188
Views
9
CrossRef citations to date
0
Altmetric
Research Articles

Neuroprotective effect of Umbelliferone against Cerebral ischemia/Reperfusion induced neurological deficits: in-vivo and in-silico studies

, , , , , & show all
Pages 4715-4725 | Received 15 Apr 2020, Accepted 04 Jun 2020, Published online: 19 Jun 2020

References

  • Abdel-Latif, R. G., Heeba, G. H., Taye, A., & Khalifa, M. M. A. (2018). Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats. Naunyn-Schmiedeberg’s Archives of Pharmacology, 391(7), 705–717. https://doi.org/10.1007/s00210-018-1497-1
  • Ali, M. Y., Jannat, S., Jung, H. A., Choi, R. J., Roy, A., & Choi, J. S. (2016). Anti-Alzheimer’s disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis. Asian Pacific Journal of Tropical Medicine, 9(2), 103–111. https://doi.org/10.1016/j.apjtm.2016.01.014
  • Anrather, J., & Iadecola, C. (2016). Inflammation and stroke: An overview. Neurotherapeutics, 13(4), 661–670. https://doi.org/10.1007/s13311-016-0483-x
  • Anwar, F., Al-Abbasi, F. A., Bhatt, P. C., Ahmad, A., Sethi, N., & Kumar, V. (2015). Umbelliferone β-D-galactopyranoside inhibits chemically induced renal carcinogenesis via alteration of oxidative stress, hyperproliferation and inflammation: Possible role of NF-κB. Toxicology Research, 4(5), 1308–1323. https://doi.org/10.1039/C5TX00146C
  • Arumugam, T. V., Okun, E., Tang, S. C., Thundyil, J., Taylor, S. M., & Woodruff, T. M. (2009). Toll-like receptors in ischemia-reperfusion injury. Shock, 32(1), 4–16. https://doi.org/10.1097/SHK.0b013e318193e333
  • Badiger, S., Akkasaligar, P. T., & Narone, U. (2013). Hyperglycemia and Stroke. International Journal of Stroke Research, 1(1), 1–6. https://doi.org/10.5923/j.stroke.20130101.01
  • Bhattacharya, P., Pandey, A. K., Paul, S., Patnaik, R., & Yavagal, D. R. (2013). Aquaporin-4 inhibition mediates piroxicam-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rodents. PLoS One, 8(9), e73481. https://doi.org/10.1371/journal.pone.0073481
  • Cai, F., Li, C.-R., Wu, J.-L., Chen, J.-G., Liu, C., Min, Q., Yu, W., Ouyang, C.-H., & Chen, J.-H. (2006). Theaflavin ameliorates cerebral ischemia-reperfusion injury in rats through its anti-inflammatory effect and modulation of STAT-1. Mediators of Inflammation, 2006(5), 30490. https://doi.org/10.1155/MI/2006/30490
  • Chan, P. H. (1996). Role of oxidants in ischemic brain damage. Stroke, 27(6), 1124–1129. https://doi.org/10.1161/01.str.27.6.1124
  • Chan, P. H. (2001). Reactive oxygen radicals in signaling and damage in the ischemic brain. Journal of Cerebral Blood Flow & Metabolism, 21(1), 2–14. https://doi.org/10.1097/00004647-200101000-00002
  • Collard, C. D., & Gelman, S. (2001). Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology, 94(6), 1133–1138. https://doi.org/10.1097/00000542-200106000-00030
  • Collino, M., Aragno, M., Mastrocola, R., Benetti, E., Gallicchio, M., Dianzani, C., Danni, O., Thiemermann, C., & Fantozzi, R. (2006). Oxidative stress and inflammatory response evoked by transient cerebral ischemia/reperfusion: Effects of the PPAR-alpha agonist WY14643. Free Radical Biology & Medicine, 41(4), 579–589. https://doi.org/10.1016/j.freeradbiomed.2006.04.030
  • Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001). Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacological Reviews, 53(1), 135–159. https://doi.org/10.1016/S0014-2999(01)01175-X
  • Donnan, G. A., Fisher, M., Macleod, M., & Davis, S. M. (2008). Stroke. The Lancet, 371(9624), 1612–1623. https://doi.org/10.1016/S0140-6736(08)60694-7
  • Eltzschig, H. K., & Eckle, T. (2011). Ischemia and reperfusion-from mechanism to translation. Nature Medicine, 17(11), 1391–1401. https://doi.org/10.1038/nm.2507
  • Feigin, V. L., Lawes, C. M., Bennett, D. A., Barker-Collo, S. L., & Parag, V. (2009). Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review. The Lancet Neurology, 8(4), 355–369. https://doi.org/10.1016/S1474-4422(09)70025-0
  • Garcia, J. H., Yoshida, Y., Chen, H., Li, Y., Zhang, Z. G., Lian, J., Chen, S., & Chopp, M. (1993). Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. The American Journal of Pathology, 142(2), 623–635.
  • Gu, J. H., Ge, J.-B., Li, M., Wu, F., Zhang, W., & Qin, Z. H. (2012). Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. European Journal of Pharmaceutical Sciences, 47(4), 652–660. https://doi.org/10.1016/j.ejps.2012.07.016
  • Hankey, G. J. (2017). Stroke. The Lancet, 389(10069), 641–654. https://doi.org/10.1016/S0140-6736(16)30962-X
  • Hobson, M. J., & Zingarelli, B. (2014). Ischemia-reperfusion injury. In Pediatric critical care medicine: Volume 1: Care of the critically ill or injured child (2nd ed., pp. 251-267). London: Springer-Verlag. https://doi.org/10.1007/978-1-4471-6362-6_24
  • Hofmeijer, J., & Van Putten, M. J. A. M. (2012). Ischemic cerebral damage: An appraisal of synaptic failure. Stroke, 43(2), 607–615. https://doi.org/10.1161/STROKEAHA.111.632943
  • Honda, H. M., Korge, P., & Weiss, J. N. (2005). Mitochondria and ischemia/reperfusion injury. Annals of the New York Academy of Sciences, 1047(1), 248–258. https://doi.org/10.1196/annals.1341.022
  • Huang, J., Upadhyay, U. M., & Tamargo, R. J. (2006). Inflammation in stroke and focal cerebral ischemia. Surgical Neurology, 66(3), 232–258. https://doi.org/10.1016/j.surneu.2005.12.028
  • Iadecola, C., & Alexander, M. (2001). Cerebral ischemia and inflammation. Current Opinion in Neurology, 14(1), 89–94. https://doi.org/10.1097/00019052-200102000-00014
  • Ishiyama, T., Shibuya, K., Ichikawa, M., Masamune, T., Kiuchi, R., Sessler, D. I., & Matsukawa, T. (2010). Cerebral pial vascular changes under propofol or sevoflurane anesthesia during global cerebral ischemia and reperfusion in rabbits. Journal of Neurosurgical Anesthesiology, 22(3), 207–213. https://doi.org/10.1097/ANA.0b013e3181cd318b
  • Kalogeris, T., Baines, C. P., Krenz, M., & Korthuis, R. J. (2016). Ischemia/reperfusion. Comprehensive Physiology, 7(1), 113–170. https://doi.org/10.1002/cphy.c160006
  • Krishnamurthi, R. V., Moran, A. E., Feigin, V. L., Barker-Collo, S., Norrving, B., Mensah, G. A., Taylor, S., Naghavi, M., Forouzanfar, M. H., Nguyen, G., Johnson, C. O., Vos, T., Murray, C. J. L., Roth, G. A., & GBD 2013 Stroke Panel Experts Group. (2015). Stroke prevalence, mortality and disability-adjusted life years in adults aged 20-64 years in 1990-2013: Data from the Global Burden of Disease 2013 Study. Neuroepidemiology, 45(3), 190–202. https://doi.org/10.1159/000441098
  • Kumar, V., Ahmed, D., Verma, A., Anwar, F., Ali, M., & Mujeeb, M. (2013). Umbelliferone β-D-galactopyranoside from Aegle marmelos (L.) corr. An ethnomedicinal plant with antidiabetic, antihyperlipidemic and antioxidative activity. BMC Complementary and Alternative Medicine, 13(1), 273. https://doi.org/10.1186/1472-6882-13-273
  • Kumar, V., Al-Abbasi, F. A., Verma, A., Mujeeb, M., & Anwar, F. (2015). Umbelliferone β-d-galactopyranoside exerts an anti-inflammatory effect by attenuating COX-1 and COX-2. Toxicology Research, 4(4), 1072–1084. https://doi.org/10.1039/C5TX00095E
  • Kumar, V., Anwar, F., Verma, A., & Mujeeb, M. (2015). Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2(I)→1(II))-α-D-glucopyranoside on adjuvant-induced arthritic rats. Journal of Food Science and Technology, 52(6), 3402–3411. https://doi.org/10.1007/s13197-014-1403-x
  • Kumar, V., Bhatt, P. C., Rahman, M., Al-Abbasi, F. A., Anwar, F., & Verma, A. (2017). Umbelliferon-α-d-glucopyranosyl-(2I→1II)-α-D-glucopyranoside ameliorates diethylnitrosamine induced precancerous lesion development in liver via regulation of inflammation, hyperproliferation and antioxidant at pre-clinicalstage. Biomedicine & Pharmacotherapy, 94, 834–842. https://doi.org/10.1016/j.biopha.2017.07.047
  • Kumar, V., Bhatt, P. C., Rahman, M., Kaithwas, G., Choudhry, H., Al-Abbasi, F. A., Anwar, F., & Verma, A. (2017). Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: In vitro and in vivo studies. International Journal of Nanomedicine, 12, 6747–6758. https://doi.org/10.2147/IJN.S136629
  • Li, K., Ding, D., & Zhang, M. (2016). Neuroprotection of osthole against cerebral ischemia/reperfusion injury through an anti-apoptotic pathway in rats. Biological & Pharmaceutical Bulletin, 39(3), 336–342. https://doi.org/10.1248/bpb.b15-00699
  • Li, W., Suwanwela, N. C., & Patumraj, S. (2016). Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R. Microvascular Research, 106, 117–127. https://doi.org/10.1016/j.mvr.2015.12.008
  • Luan, H., Kan, Z., Xu, Y., Lv, C., & Jiang, W. (2013). Rosmarinic acid protects against experimental diabetes with cerebral ischemia: Relation to inflammation response. Journal of Neuroinflammation, 10, 28. https://doi.org/10.1186/1742-2094-10-28
  • Mazimba, O. (2017). Umbelliferone: Sources, chemistry and bioactivities review. Bulletin of Faculty of Pharmacy, Cairo University, 55(2), 223–232. https://doi.org/10.1016/j.bfopcu.2017.05.001
  • Nour, M., Scalzo, F., & Liebeskind, D. S. (2012). Ischemia-reperfusion injury in stroke. Interventional Neurology, 1(3-4), 185–196. https://doi.org/10.1159/000353125
  • Parker, A. E., Arslan, F., Keogh, B., & McGuirk, P. (2010). TLR2 and TLR4 in ischemia reperfusion injury. Mediators of Inflammation, 2010, 704202. https://doi.org/10.1155/2010/704202
  • Shen, Y. C., Wang, Y. H., Chou, Y. C., Liou, K. T., Yen, J. C., Wang, W. Y., & Liao, J. F. (2008). Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation. Journal of Neurochemistry, 104(2), 558–572. https://doi.org/10.1111/j.1471-4159.2007.05058.x
  • Suwanwela, N. C., Poungvarin, N., & Asian Stroke Advisory Panel. (2016). Stroke burden and stroke care system in Asia. Neurology India, 64(7), S46–S51. https://doi.org/10.4103/0028-3886.178042
  • Tu, X.-K., Yang, W.-Z., Chen, J.-P., Chen, Y., Ouyang, L.-Q., Xu, Y.-C., & Shi, S.-S. (2014). Curcumin inhibits TLR2/4-NF-κB signaling pathway and attenuates brain damage in permanent focal cerebral ischemia in rats. Inflammation, 37(5), 1544–1551. https://doi.org/10.1007/s10753-014-9881-6
  • Ueshima, H. (2007). Explanation for the Japanese paradox: Prevention of increase in coronary heart disease and reduction in stroke. Journal of Atherosclerosis and Thrombosis, 14(6), 278–286. https://doi.org/10.5551/jat.e529
  • Vaibhav, K., Shrivastava, P., Javed, H., Khan, A., Ahmed, M. E., Tabassum, R., Khan, M. M., Khuwaja, G., Islam, F., Saeed Siddiqui, M., Safhi, M. M., & Islam, F. (2012). Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-κB in middle cerebral artery occlusion rat model. Molecular and Cellular Biochemistry, 367(1-2), 73–84. https://doi.org/10.1007/s11010-012-1321-z
  • Wang, H., Zhang, K., Zhao, L., Tang, J., Gao, L., & Wei, Z. (2014). Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury. Neuroscience Letters, 566, 247–251. https://doi.org/10.1016/j.neulet.2014.02.045
  • Wicha, P., Tocharus, J., Janyou, A., Jittiwat, J., Changtam, C., Suksamrarn, A., & Tocharus, C. (2017). Hexahydrocurcumin protects against cerebral ischemia/reperfusion injury, attenuates inflammation, and improves antioxidant defenses in a rat stroke model. PLoS One, 12(12), e0189211https://doi.org/10.1371/journal.pone.0189211
  • Wu, R., Li, X., Xu, P., Huang, L., Cheng, J., Huang, X., Jiang, J., Wu, L.-J., & Tang, Y. (2017). TREM2 protects against cerebral ischemia/reperfusion injury. Molecular Brain, 10(1), 20. https://doi.org/10.1186/s13041-017-0296-9
  • Xia, C. F., Yin, H., Yao, Y. Y., Borlongan, C. V., Chao, L., & Chao, J. (2006). Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis. Human Gene Therapy, 17(2), 206–219. https://doi.org/10.1089/hum.2006.17.206
  • Xian, W., Wu, Y., Xiong, W., Li, L., Li, T., Pan, S., Song, L., Hu, L., Pei, L., Yao, S., & Shang, Y. (2016). The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response. Biochemical and Biophysical Research Communications, 472(1), 175–181. https://doi.org/10.1016/j.bbrc.2016.02.090
  • Yang, Q-w., Li, J-c., Lu, F-l., Wen, A-q., Xiang, J., Zhang, L-l., Huang, Z-y., & Wang, J-z. (2008). Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. Journal of Cerebral Blood Flow and Metabolism, 28(9), 1588–1596. https://doi.org/10.1038/jcbfm.2008.50
  • Yao, Y., Chen, L., Xiao, J., Wang, C., Jiang, W., Zhang, R., & Hao, J. (2014). Chrysin protects against focal cerebral ischemia/reperfusion injury in mice through attenuation of oxidative stress and inflammation. International Journal of Molecular Sciences, 15(11), 20913–20926. https://doi.org/10.3390/ijms151120913
  • Yin, J., Tu, C., Zhao, J., Ou, D., Chen, G., Liu, Y., & Xiao, X. (2013). Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats. Brain Research, 1491, 188–196. https://doi.org/10.1016/j.brainres.2012.10.046
  • Zeng, X., Wang, H., Xing, X., Wang, Q., & Li, W. (2016). Dexmedetomidine protects against transient global cerebral ischemia/reperfusion induced oxidative stress and inflammation in diabetic rats. PLoS One, 11(3), e0151620. https://doi.org/10.1371/journal.pone.0151620
  • Zhang, S., Qi, Y., Xu, Y., Han, X., Peng, J., Liu, K., & Sun, C. K. (2013). Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochemistry International, 63(5), 522–532. https://doi.org/10.1016/j.neuint.2013.08.008
  • Zhao, L., Xu, L., Tao, X., Han, X., Yin, L., Qi, Y., & Peng, J. (2016). Protective effect of the total flavonoids from Rosa laevigata Michx fruit on renal ischemia-reperfusion injury through suppression of oxidative stress and inflammation. Molecules, 21(7), 952. https://doi.org/10.3390/molecules21070952
  • Zhou, F., Wang, L., Liu, P. P., Hu, W. W., Zhu, X. D., Shen, H., & Yao, Y. Y. (2014). Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response. Neural Regeneration Research, 9(23), 2074–2080. https://doi.org/10.4103/1673-5374.147934

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.