Antioxidant and anticholinesterase activities of amentoflavone isolated from Ouratea fieldingiana (Gardner) Engl. through in vitro and chemical-quantum studies

References

• Alam, M. N., Bristi, N. J., & Rafiquzzaman, M. (2013). Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharmaceutical Journal : SPJ : The Official Publication of the Saudi Pharmaceutical Society, 21(2), 143–152. https://doi.org/10.1016/j.jsps.2012.05.002
   PubMed Web of Science ®Google Scholar
• Almeida-Neto, F. W. Q., da Silva, L. P., Ferreira, M. K. A., Mendes, F. R. S., de Castro, K. K. A., Bandeira, P. N., de Menezes, J. E. S. A., dos Santos, H. S., Monteiro, N. K. V., Marinho, E. S., & de Lima-Neto, P. (2020). Characterization of the structural, spectroscopic, nonlinear optical, electronic properties and antioxidant activity of the N-{4’-[(E)-3-(Fluorophenyl)-1-(phenyl)-prop-2-en-1-one]}-acetamide. Journal of Molecular Structure, 1220, 128765. https://doi.org/10.1016/j.molstruc.2020.128765
   Web of Science ®Google Scholar
• Amic, D., Davidovic-Amic, D., Beslo, D., Rastija, V., Lucic, B., & Trinajstic, N. (2007). SAR and QSAR of the antioxidant activity of flavonoids. Current Medicinal Chemistry, 14(7), 827–845. https://doi.org/10.2174/092986707780090954
   PubMed Web of Science ®Google Scholar
• Araujo, A. K. L. (2010). Aspectos morfológicos do processo de cicatrização induzido por Ouratea sp. Dissertação (Mestrado Em Ciências Veterinárias). Faculdade de Veterinária, Universidade Estadual Do Ceará, 177.
   Google Scholar
• Araújo, C. R. M., Santos, V. L., dos, A., & Arlan, A. G. (2016). Acetilcolinesterase - AChE: Uma Enzima de Interesse Farmacológico. Revista Virtual de Química, 8(6), 1818–1834.
   Google Scholar
• Bajpai, V. K., Park, IWha., Lee, JIn., Shukla, S., Nile, S. H., Chun, H. S., Khan, I., Oh, S. Y., Lee, H., Huh, Y. S., Na, M., & Han, Y.-K. (2019). Antioxidant and antimicrobial efficacy of a biflavonoid, amentoflavone from Nandina domestica in vitro and in minced chicken meat and apple juice food models. Food Chemistry, 271(July 2018), 239–247. https://doi.org/10.1016/j.foodchem.2018.07.159
   PubMedGoogle Scholar
• Bartmess, J. E. (1994). Thermodynamics of the electron and the proton. The Journal of Physical Chemistry, 98(25), 6420–6424. https://doi.org/10.1021/j100076a029
   Web of Science ®Google Scholar
• Becke, A. D. (1988). Density-functional exchange-energy approximation with correct asymptotic behavior. Physical Review. A, General Physics, 38(6), 3098–3100. https://doi.org/10.1103/physreva.38.3098
   PubMedGoogle Scholar
• Becker, M., Nunes, G., Ribeiro, D., Silva, F., Catanante, G., & Marty, J. (2019). Determination of the antioxidant capacity of red fruits by miniaturized spectrophotometry assays. Journal of the Brazilian Chemical Society, 3(4), 223–227. https://doi.org/10.21577/0103-5053.20190003
   Google Scholar
• Bentham Science Publisher, B. S. P. (2006). Docking and scoring - theoretically easy, practically impossible? Current Medicinal Chemistry, 13(25), 2995–3003. https://doi.org/10.2174/092986706778521797
   PubMed Web of Science ®Google Scholar
• Biovia, D. S. (2017). Discovery Studio Visualizer, Dassault Systemes, BIOVIA Corp., San Diego, CA, USA.
   Google Scholar
• Boulebd, H. (2020). Comparative study of the radical scavenging behavior of ascorbic acid, BHT, BHA and Trolox: Experimental and theoretical study. Journal of Molecular Structure, 1201, 127210. https://doi.org/10.1016/j.molstruc.2019.127210
   Web of Science ®Google Scholar
• Brunton, L. L., Chabner, B. A., & Knollmann, B. C. (2006). As Bases Farmacológicas da Terapêutica de Goodman e Gilman-13. Artmed Editora.
   Google Scholar
• Cammi, R., & Tomasi, J. (1995). Remarks on the use of the apparent surface charges (ASC) methods in solvation problems: Iterative versus matrix-inversion procedures and the renormalization of the apparent charges. Journal of Computational Chemistry, 16(12), 1449–1458. https://doi.org/10.1002/jcc.540161202
   Web of Science ®Google Scholar
• Cancès, E., Mennucci, B., & Tomasi, J. (1997). A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics. The Journal of Chemical Physics, 107(8), 3032–3041. https://doi.org/10.1063/1.474659
   Web of Science ®Google Scholar
• Chen, J. H., & Ho, C.-T. (1997). Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. Journal of Agricultural and Food Chemistry, 45(7), 2374–2378. https://doi.org/10.1021/jf970055t
   Web of Science ®Google Scholar
• Corrêa, P., Chagas, M., & Pimentel, R. (2007). Anatomia foliar de Ouratea fieldingiana (Gardner) Engl. (Ochnaceae). Revista Brasileira de Biociências, 5, 813–815.
   Google Scholar
• Coutinho, M. A. S., Muzitano, M. F., & Costa, S. S. (2009). Flavonoids: Potential therapeutic agents for the inflammatory process. Revista Virtual de Química, 1(3), 241-256. https://doi.org/10.5935/1984-6835.20090024
   Google Scholar
• da Silva, W. M. B., de Oliveira Pinheiro, S., Alves, D. R., de Menezes, J. E. S. A., Magalhães, F. E. A., Silva, F. C. O., Silva, J., Marinho, E. S., & de Morais, S. M. (2020). Synthesis of quercetin-metal complexes, in vitro and in silico anticholinesterase and antioxidant evaluation, and in vivo toxicological and anxiolitic activities. Neurotoxicity Research, 37(4), 893–903. https://doi.org/10.1007/s12640-019-00142-7
   PubMed Web of Science ®Google Scholar
• De Gaion, J. P. B. F. (2020). Doença de Alzheimer: saiba mais sobre a principal causa de demência no mundo. https://www.informasus.ufscar.br/doenca-de-alzheimer-saiba-mais-sobre-a-principal-causa-de-demencia-no-mundo/
   Google Scholar
• do Nascimento, J. E. T. (2018). Caracterização química e avaliação de atividades biológicas de extratos e constituintes de Ouratea fieldingiana (Gardner) Engl.
   Google Scholar
• do Nascimento, J. E. T., Rodrigues, A. L. M., de Lisboa, D. S., Liberato, H. R., Falcão, M. J. C., da Silva, C. R., Nobre Júnior, H. V., Braz Filho, R., de Paula Junior, V. F., Alves, D. R., & de Morais, S. M. (2018). Chemical composition and antifungal in vitro and in silico, antioxidant, and anticholinesterase activities of extracts and constituents of Ouratea fieldingiana (DC.) Baill. Evidence-Based Complementary and Alternative Medicine, 2018, 1748487–1748412. https://doi.org/10.1155/2018/1748487
   PubMed Web of Science ®Google Scholar
• Dosatti, A. C., & Judice, W. A. (2012). Caracterização do Mecanismo de Inibição da Atividade de Proteases de Tripanossomatídeos por Compostos Naturais e Semi-sintéticos Derivados de Biflavonas. http://www.umc.br/_imgs/XV_congresso/artigos/AmandadeCarvalhoDosatti.pdf
   Google Scholar
• Ellman, G. L., Courtney, K. D., Andres, V., & Feather-Stone, R. M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88–95. https://doi.org/10.1016/0006-2952(61)90145-9
   PubMed Web of Science ®Google Scholar
• Frisch, M. J., Trucks, G. W., Schlegel, H. B., Scuseria, G. E., Robb, M. A., & Cheeseman, J. R., &. Gaussian 09, R. B. 0. (2009). Gaussian 09, revision B.01. Gaussian, Inc.
   Google Scholar
• Frota, L. S., Lopes, F. F. S., Alves, D. R., Freitas, L. S., Franco, G. M. G., & Morais, S. M. d. (2021). Composição química e avaliação das atividades antioxidante e anticolinesterásica do óleo dos frutos de Ouratea fieldingiana (Gargner) Engl. Research, Society and Development, 10(10), e532101019013. https://doi.org/10.33448/rsd-v10i10.19013
   Google Scholar
• Guerra, T. M. (2019). Estudos de Docking Molecular de Derivados da Tiazolidina Como Potenciais Inibidores da Enzima Cruzaína de Trypanosoma cruzi. Universidade Federal Rural de Pernambuco/Unidade Acadêmica de Serra Talhada-PE. http://hdl.handle.net/123456789/1318
   Google Scholar
• Gutteridge, J. M. C., & Halliwell, B. (2010). Antioxidants: Molecules, medicines, and myths. Biochemical and Biophysical Research Communications, 393(4), 561–564. https://doi.org/10.1016/j.bbrc.2010.02.071
   PubMed Web of Science ®Google Scholar
• Halgren, T. A. (1996). Merck molecular force field. II. MMFF94 van der Waals and electrostatic parameters for intermolecular interactions. Journal of Computational Chemistry, 17(5–6), 520–552. https://doi.org/10.1002/(SICI)1096-987X(199604)17:5/6<520::AID-JCC2>3.0.CO;2-W
   Web of Science ®Google Scholar
• Halperin, I., Ma, B., Wolfson, H., & Nussinov, R. (2002). Principles of docking: An overview of search algorithms and a guide to scoring functions. Proteins, 47(4), 409–443. https://doi.org/10.1002/prot.10115
   PubMed Web of Science ®Google Scholar
• Hanwell, M. D., Curtis, D. E., Lonie, D. C., Vandermeersch, T., Zurek, E., & Hutchison, G. R. (2012). Avogadro: An advanced semantic chemical editor, visualization, and analysis platform. Journal of Cheminformatics, 4(1), 17. https://doi.org/10.1186/1758-2946-4-17
   PubMed Web of Science ®Google Scholar
• Herranz, P., Albano, M. E. A., Cortez, L. E. R., & Cortez, D. A. G. (2017). Relação entre a formação de radicais livres e a doença de alzheimer: revisão sistemática. Revista de Ciências Médicas e Biológicas, 16(2), 197. https://doi.org/10.9771/cmbio.v16i2.21705
   Google Scholar
• Janus, C., & Westaway, D. (2001). Transgenic mouse models of Alzheimer’s disease. Physiology & Behavior, 73(5), 873–886. https://doi.org/10.1016/S0031-9384(01)00524-8
   PubMed Web of Science ®Google Scholar
• Jung, H. J., Sung, W. S., Yeo, S.-H., Kim, H. S., Lee, I.-S., Woo, E.-R., & Lee, D. G. (2006). Antifungal effect of amentoflavone derived from Selaginella tamariscina. Archives of Pharmacal Research, 29(9), 746–751. https://doi.org/10.1007/BF02974074
   PubMed Web of Science ®Google Scholar
• Karadag, A., Ozcelik, B., & Saner, S. (2009). Review of methods to determine antioxidant capacities. Food Analytical Methods, 2(1), 41–60. https://doi.org/10.1007/s12161-008-9067-7
   Web of Science ®Google Scholar
• Khanam, S., Shahid, K., Sirajuddin, M., Ali, S., & Ullah, H. (2019). Synthesis, spectral characterization and biological evaluation of organotin(IV) complexes of aniline derivatives of naturally occurring betulinic acid. Journal of the Chemical Society of Pakistan, 41(4), 725–734.
   Web of Science ®Google Scholar
• Lee, H. S., Oh, W. K., Kim, B. Y., Ahn, S. C., Kang, D. O., Shin, D. I., Kim, J., Mheen, T. I., & Ahn, J. S. (1996). Inhibition of phospholipase C gamma 1 activity by amentoflavone isolated from Selaginella tamariscina. Planta Medica, 62(4), 293–296. https://doi.org/10.1055/s-2006-957887
   PubMed Web of Science ®Google Scholar
• Li, Y., Chen, X., Niu, S., Zhou, H., & Li, Q. (2020). Protective antioxidant effects of amentoflavone and total flavonoids from hedyotis diffusa on H 2 O 2 ‐induced HL‐O2 cells through ASK1/p38 MAPK pathway. Chemistry & Biodiversity, 17(7), 1-22. https://doi.org/10.1002/cbdv.202000251
   Google Scholar
• Lindeboom, J., & Weinstein, H. (2004). Neuropsychology of cognitive ageing, minimal cognitive impairment, Alzheimer's disease, and vascular cognitive impairment. European Journal of Pharmacology, 490(1–3), 83–86. https://doi.org/10.1016/j.ejphar.2004.02.046
   PubMed Web of Science ®Google Scholar
• Li, X., Wang, L., Han, W., Mai, W., Han, L., & Chen, D. (2014). Amentoflavone protects against hydroxyl radical-induced DNA damage via antioxidant mechanism. Turkish Journal of Biochemistry, 39(1), 30–36. https://doi.org/10.5505/tjb.2014.65882
   Google Scholar
• Lobstein-Guth, A., Briançon-Scheid, F., Victoire, C., Haag-Berrurier, M., & Anton, R. (1988). Isolation of amentoflavone from Ginkgo biloba. Planta Medica, 54(6), 555–556. https://doi.org/10.1055/s-2006-962549
   PubMedGoogle Scholar
• Ma, R., Xu, X., Zhao, L., Cao, R., & Fang, Q. (2013). Mutual artificial bee colony algorithm for molecular docking. International Journal of Biomathematics, 06(06), 1350038. https://doi.org/10.1142/S1793524513500381
   Google Scholar
• Malesev, D., & Kuntic, V. (2007). Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. Journal of the Serbian Chemical Society, 72(10), 921–939. https://doi.org/10.2298/JSC0710921M
   Web of Science ®Google Scholar
• Marinho, M. M., Almeida-Neto, F. W. Q., Marinho, E. M., da Silva, L. P., Menezes, R. R. P. P. B., Dos Santos, R. P., Marinho, E. S., de Lima-Neto, P., & Martins, A. M. C. (2021). Quantum computational investigations and molecular docking studies on amentoflavone. Heliyon, 7(1), e06079 https://doi.org/10.1016/j.heliyon.2021.e06079
   PubMed Web of Science ®Google Scholar
• Melo Lucio, F. N., Da Silva, J. E., Marinho, E. M., Da Silva Mendes, F. R., Marinho, M. M., & Marinho, E. S. (2020). Methylcytisine alcaloid potentially active against dengue virus: A molecular docking study and electronic structural characterization. International Journal of Research -GRANTHAALAYAH, 8(1), 221–236. https://doi.org/10.29121/granthaalayah.v8.i1.2020.270
   Google Scholar
• Mennucci, B., Cancès, E., & Tomasi, J. (1997). Evaluation of solvent effects in isotropic and anisotropic dielectrics and in ionic solutions with a unified integral equation method: Theoretical bases, computational implementation, and numerical applications. The Journal of Physical Chemistry B, 101(49), 10506–10517. https://doi.org/10.1021/jp971959k
   Web of Science ®Google Scholar
• Miroshnychenko, K. V., & Shestopalova, A. V. (2021). Combined use of the hepatitis C drugs and amentoflavone could interfere with binding of the spike glycoprotein of SARS-CoV-2 to ACE2: The results of a molecular simulation study. Journal of Biomolecular Structure and Dynamics, x, 1–15. https://doi.org/10.1080/07391102.2021.1914168
   Google Scholar
• Morgon, N. H., & Coutinho, K. R. (2007). Métodos de química teórica e modelagem molecular. Editora Livraria da Física.
   Google Scholar
• Morris, G. M., Goodsell, D. S., Halliday, R. S., Huey, R., Hart, W. E., Belew, R. K., & Olson, A. J. (1998). Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. Journal of Computational Chemistry, 19(14), 1639–1662. https://doi.org/10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B
   Web of Science ®Google Scholar
• Ngameni, B., Fotso, G. W., Kamga, J., Ambassa, P., Abdou, T., Fankam, A. G., Voukeng, I. K., Ngadjui, B. T., Abegaz, B. M., & Kuete, V. (2013). Flavonoids and related compounds from the medicinal plants of Africa. In Victor Kuete (Ed.), Medicinal plant research in Africa. (pp. 301–350). Elsevier. https://doi.org/10.1016/B978-0-12-405927-6.00009-6
   Google Scholar
• Panthong, A., Norkaew, P., Kanjanapothi, D., Taesotikul, T., Anantachoke, N., & Reutrakul, V. (2007). Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f. Journal of Ethnopharmacology, 111(2), 335–340. https://doi.org/10.1016/j.jep.2006.11.038
   PubMed Web of Science ®Google Scholar
• Parker, V. D. (1992). Homolytic bond (H-A) dissociation free energies in solution. Applications of the standard potential of the (H+/H.bul.) couple. Journal of the American Chemical Society, 114(19), 7458–7462. https://doi.org/10.1021/ja00045a018
   Web of Science ®Google Scholar
• Parthasarathi, R., & Subramanian, V. (2006). Characterization of hydrogen bonding: From van der Waals interactions to covalency. In Sławomir J. Grabowski (Ed.), Hydrogen bonding—new insights (pp. 1–50). Netherlands: Springer. https://doi.org/10.1007/978-1-4020-4853-1_1
   Google Scholar
• Paul, R., & Borah, A. (2017). Global loss of acetylcholinesterase activity with mitochondrial complexes inhibition and inflammation in brain of hypercholesterolemic mice. Scientific Reports, 7(1), 17922. https://doi.org/10.1038/s41598-017-17911-z
   PubMedGoogle Scholar
• Paula, R. S. F., Vieira, R. S., Luna, F. M. T., Cavalcante, C. L., Figueredo, I. M., Candido, J. R., Silva, L. P., Marinho, E. S., de Lima-Neto, P., Lomonaco, D., Mazzetto, S. E., & Rios, M. A. S. (2020). A potential bio-antioxidant for mineral oil from cashew nutshell liquid: An experimental and theoretical approach. Brazilian Journal of Chemical Engineering, 37(2), 369–381. https://doi.org/10.1007/s43153-020-00031-z
   Web of Science ®Google Scholar
• Pegnyemb, D. E., Tih, R. G., Sondengam, B. L., Blond, A., & Bodo, B. (2001). Biflavonoids from Ochna afzelii. Phytochemistry, 57(4), 579–582. https://doi.org/10.1016/S0031-9422(01)00101-7
   PubMed Web of Science ®Google Scholar
• Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., & Ferrin, T. E. (2004). UCSF Chimera-a visualization system for exploratory research and analysis. Journal of Computational Chemistry, 25(13), 1605–1612. https://doi.org/10.1002/jcc.20084
   PubMed Web of Science ®Google Scholar
• Pinto, T. R. D. M. (2017). Estudo do potencial farmacoquímico do óleo de batiputá (Ouratea fieldingiana - Gardner Engl.) como insumo farmacêutico.
   Google Scholar
• Pinto, T., Magalhães, P., Fonseca, S., & Bandeira, M. (2016). Contribuição ao estudo fitoquímico dos frutos de batiputa (Ouratea fieldingiana (Gardner) Engl). Revista Encontros Universitários Da UFC, 1(1), 1.
   Google Scholar
• Poljšak, B., & Dahmane, R. (2012). Free radicals and extrinsic skin aging. Dermatology Research and Practice, 2012, 135206–135204. https://doi.org/10.1155/2012/135206
   PubMedGoogle Scholar
• Rufino, M., do, S. M., Alves, R. E., de Brito, E. S., Pérez-Jiménez, J., Saura-Calixto, F., & Mancini-Filho, J. (2010). Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chemistry, 121(4), 996–1002. https://doi.org/10.1016/j.foodchem.2010.01.037
   Web of Science ®Google Scholar
• Sies, H. (1997). Oxidative stress: Oxidants and antioxidants. Experimental Physiology, 82(2), 291–295. https://doi.org/10.1113/expphysiol.1997.sp004024
   PubMed Web of Science ®Google Scholar
• Silva, J., Marinho, M. M., Silva, J. E. d., Marinho, E. M., & Marinho, E. S. (2018). Estudo comparativo de docking molecular entre o inibidor de protease saquinavir e o carotenoide bixina como potencial inibidor do vírus HIV tipo I (1HXB). Revista Expressão Católica Saúde, 3(1), 35. https://doi.org/10.25191/recs.v3i1.2223
   Google Scholar
• Simões, V. D. N., Favarin, L. R. V., Cabeza, N. A., Oliveira, T. D. D., Fiorucci, A. R., Stropa, J. M., Rodrigues, D. C. M., Cavalheiro, A. A., & Anjos, A. D. (2013). Síntese, caracterização e estudo das propriedades de um novo complexo mononuclear contendo quercetina e íon Ga(III). Química Nova, 36(4), 495–501. https://doi.org/10.1590/S0100-40422013000400002
   Google Scholar
• Singh, S., Kumar Gupta, S., Nischal, A., Khattri, S., Nath, R., Kumar Pant, K., & Kishore Seth, P. (2011). Identification and characterization of novel small-molecule inhibitors against hepatitis delta virus replication by using docking strategies. Hepatitis Monthly, 11(10), 803–809. https://doi.org/10.5812/kowsar.1735143X.737
   PubMed Web of Science ®Google Scholar
• Sirajuddin, M., Ali, S., Shah, N. A., Khan, M. R., & Tahir, M. N. (2012). Synthesis, characterization, biological screenings and interaction with calf thymus DNA of a novel azomethine 3-((3,5-dimethylphenylimino)methyl)benzene-1,2-diol. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 94, 134–142. https://doi.org/10.1016/j.saa.2012.03.068
   PubMed Web of Science ®Google Scholar
• Sirajuddin, M., Uddin, N., Ali, S., & Tahir, M. N. (2013). Potential bioactive Schiff base compounds: Synthesis, characterization, X-ray structures, biological screenings and interaction with Salmon sperm DNA. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 116, 111–121. https://doi.org/10.1016/j.saa.2013.06.096
   PubMed Web of Science ®Google Scholar
• Solomonov, B. N., Varfolomeev, M. A., Novikov, V. B., & Klimovitskii, A. E. (2006). New thermochemical parameter for describing solvent effects on IR stretching vibration frequencies. Communication 1. Assessment of van der Waals interactionsSpectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 64(2), 397–404. https://doi.org/10.1016/j.saa.2005.07.036
   PubMed Web of Science ®Google Scholar
• Su, C., Yang, C., Gong, M., Ke, Y., Yuan, P., Wang, X., Li, M., Zheng, X., & Feng, W. (2019). Antidiabetic activity and potential mechanism of amentoflavone in diabetic mice. Molecules, 24(11), 2184. https://doi.org/10.3390/molecules24112184
   PubMed Web of Science ®Google Scholar
• Tahir, M., Sirajuddin, M., Haider, A., Ali, S., Nadhman, A., & Rizzoli, C. (2019). Synthesis, spectroscopic characterization, crystal structure, interaction with DNA, CTAB as well as evaluation of biological potency, docking and molecular dynamics studies of N-(3,4,5-trimethoxybenzylidene)-2, 3-dimethylbenzenamine. Journal of Molecular Structure, 1178, 29–38. https://doi.org/10.1016/j.molstruc.2018.10.014
   Web of Science ®Google Scholar
• Tariq, M., Khan, R., Hussain, A., Batool, A., Rasool, F., Yar, M., Ayub, K., Sirajuddin, M., Ullah, F., Ali, S., Akhtar, A., Kausar, S., & Altaf, A. A. (2021). Synthesis, characterization, antimicrobial, cytotoxic, DNA-interaction, molecular docking and DFT studies of novel di- and tri-organotin(IV) carboxylates using 3-(3-nitrophenyl)2-methylpropenoic acid. Journal of Coordination Chemistry, 74(14), 2407–2426. https://doi.org/10.1080/00958972.2021.1964019
   Web of Science ®Google Scholar
• Tinkel, J., Hassanain, H., & Khouri, S. J. (2012). Cardiovascular Antioxidant therapy: A review of supplements, pharmacotherapies, and mechanisms. Cardiology in Review, 20(2), 77–83. https://doi.org/10.1097/CRD.0b013e31823dbbad
   PubMed Web of Science ®Google Scholar
• Trott, O., & Olson, A. J. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455–461. https://doi.org/10.1002/jcc.21334
   PubMed Web of Science ®Google Scholar
• Wang, G., Xue, Y., An, L., Zheng, Y., Dou, Y., Zhang, L., & Liu, Y. (2015). Theoretical study on the structural and antioxidant properties of some recently synthesised 2,4,5-trimethoxy chalcones. Food Chemistry, 171, 89–97. https://doi.org/10.1016/j.foodchem.2014.08.106
   PubMed Web of Science ®Google Scholar
• Zafar, R., Zubair, M., Ali, S., Shahid, K., Waseem, W., Naureen, H., Haider, A., Jan, M. S., Ullah, F., Sirajuddin, M., & Sadiq, A. (2021). Zinc metal carboxylates as potential anti-Alzheimer's candidate: In vitro anticholinesterase, antioxidant and molecular docking studies. Journal of Biomolecular Structure & Dynamics, 39(3), 1044–1054. https://doi.org/10.1080/07391102.2020.1724569
   PubMed Web of Science ®Google Scholar
• Zhao, Q., & Tang, X. C. (2002). Effects of huperzine A on acetylcholinesterase isoforms in vitro: Comparison with tacrine, donepezil, rivastigmine and physostigmine. European Journal of Pharmacology, 455(2–3), 101–107. https://doi.org/10.1016/S0014-2999(02)02589-X
   PubMed Web of Science ®Google Scholar
• Zhao, Y., & Truhlar, D. G. (2008). The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: Two new functionals and systematic testing of four M06-class functionals and 12 other function. Theoretical Chemistry Accounts, 120(1–3), 215–241. https://doi.org/10.1007/s00214-007-0310-x
   Web of Science ®Google Scholar
• Zheng, Y.-Z., Deng, G., Liang, Q., Chen, D.-F., Guo, R., & Lai, R.-C. (2017). Antioxidant activity of quercetin and its glucosides from propolis: A theoretical study. Scientific Reports, 7(1), 7543. https://doi.org/10.1038/s41598-017-08024-8
   PubMed Web of Science ®Google Scholar
• Zubair, M., Sirajuddin, M., Ullah, K., Haider, A., Perveen, F., Hussain, I., Ali, S., & Tahir, M. N. (2020). Synthesis, structural peculiarities, theoretical study and biological evaluation of newly designed O-Vanillin based azomethines. Journal of Molecular Structure, 1205, 127574. https://doi.org/10.1016/j.molstruc.2019.127574
   Web of Science ®Google Scholar