Effect of structural variation on enzymatic activity in tetranuclear (Cu₄) clusters with defective cubane core

References

• Adak, P., Ghosh, B., Bauzá, A., Frontera, A., Blake, A. J., Corbella, M., Das Mukhopadhyay, C., & Chattopadhyay, S. K. (2016). Catecholase activity, DNA binding and cytotoxicity studies of a Cu( ii ) complex of a pyridoxal schiff base: Synthesis, X-ray crystal structure, spectroscopic, electrochemical and theoretical studies. RSC Advances, 6(90), 86851–86861. https://doi.org/10.1039/C6RA14059A
   Web of Science ®Google Scholar
• Ahamad, M. N., Iman, K., Raza, M. K., Kumar, M., Ansari, A., Ahmad, M., & Shahid, M. (2020). Anticancer properties, apoptosis and catecholase mimic activities of dinuclear cobalt(II) and copper(II) Schiff base complexes. Bioorganic Chemistry, 95, 103561. https://doi.org/10.1016/j.bioorg.2019.103561
   PubMed Web of Science ®Google Scholar
• Ahamad, M. N., Khan, M. S., Shahid, M., & Ahmad, M. (2020). Metal organic frameworks decorated with free carboxylic acid groups: Topology, metal capture and dye adsorption properties. Dalton Transactions (Cambridge, England: 2003), 49(41), 14690–14705. https://doi.org/10.1039/d0dt02949a
   PubMed Web of Science ®Google Scholar
• Ahmad, M. S., Khalid, M., Khan, M. S., Shahid, M., & Ahmad, M. (2020). Synthesis, characterization, and catecholase mimic activity of a new 1D Cu(II) polymer constructed from iminodiacetate. Journal of Structural Chemistry, 61(4), 533–540. https://doi.org/10.1134/S0022476620040058
   Web of Science ®Google Scholar
• Ahmad, M. S., Khalid, M., Khan, M. S., Shahid, M., Ahmad, M., Rao, M., Ansari, A., & Ashafaq, M. (2020). Exploring catecholase activity in dinuclear Mn(ii) and Cu(ii) complexes: an experimental and theoretical approach.†New Journal of Chemistry, 44, 7998–8009.
   Web of Science ®Google Scholar
• Amim, R. S., Oliveira, M. R. L., Perpetuo, G. J., Janczak, J., Miranda, L. D. L., & Rubinger, M. M. M. (2008). Syntheses, crystal structure and spectroscopic characterization of new platinum(II) dithiocarbimato complexes. Polyhedron, 27(7), 1891–1897. https://doi.org/10.1016/j.poly.2008.02.030
   Web of Science ®Google Scholar
• Ansari, I. A., Sama, F., Shahid, M., Rahisuddin, R., Arif, R., Khalid, M., & Siddiqi, Z. A. (2016). Isolation of proton transfer complexes containing 4-picolinium as cation and pyridine-2,6-dicarboxylate complex as anion: Crystallographic and spectral investigations, antioxidant activities and molecular docking studies. RSC Advances, 6(14), 11088–11098. https://doi.org/10.1039/C5RA25939H
   Web of Science ®Google Scholar
• Ashafaq, M., Khalid, M., Raizada, M., Ahmad, M. S., Khan, M. S., Shahid, M., & Ahmad, M. (2020). A Zn-based fluorescent coordination polymer as bifunctional sensor: sensitive and selective aqueous-phase detection of picric acid and heavy metal ion. Journal of Inorganic and Organometallic Polymers and Materials, 30(11), 4496–4509. https://doi.org/10.1007/s10904-020-01579-6
   Web of Science ®Google Scholar
• Banu, K. S., Chattopadhyay, T., Banerjee, A., Mukherjee, M., Bhattacharya, S., Patra, G. K., Zangrando, E., & Das, D. (2009). Mono- and dinuclear manganese(III) complexes showing efficient catechol oxidase activity: Syntheses, characterization and spectroscopic studies. Dalton Transactions, (40), 8755–8764. https://doi.org/10.1039/b902498k
   Google Scholar
• Battaini, G., Monzani, E., Casella, L., Santagostini, L., & Pagliarin, R. (2000). Inhibition of the catecholase activity of biomimetic dinuclear copper complexes by kojic acid. Journal of Biological Inorganic Chemistry: A Publication of the Society of Biological Inorganic Chemistry, 5(2), 262–268. https://doi.org/10.1007/s007750050370
   PubMed Web of Science ®Google Scholar
• Belle, C., Beguin, C., Gautier-Luneau, I., Hamman, S., Philouze, C., Pierre, J. L., Thomas, F., & Torelli, S., Saint-Aman, E., & Bonin, M. (2002). Dicopper(II) complexes of H-BPMP-TYPE LIGANDS: pH-induced changes of redox, spectroscopic (19F NMR studies of fluorinated complexes), structural properties, and catecholase activities. Inorganic Chemistry, 41, 479–491.
   PubMed Web of Science ®Google Scholar
• Bondi, A. (1964). van der Waals Volumes and Radii. The Journal of Physical Chemistry, 68(3), 441–451. https://doi.org/10.1021/j100785a001
   Web of Science ®Google Scholar
• Bourhis, L. J., Dolomanov, O. V., Gildea, R. J., Howard, J. A. K., & Puschmann, H. (2015). Crystal structure of 5,11-di­hydro­pyrido[2,3-b][1,4]benzodiazepin-6-one. Acta Crystallographica, Section A, 71, 59–60.
   Google Scholar
• Castro, K. A. D. F., Simões, M. M. Q., Neves, M. G. P. M. S., Cavaleiro, J. A. S., Ribeiro, R. R., Wypych, F., & Nakagaki, S. (2015). Synthesis of new metalloporphyrin derivatives from [5,10,15,20-tetrakis (pentafluorophenyl)porphyrin] and 4-mercaptobenzoic acid for homogeneous and heterogeneous catalysis. Applied Catalysis A: General, 503, 9–19. https://doi.org/10.1016/j.apcata.2014.12.048
   Web of Science ®Google Scholar
• Das, D., Guha, A., Das, S., Chakraborty, P., Mondal, T. K., Goswami, S., & Zangrando, E. (2012). Diastereomerism in tetranuclear copper(II) complexes of a phenol based “end-off” compartmental ligand. Inorganic Chemistry Communications, 23, 113–116. https://doi.org/10.1016/j.inoche.2012.06.020
   Web of Science ®Google Scholar
• Dasgupta, S., Majumder, I., Chakraborty, P., Zangrando, E., Bauza, A., Frontera, A., & Das, D. (2017). Ligand-flexibility controlled andsolvent-induced nuclearity conversion in cu ii -based catecholase models: A deep insight through combined experimental and theoretical investigations. European Journal of Inorganic Chemistry, 2017(1), 133–145. https://doi.org/10.1002/ejic.201600985
   Google Scholar
• Efthymiou, C. G., Papatriantafyllopoulou, C., Aromi, G., Teat, S. J., Christou, G., & Perlepes, S. P. (2011). A NiII cubane with a ligand derived from a unique metal ion-promoted, crossed-aldol reaction of acetone with di-2-pyridyl ketone. Polyhedron, 30(18), 3022–3025. https://doi.org/10.1016/j.poly.2011.02.024
   Web of Science ®Google Scholar
• Fontecave, M., & Pierre, J.-L. (1998). Oxidations by copper metalloenzymes and some biomimetic approaches. Coordination Chemistry Reviews, 170, 125–140.
   Web of Science ®Google Scholar
• Frank, C. W., & Rogers, L. B. (1966). Infrared spectral study of metal-pyridine, -substituted pyridine, and -quinoline complexes in the 667–150 cm−1 region. Inorganic Chemistry, 5(4), 615–622. https://doi.org/10.1021/ic50038a026
   Web of Science ®Google Scholar
• Fujita, M., Umemoto, K., Yoshizawa, M., Fujita, N., Kusukawa, T., & Biradha, K. (2001). Molecular paneling via coordination. Chemical Communications (6), 509–518. https://doi.org/10.1039/b008684n
   Google Scholar
• Gatehouse, M., Livingstone, S. E., Nyholm, R. S., & Inorg, J. (1958). Infrared spectra of some nitrato and other oxy-anion co-ordination complexes. Journal of Inorganic and Nuclear Chemistry, 8, 75–78. https://doi.org/10.1016/0022-1902(58)80166-9
   Web of Science ®Google Scholar
• Gronert, S., & Keeffe, J. R. (2005). Identity hydride-ion transfer from c − h donors to c acceptor sites. enthalpies of hydride addition and enthalpies of activation. Comparison with C···H···C proton transfer. An ab initio study. Journal of the American Chemical Society, 127(7), 2324–2333. https://doi.org/10.1021/ja044002l
   PubMed Web of Science ®Google Scholar
• Gungor, E., Kara, H., Colacio, E., & Mota, A. J. (2014). Two tetranuclear Copper(II) complexes with open cubane-like Cu4O4 core framework and ferromagnetic exchange interactions between Copper(II) ions: structure, magnetic properties, and density functional study. European Journal of Inorganic Chemistry, 2014(9), 1552–1560. https://doi.org/10.1002/ejic.201301515
   Web of Science ®Google Scholar
• Holm, R. H., Kennepohl, P., & Solomon, E. I. (1996). Structural and functional aspects of metal sites in biology. Chemical Reviews, 96(7), 2239–2314. https://doi.org/10.1021/cr9500390
   PubMed Web of Science ®Google Scholar
• Ibers, J. A., & Hamilton, W. C. (1974). International tables for X-ray crystallography [IV 26 SMART & SAINT Software Reference manuals, Version 6.45], 2003. Kynoch Press/Bruker Analytical X-ray Systems, Inc., 2003.
   Google Scholar
• Iman, K., Shahid, M., Khan, M. S., Ahmad, M., & Sama, F. (2019). Topology, magnetism and dye adsorption properties of metal organic frameworks (MOFs) synthesized from bench chemicals. CrystEngComm, 21(35), 5299–5309. https://doi.org/10.1039/C9CE01041F
   Web of Science ®Google Scholar
• Kamal, S., Khalid, M., Khan, M. S., Shahid, M., Ashafaq, M., Mantasha, I., Ahmad, M. S., Ahmad, M., Faizan, M., & Ahmad Inorg, S. (2020). Chimica Acta, 512, 119872.
   Google Scholar
• Karlin, K. D., Nasir, M. S., Cohen, B. I., Cruse, R. W., Kaderli, S., & Zuberbuehler, A. D. (1994). Reversible dioxygen binding and aromatic hydroxylation in O2-reactions with substituted Xylyl dinuclear copper(I) complexes: Syntheses and low-temperature kinetic/thermodynamic and spectroscopic investigations of a copper monooxygenase model system. Journal of the American Chemical Society, 116(4), 1324–1336. https://doi.org/10.1021/ja00083a018
   Web of Science ®Google Scholar
• Karlin, K. D., Wei, N., Jung, B., Kaderli, S., Niklaus, P., & Zuberbuehler, A. D. (1993). Kinetics and thermodynamics of formation of copper-dioxygen adducts: oxygenation of mononuclear copper(I) complexes containing tripodal tetradentate ligands. Journal of the American Chemical Society, 9506–9514. https://doi.org/10.1021/ja00074a015
   Google Scholar
• Khan, M. S., Hayat, M. U., Khanam, M., Saeed, H., Owais, M., Khalid, M., Shahid, M., & Ahmad, M. (2020). Journal of Biomolecular Structure and Dynamics, https://doi.org/10.1080/07391102.2020.1776156.
   Google Scholar
• Khan, M. S., Khalid, M., Ahmad, M. S., & Shahid, M., & Ahmad, M. (2020). Catalytic activity of Mn(III) and Co(III) complexes: evaluation of catechol oxidase enzymatic and photodegradation properties. Research on Chemical Intermediates, 46, 2985–3006.
   Web of Science ®Google Scholar
• Khan, M. S., Khalid, M., Ahmad, M. S., Shahid, M., & Ahmad, M. (2019). Design and Characterization of a Cu(II) Coordination Polymer Based on α-Diimine: Evaluation of the Biomimetic Activity. Journal of Structural Chemistry, 60(11), 1833–1841. https://doi.org/10.1134/S0022476619110180
   Web of Science ®Google Scholar
• Khan, M. S., Khalid, M., Ahmad, M. S., Shahid, M., & Ahmad, M. (2019). Three-in-one is really better: Exploring the sensing and adsorption properties in a newly designed metal-organic system incorporating a copper(ii) ion. Dalton Transactions (Cambridge, England : 2003), 48(34), 12918–12932. https://doi.org/10.1039/c9dt02578b
   PubMed Web of Science ®Google Scholar
• Khan, M. S., Khalid, M., & Shahid, M. (2021). A Co(II) coordination polymer derived from pentaerythritol as an efficient photocatalyst for the degradation of organic dyes. Polyhedron, 196, 114984. https://doi.org/10.1016/j.poly.2020.114984
   Web of Science ®Google Scholar
• Khan, M. S., Khalid, M., & Shahid, M. (2021). Engineered Fe 3 triangle for the rapid and selective removal of aromatic cationic pollutants: Complexity is not a necessity. RSC Advances, 11(5), 2630–2642. https://doi.org/10.1039/D0RA09586A
   PubMed Web of Science ®Google Scholar
• Khan, M. S., Khalid, M., & Shahid, M. (2020). What triggers dye adsorption by metal organic frameworks? The current perspectives. Materials Advances, 1(6), 1575–1601. https://doi.org/10.1039/D0MA00291G
   Google Scholar
• Khan, M. S., Khalid, M., Ahmad, M. S., Ahmad, M., Ashafaq, M., Rahisuddin, Arif, R., & Shahid, M. (2019). Synthesis, spectral and crystallographic study, DNA binding and molecular docking studies of homo dinuclear Co(II) and Ni(II) complexes. Journal of Molecular Structure, 1175, 889–899. https://doi.org/10.1016/j.molstruc.2018.08.048
   Web of Science ®Google Scholar
• Kitos, A. A., Efthymiou, C. G., Papatriantafyllopoulou, C., Nastopoulos, V., Tasiopoulos, A. J., Manos, M. J., Wernsdorfer, W., Christou, G., & Perlepes, S. P. (2011). The search for cobalt single-molecule magnets: A disk-like CoIIICoII6 cluster with a ligand derived from a novel transformation of 2-acetylpyridine. Polyhedron, 30(18), 2987–2996. https://doi.org/10.1016/j.poly.2011.02.013
   Web of Science ®Google Scholar
• Koval, I. A., Gamez, P., Belle, C., Selmeczi, K., & Reedijk, J. (2006). Synthetic models of the active site of catechol oxidase: mechanistic studies. Chemical Society Reviews, 35(9), 814–840. https://doi.org/10.1039/b516250p
   PubMed Web of Science ®Google Scholar
• Koval, I. A., Selmeczi, K., Belle, C., Philouze, C., Saint-Aman, E., Gautier-Luneau, I., Schuitema, A. M., Vliet, M. v., Gamez, P., Roubeau, O., LüKen, M., Krebs, B., Lutz, M., Spek, A. L., Pierre, J.-L., & Reedijk, J. (2006). Catecholase activity of a copper(II) complex with a macrocyclic ligand: Unraveling catalytic mechanisms. Chemistry (Weinheim an Der Bergstrasse, Germany), 12(23), 6138–6150. https://doi.org/10.1002/chem.200501600
   PubMed Web of Science ®Google Scholar
• Krause, R. A., Colthup, N. B., & Busch, D. H. (1961). Infrared spectra of complexes of 2-pyridinaldoxime. The Journal of Physical Chemistry, 65(12), 2216–2219. https://doi.org/10.1021/j100829a026
   Web of Science ®Google Scholar
• Lawrence, J., Beedle, C. C., Yang, E.-C., Ma, J., Hill, S., & Hendrickson, D. N. (2007). High frequency electron paramagnetic resonance (HFEPR) study of a high spin Co(II) complex. Polyhedron, 26(9–11), 2299–2303. https://doi.org/10.1016/j.poly.2006.11.018
   Web of Science ®Google Scholar
• Lever, A. B. P. (1984). Inorganic electronic spectroscopy. Elsevier.
   Google Scholar
• Liu, Y., Wu, H., Chong, Y., Wamer, W. G., Xia, Q., Cai, L., Nie, Z., Fu, P. P., & Yin, J. J. (2015). Platinum nanoparticles: Efficient and stable catechol oxidase mimetics. ACS Applied Materials & Interfaces, 7(35), 19709–19717. https://doi.org/10.1021/acsami.5b05180
   PubMed Web of Science ®Google Scholar
• Mariyam, A., Shahid, M., Mantasha, I., Khan, M. S., & Ahmad, M. S. (2020). Tetrazole based porous metal organic framework (MOF): Topological analysis and dye adsorption properties. Journal of Inorganic and Organometallic Polymers and Materials, 30(6), 1935–1943. https://doi.org/10.1007/s10904-019-01334-6
   Web of Science ®Google Scholar
• Mergehenn, R., & Haase, W. (1977). The crystal structure of cyanato(2-dimethylaminoethanolato)copper(II), C5H10 N2 O2Cu. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry, 33(6), 1877–1882. https://doi.org/10.1107/S0567740877007249
   Google Scholar
• Merz, L., & Haase, W. (1978). Crystal and molecular structure and magnetic properties of tetrakis-[(2-diethylaminoethanolato)isocyanatocopper(II)]. Journal of the Chemical Society, Dalton Transactions, (11), 1594–1598. https://doi.org/10.1039/dt9780001594
   Google Scholar
• Merz, L., & Haase, W. (1980). Exchange interaction in tetrameric oxygen-bridged copper(II) clusters of the cubane type. Journal of the Chemical Society, Dalton Transactions, (6), 875–879. https://doi.org/10.1039/dt9800000875
   Google Scholar
• Mijangos, E., Reedijk, J., & Gasque, L. (2008). Copper(ii) complexes of a polydentate imidazole-based ligand. pH effect on magnetic coupling and catecholase activity. Dalton Transactions, (14), 1857. https://doi.org/10.1039/b714283h
   Google Scholar
• Mueller-Westerhoff, U. T., Nazzal, A., & Proessdorf, W. (1981). First evidence for the existence of intramolecular carbon-hydrogen-carbon hydrogen bonds: carbanions of [1.1]ferrocenophane, 1-methyl-[1.1]ferrocenophane, and 1,12-dimethyl-[1.1]ferrocenophane. Journal of the American Chemical Society, 103(25), 7678–7681. https://doi.org/10.1021/ja00415a059
   Web of Science ®Google Scholar
• Nakamoto, K. (1986). Infrared and Raman Spectra of inorganic and coordination compounds. Wiley.
   Google Scholar
• Ording-Wenker, E. C. M., Siegler, M. A., Lutz, M., & Bouwman, E. (2015). Catalytic catechol oxidation by copper complexes: Development of a structure–activity relationship. Dalton Transactions (Cambridge, England: 2003), 44(27), 12196–12209. https://doi.org/10.1039/c5dt01041a
   PubMed Web of Science ®Google Scholar
• Papadakis, R., Rivière, E., Giorgi, M., Jamet, H., Rousselot-Pailley, P., Réglier, M., Simaan, A. J., & Tron, T. (2013). Structural and magnetic characterization of a tetranuclear copper(II) cubane stabilized by intramolecular metal cation-π interactions. Inorganic Chemistry, 52(10), 5824–5830. https://doi.org/10.1021/ic3027545
   PubMed Web of Science ®Google Scholar
• Punniyamurthy, T., Velusamy, S., & Iqbal, J. (2005). Recent advances in transition metal catalyzed oxidation of organic substrates with molecular oxygen. Chemical Reviews, 105(6), 2329–2364. https://doi.org/10.1021/cr050523v
   PubMed Web of Science ®Google Scholar
• Que, L., & Tolman, W. B. (2008). Biologically inspired oxidation catalysis. Nature, 455(7211), 333–340.
   PubMed Web of Science ®Google Scholar
• Sama, F., Ansari, I. A., Raizada, M., Ahmad, M., Nagaraja, C. M., Shahid, M., Kumar, A., Khan, K., & Siddiqi, Z. A. (2017). Design, structures and study of non-covalent interactions of mono-, di-, and tetranuclear complexes of a bifurcated quadridentate tripod ligand, N-(aminopropyl)-diethanolamine. New Journal of Chemistry, 41(5), 1959–1972. https://doi.org/10.1039/C6NJ02562E
   Web of Science ®Google Scholar
• Sama, F., Dhara, A. K., Akhtar, M. N., Chen, Y.-C., Tong, M.-L., Ansari, I. A., Raizada, M., Ahmad, M., Shahid, M., & Siddiqi, Z. A. (2017). Aminoalcohols and benzoates-friends or foes? Tuning nuclearity of Cu(ii) complexes, studies of their structures, magnetism, and catecholase-like activities as well as performing DFT and TDDFT studies. Dalton Transactions (Cambridge, England : 2003), 46(30), 9801–9823. https://doi.org/10.1039/c7dt01571b
   PubMed Web of Science ®Google Scholar
• Sénèque, O., Campion, M., Douziech, B., Giorgi, M., Rivière, E., Journaux, Y., Mest, Y. L., & Reinaud, O. (2002). Supramolecular Assembly with Calix[6]arene and copper ions − formation of a novel tetranuclear core exhibiting unusual redox properties and catecholase activity. European Journal of Inorganic Chemistry, 2002(8), 2007–2014. https://doi.org/10.1002/1099-0682(200208)2002:8<2007::AID-EJIC2007>3.0.CO;2-Z
   Google Scholar
• Sessoli, R., Gatteschi, D., Caneschi, A., & Novak, M. A. (1993). Magnetic bistability in a metal-ion cluster. Nature, 365(6442), 141–143. https://doi.org/10.1038/365141a0
   Web of Science ®Google Scholar
• Sessoli, R., Tsai, H.-L., Schake, A. R., Wang, S., Vincent, J. B., Folting, K., Gatteschi, D., Christou, G., & Hendrickson, D. N. (1993). High-spin molecules: [Mn12O12(O2CR)16(H2O)4]. Journal of the American Chemical Society, 115(5), 1804–1816. 1. https://doi.org/10.1021/ja00058a027
   Web of Science ®Google Scholar
• Sheldrick, G. M. (2002). SADABS [software for empirical absorption correction, Ver. 2.05]. University of Göttingen.
   Google Scholar
• Sreenivasulu, B., Zhao, F., Gao, S., & Vittal, J. J. (2006). Synthesis, structures and catecholase activity of a new series of Dicopper(II) Complexes of reduced schiff base ligands. European Journal of Inorganic Chemistry, 2006(13), 2656–2670. https://doi.org/10.1002/ejic.200600022
   Google Scholar
• Tan, X. S., Fujii, Y., Nukada, R., Mikuriya, M., & Nakano, Y. (1999). Crystal structure and ferromagnetic behaviour of a novel tetranuclear copper(II) complex with an open cubane-like Cu4O4 framework. Journal of the Chemical Society, Dalton Transactions, (15), 2415–2416. https://doi.org/10.1039/a903524i
   Google Scholar
• Walz, L. H., Paulus, W., & Haase, J. (1983). Chemistry Society, Dalton Transactions, 6.
   Google Scholar
• Wegner, R., Gottschaldt, M., Görls, H., Jäger, E., & Klemm, D. (2001). Copper(II) complexes of aminocarbohydrateβ-ketoenaminic ligands: efficient catalysts in catechol oxidation. Chemistry, 7(10), 2143–2157. https://doi.org/10.1002/1521-3765(20010518)7:10<2143::AID-CHEM2143>3.0.CO;2-D
   PubMed Web of Science ®Google Scholar
• XPREP. (1995), version 5.1. Siemens Industrial Automation Inc.
   Google Scholar
• Yang, L., Powell, D. R., & Houser, R. P. (2007). Structural variation in copper( i ) complexes with pyridylmethylamide ligands: Structural analysis with a new four-coordinate geometry index, τ4. Dalton Transactions, (9), 955–964. https://doi.org/10.1039/B617136B
   Google Scholar
• Yang, E.-C., Wernsdorfer, W., Zakharov, L. N., Karaki, Y., Yamaguchi, A., Isidro, R. M., Lu, G.-D., Wilson, S. A., Rheingold, A. L., Ishimoto, H., & Hendrickson, D. N. (2006). Fast magnetization tunneling in Tetranickel(II) single-molecule magnets. Inorganic Chemistry, 45(2), 529–546. https://doi.org/10.1021/ic050093r
   PubMed Web of Science ®Google Scholar
• Zhang, X.-Y., Li, B., Tang, J.-K., Tian, J.-M., Huang, J.-L., & Zhang, J.-P. (2013). Tuning the interactions from antiferro- to ferro-magnetic by molecular tailoring and manipulating. Dalton Transactions (Cambridge, England: 2003), 42(10), 3308–3317. https://doi.org/10.1039/c2dt32021e
   PubMed Web of Science ®Google Scholar