molecular dynamics system, Maestro-Desmond interoperability tools. Schrödinger.
   Google Scholar
• Serkedjieva, J., Manolova, N., & Bankova, V. (1992). Anti-influenza virus effect of some propolis constituents and their analogues (esters of substituted cinnamic acids). Journal of Natural Products, 55(3), 294–297. https://doi.org/10.1021/np50081a003
   PubMed Web of Science ®Google Scholar
• Shen, H., Yamashita, A., Nakakoshi, M., Yokoe, H., Sudo, M., Kasai, H., Tanaka, T., Fujimoto, Y., Ikeda, M., Kato, N., Sakamoto, N., Shindo, H., Maekawa, S., Enomoto, N., Tsubuki, M., & Moriishi, K. (2013). Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis c virus. PloS One, 8(12), e82299. https://doi.org/10.1371/journal.pone.0082299
   PubMed Web of Science ®Google Scholar
• Sinha, S. K., Shakya, A., Prasad, S. K., Singh, S., Gurav, N. S., Prasad, R. S., & Gurav, S. S. (2020). An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets. Journal of Biomolecular Structure and Dynamics, 1–13. https://doi.org/10.1080/07391102.2020.1762741
   PubMed Web of Science ®Google Scholar
• Sud'ina, G. F., Mirzoeva, O. K., Pushkareva, M. A., Korshunova, G. A., Sumbatyan, N. V., & Varfolomeev, S. D. (1993). Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Letters, 329(1–2), 21–24. https://doi.org/10.1016/0014-5793(93)80184-V
   PubMed Web of Science ®Google Scholar
• Thuy, B. T. P., My, T. T. A., Hai, N. T. T., Hieu, L. T., Hoa, T. T., Thi Phuong Loan, H., Triet, N. T., Anh, T. T. V., Quy, P. T., Tat, P. V., Hue, N. V., Quang, D. T., Trung, N. T., Tung, V. T., Huynh, L. K., & Nhung, N. T. A. (2020). Investigation into SARS-CoV-2 resistance of compounds in garlic essential oil. ACS Omega, 5(14), 8312–8320. https://doi.org/10.1021/acsomega.0c00772
   PubMed Web of Science ®Google Scholar
• Umesh, K. D., Selvaraj, C., Singh, S. K., & Dubey, V. K. (2020). Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target. Journal of Biomolecular Structure and Dynamics, 1–9. https://doi.org/10.1080/07391102.2020.1763202
   Web of Science ®Google Scholar
• van der Hoek, L., Pyrc, K., Jebbink, M. F., Vermeulen-Oost, W., Berkhout, R. J., Wolthers, K. C., Wertheim-van Dillen, P. M., Kaandorp, J., Spaargaren, J., & Berkhout, B. (2004). Identification of a new human coronavirus. Nature Medicine, 10(4), 368–373. https://doi.org/10.1038/nm1024
   PubMed Web of Science ®Google Scholar
• Wahedi, H. M., Ahmad, S., & Abbasi, S. W. (2020). Stilbene-based natural compounds as promising drug candidates against COVID-19. Journal of Biomolecular Structure and Dynamics, 1–16. https://doi.org/10.1080/07391102.2020.1762743
   PubMed Web of Science ®Google Scholar
• Wang, F., Chen, C., Tan, W., Yang, K., & Yang, H. (2016). Structure of main protease from human Coronavirus NL63: Insights for wide spectrum anti-coronavirus drug design. Scientific Reports, 6, 22677. https://doi.org/10.1038/srep22677
   PubMed Web of Science ®Google Scholar
• Wang, Z., Chen, X., Lu, Y., Chen, F., & Zhang, W. (2020). Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment. Bioscience Trends, 14(1), 64–68. https://doi.org/10.5582/bst.2020.01030
   PubMed Web of Science ®Google Scholar
• WHO. (2020). Coronavirus disease (COVID-19) dashboard. Retrieved May 12, 2020, from https://covid19.who.int.
   Google Scholar
• Woo, P. C., Huang, Y., Lau, S. K., & Yuen, K. Y. (2010). Coronavirus genomics and bioinformatics analysis. Viruses, 2(8), 1804–1820. https://doi.org/10.3390/v2081803
   PubMed Web of Science ®Google Scholar
• Woo, P. C. Y., Lau, S. K. P., Chu, C-m., Chan, K-h., Tsoi, H-w., Huang, Y., Wong, B. H. L., Poon, R. W. S., Cai, J. J., Luk, W-k., Poon, L. L. M., Wong, S. S. Y., Guan, Y., Peiris, J. S. M., & Yuen, K-y. (2005). Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. Journal of Virology, 79(2), 884–895. https://doi.org/10.1128/JVI.79.2.884-895.2005
   PubMed Web of Science ®Google Scholar
• Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., Yuan, M.-L., Zhang, Y.-L., Dai, F.-H., Liu, Y., Wang, Q.-M., Zheng, J.-J., Xu, L., Holmes, E. C., & Zhang, Y.-Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798), 265–269. https://doi.org/10.1038/s41586-020-2008-3
   PubMed Web of Science ®Google Scholar
• Zandi, K., Teoh, B. T., Sam, S. S., Wong, P. F., Mustafa, M. R., & AbuBakar, S. (2011). Antiviral activity of four types of bioflavonoid against dengue virus type-2. Virology Journal, 8(1), 560. https://doi.org/10.1186/1743-422X-8-560
   PubMed Web of Science ®Google Scholar
• Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
   PubMed Web of Science ®Google Scholar