Natural furin inhibitor(s) as potent therapeutic molecule to mitigate SARS-CoV-2 infection

References

• Azhar, E. I., Hui, D. S. C., Memish, Z. A., Drosten, C., & Zumla, A. (2019). The Middle East Respiratory Syndrome (MERS). Infectious Disease Clinics of North America, 33(4), 891–905. https://doi.org/10.1016/j.idc.2019.08.001
   PubMed Web of Science ®Google Scholar
• Belouzard, S., Chu, V. C., & Whittaker, G. R. (2009). Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites. Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5871–5876. https://doi.org/10.1073/pnas.0809524106
   PubMed Web of Science ®Google Scholar
• Boehm, M., & Nabel, E. G. (2002). Angiotensin-converting enzyme 2—A new cardiac regulator. The New England Journal of Medicine, 347(22), 1795–1797. https://doi.org/10.1056/NEJMcibr022472
   PubMed Web of Science ®Google Scholar
• Couture, F., Kwiatkowska, A., Dory, Y. L., & Day, R. (2015). Therapeutic uses of furin and its inhibitors: A patent review. Expert Opinion on Therapeutic Patents, 25(4), 379–396. https://doi.org/10.1517/13543776.2014.1000303
   PubMed Web of Science ®Google Scholar
• Dales, N. A., Gould, A. E., Brown, J. A., Calderwood, E. F., Guan, B., Minor, C. A., Gavin, J. M., Hales, P., Kaushik, V. K., Stewart, M., Tummino, P. J., Vickers, C. S., Ocain, T. D., & Patane, M. A. (2002). Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. Journal of the American Chemical Society, 124(40), 11852–11853. https://doi.org/10.1021/ja0277226
   PubMed Web of Science ®Google Scholar
• Fang, L., Karakiulakis, G., & Roth, M. (2020). Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? The Lancet Respiratory Medicine, 8(4), e21. https://doi.org/10.1016/S2213-2600(20)30116-8
   PubMed Web of Science ®Google Scholar
• Ferrario, C. M., Jessup, J., Chappell, M. C., Averill, D. B., Brosnihan, K. B., Tallant, E. A., Diz, D. I., & Gallagher, P. E. (2005). Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation, 111(20), 2605–2610. https://doi.org/10.1161/CIRCULATIONAHA.104.510461
   PubMed Web of Science ®Google Scholar
• Furin cleavage site in the SARS-CoV-2 coronavirus glycoprotein.
   Google Scholar
• GISAID Global Initiative on Sharing All Influenza Data. Phylogeny of SARS-like betacoronaviruses including novel coronavirus (nCoV).
   Google Scholar
• Huang, M-l., Li, X., Meng, Y., Xiao, B., Ma, Q., Ying, S-s., Wu, P-s., & Zhang, Z-s (2010). Upregulation of angiotensin‐converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clinical and Experimental Pharmacology & Physiology, 37(1), e1–e6. https://doi.org/10.1111/j.1440-1681.2009.05302.x
   PubMed Web of Science ®Google Scholar
• Jaaks, P., & Bernasconi, M. (2017). The proprotein convertase furin in tumour progression. International Journal of Cancer, 141(4), 654–663. https://doi.org/10.1002/ijc.30714
   PubMed Web of Science ®Google Scholar
• Kirchdoerfer, R. N., Cottrell, C. A., Wang, N., Pallesen, J., Yassine, H. M., Turner, H. L., Corbett, K. S., Graham, B. S., McLellan, J. S., & Ward, A. B. (2016). Pre-fusion structure of a human coronavirus spike protein. Nature, 531(7592), 118–121. https://doi.org/10.1038/nature17200
   PubMed Web of Science ®Google Scholar
• Lam, C. W., Chan, M. H., & Wong, C. K. (2004). Severe acute respiratory syndrome: Clinical and laboratory manifestations. The Clinical Biochemist. Reviews, 25(2), 121–132.
   PubMedGoogle Scholar
• Mahdevar, E. (2021). Exploring the cancer-testis antigen BORIS to design a novel multi-epitope vaccine against breast cancer based on immunoinformatics approaches. Journal of Biomolecular Structure and Dynamics, 1–18. https://doi.org/10.1080/07391102.2021.1883111
   Google Scholar
• Millet, J. K., & Whittaker, G. R. (2014). Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. Proceedings of the National Academy of Sciences of the United States of America, 111(42), 15214–15219. https://doi.org/10.1073/pnas.1407087111
   PubMed Web of Science ®Google Scholar
• Prompetchara, E., Ketloy, C., & Palaga, T. (2020). Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pacific Journal of Allergy and Immunology, 38(1), 1–9.
   PubMed Web of Science ®Google Scholar
• Roncati, L., Gallo, G., Manenti, A., & Palmieri, B. (2020). Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2. Medical Hypotheses, 140, 109686. https://doi.org/10.1016/j.mehy.2020.109686
   PubMed Web of Science ®Google Scholar
• Rottier, P. J. (1995). The coronaviridae. (pp. 115–139). Springer.
   Google Scholar
• Safavi, A., Kefayat, A., Abiri, A., Mahdevar, E., Behnia, A. H., & Ghahremani, F. (2019). In silico analysis of transmembrane protein 31 (TMEM31) antigen to design novel multiepitope peptide and DNA cancer vaccines against melanoma. Molecular Immunology, 112, 93–102. https://doi.org/10.1016/j.molimm.2019.04.030
   PubMed Web of Science ®Google Scholar
• Safavi, A., Kefayat, A., Sotoodehnejadnematalahi, F., Salehi, M., & Modarressi, M. H. (2019). In silico analysis of synaptonemal complex protein 1 (SYCP1) and acrosin binding protein (ACRBP) antigens to design novel multiepitope peptide cancer vaccine against breast cancer. International Journal of Peptide Research and Therapeutics, 25(4), 1343–1359. https://doi.org/10.1007/s10989-018-9780-z
   Web of Science ®Google Scholar
• Tyrrell, D. A., & Bynoe, M. L. (1966). Cultivation of viruses from a high proportion of patients with colds. Lancet (London, England), 1(7428), 76–77. https://doi.org/10.1016/S0140-6736(66)92364-6
   PubMed Web of Science ®Google Scholar
• van Doremalen, N., Bushmaker, T., Morris, D. H., Holbrook, M. G., Gamble, A., Williamson, B. N., Tamin, A., Harcourt, J. L., Thornburg, N. J., Gerber, S. I., Lloyd-Smith, J. O., de Wit, E., & Munster, V. J. (2020). Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1. The New England Journal of Medicine, 382(16), 1564–1567. https://doi.org/10.1056/NEJMc2004973
   PubMed Web of Science ®Google Scholar
• Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020). Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell, 181(2), 281–292.e6. e286 https://doi.org/10.1016/j.cell.2020.02.058
   PubMed Web of Science ®Google Scholar
• Weekly epidemiological update on COVID-19 - 10 (August 2022).
   Google Scholar
• WHO Situation Report (2020).
   Google Scholar
• Why the Coronavirus Has Been So Successful. (2020). By Ed Yong March 20, 2020.
   Google Scholar
• World Health Organization. WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020.
   Google Scholar
• Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., Hu, Y., Tao, Z.-W., Tian, J.-H., Pei, Y.-Y., Yuan, M.-L., Zhang, Y.-L., Dai, F.-H., Liu, Y., Wang, Q.-M., Zheng, J.-J., Xu, L., Holmes, E. C., & Zhang, Y.-Z. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798), 265–269. https://doi.org/10.1038/s41586-020-2008-3
   PubMed Web of Science ®Google Scholar
• Wu, Y., & Zhao, S. (2020). Furin cleavage sites naturally occur in coronaviruses. Stem Cell Research, 50, 102115. https://doi.org/10.1016/j.scr.2020.102115
   PubMed Web of Science ®Google Scholar
• Xia, S., Zhu, Y., Liu, M., Lan, Q., Xu, W., Wu, Y., Ying, T., Liu, S., Shi, Z., Jiang, S., & Lu, L. (2020). Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. Cellular & Molecular Immunology, 17(7), 765–767. https://doi.org/10.1038/s41423-020-0374-2
   PubMed Web of Science ®Google Scholar
• Zhang, H., Penninger, J. M., Li, Y., Zhong, N., & Slutsky, A. S. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: Molecular mechanisms and potential therapeutic target. Intensive Care Medicine, 46(4), 586–590. https://doi.org/10.1007/s00134-020-05985-9
   PubMed Web of Science ®Google Scholar
• Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., Chen, H.-D., Chen, J., Luo, Y., Guo, H., Jiang, R.-D., Liu, M.-Q., Chen, Y., Shen, X.-R., Wang, X., … Shi, Z.-L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270–273. https://doi.org/10.1038/s41586-020-2012-7
   PubMed Web of Science ®Google Scholar
• Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., Niu, P., Zhan, F., Ma, X., Wang, D., Xu, W., Wu, G., Gao, G. F., & Tan, W, China Novel Coronavirus Investigating and Research Team (2020). A novel coronavirus from patients with pneumonia in China, 2019. The New England Journal of Medicine, 382(8), 727–733. https://doi.org/10.1056/NEJMoa2001017
   PubMed Web of Science ®Google Scholar