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Research Articles

An in-silico insight into the predictive interaction of Apolipoprotein-E with Epstein-Barr virus proteins and their probable role in mediating Alzheimer’s disease

, , , , & ORCID Icon
Pages 8918-8926 | Received 03 Aug 2022, Accepted 16 Oct 2022, Published online: 28 Oct 2022

References

  • Allnutt, M. A., Johnson, K., Bennett, D. A., Connor, S. M., Troncoso, J. C., Pletnikova, O., Albert, M. S., Resnick, S. M., Scholz, S. W., De Jager, P. L., & Jacobson, S. (2020). Human Herpesvirus 6 detection in Alzheimer’s disease cases and controls across multiple cohorts. Neuron, 105(6), 1027–1035. https://doi.org/10.1016/j.neuron.2019.12.031
  • Burgos, J. S., Ramirez, C., Sastre, I., Bullido, M. J., & Valdivieso, F. (2003). ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1. NeuroReport, 14(14), 1825–1827. https://doi.org/10.1097/00001756-200310060-00013
  • Burgos, J. S., Ramirez, C., Sastre, I., & Valdivieso, F. (2006). Effect of Apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA. Journal of Virology, 80(11), 5383–5387. https://doi.org/10.1128/JVI.00006-06
  • Burgos, J. S., & Valdivieso, F. (2007). Understanding the relationship between ApoE and HSV-1 and its possible significance in Alzheimer’s disease. Future Virology, 2(3), 239–242. https://doi.org/10.2217/17460794.2.3.239
  • Carbone, I., Lazzarotto, T., Ianni, M., Porcellini, E., Forti, P., Masliah, E., Gabrielli, L., & Licastro, F. (2014). Herpes virus in Alzheimer’s disease: Relation to progression of the disease. Neurobiology of Aging, 35(1), 122–129. https://doi.org/10.1016/j.neurobiolaging.2013.06.024
  • Chen, J., Li, Q., & Wang, J. (2011). Topology of human Apolipoprotein E3 uniquely regulates its diverse biological functions. Proceedings of the National Academy of Sciences of the United States of America, 108(36), 14813–14818. https://doi.org/10.1073/pnas.1106420108
  • Das, H. K., McPherson, J., Bruns, G. A., Karathanasis, S. K., & Breslow, J. L. (1985). Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene. The Journal of Biological Chemistry, 260(10), 6240–6247. https://doi.org/10.1016/S0021-9258(18)88963-3
  • Deroo, S., Stengel, F., Mohammadi, A., Henry, N., Hubin, E., Krammer, E.-M., Aebersold, R., & Raussens, V. (2015). Chemical cross-linking/mass spectrometry maps the Amyloid β peptide binding region on both apolipoprotein E domains. ACS Chemical Biology, 10(4), 1010–1016. https://doi.org/10.1021/cb500994j
  • Gate, D., Saligrama, N., Leventhal, O., Yang, A. C., Unger, M. S., Middeldorp, J., Chen, K., Lehallier, B., Channappa, D., De Los Santos, M. B., McBride, A., Pluvinage, J., Elahi, F., Tam, G. K.-Y., Kim, Y., Greicius, M., Wagner, A. D., Aigner, L., Galasko, D. R., Davis, M. M., & Wyss-Coray, T. (2020). Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease. Nature, 577(7790), 399–404. https://doi.org/10.1038/s41586-019-1895-7
  • Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006). Apolipoprotein E structure: Insights into function. Trends in Biochemical Sciences, 31(8), 445–454. https://doi.org/10.1016/j.tibs.2006.06.008
  • Hess, B., Kutzner, C., van der Spoel, D., & Lindahl, E. (2008). GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation. Journal of Chemical Theory and Computation, 4(3), 435–447. https://doi.org/10.1021/ct700301q
  • Hogestyn, J., Mock, D., & Mayer-Proschel, M. (2018). Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology. Neural Regeneration Research, 13(2), 211–221. https://doi.org/10.4103/1673-5374.226380
  • Holtzman, D. M. (2001). Role of apoE/Aβ interactions in the pathogenesis of Alzheimer’s disease and cerebral amyloid angiopathy. Journal of Molecular Neuroscience: MN, 17(2), 147–155. https://doi.org/10.1385/JMN:17:2:147
  • Hone, E., Lim, F., & Martins, I. J. (2019). Fat and Lipid Metabolism and the Involvement of Apolipoprotein E in Alzheimer’s Disease. In R. N. Martins, C. S. Brennan, W. M. A. D. B. Fernando, M. A. Brennan, & S. J. Fuller (Eds.), Neurodegeneration and Alzheimer’s disease (pp. 189–231). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781119356752.ch7
  • Huang, S.-Y., Yang, Y.-X., Kuo, K., Li, H.-Q., Shen, X.-N., Chen, S.-D., Cui, M., Tan, L., Dong, Q., & Yu, J.-T. (2021). Herpesvirus infections and Alzheimer’s disease: A Mendelian randomization study. Alzheimer’s Research & Therapy, 13(1), 158. https://doi.org/10.1186/s13195-021-00905-5
  • Jakhmola, S., & Jha, H. C. (2021). Glial cell response to Epstein-Barr virus infection: A plausible contribution to virus-associated inflammatory reactions in the brain. Virology, 559, 182–195. https://doi.org/10.1016/j.virol.2021.04.005
  • Jha, H. C., Mehta, D., Lu, J., El-Naccache, D., Shukla, S. K., Kovacsics, C., Kolson, D., & Robertson, E. S. (2015). Gammaherpesvirus infection of human neuronal cells. MBio, 6(6). https://doi.org/10.1128/mBio.01844-15
  • Jiang, J., Cun, W., Wu, X., Shi, Q., Tang, H., & Luo, G. (2012). Hepatitis C virus attachment mediated by Apolipoprotein E binding to cell surface Heparan sulfate. Journal of Virology, 86(13), 7256–7267. https://doi.org/10.1128/JVI.07222-11
  • Jorgensen, W. L., Chandrasekhar, J., Madura, J. D., Impey, R. W., & Klein, M. L. (1983). Comparison of simple potential functions for simulating liquid water. The Journal of Chemical Physics, 79(2), 926–935. https://doi.org/10.1063/1.445869
  • Kanekiyo, T., Xu, H., & Bu, G. (2014). ApoE and Aβ in Alzheimer’s disease: Accidental encounters or partners? Neuron, 81(4), 740–754. https://doi.org/10.1016/j.neuron.2014.01.045
  • Karantzoulis, S., & Galvin, J. E. (2011). Distinguishing Alzheimer’s disease from other major forms of dementia. Expert Review of Neurotherapeutics, 11(11), 1579–1591. https://doi.org/10.1586/ern.11.155
  • Khan, N., Datta, G., Geiger, J. D., & Chen, X. (2018). Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation. Journal of Neuroinflammation, 15(1), 91. https://doi.org/10.1186/s12974-018-1129-1
  • Kim, J., Basak, J. M., & Holtzman, D. M. (2009). The role of Apolipoprotein E in Alzheimer’s disease. Neuron, 63(3), 287–303. https://doi.org/10.1016/j.neuron.2009.06.026
  • Koudinov, A. R., Berezov, T. T., & Koudinova, N. V. (1998). Alzheimer’s amyloid beta and lipid metabolism: A missing link? FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 12(12), 1097–1099. https://doi.org/10.1096/fasebj.12.12.1097
  • Kurki, S. N., Kantonen, J., Kaivola, K., Hokkanen, L., Mäyränpää, M. I., Puttonen, H., Martola, J., Pöyhönen, M., Kero, M., Tuimala, J., Carpén, O., Kantele, A., Vapalahti, O., Tiainen, M., Tienari, P. J., Kaila, K., Hästbacka, J., & Myllykangas, L. (2021). APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: A Finnish biobank, autopsy and clinical study. Acta Neuropathologica Communications, 9(1), 199. https://doi.org/10.1186/s40478-021-01302-7
  • Li, Y., Webster-Cyriaque, J., Tomlinson, C. C., Yohe, M., & Kenney, S. (2004). Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression. Journal of Virology, 78(8), 4197–4206. https://doi.org/10.1128/jvi.78.8.4197-4206.2004
  • Linard, M., Letenneur, L., Garrigue, I., Doize, A., Dartigues, J.-F., & Helmer, C. (2020). Interaction between APOE4 and herpes simplex virus type 1 in Alzheimer’s disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 16(1), 200–208. https://doi.org/10.1002/alz.12008
  • Lindorff-Larsen, K., Piana, S., Palmo, K., Maragakis, P., Klepeis, J. L., Dror, R. O., & Shaw, D. E. (2010). Improved side-chain torsion potentials for the Amber ff99SB protein force field: Improved protein side-chain potentials. Proteins: Structure, Function, and Bioinformatics, 78(8), 1950–1958. https://doi.org/10.1002/prot.22711
  • Liu, Q., Wu, W., Fang, C., Li, R., Liu, P., Lei, P., Hu, J., Sun, X., Zheng, Y., Zhao, Y., & Li, Y. (2011). Mapping ApoE/Aβ binding regions to guide inhibitor discovery. Molecular bioSystems, 7(5), 1693–1700. https://doi.org/10.1039/c1mb05019b
  • Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., … Vos, T. (2022). Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. The Lancet Public Health, 7(2), e105–e125. https://doi.org/10.1016/S2468-2667(21)00249-8
  • Petrlova, J., Hong, H.-S., Bricarello, D. A., Harishchandra, G., Lorigan, G. A., Jin, L.-W., & Voss, J. C. (2011). A differential association of Apolipoprotein E isoforms with the amyloid-β oligomer in solution: Association of apoE Isoforms with a TOAC-Ab. Proteins, 79(2), 402–416. https://doi.org/10.1002/prot.22891
  • Qiao, L., & Luo, G. G. (2019). Human apolipoprotein E promotes hepatitis B virus infection and production. PLoS Pathogens, 15(8), e1007874. https://doi.org/10.1371/journal.ppat.1007874
  • Siddiqui, R., Suzu, S., Ueno, M., Nasser, H., Koba, R., Bhuyan, F., Noyori, O., Hamidi, S., Sheng, G., Yasuda-Inoue, M., Hishiki, T., Sukegawa, S., Miyagi, E., Strebel, K., Matsushita, S., Shimotohno, K., & Ariumi, Y. (2018). Apolipoprotein E is an HIV-1-inducible inhibitor of viral production and infectivity in macrophages. PLoS Pathogens, 14(11), e1007372. https://doi.org/10.1371/journal.ppat.1007372
  • Singh, P. P., Singh, M., & Mastana, S. S. (2006). APOE distribution in world populations with new data from India and the UK. Annals of Human Biology, 33(3), 279–308. https://doi.org/10.1080/03014460600594513
  • Soman, S. S., Sivakumar, K. C., & Sreekumar, E. (2010). Molecular dynamics simulation studies and in vitro site directed mutagenesis of avian beta-defensin Apl_AvBD2. BMC Bioinformatics, 11(Suppl 1), S7. https://doi.org/10.1186/1471-2105-11-S1-S7
  • Sousa da Silva, A. W., & Vranken, W. F. (2012). ACPYPE - AnteChamber PYthon Parser interfacE. BMC Research Notes, 5(1), 367. https://doi.org/10.1186/1756-0500-5-367
  • Tiwari, D., Jakhmola, S., Pathak, D. K., Kumar, R., & Jha, H. C. (2020). Temporal in vitro Raman spectroscopy for monitoring replication kinetics of Epstein–Barr virus infection in glial cells. ACS Omega, 5(45), 29547–29560. https://doi.org/10.1021/acsomega.0c04525
  • Tiwari, D., Singh, V. K., Baral, B., Pathak, D. K., Jayabalan, J., Kumar, R., Tapryal, S., & Jha, H. C. (2021). Indication of neurodegenerative cascade initiation by amyloid-like aggregate-forming EBV proteins and peptide in Alzheimer’s disease. ACS Chemical Neuroscience, 12(20), 3957–3967. https://doi.org/10.1021/acschemneuro.1c00584
  • Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A. E., Berendsen, H., & J., C. (2005). GROMACS: Fast, flexible, and free. Journal of Computational Chemistry, 26(16), 1701–1718. https://doi.org/10.1002/jcc.20291
  • Weisgraber, K. H., & Mahley, R. W. (1996). Human Apolipoprotein E: The Alzheimer’s disease connection. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 10(13), 1485–1494. https://doi.org/10.1096/fasebj.10.13.8940294
  • Wildsmith, K. R., Holley, M., Savage, J. C., Skerrett, R., & Landreth, G. E. (2013). Evidence for impaired amyloid β clearance in Alzheimer’s disease. Alzheimer’s Research & Therapy, 5(4), 33. https://doi.org/10.1186/alzrt187
  • Wozniak, M. A., Shipley, S. J., Dobson, C. B., Parker, S. P., Scott, F. T., Leedham-Green, M., Breuer, J., & Itzhaki, R. F. (2007). Does Apolipoprotein E determine outcome of infection by varicella zoster virus and by Epstein Barr virus? European Journal of Human Genetics: EJHG, 15(6), 672–678. https://doi.org/10.1038/sj.ejhg.5201812
  • Yan, L. O., Li., Z. U., & Guang-rong, L. I. (2008). Influences of EBV infection and single nucleotide polymorphism of apolipoprotein E gene on Alzheimer’s disease. Chinese Journal of Public Health, 24(5), 573–574. https://doi.org/10.11847/zgggws2008-24-05-30
  • Yang, D.-S., Small, D. H., Seydel, U., Smith, J. D., Hallmayer, J., Gandy, S. E., & Martins, R. N. (1999). Apolipoprotein E promotes the binding and uptake of β-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience, 90(4), 1217–1226. https://doi.org/10.1016/S0306-4522(98)00561-2
  • Zhang, N., Zuo, Y., Jiang, L., Peng, Y., Huang, X., & Zuo, L. (2022). Epstein-Barr virus and neurological diseases. Frontiers in Molecular Biosciences, 8, 816098. https://doi.org/10.3389/fmolb.2021.816098

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