References
- Anderson, M. O., Sherrill, J., Madrid, P. B., Liou, A. P., Weisman, J. L., DeRisi, J. L., & Guy, R. K. (2006). Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Bioorganic & Medicinal Chemistry, 14(2), 334–343. https://doi.org/https://doi.org/10.1016/j.bmc.2005.08.017
- Barros, R. O., Junior, F. L. C. C., Pereira, W. S., Oliveira, N. M. N., & Ramos, R. (2020). Interaction of drugs candidates with various SARS-CoV-2 receptors: An in silico study to combat COVID-19. ChemRxiv. Preprint. https://doi.org/https://doi.org/10.26434/chemrxiv.12100968.v4
- Cao, B., Wang, Y., Wen, D., Liu, W., Wang, J., Fan, G., Ruan, L., Song, B., Cai, Y., Wei, M., Li, X., Xia, J., Chen, N., Xiang, J., Yu, T., Bai, T., Xie, X., Zhang, L., Li, C., … Wang, C. (2020). A trial of lopinavir-ritonavir in adults hospitalized with severe Covid-19. The New England Journal of Medicine, 382(19), 1787–1799. https://doi.org/https://doi.org/10.1056/NEJMoa2001282
- Chang, L., Yan, Y., & Wang, L. (2020). Coronavirus disease 2019: Coronaviruses and blood safety. Transfusion Medicine Reviews, 34(2), 75–80. https://doi.org/https://doi.org/10.1016/j.tmrv.2020.02.003
- De Wit, E., Van Doremalen, N., Falzarano, D., & Munster, V. J. (2016). SARS and MERS: Recent insights into emerging coronaviruses. Nature Reviews. Microbiology, 14(8), 523–534. https://doi.org/https://doi.org/10.1038/nrmicro.2016.81
- Dickens, B. F., Weglicki, W. B., Boehme, P. A., & Mak, I. T. (2002). Antioxidant and lysosomotropic properties of acridine-propranolol: Protection against oxidative endothelial cell injury. Journal of Molecular and Cellular Cardiology, 34(2), 129–137. https://doi.org/10.1056/NEJMoa2001282 https://doi.org/https://doi.org/10.1006/jmcc.2001.1495
- Friesner, R. A., Murphy, R. B., Repasky, M. P., Frye, L. L., Greenwood, J. R., Halgren, T. A., Sanschagrin, P. C., & Mainz, D. T. (2006). Extra precision glide: Docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes. Journal of Medicinal Chemistry, 49(21), 6177–6196. https://doi.org/https://doi.org/10.1021/jm051256o
- Giorgio, C. D., Shimi, K., Boyer, G., Delmas, F., & Galy, J. P. (2007). Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine. European Journal of Medicinal Chemistry, 42(10), 1277–1284. https://doi.org/https://doi.org/10.1016/j.ejmech.2007.02.010
- Goodell, J. R., Madhok, A. A., Hiasa, H., & Ferguson, D. M. (2006). Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity. Bioorganic & Medicinal Chemistry, 14(16), 5467–5480. https://doi.org/https://doi.org/10.1016/j.bmc.2006.04.044
- Govindarajan, M., Periandy, S., & Carthigayen, K. (2012). FT-IR and FT-Raman spectra, thermo dynamical behavior, HOMO and LUMO, UV, NLO properties, computed frequency estimation analysis and electronic structure calculations on α-bromotoluene. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 97, 411–422. https://doi.org/https://doi.org/10.1016/j.saa.2012.06.028
- Gu, J., Han, B., & Wang, J. (2020). COVID-19: Gastrointestinal manifestations and potential fecal -oral transmission. Gastroenterology, 158, 1518–1519. https://doi.org/https://doi.org/10.1053/j.gastro.2020.02.054
- Guo, Z., Mohanty, U., Noehre, J., Sawyer, T. K., Sherman, W., & Krilov, G. (2010). Probing the alpha-helical structural stability of stapled p53 peptides: Molecular dynamics simulations and analysis. Chemical Biology & Drug Design, 75(4), 348–359. https://doi.org/https://doi.org/10.1111/j.1747-0285.2010.00951.x
- Holshue, M. L., DeBolt, C., Lindquist, S., Lofy, K. H., Wiesman, J., Bruce, H., Spitters, C., Ericson, K., Wilkerson, S., Tural, A., Diaz, G., Cohn, A., Fox, L., Patel, A., Gerber, S. I., Kim, L., Tong, S., Lu, X., Lindstrom, S., … Pillai, S. K. (2020). First case of 2019 novel coronavirus in the United States. New England Journal of Medicine, 382(10), 929–936. https://doi.org/https://doi.org/10.1056/NEJMoa2001191
- Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., & Hu, Y. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497–506. https://doi.org/https://doi.org/10.1016/s0140-6736(20)30183-5
- Huang, Q., & Herrmann, A. (2020). Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV). BioRxiv 930537. https://doi.org/https://doi.org/10.1101/2020.02.01.930537
- Jacobson, M. P., Pincus, D. L., Rapp, C. S., Day, T. J. F., Honig, B., Shaw, D. E., & Friesner, R. A. (2004). A hierarchical approach to all-atom protein loop prediction. Proteins, 55(2), 351–367. https://doi.org/https://doi.org/10.1002/prot.10613
- Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., & Klein, M. L. (1983). Comparison of simple potential functions for simulating liquid water. The Journal of Chemical Physics, 79(2), 926–935. https://doi.org/https://doi.org/10.1063/1.445869
- Kalirajan, R., Gaurav, K., Pandiselvi, A., Gowramma, B., & Sankar, S. (2019). Novel thiazine substituted 9-anilinoacridines: Synthesis, antitumour activity and structure activity relationships. Anti-Cancer Agents in Medicinal Chemistry, 19(11), 1350–1358. https://doi.org/https://doi.org/10.2174/1871520619666190408134224
- Kalirajan, R., Gowramma, B., Jubie, S., & Sankar, S. (2017). Molecular docking studies and in silico ADMET screening of some novel heterocyclic substituted 9-anilinoacridines as topoisomerase II inhibitors. JSM Chemistry, 5(1), 1039–1044.
- Kalirajan, R., Kulshrestha, V., & Sankar, S. (2018). Synthesis, characterization and evaluation for antitumour activity of some novel oxazine substituted 9-anilinoacridines and their 3D-QSAR studies. Indian Journal of Pharmaceutical Sciences, 80(5), 921–929. https://doi.org/https://doi.org/10.4172/pharmaceutical-sciences.1000439
- Kalirajan, R., Kulshrestha, V., Sankar, S., & Jubie, S. (2012). Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer activities as topoisomerase II inhibitors. European Journal of Medicinal Chemistry, 56, 217–224. https://doi.org/https://doi.org/10.1016/j.ejmech.2012.08.025
- Kalirajan, R., Mohammed Rafick, M. H., Jubie, S., & Sankar, S. (2012). Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole substituted 9-anilinoacridine derivatives. The Scientific World Journal, 2012, 1–6. 2012. https://doi.org/https://doi.org/10.1100/2012/165258,
- Kalirajan, R., Mohammed Rafick, M. H., Sankar, S., & Gowramma, B. (2018). Green synthesis of some novel chalcone and isoxazole substituted 9-anilinoacridine derivatives and evaluation of their antimicrobial and larvicidal activities. Indian Journal of Chemistry, 57B, 583–590.
- Kalirajan, R., Muralidharan, V., Jubie, S., Gowramma, B., Gomathy, S., Sankar, S., & Elango, K. (2012). Synthesis of some novel pyrazole substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and cytotoxic activities. Journal of Heterocyclic Chemistry, 49(4), 748–754. https://doi.org/https://doi.org/10.1002/jhet.848
- Kalirajan, R., Muralidharan, V., Jubie, S., & Sankar, S. (2013). Microwave assisted synthesis, characterization and evaluation for their antimicrobial activities of some novel pyrazole substituted 9-anilino acridine derivatives. International Journal of Health & Allied Sciences, 2(2), 81–87. https://doi.org/https://doi.org/10.4103/2278-344X.115682
- Kalirajan, R., Pandiselvi, A., Gowramma, B., & Balachandran, P. (2019). In-silico design, ADMET screening, MM-GBSA binding free energy of some novel isoxazole substituted 9-anilinoacridines as HER2 inhibitors targeting breast cancer. Current Drug Research Reviews, 11(2), 118–128. https://doi.org/https://doi.org/10.2174/2589977511666190912154817
- Kalirajan, R., Rathore, L., Jubie, S., Gowramma, B., Gomathy, S., & Sankar, S. (2011). Microwave assisted synthesis of some novel pyrazole substituted benzimidazoles and evaluation of their biological activities. Indian Journal of Chemistry, 50B, 1794–1801. https://doi.org/https://doi.org/10.1002/chin.201216123
- Kalirajan, R., Sankar, S., Jubie, S., and., & Gowramma, B. (2017). Molecular docking studies and in-silico ADMET screening of some novel oxazine substituted 9-anilinoacridines as topoisomerase II inhibitors. Indian Journal of Pharmaceutical Education and Research, 51(1), 110–115. https://doi.org/https://doi.org/10.5530/ijper.51.1.15
- Kalirajan, R., Sivakumar, S. U., Jubie, S., Gowramma, B., & Suresh, B. (2009). Synthesis and biological evaluation of some heterocyclic derivatives of chalcones. International Journal of Chemical Science, 1(1), 27–34.
- Kapuriya, N., Kapuriya, K., Zhang, X., Chou, T.-C., Kakadiya, R., Wu, Y.-T., Tsai, T.-H., Chen, Y.-T., Lee, T.-C., Shah, A., Naliapara, Y., & Su, T.-L. (2008). Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorganic & Medicinal Chemistry, 16(10), 5413–5423. https://doi.org/https://doi.org/10.1016/j.bmc.2008.04.024
- Li, J., Abel, R., Zhu, K., Cao, Y., Zhao, S., & Friesner, R. A. (2011). The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling. Proteins, 79(10), 2794–2812. https://doi.org/https://doi.org/10.1002/prot.23106
- Llama, E. F., Campo, C. D., Capo, M., & Anadon, M. (1989). Synthesis and antinociceptive activity of 9-phenyl-oxy or 9-acyl-oxy derivatives of xanthene, thioxanthene and acridine. European Journal of Medicinal Chemistry, 24(4), 391–396. https://doi.org/https://doi.org/10.1016/0223-5234(89)90083-4
- Lu, R., Zhao, X., & Li, J. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet, 395(10224), 565–574. https://doi.org/https://doi.org/10.1016/S0140-6736(20)3025
- Martyna, G. J., Klein, M. L., & Tuckerman, M. (1992). Nose- Hoover chains-the canonical ensemble via continuous dynamics. The Journal of Chemical Physics, 97(4), 2635–2643. https://doi.org/https://doi.org/10.1063/1.463940
- Martyna, G. J., Tobias, D. J., & Klein, M. L. (1994). Constant-pressure molecular dynamics algorithms. The Journal of Chemical Physics, 101(5), 4177–4189. https://doi.org/https://doi.org/10.1063/1.467468
- Nadaraj, V., Selvi, S. T., & Mohan, S. (2009). Microwave-induced synthesis and anti-microbial activities of 7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives. European Journal of Medicinal Chemistry, 44(3), 976–980. https://doi.org/https://doi.org/10.1016/j.ejmech.2008.07.004
- Rastogi, K., Chang, J.-Y., Pan, W.-Y., Chen, C.-H., Chou, T.-C., Chen, L.-T., & Su, T.-L. (2002). Antitumor AHMA linked to DNA minor groove binding agents: Synthesis and biological evaluation. Journal of Medicinal Chemistry, 45(20), 4485–4493. https://doi.org/https://doi.org/10.1021/jm0200714
- Recanatini, M., Cavalli, A., Belluti, F., Piazzi, L., Rampa, A., Bisi, A., Gobbi, S., Valenti, P., Andrisano, V., Bartolini, M., & Cavrini, V. (2000). SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues . Journal of Medicinal Chemistry, 43(10), 2007–2018. https://doi.org/https://doi.org/10.1021/jm990971t
- Sastry, G. M., Adzhigirey, M., Day, T., Annabhimoju, R., & Sherman, W. (2013). Protein and ligand preparation: Parameters, protocols, and influence on virtual screening enrichments. Journal of Computer-Aided Molecular Design, 27(3), 221–234. https://doi.org/https://doi.org/10.1007/s10822-013-9644-8
- Sondhi, S. M., Johar, M., Nirupama, S., Sukla, R., Raghubir, R., & Dastidar, S. G. (2002). Synthesis of sulpha drug acridine derivatives and their evaluation for anti-anflammatory, analgesic and anticancer activity. Indian Journal of Chemistry, 41B, 2659–2666.
- Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Zhao, W., Han, Y., & Qin, C. (2019). From SARS to MERS, thrusting coronaviruses into the spotlight. Viruses, 11(1), 59. https://doi.org/https://doi.org/10.3390/v11010059
- To, K. K., Tsang, O. T., & Chik-Yan Yip, C. (2020). Consistent detection of 2019 novel coronavirus in saliva. Clinical Infectious Diseases. https://doi.org/https://doi.org/10.1093/cid/ciaa149
- Wakelin, L. P. G., Bu, X., Eleftheriou, A., Parmar, A., Hayek, C., & Stewart, B. W. (2003). Bisintercalating threading diacridines: Relationships between DNA binding, cytotoxicity, and cell cycle arrest. Journal of Medicinal Chemistry, 46(26), 5790–5802. https://doi.org/https://doi.org/10.1021/jm030253d
- Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA, 323(11), 1061. https://doi.org/https://doi.org/10.1001/jama.2020.1585
- Zhang, H., Kang, Z. J., & Gong, H. Y. (2020). The digestive system is a potential route of 2019-nCov infection: A bioinformatics analysis based on single-cell transcriptomes. BioRxiv 927806. https://doi.org/https://doi.org/10.1101/2020.01.30.927806
- Zhou, Y., Hou, Y., Shen, J., Huang, Y., Martin, W., & Cheng, F. (2020). Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discovery, 6, 14–19. https://doi.org/https://doi.org/10.1038/s41421-020-0153-3
- Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/https://doi.org/10.1038/s41586-020-2012-7,