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Research Articles

Salinomycin mediated therapeutic targeting of circulating stem like cell population in oral cancer

, , , , , & ORCID Icon show all
Pages 11141-11153 | Received 12 Feb 2021, Accepted 10 Jul 2021, Published online: 26 Jul 2021

References

  • An, H., Kim, J. Y., Oh, E., Lee, N., Cho, Y., & Seo, J. H. (2015). Salinomycin promotes anoikis and decreases the CD44+/CD24-stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells. PLoS One, 10(11), e0141919.
  • Atashpour, S., Fouladdel, S., Movahhed, T. K., Barzegar, E., Ghahremani, M. H., Ostad, S. N., & Azizi, E. (2021). Quercetin induces cell cycle arrest and apoptosis in CD133+ cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin. Iranian Journal of Basic Medical Sciences, 18(7), 635. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556754/
  • Baillie, R., Tan, S. T., & Itinteang, T. (2017). Cancer stem cells in oral cavity squamous cell carcinoma: A review. Frontiers in Oncology, 7, 112. https://doi.org/10.3389/fonc.2017.00112
  • Bajorath, J., Greenfield, B., Munro, S. B., Day, A. J., & Aruffo, A. (2021). Identification of CD44 residues important for hyaluronan binding and delineation of the binding site. Journal of Biological Chemistry, 273(1), 338–343.
  • Bourguignon, L. Y., Earle, C., & Shiina, M. (2017). Activation of matrix hyaluronan-mediated CD44 signaling, epigenetic regulation and chemoresistance in head and neck cancer stem cells. International Journal of Molecular Sciences, 18(9), 1849.
  • Chang, L., Graham, P. H., Hao, J., Ni, J., Bucci, J., Cozzi, P. J., Kearsley, J. H., & Li, Y. (2013). Acquisition of epithelial–mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate. Cell Death & Disease, 4(10), e875.
  • Chikamatsu, K., Takahashi, G., Sakakura, K., Ferrone, S., & Masuyama, K. (2011). Immunoregulatory properties of CD44+ cancer stem-like cells in squamous cell carcinoma of the head and neck. Head & Neck, 33(2), 208–215. https://doi.org/10.1002/hed.21420
  • Duan, Y., Wu, C., Chowdhury, S., Lee, M. C., Xiong, G., Zhang, W., Yang, R., Cieplak, P., Luo, R., Lee, T., Caldwell, J., Wang, J., & Kollman, P. (2003). A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. Journal of Computational Chemistry, 24(16), 1999–2012. https://doi.org/10.1002/jcc.10349
  • Hochmair, M., Rath, B., Klameth, L., Ulsperger, E., Weinlinger, C., Fazekas, A., Plangger, A., Zeillinger, R., & Hamilton, G. (2020). Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines. Investigational New Drugs, 38(4), 946–955. https://doi.org/10.1007/s10637-019-00847-8
  • Hu, J., Mirshahidi, S., Simental, A., Lee, S. C., De Andrade Filho, P. A., Peterson, N. R., Duerksen-Hughes, P., & Yuan, X. (2019). Cancer stem cell self-renewal as a therapeutic target in human oral cancer. Oncogene, 38(27), 5440–5456.
  • Humphrey, W., Dalke, A., & Schulten, K. (2020). VMD: Visual molecular dynamics. Journal of Molecular Graphics, 14(1), 33–38.
  • Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., & Wicha, M. S. (2010). Targeting breast stem cells with the cancer preventive compounds curcumin and piperine. Breast Cancer Research and Treatment, 122(3), 777–785. https://doi.org/10.1007/s10549-009-0612-x
  • Kauntz, H., Bousserouel, S., Gossé, F., & Raul, F. (2011). Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis: An International Journal on Programmed Cell Death, 16(10), 1042–1053. https://doi.org/10.1007/s10495-011-0631-z
  • Klose, J., Trefz, S., Wagner, T., Steffen, L., Preißendörfer Charrier, A., Radhakrishnan, P., Volz, C., Schmidt, T., Ulrich, A., Dieter, S. M., Ball, C., Glimm, H., & Schneider, M. (2019). Salinomycin: Anti-tumor activity in a preclinical colorectal cancer model. PLoS One, 14(2), e0211916. https://doi.org/10.1371/journal.pone.0211916
  • Koukourakis, M., Giatromanolaki, A., Tsakmaki, V., Danielidis, V., & Sivridis, E. (2012). Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head–neck cancer. British Journal of Cancer, 106(5), 846–853.
  • Krieger, E., Darden, T., Nabuurs, S. B., Finkelstein, A., & Vriend, G. (2004). Making optimal use of empirical energy functions: Force-field parameterization in crystal space. Proteins Struct Proteins, 57(4), 678–683. https://doi.org/10.1002/prot.20251
  • Kuo, S. Z., Blair, K. J., Rahimy, E., Kiang, A., Abhold, E., Fan, J.-B., Wang-Rodriguez, J., Altuna, X., & Ongkeko, W. M. (2012). Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. BMC Cancer, 12, 556. https://doi.org/10.1186/1471-2407-12-556
  • Li, W., Jia, H., Wang, J., Guan, H., Li, Y., Zhang, D., Tang, Y., Wang, T. D., & Lu, S. (2021). A CD44-specific peptide, RP-1, exhibits capacities of assisting diagnosis and predicting prognosis of gastric cancer. Oncotarget, 8(18), 30063.
  • Mack, B., & Gires, O. (2008). CD44s and CD44v6 expression in head and neck epithelia. PLoS One, 3(10), e3360. https://doi.org/10.1371/journal.pone.0003360
  • Naujokat, C., & Steinhart, R. (2020). Salinomycin as a drug for targeting human cancer stem cells. Journal of Biomedicine and Biotechnology, 2012, 17.
  • Oliveira, L. R., Castilho-Fernandes, A., Oliveira-Costa, J. P., Soares, F. A., Zucoloto, S., & Ribeiro-Silva, A. (2014). CD44+/CD133+ immunophenotype and matrix metalloproteinase-9: Influence on prognosis in early-stage oral squamous cell carcinoma. Head & Neck, 36(12), 1718–1726. https://doi.org/10.1002/hed.23527
  • Orian-Rousseau, V. (2015). CD44 acts as a signaling platform controlling tumor progression and metastasis. Frontiers in  Immunology, 6, 154. https://doi.org/10.3389/fimmu.2015.00154
  • Pandey, P. R., Okuda, H., Watabe, M., Pai, S. K., Liu, W., Kobayashi, A., Xing, F., Fukuda, K., Hirota, S., Sugai, T., Wakabayashi, G., Koeda, K., Kashiwaba, M., Suzuki, K., Chiba, T., Endo, M., Fujioka, T., Tanji, S., Mo, Y.-Y., … Watabe, K. (2011). Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase. Breast Cancer Research and Treatment, 130(2), 387–398. https://doi.org/10.1007/s10549-010-1300-6
  • Papaccio, F. (2020). Circulating cancer stem cells: An interesting niche to explore. Exploration of Targeted anti-Tumor Therapy, 1(4), 253–258. https://doi.org/10.37349/etat.2020.00016
  • Patel, S., Shah, K., Mirza, S., Shah, K., & Rawal, R. (2016). Circulating tumor stem like cells in oral squamous cell carcinoma: An unresolved paradox. Oral Oncology, 62, 139–146. https://doi.org/10.1016/j.oraloncology.2016.10.019
  • Patel, S., Waghela, B., Shah, K., Vaidya, F., Mirza, S., Patel, S., Pathak, C., & Rawal, R. (2018). Silibinin, a natural blend in polytherapy formulation for targeting Cd44v6 expressing colon cancer stem cells. Scientific Reports, 8(1), 16985. https://doi.org/10.1038/s41598-018-36920-0
  • Pikkemaat, M. G., Linssen, A. B. M., Berendsen, H. J. C., & Janssen, D. B. (2002). Molecular dynamics simulations as a tool for improving protein stability. Protein Engineering, 15(3), 185–192. https://doi.org/10.1093/protein/15.3.185
  • Rivas, S., Gómez-Oro, C., Antón, I. M., & Wandosell, F. (2018). Role of Akt isoforms controlling cancer stem cell survival, phenotype and self-renewal. Biomedicines, 6(1), 29. https://doi.org/10.3390/biomedicines6010029
  • Ruiz-Moreno, A. J., Reyes-Romero, A., Dömling, A., & Velasco-Velázquez, M. A. (2021). In silico design and selection of new tetrahydroisoquinoline-based CD44 antagonist candidates. Molecules, 26(7), 1877. https://doi.org/10.3390/molecules26071877
  • Samykutty, A., Shetty, A. V., Dakshinamoorthy, G., Bartik, M. M., Johnson, G. L., Webb, B., Zheng, G., Chen, A., Kalyanasundaram, R., & Munirathinam, G. (2013). Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen dependent and androgen independent prostate cancer cells. PLoS One, 8(6), e65889. https://doi.org/10.1371/journal.pone.0065889
  • Shankar, S., Nall, D., Tang, S.-N., Meeker, D., Passarini, J., Sharma, J., & Srivastava, R. K. (2011). Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PLoS One, 6(1), e16530. https://doi.org/10.1371/journal.pone.0016530
  • Singh, R., Bhardwaj, V., Das, P., & Purohit, R. (2020). Natural analogues inhibiting selective cyclin-dependent kinase protein isoforms: A computational perspective. Journal of Biomolecular Structure & Dynamics, 38(17), 5126–5135. https://doi.org/10.1080/07391102.2019.1696709
  • Spaderna, S., Schmalhofer, O., Wahlbuhl, M., Dimmler, A., Bauer, K., Sultan, A., Hlubek, F., Jung, A., Strand, D., Eger, A., Kirchner, T., Behrens, J., & Brabletz, T. (2008). The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Research, 68(2), 537–544. https://doi.org/10.1158/0008-5472.CAN-07-5682
  • Todaro, M., Gaggianesi, M., Catalano, V., Benfante, A., Iovino, F., Biffoni, M., Apuzzo, T., Sperduti, I., Volpe, S., Cocorullo, G., & Gulotta, G. (2020). CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell, 14(3), 342–356.
  • Versini, A., Colombeau, L., Hienzsch, A., Gaillet, C., Retailleau, P., Debieu, S., Müller, S., Cañeque, T., & Rodriguez, R. (2020). Salinomycin derivatives kill breast cancer stem cells by lysosomal iron targeting. Chemistry (Weinheim an der Bergstrasse, Germany), 26(33), 7416–7424. https://doi.org/10.1002/chem.202000335
  • Wallace, A. C., Laskowski, R. A., & Thornton, J. M. (1995). Ligplot: A program to generate schematic diagrams of protein-ligand interactions. Protein Engineering, 8(2), 127–134. https://doi.org/10.1093/protein/8.2.127
  • Yang, M. H., Imrali, A., & Heeschen, C. (2015). Circulating cancer stem cells: The importance to select. Chinese Journal of Cancer Research, 27(5), 437–449.
  • Ye, T., Li, J., Sun, Z., Liu, D., Zeng, B., Zhao, Q., Wang, J., & Xing, H. R. (2020). Cdh1 functions as an oncogene by inducing self-renewal of lung cancer stem-like cells via oncogenic pathways. International Journal of Biological Sciences, 16(3), 447.
  • Yoon, C., Lu, J., Brendan, C., Chang, K. K., Simon, M. C., Ryeom, S., & Yoon, S. S. (2021). PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas. Oncogenesis, 10(1), 1–14.
  • Zhang, Y., Liu, L., Li, F., Wu, T., Jiang, H., Jiang, X., Du, X., & Wang, Y. (2017). Salinomycin exerts anticancer effects on PC-3 cells and PC-3-derived cancer stem cells in vitro and in vivo. BioMed Research International, 2017, 4101653. https://doi.org/10.1155/2017/4101653
  • Zhang, Z., Filho, M. S. A., & Nör, J. E. (2012). The biology of head and neck cancer stem cells. Oral Oncology, 48(1), 1–9. https://doi.org/10.1016/j.oraloncology.2011.10.004

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