Antiviral activity of Cenostigma pluviosum var. peltophoroides extract and fractions against SARS-CoV-2

References

• Abdo, N. Moheyeldin, O., Shehata, M. G., & El Sohaimy, S. (2021). Inhibition of COVID-19 RNA-Dependent RNA Polymerase by Natural Bioactive Compounds: Molecular Docking Analysis. Egyptian Journal of Chemistry, 64(4), 1989–2001.
   Google Scholar
• Andriani, G. M., Morguette, A. E. B., Spoladori, L. F. A., Pereira, P. M. L., Cabral, W. R. C., Fernandes, B. T., Tavares, E. R., Almeida, R. S., Lancheros, C. A. C., Nakamura, C. V., Mello, J. C. P., Yamauchi, L. M., & Yamada-Ogatta, S. F. (2021). Antifungal combination of ethyl acetate extract of Poincianella pluviosa (DC.) L. P. queiros stem bark with Amphotericin B in Cryptococcus neoformans. Frontiers in Microbiology, 12, 660645. https://doi.org/10.3389/fmicb.2021.660645
   PubMed Web of Science ®Google Scholar
• Beigel, J. H., Tomashek, K. M., Dodd, L. E., Mehta, A. K., Zingman, B. S., Kalil, A. C., Hohmann, E., Chu, H. Y., Luetkemeyer, A., Kline, S., Lopez de Castilla, D., Finberg, R. W., Dierberg, K., Tapson, V., Hsieh, L., Patterson, T. F., Paredes, R., Sweeney, D. A., Short, W. R., … Lane, H. C. (2020). Remdesivir for the treatment of Covid-19 — Final report. New England Journal of Medicine, 383(19), 1813–1826. https://doi.org/10.1056/NEJMOA2007764/SUPPL_FILE/NEJMOA2007764_DATA-SHARING.PDF
   PubMed Web of Science ®Google Scholar
• Ben-Shabat, S., Yarmolinsky, L., Porat, D., & Dahan, A. (2020). Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies. Drug Delivery and Translational Research, 10(2), 354–367. https://doi.org/10.1007/S13346-019-00691-6
   PubMed Web of Science ®Google Scholar
• Bitencourt-Ferreira, G., & de Azevedo, W. F. (2019). Molegro virtual docker for docking. Methods in Molecular Biology (Clifton, N.J.), 2053, 149–167. https://doi.org/10.1007/978-1-4939-9752-7_10
   PubMedGoogle Scholar
• Bueno, F. G., Panizzon, G. P., de Leite Mello, E. V. S., Lechtenberg, M., Petereit, F., de Mello, J. C. P., & Hensel, A. (2014). Hydrolyzable tannins from hydroalcoholic extract from Poincianella pluviosa stem bark and its wound-healing properties: Phytochemical investigations and influence on in vitro cell physiology of human keratinocytes and dermal fibroblasts. Fitoterapia, 99, 252–260. https://doi.org/10.1016/j.fitote.2014.10.007
   PubMed Web of Science ®Google Scholar
• Chen, R. H., Yang, L. J., Hamdoun, S., Chung, S. K., Lam, C. W., Zhang, K. X., Guo, X., Xia, C., Law, B. Y. K., & Wong, V. K. W. (2021). 1,2,3,4,6-Pentagalloyl glucose, a RBD-ACE2 binding inhibitor to prevent SARS-CoV-2 infection. Frontiers in Pharmacology, 12, 150. https://doi.org/10.3389/fphar.2021.634176
   Web of Science ®Google Scholar
• Chew, Y. L., Ling Chan, E. W., Tan, P. L., Lim, Y. Y., Stanslas, J., & Goh, J. K. (2011). Assessment of phytochemical content, polyphenolic composition, antioxidant and antibacterial activities of Leguminosae medicinal plants in Peninsular Malaysia. BMC Complementary and Alternative Medicine, 11, 12. https://doi.org/10.1186/1472-6882-11-12
   PubMed Web of Science ®Google Scholar
• Chierrito, D., Villas-Boas, C. B., Tonin, F. S., Fernandez-Llimos, F., Sanches, A. C. C., & de Mello, J. C. P. (2019). Using cell cultures for the investigation of treatments for attention deficit hyperactivity disorder: A systematic review. Current Neuropharmacology, 17(10), 916–925. https://doi.org/10.2174/1570159X17666190409143155
   PubMed Web of Science ®Google Scholar
• Dai, W., Zhang, B., Jiang, X.-M., Su, H., Li, J., Zhao, Y., Xie, X., Jin, Z., Peng, J., Liu, F., Li, C., Li, Y., Bai, F., Wang, H., Cheng, X., Cen, X., Hu, S., Yang, X., Wang, J., … Liu, H. (2020). Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science (New York, N.Y.), 368(6497), 1331–1335. https://doi.org/10.1126/SCIENCE.ABB4489/SUPPL_FILE/PAP.PDF
   PubMed Web of Science ®Google Scholar
• Dallakyan, S., & Olson, A. J. (2015). Small-molecule library screening by docking with PyRx. Methods in Molecular Biology (Clifton, N.J.), 1263, 243–250. https://doi.org/10.1007/978-1-4939-2269-7_19.
   PubMedGoogle Scholar
• David, A., Ben, Diamant, E., Dor, E., Barnea, A., Natan, N., Levin, L., Chapman, S., Mimran, L. C., Epstein, E., Zichel, R., & Torgeman, A. (2021). Identification of SARS-CoV-2 receptor binding inhibitors by in vitro screening of drug libraries. Molecules, 26(11), 3213. https://doi.org/10.3390/molecules26113213
   PubMed Web of Science ®Google Scholar
• Dias, A. M. A., Rey-Rico, A., Oliveira, R. A., Marceneiro, S., Alvarez-Lorenzo, C., Concheiro, A., Júnior, R. N. C., Braga, M. E. M., & de Sousa, H. C. (2013). Wound dressings loaded with an anti-inflammatory jucá (Libidibia ferrea) extract using supercritical carbon dioxide technology. The Journal of Supercritical Fluids, 74, 34–45. https://doi.org/10.1016/j.supflu.2012.12.007
   Web of Science ®Google Scholar
• DiMasi, J. A., Grabowski, H. G., & Hansen, R. W. (2016). Innovation in the pharmaceutical industry: New estimates of R&D costs. Journal of Health Economics, 47, 20–33. https://doi.org/10.1016/J.JHEALECO.2016.01.012
   PubMed Web of Science ®Google Scholar
• Espada, S., Faccin-Galhardi, L., Rincao, V., Bernardi, A., Lopes, N., Longhini, R., de Mello, J., Linhares, R., & Nozawa, C. (2015). Antiviral activity of Trichilia catigua bark extracts for herpesvirus and poliovirus. Current Pharmaceutical Biotechnology, 16(8), 724–732. https://doi.org/10.2174/1389201016666150505125235
   PubMed Web of Science ®Google Scholar
• Felipe, A. M. M., Rincão, V. P., Benati, F. J., Linhares, R. E. C., Galina, K. J., Toledo, C. E. M., De, Lopes, G. C., Mello, J. C. P., De., & Nozawa, C. (2006). Antiviral effect of Guazuma ulmifolia and Stryphnodendron adstringens on poliovirus and bovine herpesvirus. Biological and Pharmaceutical Bulletin, 29(6), 1092–1095. https://doi.org/10.1248/bpb.29.1092
   PubMed Web of Science ®Google Scholar
• Ferreira, A. B. d. H. (1986). Novo dicionário Aurélio da língua portuguesa (2nd ed.). Nova Fronteira. https://nurc.fflch.usp.br/node/591
   Google Scholar
• Gaem, P. H. (2020). Cenostigma in Flora e Funga do Brasil. Jardim Botânico Do Rio de Janeiro. https://floradobrasil.jbrj.gov.br/FB78635
   Google Scholar
• Gagnon, E., Bruneau, A., Hughes, C. E., de Queiroz, L. P., & Lewis, G. P. (2016). A new generic system for the pantropical Caesalpinia group (Leguminosae). PhytoKeys, 7171(1), 1–160. 1160 https://doi.org/10.3897/phytokeys.71.9203
   Google Scholar
• Gagnon, E., Lewis, G. P., Solange Sotuyo, J., Hughes, C. E., & Bruneau, A. (2013). A molecular phylogeny of Caesalpinia sensu lato: Increased sampling reveals new insights and more genera than expected. South African Journal of Botany, 89, 111–127. https://doi.org/10.1016/j.sajb.2013.07.027
   Web of Science ®Google Scholar
• Gao, T., Yao, H., Song, J., Liu, C., Zhu, Y., Ma, X., Pang, X., Xu, H., & Chen, S. (2010). Identification of medicinal plants in the family Fabaceae using a potential DNA barcode ITS2. Journal of Ethnopharmacology, 130(1), 116–121. https://doi.org/10.1016/J.JEP.2010.04.026
   PubMed Web of Science ®Google Scholar
• Goli, M. (2020). Review of novel human β‐coronavirus (2019‐nCoV or SARS‐CoV‐2) from the food industry perspective—Appropriate approaches to food production technology. Food Science & Nutrition, 8(10), 5228–5237. https://doi.org/10.1002/FSN3.1892
   PubMed Web of Science ®Google Scholar
• Gorbalenya, A. E., & Snijder, E. J. (1996). Viral cysteine proteinases. Perspectives in Drug Discovery and Design: PD3, 6(1), 64–86. https://doi.org/10.1007/BF02174046
   PubMedGoogle Scholar
• Guidi, A. C., de Paula, M. N., Mosela, M., Delanora, L. A., Soares, G. C. A., de Morais, G. R., Medeiros, D. C., de, de Oliveira Junior, A. G., Novello, C. R., Baesso, M. L., Leite-Mello, E. V. d S., & Mello, J. C. P. d (2020). Stem bark extract of Poincianella pluviosa incorporated in polymer film: Evaluation of wound healing and anti-staphylococcal activities. Injury, 51(4), 840–849. https://doi.org/10.1016/J.INJURY.2020.02.027
   PubMed Web of Science ®Google Scholar
• Haslam, E. (1996). Natural polyphenols (vegetable tannins) as drugs: Possible modes of action. Journal of Natural Products, 59(2), 205–215. https://doi.org/10.1021/np960040 + 
   PubMed Web of Science ®Google Scholar
• Hegyi, A., & Ziebuhr, J. (2002). Conservation of substrate specificities among coronavirus main proteases. The Journal of General Virology, 83(Pt 3), 595–599. https://doi.org/10.1099/0022-1317-83-3-595/CITE/REFWORKS
   PubMedGoogle Scholar
• Hsu, F. L., Huang, W. J., Wu, T. H., Lee, M. H., Chen, L. C., Lu, H. J., Hou, W. C., & Lin, M. H. (2012). Evaluation of antioxidant and free radical scavenging capacities of polyphenolics from pods of Caesalpinia pulcherrima. International Journal of Molecular Sciences, 13(5), 6073–6088. https://doi.org/10.3390/IJMS13056073
   PubMed Web of Science ®Google Scholar
• Humphrey, W., Dalke, A., & Schulten, K. (1996). VMD: Visual molecular dynamics. Journal of Molecular Graphics, 14(1)27-28, 33–38.
   PubMedGoogle Scholar
• Islam, M. T., Sarkar, C., El-Kersh, D. M., Jamaddar, S., Uddin, S. J., Shilpi, J. A., & Mubarak, M. S. (2020). Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data. Phytotherapy Research: PTR, 34(10), 2471–2492. https://doi.org/10.1002/PTR.6700
   PubMed Web of Science ®Google Scholar
• Jin, Z., Du, X., Xu, Y., Deng, Y., Liu, M., Zhao, Y., Zhang, B., Li, X., Zhang, L., Peng, C., Duan, Y., Yu, J., Wang, L., Yang, K., Liu, F., Jiang, R., Yang, X., You, T., Liu, X., … Yang, H. (2020). Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature, 582(7811), 289–293. https://doi.org/10.1038/s41586-020-2223-y
   PubMed Web of Science ®Google Scholar
• Kato-Schwartz, C. G., Bracht, F., de Almeida Gonçalves, G., Soares, A. A., Vieira, T. F., Brugnari, T., Bracht, A., & Peralta, R. M. (2018). Inhibition of α-amylases by pentagalloyl glucose: Kinetics, molecular dynamics and consequences for starch absorption. Journal of Functional Foods, 44, 265–273. https://doi.org/10.1016/j.jff.2018.03.025
   Web of Science ®Google Scholar
• Kato-Schwartz, C. G., Corrêa, R. C. G., de Souza Lima, D., de Sá-Nakanishi, A. B., de Almeida Gonçalves, G., Seixas, F. A. V., Haminiuk, C. W. I., Barros, L., Ferreira, I. C. F. R., Bracht, A., & Peralta, R. M. (2020). Potential anti-diabetic properties of Merlot grape pomace extract: An in vitro, in silico and in vivo study of α-amylase and α-glucosidase inhibition. Food Research International (Ottawa, Ont.), 137, 109462. https://doi.org/10.1016/j.foodres.2020.109462
   PubMed Web of Science ®Google Scholar
• Kim, Y. S., Chung, H.-S., Noh, S. G., Lee, B., Chung, H. Y., & Choi, J.-G. (2021). Geraniin inhibits the entry of SARS-CoV-2 by blocking the interaction between spike protein RBD and human ACE2 receptor. International Journal of Molecular Sciences, 22(16), 8604. https://doi.org/10.3390/ijms22168604
   PubMed Web of Science ®Google Scholar
• Kim, K. J., Yu, H. H., Jeong, S., il, Cha, J. D., Kim, S. M., & You, Y. O. (2004). Inhibitory effects of Caesalpinia sappan on growth and invasion of methicillin-resistant Staphylococcus aureus. Journal of Ethnopharmacology, 91(1), 81–87. https://doi.org/10.1016/J.JEP.2003.11.017
   PubMed Web of Science ®Google Scholar
• Kumar, A., & Darreh-Shori, T. (2017). DMSO: A mixed-competitive inhibitor of human acetylcholinesterase. ACS Chemical Neuroscience, 8(12), 2618–2625. https://doi.org/10.1021/ACSCHEMNEURO.7B00344
   PubMed Web of Science ®Google Scholar
• Leytus, S. P., Patterson, W. L., & Mangel, W. F. (1983). New class of sensitive and selective fluorogenic substrates for serine proteinases. Amino acid and dipeptide derivatives of rhodamine. The Biochemical Journal, 215(2), 253–260. https://doi.org/10.1042/BJ2150253
   PubMed Web of Science ®Google Scholar
• Li, Q., & Kang, C. (2020). Progress in developing inhibitors of SARS-CoV-2 3C-like protease. Microorganisms, 8(8), 1250–1218. https://doi.org/10.3390/microorganisms8081250
   PubMed Web of Science ®Google Scholar
• Li, L., Shaik, A. A., Zhang, J., Nhkata, K., Wang, L., Zhang, Y., Xing, C., Kim, S. H., & Lü, J. (2011). Preparation of Penta-O-galloyl-β-D-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC. Journal of Pharmaceutical and Biomedical Analysis, 54(3), 545–550. https://doi.org/10.1016/J.JPBA.2010.09.028
   PubMed Web of Science ®Google Scholar
• Li, Q., Yi, D., Lei, X., Zhao, J., Zhang, Y., Cui, X., Xiao, X., Jiao, T., Dong, X., Zhao, X., Zeng, H., Liang, C., Ren, L., Guo, F., Li, X., Wang, J., & Cen, S. (2021). Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase. Acta Pharmaceutica Sinica. B, 11(6), 1555–1567. https://doi.org/10.1016/J.APSB.2021.02.011
   PubMed Web of Science ®Google Scholar
• Mackerell, A. D., Feig, M., & Brooks, C. L. (2004). Extending the treatment of backbone energetics in protein force fields: Limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations. Journal of Computational Chemistry, 25(11), 1400–1415. https://doi.org/10.1002/jcc.20065
   PubMed Web of Science ®Google Scholar
• Marcovicz, C., Ferreira, R. C., Santos, A. B. S., Reyna, A. S., de Araújo, C. B., Malvestiti, I., & Falcão, E. H. L. (2018). Nonlinear optical behavior of two tetrathiafulvalene derivatives in the picosecond regime. Chemical Physics Letters, 702, 16–20. https://doi.org/10.1016/j.cplett.2018.04.053
   Web of Science ®Google Scholar
• Misuri, L., Cappiello, M., Balestri, F., Moschini, R., Barracco, V., Mura, U., & Del-Corso, A. (2017). The use of dimethylsulfoxide as a solvent in enzyme inhibition studies: The case of aldose reductase. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 1152–1158. https://doi.org/10.1080/14756366.2017.1363744
   PubMed Web of Science ®Google Scholar
• Modrzyński, J. J., Christensen, J. H., & Brandt, K. K. (2019). Evaluation of dimethyl sulfoxide (DMSO) as a co-solvent for toxicity testing of hydrophobic organic compounds. Ecotoxicology (London, England), 28(9), 1136–1141. https://doi.org/10.1007/S10646-019-02107-0/TABLES/1
   PubMed Web of Science ®Google Scholar
• Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M. C., Milne, G. W. A., Proksa, B., & Pommier, Y. (1997). Depsides and depsidones as inhibitors of HIV-1 integrase: Discovery of novel inhibitors through 3D database searching. Journal of Medicinal Chemistry, 40(6), 942–951. https://doi.org/10.1021/JM960759E
   PubMed Web of Science ®Google Scholar
• Needle, D., Lountos, G. T., & Waugh, D. S. (2015). Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity. Acta Crystallographica. Section D, Biological Crystallography, 71(Pt 5), 1102–1111. https://doi.org/10.1107/S1399004715003521
   PubMedGoogle Scholar
• O’Boyle, N. M., Banck, M., James, C. A., Morley, C., Vandermeersch, T., & Hutchison, G. R. (2011). (2011). Open Babel: An open chemical toolbox. Journal of Cheminformatics, 3(1), 33–14. https://doi.org/10.1186/1758-2946-3-33
   PubMed Web of Science ®Google Scholar
• Oleg, T., & Olson, A. J. (2009). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455-461. https://doi.org/10.1002/jcc.21334
   Google Scholar
• Phillips, J. C., Braun, R., Wang, W., Gumbart, J., Tajkhorshid, E., Villa, E., Chipot, C., Skeel, R. D., Kale, L., & Schulten, K. (2005). Scalable molecular dynamics with NAMD. Journal of Computational Chemistry, 26(16), 1781–1802. https://doi.org/10.1002/jcc.20289
   PubMed Web of Science ®Google Scholar
• Pillaiyar, T., Manickam, M., Namasivayam, V., Hayashi, Y., & Jung, S.-H. (2016). An overview of severe acute respiratory syndrome–coronavirus (SARS-CoV) 3CL protease inhibitors: Peptidomimetics and small molecule chemotherapy. Journal of Medicinal Chemistry, 59(14), 6595–6628. https://doi.org/10.1021/ACS.JMEDCHEM.5B01461
   PubMed Web of Science ®Google Scholar
• Pizzi, A. (2019). Tannins: Prospectives and actual industrial applications. Biomolecules, 9(8), 344. https://doi.org/10.3390/biom9080344
   PubMed Web of Science ®Google Scholar
• Pontes, C. A., Corte, V. B., de Lima e Borges, E. E., da Silva, A. G., & de Cássia Gonçalves Borges, R. (2006). Influência da temperatura de armazenamento na qualidade das sementes de Caesalpinia peltophoroides Benth. (Sibipiruna). Revista Árvore, 30(1), 43–48. https://doi.org/10.1590/S0100-67622006000100006
   Google Scholar
• Qiao, C., Yanfei, H., Jinhua, L., & Qingxi, C. (2005). Effect of dimethyl sulfxide (DMSO) on activity and conformation of alkaline phosphatase from Haliotis diversicolor. Xiamen Da Xue Xue Bao. Zi Ran Ke Xue Ban. = Journal of Xiamen University. Natural Science, 44(6), 836–838.
   Google Scholar
• Rappe, A. K., Casewit, C. J., Colwell, K. S., Goddard, W. A., & Skiff, W. M. (1992). UFF, a full periodic table force field for molecular mechanics and molecular dynamics simulations. Journal of the American Chemical Society, 114(25), 10024–10035. https://doi.org/10.1021/ja00051a040
   Web of Science ®Google Scholar
• Sambrook, J., & Russell, D. W. (2006). The condensed protocols from molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press.
   Google Scholar
• Schomburg, I., Chang, A., Placzek, S., Sohngen, C., Rother, M., Lang, M., Munaretto, C., Ulas, S., Stelzer, M., Grote, A., Scheer, M., & Schomburg, D. (2013). BRENDA in 2013: Integrated reactions, kinetic data, enzyme function data, improved disease classification: New options and contents in BRENDA. Nucleic Acids Research, 41(Database issue), D764–72. https://doi.org/10.1093/nar/gks1049
   PubMedGoogle Scholar
• Scudellari, M. (2021). How the coronavirus infects cells—And why Delta is so dangerous. Nature, 595(7869), 640–644. https://doi.org/10.1038/d41586-021-02039-y
   PubMed Web of Science ®Google Scholar
• Serrano, J., Puupponen-Pimiä, R., Dauer, A., Aura, A. M., & Saura-Calixto, F. (2009). Tannins: Current knowledge of food sources, intake, bioavailability and biological effects. Molecular Nutrition & Food Research, 53(S2), S310–S329. https://doi.org/10.1002/mnfr.200900039
   PubMedGoogle Scholar
• Silvestrini, L., Belhaj, N., Comez, L., Gerelli, Y., Lauria, A., Libera, V., Mariani, P., Marzullo, P., Ortore, M. G., Palumbo Piccionello, A., Petrillo, C., Savini, L., Paciaroni, A., & Spinozzi, F. (2021). The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors. Scientific Reports, 11(1), 9283. https://doi.org/10.1038/s41598-021-88630-9
   PubMed Web of Science ®Google Scholar
• Su, H., Yao, S., Zhao, W., Zhang, Y., Liu, J., Shao, Q., Wang, Q., Li, M., Xie, H., Shang, W., Ke, C., Feng, L., Jiang, X., Shen, J., Xiao, G., Jiang, H., Zhang, L., Ye, Y., & Xu, Y. (2021). Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nature Communications, 12(1), 1-12. https://doi.org/10.1038/s41467-021-23751-3
   Google Scholar
• Subissi, L., Posthuma, C. C., Collet, A., Zevenhoven-Dobbe, J. C., Gorbalenya, A. E., Decroly, E., Snijder, E. J., Canard, B., & Imbert, I. (2014). One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. Proceedings of the National Academy of Sciences of the United States of America, 111(37), E3900–E3909. https://doi.org/10.1073/PNAS.1323705111/-/DCSUPPLEMENTAL
   PubMed Web of Science ®Google Scholar
• Tan, J., Verschueren, K. H. G., Anand, K., Shen, J., Yang, M., Xu, Y., Rao, Z., Bigalke, J., Heisen, B., Mesters, J. R., Chen, K., Shen, X., Jiang, H., & Hilgenfeld, R. (2005). pH-dependent conformational flexibility of the SARS-CoV main proteinase (Mpro) dimer: Molecular dynamics simulations and multiple X-ray structure analyses. Journal of Molecular Biology, 354(1), 25–40. https://doi.org/10.1016/J.JMB.2005.09.012
   PubMed Web of Science ®Google Scholar
• Ubillas, R., Jolad, S. D., Bruening, R. C., Kernan, M. R., King, S. R., Sesin, D. F., Barrett, M., Stoddart, C. A., Flaster, T., Kuo, J., Ayala, F., Meza, E., Castañel, M., McMeekin, D., Rozhon, E., Tempesta, M. S., Barnard, D., Huffman, J., Smee, D., … Nakanishi, K. (1994). SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago). Phytomedicine, 1(2), 77–106. https://doi.org/10.1016/S0944-7113(11)80026-7
   PubMedGoogle Scholar
• Ueda, K., Kawabata, R., Irie, T., Nakai, Y., Tohya, Y., & Sakaguchi, T. (2013). Inactivation of pathogenic viruses by plant-derived tannins: Strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses. PLoS One. 8(1), e55343. https://doi.org/10.1371/journal.pone.0055343
   PubMed Web of Science ®Google Scholar
• Umashankar, V., Deshpande, S. H., Hegde, H. V., Singh, I., & Chattopadhyay, D. (2021). Phytochemical moieties from Indian traditional medicine for targeting dual hotspots on SARS-CoV-2 spike protein: An integrative in-silico approach. Frontiers in Medicine, 8, 672629. https://doi.org/10.3389/FMED.2021.672629
   Web of Science ®Google Scholar
• Vu, T. H., Le Lamer, A.-C., Lalli, C., Boustie, J., Samson, M., Lohézic-Le Dévéhat, F., & Le Seyec, J. (2015). Depsides: Lichen metabolites active against Hepatitis C virus. PLoS One, 10(3), e0120405. https://doi.org/10.1371/JOURNAL.PONE.0120405
   PubMed Web of Science ®Google Scholar
• Wang, F., Chen, C., Tan, W., Yang, K., & Yang, H. (2016). (2016). Structure of main protease from human coronavirus NL63: Insights for wide spectrum anti-coronavirus drug design. Scientific Reports, 6(1), 22677–22612. https://doi.org/10.1038/srep22677
   PubMedGoogle Scholar
• Wang, S.-C., Chen, Y., Wang, Y.-C., Wang, W.-J., Yang, C.-S., Tsai, C.-L., Hou, M.-H., Chen, H.-F., Shen, Y.-C., & Hung, M.-C. (2020). Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. American Journal of Cancer Research, 10(12), 4538–4546.
   PubMed Web of Science ®Google Scholar
• Wang, S., Meng, X., Zhou, H., Liu, Y., Secundo, F., & Liu, Y. (2016). Enzyme stability and activity in non-aqueous reaction systems: A mini review. Catalysts, 6(2), 32. https://doi.org/10.3390/catal6020032
   Web of Science ®Google Scholar
• Wang, Y., Zhang, D., Du, G., Du, R., Zhao, J., Jin, Y., Fu, S., Gao, L., Cheng, Z., Lu, Q., Hu, Y., Luo, G., Wang, K., Lu, Y., Li, H., Wang, S., Ruan, S., Yang, C., Mei, C., … Wang, C. (2020). Remdesivir in adults with severe COVID-19: A randomised, double-blind, placebo-controlled, multicentre trial. The Lancet, 395(10236), 1569–1578. https://doi.org/10.1016/S0140-6736(20)31022-9/ATTACHMENT/9A4ED53E-D80B-42D4-9441-05DC6FC80E61/MMC1.PDF
   PubMed Web of Science ®Google Scholar
• Wilkins, M. R., Gasteiger, E., Bairoch, A., Sanchez, J. C., Williams, K. L., Appel, R. D., & Hochstrasser, D. F. (1999). Protein identification and analysis tools in the ExPASy server. Methods in Molecular Biology (Clifton, N.J.), 112, 531–552. https://doi.org/10.1385/1-59259-584-7:531
   PubMedGoogle Scholar
• Xue, X., Yu, H., Yang, H., Xue, F., Wu, Z., Shen, W., Li, J., Zhou, Z., Ding, Y., Zhao, Q., Zhang, X. C., Liao, M., Bartlam, M., & Rao, Z. (2008). Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design. Journal of Virology, 82(5), 2515–2527. https://doi.org/10.1128/JVI.02114-07
   PubMed Web of Science ®Google Scholar
• Yang, L. J., Chen, R. H., Hamdoun, S., Coghi, P., Ng, J. P. L., Zhang, D. W., Guo, X., Xia, C., Law, B. Y. K., & Wong, V. K. W. (2021). Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding. Phytomedicine, 87, 153591. https://doi.org/10.1016/J.PHYMED.2021.153591
   PubMed Web of Science ®Google Scholar
• Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Zhao, Q., Zhou, Z., Pei, D., Ziebuhr, J., Hilgenfeld, R., Kwok, Y. Y., Wong, L., Gao, G., Chen, S., Chen, Z., Ma, D., Bartlam, M., & Rao, Z. (2005). Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biology, 3(10), e324. https://doi.org/10.1371/JOURNAL.PBIO.0030324
   PubMed Web of Science ®Google Scholar
• Zhang, L., Lin, D., Sun, X., Curth, U., Drosten, C., Sauerhering, L., Becker, S., Rox, K., & Hilgenfeld, R. (2020). Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science (New York, N.Y.), 368(6489), 409–412. https://doi.org/10.1126/SCIENCE.ABB3405
   PubMed Web of Science ®Google Scholar
• Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
   PubMed Web of Science ®Google Scholar
• Zoete, V., Cuendet, M. A., Grosdidier, A., & Michielin, O. (2011). SwissParam: A fast force field generation tool for small organic molecules. Journal of Computational Chemistry, 32(11), 2359–2368. https://doi.org/10.1002/jcc.21816
   PubMed Web of Science ®Google Scholar