References
- Abd El-Baky, H. H., El Baz, F. K., & El-Baroty, G. S. (2009). Production of phenolic compounds from Spirulina maxima microalgae and its protective effects in vitro toward hepatotoxicity model. African Journal of Pharmacy and Pharmacology, 3(4), 133–139.
- Abdullahi, A. S., Underwood, G. J. C., & Gretz, M. R. (2006). Extracellular matrix assembly in diatoms (Bacillariophyceae). V. Environmental effects on polysaccharide synthesis in the model diatom, Phaeodactylum tricornutum. Journal of Phycology, 42(2), 363–378. https://doi.org/https://doi.org/10.1111/j.1529-8817.2006.00193.x
- Amaro, H., Guedes, A., & Malcata, F. (2011). Antimicrobial activities of microalgae: An invited review. Science against Microbial Pathogens: Communicating Current Research and Technological Advances, 1272–1280.
- Ambrosi, M., Cameron, N. R., & Davis, B. G. (2005). Lectins: Tools for the molecular understanding of the glycocode. Organic and Biomolecular Chemistry. https://doi.org/https://doi.org/10.1039/b414350g
- Andrianasolo, E. H., Gross, H., Goeger, D., Musafija-Girt, M., McPhail, K., Leal, R. M., Mooberry, S. L., & Gerwick, W. H. (2005). Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Organic Letters, 7(7), 1375–1378. https://doi.org/https://doi.org/10.1021/ol050188x
- Arad, S., & Levy-Ontman, O. (2010). Red microalgal cell-wall polysaccharides: Biotechnological aspects. Current Opinion in Biotechnology, 21(3), 358–364. https://doi.org/https://doi.org/10.1016/j.copbio.2010.02.008
- Babu, B., & Wu, J. T. (2008). Production of natural butylated hydroxytoluene as an antioxidant by freshwater phytoplankton. Journal of Phycology, 44(6), 1447–1454. https://doi.org/https://doi.org/10.1111/j.1529-8817.2008.00596.x
- Back, S. (2005). Production of cryptophycin from blue-green algae. Journal of Young Investigators, 12.
- Bai, R., Pettit, G. R., & Hamel, E. (1990). Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10. Biochemical Pharmacology, 40(8), 1859–1864. https://doi.org/https://doi.org/10.1016/0006-2952(90)90367-T
- Balzarini, J., Van Herrewege, Y., Vermeire, K., Vanham, G., & Schols, D. (2007). Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes. Molecular Pharmacology, 71(1), 3–11. https://doi.org/https://doi.org/10.1124/mol.106.030155
- Banker, R., & Carmeli, S. (1998). Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue. Journal of Natural Products, 61(10), 1248–1251. https://doi.org/https://doi.org/10.1021/np980138j
- Barrientos, L. G., O’Keefe, B. R., Bray, M., Sanchez, A., Gronenborn, A. M., & Boyd, M. R. (2003). Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus. Antiviral Research, 58(1), 47–56. https://doi.org/https://doi.org/10.1016/S0166-3542(02)00183-3
- Barrow, C., & Shahidi, F. (2008). Marine nutraceuticals and functional foods.
- Becker, E. W. (2004). Microalgae in human and animal nutrition. In A. Richmond (Ed.), Handbook of microalgal culture: Biotechnology and applied phycology. https://doi.org/https://doi.org/10.1002/9780470995280
- Bernardo, P. H., Chai, C. L. L., Guen, M. L., Smith, G. D., & Waring, P. (2007). Structure-activity delineation of quinones related to the biologically active Calothrixin B. Bioorganic and Medicinal Chemistry Letters. https://doi.org/https://doi.org/10.1016/j.bmcl.2006.09.090
- Bhagavathy, S., Sumathi, P., & Jancy Sherene Bell, I. (2011). Green algae Chlorococcum humicola- a new source of bioactive compounds with antimicrobial activity. Asian Pacific Journal of Tropical Biomedicine, 1(1), S1–S7. https://doi.org/https://doi.org/10.1016/S2221-1691(11)60111-1
- Bhaskar, V., Law, D. A., Ibsen, E., Breinberg, D., Cass, K. M., DuBridge, R. B., … Ramakrishnan, V. (2003). E-selectin up-regulation allows for targeted drug delivery in prostate cancer. Cancer Research.
- Bhat, V. B., & Madyastha, K. M. (2001). Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: Protection against oxidative damage to DNA. Biochemical and Biophysical Research Communications, 285(2), 262–266. https://doi.org/https://doi.org/10.1006/bbrc.2001.5195
- Bokesch, H. R., O’Keefe, B. R., McKee, T. C., Pannell, L. K., Patterson, G. M. L., Gardella, R. S., Sowder, R. C., Turpin, J., Watson, K., Buckheit, R. W., & Boyd, M. R. (2003). A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Biochemistry, 42(9), 2578–2584. https://doi.org/https://doi.org/10.1021/bi0205698
- Bonnard, I., Rolland, M., Salmon, J.-M., Debiton, E., Barthomeuf, C., & Banaigs, B. (2007). Total structure and inhibition of tumor cell proliferation of laxaphycins. Journal of Medicinal Chemistry, 50(6), 1266–1279. https://doi.org/https://doi.org/10.1021/jm061307x
- Botos, I., O’Keefe, B. R., Shenoy, S. R., Cartner, L. K., Ratner, D. M., Seeberger, P. H., Boyd, M. R., & Wlodawer, A. (2002). Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. The Journal of Biological Chemistry, 277(37), 34336–34342. https://doi.org/https://doi.org/10.1074/jbc.M205909200
- Boudreau, P. D., Byrum, T., Liu, W. T., Dorrestein, P. C., & Gerwick, W. H. (2012). Viequeamide a, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. Journal of Natural Products, 75(9), 1560–1570. https://doi.org/https://doi.org/10.1021/np300321b
- Boyd, M. R., Gustafson, K. R., McMahon, J. B., Shoemaker, R. H., O’Keefe, B. R., Mori, T., Gulakowski, R. J., Wu, L., Rivera, M. I., Laurencot, C. M., Currens, M. J., Cardellina, J. H., Buckheit, R. W., Nara, P. L., Pannell, L. K., Sowder, R. C., & Henderson, L. E. (1997). Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: Potential applications to microbicide development. Antimicrobial Agents and Chemotherapy, 41(7), 1521–1530. https://doi.org/https://doi.org/10.1128/AAC.41.7.1521
- Buffa, V., Stieh, D., Mamhood, N., Hu, Q., Fletcher, P., & Shattock, R. J. (2009). Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models. The Journal of General Virology, 90(1), 234–243. https://doi.org/https://doi.org/10.1099/vir.0.004358-0
- Bui, H. T. N., Jansen, R., Pham, H. T. L., & Mundt, S. (2007). Carbamidocyclophanes A-E, chlorinated paracyclophanes with cytotoxic and antibiotic activity from the Vietnamese cyanobacterium Nostoc sp. Journal of Natural Products, 70(4), 499–503. https://doi.org/https://doi.org/10.1021/np060324m
- Bui, T.-H., Wray, V., Nimtz, M., Fossen, T., Preisitsch, M., Schröder, G., Wende, K., Heiden, S. E., & Mundt, S. (2014). Balticidins A-D, antifungal hassallidin-like lipopeptides from the Baltic Sea cyanobacterium Anabaena cylindrica Bio33. Journal of Natural Products, 77(6), 1287–1296. https://doi.org/https://doi.org/10.1021/np401020a
- Burja, A. M., Banaigs, B., Abou-Mansour, E., Grant Burgess, J., & Wright, P. C. (2001). Marine cyanobacteria - A prolific source of natural products. Tetrahedron, 57(46), 9347–9377. https://doi.org/https://doi.org/10.1016/S0040-4020(01)00931-0
- Burton, D. R., Poignard, P., Stanfield, R. L., & Wilson, I. A. (2012). Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science (New York, N.Y.), 337(6091), 183–186. https://doi.org/https://doi.org/10.1126/science.1225416
- Cao, Z., Gerwick, W. H., & Murray, T. F. (2010). Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits. BMC Neuroscience, 11(1), 154. https://doi.org/https://doi.org/10.1186/1471-2202-11-154
- Cardellina, J. H., Marner, F. J., & Moore, R. E. (1979). Seaweed dermatitis: Structure of lyngbyatoxin A. Science (New York, N.Y.), 204(4389), 193–195. https://doi.org/https://doi.org/10.1126/science.107586
- Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. R., Tonon, A. P., Lopes, N. P., … Pinto, E. (2007). Metabolites from algae with economical impact. Comparative Biochemistry and Physiology - C Toxicology and Pharmacology. https://doi.org/https://doi.org/10.1016/j.cbpc.2006.05.007
- Carter, D. C., Moore, R. E., Mynderse, J. S., Niemczura, W. P., & Todd, J. S. (1984). Structure of Majusculamide C, a cyclic depsipeptide from Lyngbya majuscula. Journal of Organic Chemistry, https://doi.org/https://doi.org/10.1021/jo00176a004
- Carvalho, A. P., & Malcata, F. X. (2000). Effect of culture media on production of polyunsaturated fatty acids by Pavlova lutheri. Cryptogamie, Algologie, https://doi.org/https://doi.org/10.1016/S0181-1568(00)00101-X
- Catassi, A., Cesario, A., Arzani, D., Menichini, P., Alama, A., Bruzzo, C., Imperatori, A., Rotolo, N., Granone, P., & Russo, P. (2006). Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells. Cellular and Molecular Life Sciences: CMLS, 63(19–20), 2377–2386. https://doi.org/https://doi.org/10.1007/s00018-006-6264-7
- Cazzonelli, C. I. (2011). Carotenoids in nature: Insights from plants and beyond. Functional Plant Biology: FPB, 38(11), 833. https://doi.org/https://doi.org/10.1071/FP11192
- Chang, C. S., Sun, H. L., Lii, C. K., Chen, H. W., Chen, P. Y., & Liu, K. L. (2010). Gamma-linolenic acid inhibits inflammatory responses by regulating nf-κB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages. Inflammation, 33(1), 46–57. https://doi.org/https://doi.org/10.1007/s10753-009-9157-8
- Chang, Z., Sitachitta, N., Rossi, J. V., Roberts, M. A., Flatt, P. M., Jia, J., Sherman, D. H., & Gerwick, W. H. (2004). Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 67(8), 1356–1367. https://doi.org/https://doi.org/10.1021/np0499261
- Charnock, J. S. (1999). The role of omega-3 polyunsaturated fatty acid-enriched diets in the prevention of ventricular fibrillation. Asia Pacific Journal of Clinical Nutrition, 8(3), 226–230. https://doi.org/https://doi.org/10.1046/j.1440-6047.1999.00115.x
- Chen, X., Smith, G. D., & Waring, P. (2003). Human cancer cell (Jurkat) killing by the cyanobacterial metabolite calothrixin A. Journal of Applied Phycology, https://doi.org/https://doi.org/10.1023/A:1025134106985
- Chisté, R. C., Freitas, M., Mercadante, A. Z., & Fernandes, E. (2014). Carotenoids inhibit lipid peroxidation and hemoglobin oxidation, but not the depletion of glutathione induced by ROS in human erythrocytes. Life Sciences, 99(1-2), 52–60. https://doi.org/https://doi.org/10.1016/j.lfs.2014.01.059
- Choi, H., Pereira, A. R., Cao, Z., Shuman, C. F., Engene, N., Byrum, T., Matainaho, T., Murray, T. F., Mangoni, A., & Gerwick, W. H. (2010). The hoiamides, structurally intriguing neurotoxic Lipopeptides from Papua New Guinea marine cyanobacteria. Journal of Natural Products, 73(8), 1411–1421. https://doi.org/https://doi.org/10.1021/np100468n
- Costa, M. S., Rego, A., Ramos, V., Afonso, T. B., Freitas, S., Preto, M., Lopes, V., Vasconcelos, V., Magalhães, C., & Leão, P. N. (2016). The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria. Scientific Reports, 6, 23436 https://doi.org/https://doi.org/10.1038/srep23436
- Davidson, B. S. (1995). New dimensions in natural products research: Cultured marine microorganisms. Current Opinion in Biotechnology, 6(3), 284–291. https://doi.org/https://doi.org/10.1016/0958-1669(95)80049-2
- Davies-Coleman, M. T., Dzeha, T. M., Gray, C. A., Hess, S., Pannell, L. K., Hendricks, D. T., & Arendse, C. E. (2003). Isolation of homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula. Journal of Natural Products, 66(5), 712–715. https://doi.org/https://doi.org/10.1021/np030014t
- Deeks, E. D. (2019). Polatuzumab vedotin: First global Approval. Drugs, 79(13), 1467–1475. https://doi.org/https://doi.org/10.1007/s40265-019-01175-0
- Dey, B., Lerner, D. L., Lusso, P., Boyd, M. R., Elder, J. H., & Berger, E. A. (2000). Multiple antiviral activities of Cyanovirin-N: Blocking of human immunodeficiency virus type 1 gp120 interaction with CD4 and coreceptor and inhibition of diverse enveloped viruses. Journal of Virology, 74(10), 4562–4569. https://doi.org/https://doi.org/10.1128/JVI.74.10.4562-4569.2000
- DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Van De Putte, L. B. A., & Lipsky, P. E. (1998). Cyclooxygenase in biology and disease. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 12(12), 1063–1073. https://doi.org/https://doi.org/10.1096/fasebj.12.12.1063https://doi.org/https://doi.org/10.1096/fasebj.12.12.1063
- El-Fakharany, E. M., Saad, M. H., Salem, M. S., & Sidkey, N. M. (2020). Biochemical characterization and application of a novel lectin from the cyanobacterium Lyngabya confervoides MK012409 as an antiviral and anticancer agent. International Journal of Biological Macromolecules, 161, 417–430. https://doi.org/https://doi.org/10.1016/j.ijbiomac.2020.06.046
- Falch, B. S., König, G. M., Wright, A. D., Sticher, O., Röegger, H., & Bernardinelli, G. (1993). Ambigol A and B: New Biologically active polychlorinated aromatic compounds from the terrestrial blue-green alga Fischerella ambigua. Journal of Organic Chemistry. https://doi.org/https://doi.org/10.1021/jo00076a013
- Feng, S. S., & Chien, S. (2003). Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases. Chemical Engineering Science, 58(18), 4087–4114. https://doi.org/https://doi.org/10.1016/S0009-2509(03)00234-3
- Fennell, B. J., Carolan, S., Pettit, G. R., & Bell, A. (2003). Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum. The Journal of Antimicrobial Chemotherapy, 51(4), 833–841. https://doi.org/https://doi.org/10.1093/jac/dkg151
- Férir, G., Huskens, D., Noppen, S., Koharudin, L. M. I., Gronenborn, A. M., & Schols, D. (2014). Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family. The Journal of Antimicrobial Chemotherapy, 69(10), 2746–2758. https://doi.org/https://doi.org/10.1093/jac/dku220
- Fewer, D. P., Jokela, J., Rouhiainen, L., Wahlsten, M., Koskenniemi, K., Stal, L. J., & Sivonen, K. (2009). The non-ribosomal assembly and frequent occurrence of the protease inhibitors spumigins in the bloom-forming cyanobacterium Nodularis spumigena. Molecular Microbiology, 73(5), 924–937. https://doi.org/https://doi.org/10.1111/j.1365-2958.2009.06816.x
- Flahive, E., & Srirangam, J. (2005). The dolastatins: Novel antitumor agents from dolabella auricularia. In Anticancer agents from natural products.
- Gal, A. F., Andrei, S., Cernea, C., Taulescu, M., & Catoi, C. (2012). Effects of astaxanthin supplementation on chemically induced tumorigenesis in Wistar rats. Acta Veterinaria Scandinavica, 54(1) https://doi.org/https://doi.org/10.1186/1751-0147-54-50
- Garrison, A. R., Giomarelli, B. G., Lear-Rooney, C. M., Saucedo, C. J., Yellayi, S., Krumpe, L. R. H., Rose, M., Paragas, J., Bray, M., Olinger, G. G., McMahon, J. B., Huggins, J., & O’Keefe, B. R. (2014). The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus. Antiviral Research, 112, 1–7. https://doi.org/https://doi.org/10.1016/j.antiviral.2014.09.012
- Gekwick, W. H., Reyes, S., & Alvarado, B. (1987). Two malyngamides from the caribbean cyanobacterium Lyngbya majuscula. Phytochemistry, 26(6), 1701–1704. https://doi.org/https://doi.org/10.1016/S0031-9422(00)82271-2
- Gesner-Apter, S., & Carmeli, S. (2008). Three novel metabolites from a bloom of the cyanobacterium Microcystis sp. Tetrahedron, 64(28), 6628–6634. https://doi.org/https://doi.org/10.1016/j.tet.2008.05.031
- Golakoti, T., Yoshida, W. Y., Chaganty, S., & Moore, R. E. (2001). Isolation and structure determination of nostocyclopeptides A1 and A2 from the terrestrial cyanobacterium Nostoc sp. ATCC53789. Journal of Natural Products, 64(1), 54–59. https://doi.org/https://doi.org/10.1021/np000316k
- Gupta, A., & Sainis, J. K. (2010). Isolation of C-phycocyanin from Synechococcus sp., (Anacystis nidulans BD1). Journal of Applied Phycology, 22(3), 231–233. https://doi.org/https://doi.org/10.1007/s10811-009-9449-2
- Gupta, C., Prakash, D., Garg, A. P., & Gupta, S. (2012). Whey proteins: A novel source of bioceuticals. Middle East Journal of Scientific Research. https://doi.org/https://doi.org/10.5829/idosi.mejsr.2012.12.3.64227
- Gustafson, K. R., Sowder, R. C., Henderson, L. E., Cardellina, J. H., McMahon, J. B., Rajamani, U., Pannell, L. K., & Boyd, M. R. (1997). Isolation, primary sequence determination, and disulfide bond structure of cyanovirin-N, an anti-HIV (Human Immunodeficiency Virus) protein from the cyanobacterium Nostoc ellipsosporum. Biochemical and Biophysical Research Communications, 238(1), 223–228. https://doi.org/https://doi.org/10.1006/bbrc.1997.7203
- Guzmán, S., Gato, A., Lamela, M., Freire-Garabal, M., & Calleja, J. M. (2003). Anti-inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum. Phytotherapy Research: PTR, 17(6), 665–670. https://doi.org/https://doi.org/10.1002/ptr.1227
- Han, B., Goeger, D., Maier, C. S., & Gerwick, W. H. (2005). The wewakpeptins, cyclic depsipeptides from a Papua new guinea collection of the marine cyanobacterium Lyngbya semiplena. Journal of Organic Chemistry. https://doi.org/https://doi.org/10.1021/jo0478858
- Han, B., Gross, H., Goeger, D. E., Mooberry, S. L., & Gerwick, W. H. (2006). Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 69(4), 572–575. https://doi.org/https://doi.org/10.1021/np0503911
- Harari, A., Abecassis, R., Relevi, N., Levi, Z., Ben-Amotz, A., Kamari, Y., Harats, D., & Shaish, A. (2013). Prevention of atherosclerosis progression by 9-cis-β-carotene rich alga dunaliella in apoE-deficient mice. BioMed Research International, 2013, 169517. https://doi.org/https://doi.org/10.1155/2013/169517
- Hayashi, K., Hayashi, T., & Kojima, I. (1996). A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: In vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS Res Hum Retroviruses, 12(15), 1463–1471. https://doi.org/https://doi.org/10.1089/aid.1996.12.1463
- Hayashi, K., Kanekiyo, K., Ohta, Y., Lee, J., Takenaka, H., & Hayashi, T. (2008). Anti-influenza A virus activity of an acidic polysaccharide from a blue-green alga Nostoc flagelliforme. Planta Medica. https://doi.org/https://doi.org/10.1055/s-0028-1084032
- Hejazi, M. A., & Wijffels, R. H. (2004). Milking of microalgae. Trends in Biotechnology, 22(4), 189–194. https://doi.org/https://doi.org/10.1016/j.tibtech.2004.02.009
- Helle, F., Wychowski, C., Vu-Dac, N., Gustafson, K. R., Voisset, C., & Dubuisson, J. (2006). Cyanovirin-N inhibits hepatitis C virus entry by binding to envelope protein glycans. The Journal of Biological Chemistry, 281(35), 25177–25183. https://doi.org/https://doi.org/10.1074/jbc.M602431200
- Herrero, M., Castro-Puyana, M., Mendiola, J. A., & Ibañez, E. (2013). Compressed fluids for the extraction of bioactive compounds. TrAC - Trends in Analytical Chemistry. https://doi.org/https://doi.org/10.1016/j.trac.2012.12.008
- Hillwig, M. L., Zhu, Q., & Liu, X. (2014). Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua. ACS Chemical Biology, 9(2), 372–377. https://doi.org/https://doi.org/10.1021/cb400681n
- Hirschberg, J., & Chamovitz, D. (1994). Carotenoids in Cyanobacteria. In The molecular biology of cyanobacteria. https://doi.org/https://doi.org/10.1007/978-94-011-0227-8_18
- Horgen, F. D., Kazmierski, E. B., Westenburg, H. E., Yoshida, W. Y., & Scheuer, P. J. (2002). Malevamide D: Isolation and structure determination of an isodolastatin H analogue from the marine cyanobacterium Symploca hydnoides. Journal of Natural Products, 65(4), 487–491. https://doi.org/https://doi.org/10.1021/np010560r
- Huskens, D., Férir, G., Vermeire, K., Kehr, J. C., Balzarini, J., Dittmann, E., & Schols, D. (2010). Microvirin, a novel α(1,2)-mannose-specific lectin isolated from Microcystis aeruginosa, has anti-HIV-1 activity comparable with that of cyanovirin-N but a much higher safety profile. The Journal of Biological Chemistry, 285(32), 24845–24854. https://doi.org/https://doi.org/10.1074/jbc.M110.128546
- Ishida, K., Christiansen, G., Yoshida, W. Y., Kurmayer, R., Welker, M., Valls, N., … Dittmann, E. (2007). Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-Carboxy-6-Hydroxyoctahydroindole moiety. Chemistry and Biology. https://doi.org/https://doi.org/10.1016/j.chembiol.2007.04.006
- Ishida, K., Matsuda, H., Murakami, M., & Yamaguchi, K. (1997). Kawaguchipeptin B, an antibacterial cyclic undecapeptide from the cyanobacterium Microcystis aeruginosa. Journal of Natural Products, 60(7), 724–726. https://doi.org/https://doi.org/10.1021/np970146k
- Ishida, K., Okita, Y., Matsuda, H., Okino, T., & Murakami, M. (1999). Aeruginosins, protease inhibitors from the cyanobacterium Microcystis aeruginosa. Tetrahedron, 55(36), 10971–10988. https://doi.org/https://doi.org/10.1016/S0040-4020(99)00621-3
- Ishihara, K., Murata, M., Kaneniwa, M., Saito, H., Shinohara, K., Maeda-Yamamoto, M., Kawasaki, K.-I., & Ooizumi, T. (1998). Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. Lipids, 33(11), 1107–1114. https://doi.org/https://doi.org/10.1007/s11745-998-0312-9
- Iwasaki, A., Shiota, I., Sumimoto, S., Matsubara, T., Sato, T., & Suenaga, K. (2017). Kohamamides A, B, and C, cyclic depsipeptides from an Okeania sp. marine cyanobacterium. Journal of Natural Products, 80(6), 1948–1952. https://doi.org/https://doi.org/10.1021/acs.jnatprod.7b00256
- Jaki, B., Orjala, J., & Sticher, O. (1999). A novel extracellular diterpenoid with antibacterial activity from the cyanobacterium Nostoc commune. Journal of Natural Products, 62(3), 502–503. https://doi.org/https://doi.org/10.1021/np980444x
- Jaki, B., Zerbe, O., Heilmann, J., & Sticher, O. (2001). Two novel cyclic peptides with antifungal activity from the cyanobacterium Tolypothrix byssoidea (EAWAG 195). Journal of Natural Products, 64(2), 154–158. https://doi.org/https://doi.org/10.1021/np000297e
- Jiménez, J. I., & Scheuer, P. J. (2001). New lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. Journal of Natural Products, 64(2), 200–203. https://doi.org/https://doi.org/10.1021/np000462q
- Kachko, A., Loesgen, S., Shahzad-Ul-Hussan, S., Tan, W., Zubkova, I., Takeda, K., Wells, F., Rubin, S., Bewley, C. A., & Major, M. E. (2013). Inhibition of hepatitis C virus by the cyanobacterial protein microcystis viridis lectin: Mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA. Molecular Pharmaceutics, 10(12), 4590–4602. https://doi.org/https://doi.org/10.1021/mp400399b
- Kajiyama, S., Kanzaki, H., Kawazu, K., & Kobayashi, A. (1998). Nostofungicidine, an antifungal lipopeptide from the field-grown terrestrial blue-green alga Nostoc commune. Tetrahedron Letters, 39(22), 3737–3740. https://doi.org/https://doi.org/10.1016/S0040-4039(98)00573-5
- Kalemkerian, G. P., Ou, X., Adil, M. R., Rosati, R., Khoulani, M. M., Madan, S. K., & Pettit, G. R. (1999). Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: Induction of apoptosis and bcl-2 modification. Cancer Chemotherapy and Pharmacology, 43(6), 507–515. https://doi.org/https://doi.org/10.1007/s002800050931
- Kaloyannidis, P., Hertzberg, M., Webb, K., Zomas, A., Schrover, R., Hurst, M., Jacob, I., Nikoglou, T., & Connors, J. M. (2020). Brentuximab vedotin for the treatment of patients with relapsed or refractory Hodgkin lymphoma after autologous stem cell transplantation. British Journal of Haematology, 188(4), 540–549. https://doi.org/https://doi.org/10.1111/bjh.16201
- Kanada, R. M., Taniguchi, T., & Ogasawara, K. (2000). The first synthesis of (+)-tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. Synlett, 2000(07), 1019–1021.
- Kanekiyo, K., Lee, J. B., Hayashi, K., Takenaka, H., Hayakawa, Y., Endo, S., & Hayashi, T. (2005). Isolation of an antiviral polysaccharide, nostoflan, from a terrestrial cyanobacterium, Nostoc flagelliforme. Journal of Natural Products, 68(7), 1037–1041. https://doi.org/https://doi.org/10.1021/np050056c
- Kaplon, H., Muralidharan, M., Schneider, Z., & Reichert, J. M. (2020). Antibodies to watch in 2020. mAbs, 12(1), 1703531Taylor & Francis. https://doi.org/https://doi.org/10.1080/19420862.2019.1703531
- Kapuścik, A., Hrouzek, P., Kuzma, M., Bártová, S., Novák, P., Jokela, J., Pflüger, M., Eger, A., Hundsberger, H., & Kopecký, J. (2013). Novel aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. ChemBioChem: A European Journal of Chemical Biology, 14(17), 2329–2337. https://doi.org/https://doi.org/10.1002/cbic.201300246
- Khan, M. N. A., Cho, J. Y., Lee, M. C., Kang, J. Y., Nam, G. P., Fujii, H., & Hong, Y. K. (2007). Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. Journal of Agricultural and Food Chemistry, 55(17), 6984–6988. https://doi.org/https://doi.org/10.1021/jf071791s
- Khan, Q. A., Lu, J., & Hecht, S. M. (2009). Calothrixins, a new class of human DNA topoisomerase i poisons. Journal of Natural Products, 72(3), 438–442. https://doi.org/https://doi.org/10.1021/np8007232
- Kim, M., Yim, J. H., Kim, S.-Y., Kim, H. S., Lee, W. G., Kim, S. J., Kang, P.-S., & Lee, C.-K. (2012). In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03. Antiviral Research, 93(2), 253–259. https://doi.org/https://doi.org/10.1016/j.antiviral.2011.12.006
- Klisch, M., & Häder, D. (2008). Mycosporine-like amino acids and marine toxins - the common and the different. Marine Drugs, 6(2), 147–163. https://doi.org/https://doi.org/10.3390/md20080008
- Kobayashi, M., Hirai, N., Kurimura, Y., Ohigashi, H., & Tsuji, Y. (1997). Abscisic acid-dependent algal morphogenesis in the unicellular green alga Haematococcus pluvialis. Plant Growth Regulation, 22(2), 79–85. https://doi.org/https://doi.org/10.1023/A:1005862809711
- Kobayashi, M., Kakizono, T., & Nagai, S. (1993). Enhanced carotenoid biosynthesis by oxidative stress in acetate-induced cyst cells of a green unicellular alga, Haematococcus pluvialis. Applied and Environmental Microbiology, 59(3), 867–873. https://doi.org/https://doi.org/10.1128/AEM.59.3.867-873.1993
- Koehn, F. E., Longley, R. E., & Reed, J. K. (1992). Microcolins a and b, new immunosuppressive peptides from the blue-green alga lyngbya majuscula. Journal of Natural Products, 55(5), 613–619. https://doi.org/https://doi.org/10.1021/np50083a009
- Komárek, J., Kaštovský, J., Mareš, J., & Johansen, J. R. (2014). Taxonomic classification of cyanoprokaryotes (cyanobacterial genera) 2014, using a polyphasic approach. Preslia, 86(4), 295–335.
- Kosalec, I., Kremer, D., Locatelli, M., Epifano, F., Genovese, S., Carlucci, G., Randić, M., & Zovko Končić, M. (2013). Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila. Food Chemistry, 136(2), 335–341. https://doi.org/https://doi.org/10.1016/j.foodchem.2012.08.026
- Kosourov, S., Murukesan, G., Jokela, J., & Allahverdiyeva, Y. (2016). Carotenoid biosynthesis in calothrix sp. 336/3: Composition of carotenoids on full medium, during diazotrophic growth and after long-term H2 photoproduction. Plant & Cell Physiology, 57(11), 2269–2282. https://doi.org/https://doi.org/10.1093/pcp/pcw143
- Kowshik, J., Baba, A. B., Giri, H., Reddy, G. D., Dixit, M., & Nagini, S. (2014). Astaxanthin inhibits JAK/STAT-3 signaling to abrogate cell proliferation, invasion and angiogenesis in a hamster model of oral cancer. PLoS One., 9(10), e109114. https://doi.org/https://doi.org/10.1371/journal.pone.0109114
- Kwang, H. C., Song, Y. I. K., & Lee, D. U. (2008). Antiproliferative effects of carotenoids extracted from Chlorella ellipsoidea and Chlorella vulgaris on human colon cancer cells. Journal of Agricultural and Food Chemistry, 56(22), 10521–10526. https://doi.org/https://doi.org/10.1021/jf802111x
- Lai, Q., Wu, M., Wang, R., Lai, W., Tao, Y., Lu, Y., Wang, Y., Yu, L., Zhang, R., Peng, Y., Jiang, X., Fu, Y., Wang, X., Zhang, Z., Guo, C., Liao, W., Zhang, Y., Kang, T., Chen, H., … Yang, J. (2020). Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies. European Journal of Medicinal Chemistry, 199, 112364. https://doi.org/https://doi.org/10.1016/j.ejmech.2020.112364
- Leya, T., Rahn, A., Lã¼Tz, C., & Remias, D. (2009). Response of arctic snow and permafrost algae to high light and nitrogen stress by changes in pigment composition and applied aspects for biotechnology. FEMS Microbiology Ecology, 67(3), 432–443. https://doi.org/https://doi.org/10.1111/j.1574-6941.2008.00641.x
- Li, H. B., Cheng, K. W., Wong, C. C., Fan, K. W., Chen, F., & Jiang, Y. (2007). Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae. Food Chemistry, 102(3), 771–776. https://doi.org/https://doi.org/10.1016/j.foodchem.2006.06.022
- Li, W. I., Berman, F. W., Okino, T., Yokokawa, F., Shioiri, T., Gerwick, W. H., & Murray, T. F. (2001). Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels. Proceedings of the National Academy of Sciences of the United States of America, 98(13), 7599–7604. https://doi.org/https://doi.org/10.1073/pnas.121085898
- Liang, T. J. (2013). Current progress in development of hepatitis C virus vaccines. Nature Medicine, 19(7), 869–878. https://doi.org/https://doi.org/10.1038/nm.3183
- Linington, R. G., Edwards, D. J., Shuman, C. F., McPhail, K. L., Matainaho, T., & Gerwick, W. H. (2008). Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine cyanobacterium Symploca sp. Journal of Natural Products, 71(1), 22–27. https://doi.org/https://doi.org/10.1021/np070280x
- López, A., Rico, M., Santana-Casiano, J. M., González, A. G., & González-Dávila, M. (2015). Phenolic profile of Dunaliella tertiolecta growing under high levels of copper and iron. Environmental Science and Pollution Research International, 22(19), 14820–14828. https://doi.org/https://doi.org/10.1007/s11356-015-4717-y
- Loya, S., Reshef, V., Mizrachi, E., Silberstein, C., Rachamim, Y., Carmeli, S., & Hizi, A. (1998). The inhibition of the reverse transcriptase of HIV-1 by the natural sulfoglycolipids from cyanobacteria: Contribution of different moieties to their high potency. Journal of Natural Products, 61(7), 891–895. https://doi.org/https://doi.org/10.1021/np970585j
- Luan, X., Wu, Y., Shen, Y.-W., Zhang, H., Zhou, Y.-D., Chen, H.-Z., Nagle, D. G., & Zhang, W.-D. (2020). Cytotoxic and antitumor peptides as novel chemotherapeutics. Natural Product Reports. https://doi.org/https://doi.org/10.1039/D0NP00019A
- Luesch, H., Pangilinan, R., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2001). Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 64(3), 304–307. https://doi.org/https://doi.org/10.1021/np000456u
- Luesch, H., Yoshida, W. Y., Harrigan, G. G., Doom, J. P., Moore, R. E., & Paul, V. J. (2002). Lyngbyaloside b, a new glycoside macrolide from a Palauan marine cyanobacterium, Lyngbya sp. Journal of Natural Products, 65(12), 1945–1948. https://doi.org/https://doi.org/10.1021/np0202879
- Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., & Mooberry, S. L. (2000). Isolation, structure determination, and biological activity of lyngbyabellin A from the marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 63(5), 611–615. https://doi.org/https://doi.org/10.1021/np990543q
- MacMillan, J. B., & Molinski, T. F. (2002). Caylobolide A, a unique 36-membered macrolactone from a Bahamian Lyngbya majuscula. Organic Letters, 4(9), 1535–1538. https://doi.org/https://doi.org/10.1021/ol025759p
- MacMillan, J. B., Ernst-Russell, M. A., De Ropp, J. S., & Molinski, T. F. (2002). Lobocyclamides A − C, Lipopeptides from a cryptic cyanobacterial mat containing Lyngbya c onfervoides. The Journal of Organic Chemistry, 67(23), 8210–8215. https://doi.org/https://doi.org/10.1021/jo0261909
- Madigan, Cossio, M. L. T., Giesen, L. F., Araya, G., Pérez-Cotapos, M. L. S., Vergara, R. L., & Héritier, F. (2012). Microbiologia brock. In Instrumentos familiares. https://doi.org/https://doi.org/10.1007/s13398-014-0173-7.2
- Malloy, K. L., Villa, F. A., Engene, N., Matainaho, T., Gerwick, L., & Gerwick, W. H. (2011). Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. Journal of Natural Products, 74(1), 95–98. https://doi.org/https://doi.org/10.1021/np1005407
- Marner, F. J., Moore, R. E., Hirotsu, K., & Clardy, J. (1977). Majusculamides A and B, Two Epimeric Lipodipeptides from Lyngbya majuscula Gomont. Journal of Organic Chemistry. https://doi.org/https://doi.org/10.1021/jo00437a005
- Marquez, B. L., Watts, K. S., Yokochi, A., Roberts, M. A., Verdier-Pinard, P., Jimenez, J. I., Hamel, E., Scheuer, P. J., & Gerwick, W. H. (2002). Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. Journal of Natural Products, 65(6), 866–871. https://doi.org/https://doi.org/10.1021/np0106283
- Matsubara, K., Sumi, H., & Hori, K. (1996). Platelet aggregation is inhibited by phycolectins. Experientia, 52(6), 540–543. https://doi.org/https://doi.org/10.1007/BF01969724
- Matsui, M. S., Muizzuddin, N., Arad, S., & Marenus, K. (2003). Sulfated polysaccharides from red microalgae have antiinflammatory properties in vitro and in vivo. Applied Biochemistry and Biotechnology, 104(1), 13–22. https://doi.org/https://doi.org/10.1385/ABAB:104:1:13
- Matthew, S., Ross, C., Rocca, J. R., Paul, V. J., & Luesch, H. (2007). Lyngbyastatin 4, a dolastatin 13 analogue with elastase and chymotrypsin inhibitory activity from the marine cyanobacterium Lyngbya confervoides. Journal of Natural Products, 70(1), 124–127. https://doi.org/https://doi.org/10.1021/np060471k
- Matthew, S., Schupp, P. J., & Luesch, H. (2008). Apratoxin E, a cytotoxic peptolide from a guamanian collection of the marine cyanobacterium Lyngbya bouillonii. Journal of Natural Products, 71(6), 1113–1116. https://doi.org/https://doi.org/10.1021/np700717s
- McCusker, M. M., & Grant-Kels, J. M. (2010). Healing fats of the skin: The structural and immunologic roles of the Ω-6 and Ω-3 fatty acids. Clinics in Dermatology, 28(4), 440–451. https://doi.org/https://doi.org/10.1016/j.clindermatol.2010.03.020
- Medina, R. A., Goeger, D. E., Hills, P., Mooberry, S. L., Huang, N., Romero, L. I., Ortega-Barría, E., Gerwick, W. H., & McPhail, K. L. (2008). Coibamide A, a potent antiproliferative cyclic depsipeptide from the panamanian marine cyanobacterium Leptolyngbya sp. Journal of the American Chemical Society, 130(20), 6324–6325. https://doi.org/https://doi.org/10.1021/ja801383f
- Meickle, T., Matthew, S., Ross, C., Luesch, H., & Paul, V. (2009). Bioassay-guided isolation and identification of desacetylmicrocolin B from lyngbya cf. polychroa. Planta Medica, 75(13), 1427–1430. https://doi.org/https://doi.org/10.1055/s-0029-1185675
- Meng, Y., Jiang, J., Wang, H., Cao, X., Xue, S., Yang, Q., & Wang, W. (2015). The characteristics of TAG and EPA accumulation in Nannochloropsis oceanica IMET1 under different nitrogen supply regimes. Bioresource Technology, 179, 483–489. https://doi.org/https://doi.org/10.1016/j.biortech.2014.12.012
- Mevers, E., Liu, W.-T., Engene, N., Mohimani, H., Byrum, T., Pevzner, P. A., Dorrestein, P. C., Spadafora, C., & Gerwick, W. H. (2011). Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. Journal of Natural Products, 74(5), 928–936. https://doi.org/https://doi.org/10.1021/np200077f
- Milligan, K. E., Marquez, B. L., Williamson, R. T., & Gerwick, W. H. (2000). Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya m ajuscula. Journal of Natural Products, 63(10), 1440–1443. https://doi.org/https://doi.org/10.1021/np000133y
- Mishra, A., & Jha, B. (2009). Isolation and characterization of extracellular polymeric substances from micro-algae Dunaliella salina under salt stress. Bioresource Technology, 100(13), 3382–3386. https://doi.org/https://doi.org/10.1016/j.biortech.2009.02.006
- Mitra, A., & Sept, D. (2004). Localization of the antimitotic peptide and depsipeptide binding site on β-tubulin. Biochemistry, 43(44), 13955–13962. https://doi.org/https://doi.org/10.1021/bi0487387
- Mittler, R., Vanderauwera, S., Gollery, M., & Van Breusegem, F. (2004). Reactive oxygen gene network of plants. Trends in Plant Science, 9(10), 490–498. https://doi.org/https://doi.org/10.1016/j.tplants.2004.08.009
- Mo, S., Krunic, A., Pegan, S. D., Franzblau, S. G., & Orjala, J. (2009). An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp. Journal of Natural Products, 72(11), 2043–2045. https://doi.org/https://doi.org/10.1021/np900288x
- Mohamed, Z. A. (2008). Polysaccharides as a protective response against microcystin-induced oxidative stress in Chlorella vulgaris and Scenedesmus quadricauda and their possible significance in the aquatic ecosystem. Ecotoxicology (London, England), 17(6), 504–516. https://doi.org/https://doi.org/10.1007/s10646-008-0204-2
- Montaser, R., Abboud, K. A., Paul, V. J., & Luesch, H. (2011a). Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from guam. Journal of Natural Products, 74(1), 109–112. https://doi.org/https://doi.org/10.1021/np1006839
- Montaser, R., Paul, V. J., & Luesch, H. (2011b). Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry, 72(16), 2068–2074. https://doi.org/https://doi.org/10.1016/j.phytochem.2011.07.014
- Mooberry, S. L., Busquets, L., & Tien, G. (1997). Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent. International Journal of Cancer, 73(3), 440–448. https://doi.org/https://doi.org/10.1002/(sici)1097-0215(19971104)73:3 < 440::aid-ijc20 > 3.3.co;2-x
- Mooberry, S. L., Leal, R. M., Tinley, T. L., Luesch, H., Moore, R. E., & Corbett, T. H. (2003). The molecular pharmacology of symplostatin 1: A new antimitotic dolastatin 10 analog. International Journal of Cancer, 104(4), 512–521. https://doi.org/https://doi.org/10.1002/ijc.10982
- Moore, R. E., & Entzeroth, M. (1988). Majusculamide D and deoxymajusculamide D, two cytotoxins from Lyngbya majuscula. Phytochemistry, 27(10), 3101–3103. https://doi.org/https://doi.org/10.1016/0031-9422(88)80008-6
- Moore, R. E., Cheuk, C., Yang, X., Qiang, G., Patterson, G. M. L., Bonjouklian, R., Smitka, T. A., … Deeter, J. B. (1987). Hapalindoles, antibacterial and antimycotic alkaloids from the cyanophyte hapalosiphon fontinalis. Journal of Organic Chemistry, https://doi.org/https://doi.org/10.1021/jo00382a012
- Nagatsu, A., Kajitani, H., & Sakakibara, J. (1995). Muscoride A: A new oxazole peptide alkaloid from freshwater cyanobacterium Nostoc muscorum. Tetrahedron Letters, 36(23), 4097–4100. https://doi.org/https://doi.org/10.1016/0040-4039(95)00724-Q
- Nakamura, H., Kobayashi, J., & Hirata, Y. (1982). Separation of mycosporine-like amino acids in marine organisms using reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 250, 113–118. https://doi.org/https://doi.org/10.1016/S0021-9673(00)95219-1
- Natsume, T., Watanabe, J-i., Koh, Y., Fujio, N., Ohe, Y., Horiuchi, T., Saijo, N., Nishio, K., & Kobayashi, M. (2003). Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo. Cancer Science, 94(9), 826–833. https://doi.org/https://doi.org/10.1111/j.1349-7006.2003.tb01526.x
- Neuhof, T., Schmieder, P., Preussel, K., Dieckmann, R., Pham, H., Bartl, F., & Von Döhren, H. (2005). Hassallidin A, a glycosylated lipopeptide with antifungal activity from the cyanobacterium Hassallia sp. Journal of Natural Products, 68(5), 695–700. https://doi.org/https://doi.org/10.1021/np049671r
- Neuhof, T., Schmieder, P., Seibold, M., Preussel, K., & von Döhren, H. (2006). Hassallidin B-second antifungal member of the Hassallidin family. Bioorganic and Medicinal Chemistry Letters, https://doi.org/https://doi.org/10.1016/j.bmcl.2006.05.094
- Newman, D. J., & Cragg, G. M. (2012). Natural products as sources of new drugs over the 30 years from 1981 to 2010. Journal of Natural Products, 75(3), 311–335. https://doi.org/https://doi.org/10.1021/np200906s
- Niedermeyer, T. H. J., Daily, A., Swiatecka-Hagenbruch, M., & Moscow, J. A. (2014). Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells. PloS One, 9(3), e91476 https://doi.org/https://doi.org/10.1371/journal.pone.0091476
- Northrop, R. B., & Connor, A. N. (2008). Introduction to molecular biology, genomics and proteomics for biomedical engineers. https://doi.org/https://doi.org/10.1201/b15770
- O’Keefe, B. R., Smee, D. F., Turpin, J. A., Saucedo, C. J., Gustafson, K. R., Mori, T., Blakeslee, D., Buckheit, R., & Boyd, M. R. (2003). Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother, 47(8), 2518–2525. https://doi.org/https://doi.org/10.1128/aac.47.8.2518-2525.2003
- Ogawa, H., Iwasaki, A., Sumimoto, S., Iwatsuki, M., Ishiyama, A., Hokari, R., Otoguro, K., O̅Mura, S., & Suenaga, K. (2017). Isolation and total synthesis of hoshinolactam, an antitrypanosomal lactam from a marine cyanobacterium. Organic Letters, 19(4), 890–893. https://doi.org/https://doi.org/10.1021/acs.orglett.7b00047
- Padrines, M., Wolf, M., Walz, A., & Baggiolini, M. (1994). Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. FEBS Letters, 352(2), 231–235. https://doi.org/https://doi.org/10.1016/0014-5793(94)00952-X
- Pancrace, C., Jokela, J., Sassoon, N., Ganneau, C., Desnos-Ollivier, M., Wahlsten, M., Humisto, A., Calteau, A., Bay, S., Fewer, D. P., Sivonen, K., & Gugger, M. (2017). Rearranged biosynthetic gene cluster and synthesis of hassallidin e in Planktothrix serta PCC 8927. ACS Chemical Biology, 12(7), 1796–1804. https://doi.org/https://doi.org/10.1021/acschembio.7b00093
- Park, J. G., Kim, S. C., Kim, Y. H., Yang, W. S., Kim, Y., Hong, S., Kim, K.-H., Yoo, B. C., Kim, S. H., Kim, J.-H., & Cho, J. Y. (2016). Anti-inflammatory and antinociceptive activities of anthraquinone-2-carboxylic acid. Mediators of Inflammation, 2016, 1903849. https://doi.org/https://doi.org/10.1155/2016/1903849
- Park, J. K., Kim, Z.-H., Lee, C. G., Synytsya, A., Jo, H. S., Kim, S. O., Park, J. W., & Park, Y. I. (2011). Characterization and immunostimulating activity of a water-soluble polysaccharide isolated from Haematococcus lacustris. Biotechnology and Bioprocess Engineering, 16(6), 1090–1098. https://doi.org/https://doi.org/10.1007/s12257-011-0173-9
- Pereira, R. B., Evdokimov, N. M., Lefranc, F., Valentão, P., Kornienko, A., Pereira, D. M., Andrade, P. B., & Gomes, N. G. M. (2019). Marine-derived anticancer agents: Clinical benefits, innovative mechanisms, and new targets. Marine Drugs, 17(6), 329. https://doi.org/https://doi.org/10.3390/md17060329
- Pergament, I., & Carmeli, S. (1994). Schizotrin A; a novel antimicrobial cyclic peptide from a cyanobacterium. Tetrahedron Letters, 35(45), 8473–8476. https://doi.org/https://doi.org/10.1016/S0040-4039(00)74436-4
- Pettit, G. R. (1997). The dolastatins. Fortschritte Der Chemie Organischer Naturstoffe. Progress in the Chemistry of Organic Natural Products. Progrès Dans La Chimie Des Substances Organiques Naturelles. https://doi.org/https://doi.org/10.1201/b11185-12
- Pettit, G. R., Hogan, F., Xu, J.-P., Tan, R., Nogawa, T., Cichacz, Z., Pettit, R. K., Du, J., Ye, Q.-H., Cragg, G. M., Herald, C. L., Hoard, M. S., Goswami, A., Searcy, J., Tackett, L., Doubek, D. L., Williams, L., Hooper, J. N. A., Schmidt, J. M., … Craciunescu, F. (2008). Antineoplastic Agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms. Journal of Natural Products, 71(3), 438–444. https://doi.org/https://doi.org/10.1021/np700738k
- Peumans, W. J., & Van Damme, E. J. (1995). Lectins as plant defense proteins. Plant Physiology, 109(2), 347–352. https://doi.org/https://doi.org/10.1104/pp.109.2.347
- Pham, C. T. N. (2006). Neutrophil serine proteases: Specific regulators of inflammation. Nature Reviews Immunology, 6(7), 541–550. https://doi.org/https://doi.org/10.1038/nri1841
- Prakash, J. W., Johnson, M., & Jeeva, S. (2011). Antimicrobial activity of certain fresh water microalgae from Thamirabarani River, Tamil Nadu, South India. Asian Pacific Journal of Tropical Biomedicine, 1(2), S170–S173. https://doi.org/https://doi.org/10.1016/S2221-1691(11)60149-4
- Priyadarshani, I., & Rath, B. (2012). Commercial and industrial applications of micro-algae a review. Journal of Algal Biomass Utilization, 3(4), 89–100.
- Puviani, M., Barcella, A., & Milani, M. (2013). Efficacy of a photolyase-based device in the treatment of cancerization field in patients with actinic keratosis and non-melanoma skin cancer. Giornale Italiano Di Dermatologia e Venereologia.
- Qu, L., Ji, X.-J., Ren, L.-J., Nie, Z.-K., Feng, Y., Wu, W.-J., Ouyang, P.-K., & Huang, H. (2011). Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient. Letters in Applied Microbiology, 52(1), 22–27. https://doi.org/https://doi.org/10.1111/j.1472-765X.2010.02960.x
- Rastogi, R. P., Sonani, R. R., & Madamwar, D. (2015). Cyanobacterial Sunscreen scytonemin: Role in photoprotection and biomedical research. Applied Biochemistry and Biotechnology. https://doi.org/https://doi.org/10.1007/s12010-015-1676-1
- Rastogi, R. P., & Incharoensakdi, A. (2014). UV radiation-induced biosynthesis, stability and antioxidant activity of mycosporine-like amino acids (MAAs) in a unicellular cyanobacterium Gloeocapsa sp. CU2556. Journal of Photochemistry and Photobiology B: Biology, 130, 287–292. https://doi.org/https://doi.org/10.1016/j.jphotobiol.2013.12.001
- Rastogi, R. P., Richa, Sinha, R. P., Singh, S. P., & Häder, D. P. (2010). Photoprotective compounds from marine organisms. Journal of Industrial Microbiology and Biotechnology. https://doi.org/https://doi.org/10.1007/s10295-010-0718-5
- Ravi, M., Tentu, S., Baskar, G., Rohan Prasad, S., Raghavan, S., Jayaprakash, P., Jeyakanthan, J., Rayala, S. K., & Venkatraman, G. (2015). Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells. BMC Cancer, 15(1) https://doi.org/https://doi.org/10.1186/s12885-015-1784-x
- Reese, M. T., Gulavita, N. K., Nakao, Y., Hamann, M. T., Yoshida, W. Y., Coval, S. J., & Scheuer, P. J. (1996). Kulolide: A cytotoxic depsipeptide from a cephalaspidean mollusk, Philinopsis speciosa. Journal of the American Chemical Society, 118(45), 11081–11084. https://doi.org/https://doi.org/10.1021/ja9620301
- Rogers, D. J., Blunden, G., & Evans, P. R. (1977). Ptilota plumosa, a new source of a blood-group B specific lectin. Medical Laboratory Sciences.
- Román, R. B., Alvárez-Pez, J. M., Fernández, F. G. A., & Grima, E. M. (2002). Recovery of pure b-phycoerythrin from the microalga porphyridium cruentum. Journal of Biotechnology. https://doi.org/https://doi.org/10.1016/S0168-1656(01)00385-6
- Romay, C., Gonzalez, R., Ledon, N., Remirez, D., & Rimbau, V. (2003). C-Phycocyanin: A biliprotein with antioxidant, anti-inflammatory and neuroprotective effects. Current Protein & Peptide Science, 4(3), 207–216. https://doi.org/https://doi.org/10.2174/1389203033487216
- Rubio, B. K., Parrish, S. M., Yoshida, W., Schupp, P. J., Schils, T., & Williams, P. G. (2010). Depsipeptides from a Guamanian marine cyanobacterium, Lyngbya bouillonii, with selective inhibition of serine proteases. Tetrahedron Letters, 51(51), 6718–6721. https://doi.org/https://doi.org/10.1016/j.tetlet.2010.10.062
- Ruiz-Domínguez, M. C., Vaquero, I., Obregón, V., de la Morena, B., Vílchez, C., & Vega, J. M. (2015). Lipid accumulation and antioxidant activity in the eukaryotic acidophilic microalga Coccomyxa sp. (strain onubensis) under nutrient starvation. Journal of Applied Phycology, 27(3), 1099–1108. https://doi.org/https://doi.org/10.1007/s10811-014-0403-6
- Saini, M. K., Vaish, V., & Sanyal, S. N. (2013). Role of cytokines and Jak3/Stat3 signaling in the 1,2-dimethylhydrazine dihydrochloride-induced rat model of colon carcinogenesis: Early target in the anticancer strategy. European Journal of Cancer Prevention : The Official Journal of the European Cancer Prevention Organisation (ECP), 22(3), 215–228. https://doi.org/https://doi.org/10.1097/CEJ.0b013e3283584932
- Salvador, L. A., Paul, V. J., & Luesch, H. (2010). Caylobolide B, a macrolactone from symplostatin 1-producing marine cyanobacteria Phormidium spp. from Florida. Journal of Natural Products, 73(9), 1606–1609. https://doi.org/https://doi.org/10.1021/np100467d
- Santos, A. F. S., Da Silva, M. D. C., Napoleão, T. H., Paiva, P. M. G., Correia, M. T. S., & Coelho, L. C. B. B. (2014). Lectins: Function, structure, biological properties and potential applications. Current Topics in Peptide and Protein Research.
- Schepetkin, I. A., & Quinn, M. T. (2006). Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential. International Immunopharmacology, 6(3), 317–333. https://doi.org/https://doi.org/10.1016/j.intimp.2005.10.005
- Shah, S. A. A., Akhter, N., Auckloo, B., Khan, I., Lu, Y., Wang, K., Wu, B., & Guo, Y.-W. (2017). Structural diversity, biological properties and applications of natural products from cyanobacteria. A review. Marine Drugs, 15(11), 354. https://doi.org/https://doi.org/10.3390/md15110354
- Shahzad-Ul-Hussan, S., Gustchina, E., Ghirlando, R., Clore, G. M., & Bewley, C. A. (2011). Solution structure of the monovalent lectin microvirin in complex with Manα(1-2)Man provides a basis for anti-HIV activity with low toxicity. The Journal of Biological Chemistry, 286(23), 20788–20796. https://doi.org/https://doi.org/10.1074/jbc.M111.232678
- Shih, C., & Teicher, B. (2001). Cryptophycins: A novel class of potent antimitotic antitumor depsipeptides. Current Pharmaceutical Design, 7(13), 1259–1276. https://doi.org/https://doi.org/10.2174/1381612013397474
- Shiomi, K., Yamanaka, H., & Kikuchi, T. (1981). Purification and physicochemical properties of a hemagglutinin (GVA-1) in the Red Alga Gracilaria verrucosa. Nippon Suisan Gakkaishi (Japanese Edition), 47(8), 1079–1084. https://doi.org/https://doi.org/10.2331/suisan.47.1079
- Simmons, T. L., Nogle, L. M., Media, J., Valeriote, F. A., Mooberry, S. L., & Gerwick, W. H. (2009). Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. Journal of Natural Products, 72(6), 1011–1016. https://doi.org/https://doi.org/10.1021/np9001674
- Singh, I. P., Milligan, K. E., & Gerwick, W. H. (1999a). Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya m ajuscula. Journal of Natural Products, 62(9), 1333–1335. https://doi.org/https://doi.org/10.1021/np990162c
- Singh, R. S., Bhari, R., & Kaur, H. P. (2010). Mushroom lectins: Current status and future perspectives. Critical Reviews in Biotechnology, 30(2), 99–126. https://doi.org/https://doi.org/10.3109/07388550903365048
- Singh, R. S., Bhari, R., & Kaur, H. P. (2011). Current trends of lectins from microfungi. Critical Reviews in Biotechnology, 31(3), 193–210. https://doi.org/https://doi.org/10.3109/07388551.2010.505911
- Singh, R. S., Tiwary, A. K., & Kennedy, J. F. (1999b). Lectins: Sources, activities, and applications. Critical Reviews in Biotechnology, 19(2), 145–178. https://doi.org/https://doi.org/10.1080/0738-859991229224
- Smith, V. J., Desbois, A. P., & Dyrynda, E. A. (2010). Conventional and unconventional antimicrobials from fish, marine invertebrates and micro-algae. Marine Drugs, 8(4), 1213–1262. https://doi.org/https://doi.org/10.3390/md8041213
- Soares, A. R., Engene, N., Gunasekera, S. P., Sneed, J. M., & Paul, V. J. (2015). Carriebowlinol, an antimicrobial tetrahydroquinolinol from an assemblage of marine cyanobacteria containing a novel taxon. Journal of Natural Products, 78(3), 534–538. https://doi.org/https://doi.org/10.1021/np500598x
- Soria-Mercado, I. E., Pereira, A., Cao, Z., Murray, T. F., & Gerwick, W. H. (2009). Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. Organic Letters, 11(20), 4704–4707. https://doi.org/https://doi.org/10.1021/ol901438b
- Spolaore, P., Joannis-Cassan, C., Duran, E., & Isambert, A. (2006). Commercial applications of microalgae. Journal of Bioscience and Bioengineering, 101(2), 87–96. https://doi.org/https://doi.org/10.1263/jbb.101.87
- Stevenson, C. S., Capper, E. A., Roshak, A. K., Marquez, B., Eichman, C., Jackson, J. R., Mattern, M., Gerwick, W. H., Jacobs, R. S., & Marshall, L. A. (2002a). The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. The Journal of Pharmacology and Experimental Therapeutics, 303(2), 858–866. https://doi.org/https://doi.org/10.1124/jpet.102.036350
- Stevenson, C. S., Capper, E. A., Roshak, A. K., Marquez, B., Grace, K., Gerwick, W. H., Jacobs, R. S., & Marshall, L. A. (2002b). Scytonemin - A marine natural product inhibitor of kinases key in hyperproliferative inflammatory diseases. Inflammation Research : Official Journal of the European Histamine Research Society. [et al.], 51(2), 112–114. https://doi.org/https://doi.org/10.1007/BF02684014
- Stratmann, K., Moore, R. E., Bonjouklian, R., Deeter, J. B., Patterson, G. M. L., Shaffer, S., Smith, C. D., & Smitka, T. A. (1994). Welwitindolinones, unusual alkaloids from the blue-green algae hapalosiphon welwitschii and Westiella intricata. Relationship to fischerindoles and hapalinodoles. Journal of the American Chemical Society, 116(22), 9935–9942. https://doi.org/https://doi.org/10.1021/ja00101a015
- Suh, S.-S., Hwang, J., Park, M., Seo, H. H., Kim, H.-S., Lee, J. H., Moh, S. H., & Lee, T.-K. (2014). Anti-inflammation activities of mycosporine-like amino acids (MAAs) in response to UV radiation suggest potential anti-skin aging activity. Marine Drugs, 12(10), 5174–5187. https://doi.org/https://doi.org/10.3390/md12105174
- Sumiya, E., Shimogawa, H., Sasaki, H., Tsutsumi, M., Yoshita, K., Ojika, M., Suenaga, K., & Uesugi, M. (2011). Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chemical Biology, 6(5), 425–431. https://doi.org/https://doi.org/10.1021/cb1003459
- Takano, S., Nakanishi, A., Uemura, D., & Hirata, Y. (1979). Isolation and structure of A 334 NM UV-absorbing substance, Porphyra-334 from the red alga porphyra tenera kjellman. Chemistry Letters, 8(4), 419–420. https://doi.org/https://doi.org/10.1246/cl.1979.419
- Takebe, Y., Saucedo, C. J., Lund, G., Uenishi, R., Hase, S., Tsuchiura, T., Kneteman, N., Ramessar, K., Tyrrell, D. L. J., Shirakura, M., Wakita, T., McMahon, J. B., & O’Keefe, B. R. (2013). Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against Hepatitis C Virus. PLoS One, 8(5), e64449. https://doi.org/https://doi.org/10.1371/journal.pone.0064449
- Tan, L. T., Goh, B. P. L., Tripathi, A., Lim, M. G., Dickinson, G. H., Lee, S. S. C., & Teo, S. L. M. (2010). Natural antifoulants from the marine cyanobacterium Lyngbya majuscula. Biofouling, 26(6), 685–695. https://doi.org/https://doi.org/10.1080/08927014.2010.508343
- Taniguchi, M., Nunnery, J. K., Engene, N., Esquenazi, E., Byrum, T., Dorrestein, P. C., & Gerwick, W. H. (2010). Palmyramide a, a cyclic depsipeptide from a palmyra atoll collection of the marine cyanobacterium lyngbya majuscula. Journal of Natural Products, 73(3), 393–398. https://doi.org/https://doi.org/10.1021/np900428h
- Tannin-Spitz, T., Bergman, M., Van-Moppes, D., Grossman, S., & Arad, S. (2005). Antioxidant activity of the polysaccharide of the red microalga Porphyridium sp. Journal of Applied Phycology, 17(3), 215–222. https://doi.org/https://doi.org/10.1007/s10811-005-0679-7
- Taori, K., Matthew, S., Rocca, J. R., Paul, V. J., & Luesch, H. (2007). Lyngbyastatins 5-7, potent elastase inhibitors from Floridian marine cyanobacteria, Lyngbya spp. Journal of Natural Products, 70(10), 1593–1600. https://doi.org/https://doi.org/10.1021/np0702436
- Taori, K., Paul, V. J., & Luesch, H. (2008a). Kempopeptins A and B, serine protease inhibitors with different selectivity profiles from a marine cyanobacterium, Lyngbya sp. Journal of Natural Products, 71(9), 1625–1629. https://doi.org/https://doi.org/10.1021/np8002172
- Taori, K., Paul, V. J., & Luesch, H. (2008b). Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp. Journal of the American Chemical Society, 130(6), 1806–1807. https://doi.org/https://doi.org/10.1021/ja7110064
- Teruya, T., Sasaki, H., Kitamura, K., Nakayama, T., & Suenaga, K. (2009). Biselyngbyaside, a macrolide glycoside from the marine cyanobacterium lyngbya sp. Organic Letters, 11(11), 2421–2424. https://doi.org/https://doi.org/10.1021/ol900579k
- Tidgewell, K., Engene, N., Byrum, T., Media, J., Doi, T., Valeriote, F. A., & Gerwick, W. H. (2010). Evolved diversification of a modular natural product pathway: Apratoxins F and G, two cytotoxic cyclic depsipeptides from a palmyra collection of Lyngbya bouillonii. ChemBioChem, 11(10), 1458–1466. https://doi.org/https://doi.org/10.1002/cbic.201000070
- Tonon, T., Harvey, D., Larson, T. R., & Graham, I. A. (2002). Long chain polyunsaturated fatty acid production and partitioning to triacylglycerols in four microalgae. Phytochemistry, 61(1), 15–24. https://doi.org/https://doi.org/10.1016/S0031-9422(02)00201-7
- Tripathi, A., Puddick, J., Prinsep, M. R., Rottmann, M., Chan, K. P., Chen, D. Y. K., & Tan, L. T. (2011). Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry, 72(18), 2369–2375. https://doi.org/https://doi.org/10.1016/j.phytochem.2011.08.019
- Van Damme, E. J. M., Peumans, W. J., Barre, A., & Rougé, P. (1998). Plant lectins: A composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles. Critical Reviews in Plant Sciences, 17(6), 575–692. https://doi.org/https://doi.org/10.1016/S0735-2689(98)00365-7
- Vass, I. Z., Kõs, P. B., Sass, L., Nagy, C. I., & Vass, I. (2013). The ability of cyanobacterial cells to restore UV-B radiation induced damage to photosystem II is influenced by photolyase dependent DNA repair. Photochemistry and Photobiology, 89(2), 384–390. https://doi.org/https://doi.org/10.1111/php.12012
- Vestola, J., Shishido, T. K., Jokela, J., Fewer, D. P., Aitio, O., Permi, P., Wahlsten, M., Wang, H., Rouhiainen, L., & Sivonen, K. (2014). Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. Proceedings of the National Academy of Sciences of the United States of America, 111(18), E1909–E1917. https://doi.org/https://doi.org/10.1073/pnas.1320913111
- Vining, O. B., Medina, R. A., Mitchell, E. A., Videau, P., Li, D., Serrill, J. D., Kelly, J. X., Gerwick, W. H., Proteau, P. J., Ishmael, J. E., & McPhail, K. L. (2015). Depsipeptide companeramides from a panamanian marine cyanobacterium associated with the coibamide producer. Journal of Natural Products, 78(3), 413–420. https://doi.org/https://doi.org/10.1021/np5007907
- Viskari, P. J., & Colyer, C. L. (2003). Rapid extraction of phycobiliproteins from cultured cyanobacteria samples. Analytical Biochemistry, 319(2), 263–271. https://doi.org/https://doi.org/10.1016/S0003-2697(03)00294-X
- Wada, N., Sakamoto, T., & Matsugo, S. (2013). Multiple roles of photosynthetic and sunscreen pigments in cyanobacteria focusing on the oxidative stress. Metabolites, 3(2), 463–483. https://doi.org/https://doi.org/10.3390/metabo3020463
- Waditee-Sirisattha, R., Kageyama, H., Sopun, W., Tanaka, Y., & Takabe, T. (2014). Identification and upregulation of biosynthetic genes required for accumulation of mycosporine-2-glycine under salt stress conditions in the halotolerant cyanobacterium Aphanothece halophytica. Applied and Environmental Microbiology, 80(5), 1763–1769. https://doi.org/https://doi.org/10.1128/AEM.03729-13
- Weaver, K. L., Ivester, P., Seeds, M., Case, L. D., Arm, J. P., & Chilton, F. H. (2009). Effect of dietary fatty acids on inflammatory gene expression in health humans. Journal of Biological Chemistry, 284(23), 15400–15407. https://doi.org/https://doi.org/10.1074/jbc.M109.004861
- Wei, D., Chen, F., Chen, G., Zhang, X. W., Liu, L. J., & Zhang, H. (2008). Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress. Science in China, Series C: Life Sciences. https://doi.org/https://doi.org/10.1007/s11427-008-0145-2
- Wiedow, O., & Meyer-Hoffert, U. (2005). Neutrophil serine proteases: Potential key regulators of cell signalling during inflammation. Journal of Internal Medicine, 257(4), 319–328. https://doi.org/https://doi.org/10.1111/j.1365-2796.2005.01476.x
- Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2002). Tasiamide, a cytotoxic peptide from the marine cyanobacterium Symploca sp. Journal of Natural Products, 65(9), 1336–1339. https://doi.org/https://doi.org/10.1021/np020184q
- Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2003a). Tasipeptins A and B: New cytotoxic depsipeptides from the marine cyanobacterium Symploca sp. Journal of Natural Products, 66(5), 620–624. https://doi.org/https://doi.org/10.1021/np020582t
- Williams, P. G., Yoshida, W. Y., Quon, M. K., Moore, R. E., & Paul, V. J. (2003b). The structure of Palau’amide, a potent cytotoxin from a species of the marine cyanobacterium Lyngbya. Journal of Natural Products, 66(12), 1545–1549. https://doi.org/https://doi.org/10.1021/np034001r
- Williams, P. G., Yoshida, W. Y., Quon, M. K., Moore, R. E., & Paul, V. J. (2003c). Ulongapeptin, a cytotoxic cyclic depsipeptide from a Palauan marine cyanobacterium Lyngbya sp. Journal of Natural Products, 66(5), 651–654. https://doi.org/https://doi.org/10.1021/np030050s
- Wrasidlo, W., Mielgo, A., Torres, V. A., Barbero, S., Stoletov, K., Suyama, T. L., Klemke, R. L., Gerwick, W. H., Carson, D. A., & Stupack, D. G. (2008). The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2313–2318. https://doi.org/https://doi.org/10.1073/pnas.0712198105
- Xiong, C., O’Keefe, B. R., Botos, I., Wlodawer, A., & McMahon, J. B. (2006a). Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium. Protein Expression and Purification, 46(2), 233–239. https://doi.org/https://doi.org/10.1016/j.pep.2005.09.019
- Xiong, C., O’Keefe, B. R., Byrd, R. A., & McMahon, J. B. (2006b). Potent anti-HIV activity of scytovirin domain 1 peptide. Peptides, 27(7), 1668–1675. https://doi.org/https://doi.org/10.1016/j.peptides.2006.03.018
- Yamaguchi, M., Ogawa, T., Muramoto, K., Kamio, Y., Jimbo, M., & Kamiya, H. (1999). Isolation and characterization of a mannan-binding lectin from the freshwater cyanobacterium (blue-green algae) Microcystis viridis. Biochemical and Biophysical Research Communications, 265(3), 703–708. https://doi.org/https://doi.org/10.1006/bbrc.1999.1749
- Yang, E. J., Kim, S. H., Lee, K. Y., & Song, K. S. (2018). Neuroprotective and anti-neuroinflammatory activities of anthraquinones isolated from Photorhabdus temperata culture broth. Journal of Microbiology and Biotechnology, 28(1), 12–21. https://doi.org/https://doi.org/10.4014/jmb.1708.08067
- Yen, G. C., Duh, P. D., & Chuang, D. Y. (2000). Antioxidant activity of anthraquinones and anthrone. Food Chemistry, 70(4), 437–441. https://doi.org/https://doi.org/10.1016/S0308-8146(00)00108-4
- Yin-Nin Ma, R., & Chen, F. (2001). Induction of astaxanthin formation by reactive oxygen species in mixotrophic culture of Chlorococcum sp. Biotechnology Letters, 23(7), 519–523. https://doi.org/https://doi.org/10.1023/A:1010370401235
- Zainuddin, E. N., Mentel, R., Wray, V., Jansen, R., Nimtz, M., Lalk, M., & Mundt, S. (2007). Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe. Journal of Natural Products, 70(7), 1084–1088. https://doi.org/https://doi.org/10.1021/np060303s
- Zhang, P. Y., Xu, X., & Li, X. C. (2014). Cardiovascular diseases: Oxidative damage and antioxidant protection. European Review for Medical and Pharmacological Sciences,
- Zheng, Y., Li, Z., Tao, M., Li, J., & Hu, Z. (2017). Effects of selenite on green microalga Haematococcus pluvialis: Bioaccumulation of selenium and enhancement of astaxanthin production. Aquatic Toxicology (Amsterdam, Netherlands), 183, 21–27. https://doi.org/https://doi.org/10.1016/j.aquatox.2016.12.008
- Zou, B., Long, K., & Ma, D. (2005). Total synthesis and cytotoxicity studies of a cyclic depsipeptide with proposed structure of palau’amide. Organic Letters, 7(19), 4237–4240. . https://doi.org/https://doi.org/10.1021/ol051685g