Structure-based molecular networking, molecular docking, dynamics simulation and pharmacokinetic studies of Olax subscorpioidea for identification of potential inhibitors against selected cancer targets

References

• Abotaleb, M., Samuel, S. M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A. & Büsselberg, D. (2018). Flavonoids in cancer and apoptosis. Cancers, 11, 28. https://doi.org/10.3390/cancers11010028
   PubMed Web of Science ®Google Scholar
• Adeoluwa, A. O., Aderibigbe, O. A., Agboola, I. O., Olonode, T. E., & Ben-Azu, B. (2019). Butanol fraction of Olax subscorpioidea produces antidepressant effect: evidence for the involvement of monoaminergic neurotransmission. Drug Research, 69(1), 53–60. https://doi.org/10.1055/a-0651-7939
   Web of Science ®Google Scholar
• Alaribe, C. S., Oladipupo, A. R., & Ariyo, I. A. (2021). Total phenolic and flavonoid contents, metabolic profiling, and in vitro and in silico antioxidant studies of the leaf and stem extracts of Acalypha fimbriata Schum. & Thonn. (Euphorbiaceae). Ethiopian Pharmaceutical Journal, 37(1), 1–14. https://doi.org/10.4314/epj.v37i1.1
   Google Scholar
• Alaribe, C. S., Oladipupo, A. R., Ojo-Nosakhare, O., Kehinde, O., & Ogunlaja, A. S. (2020). GC-MS analysis and mitochondrial functionality potential of the fruits of Tetrapleura tetraptera by cupric reducing antioxidant capacity assay. Journal of Phytomedicine and Therapeutics, 19(1), 338–347. https://doi.org/10.4314/jopat.v19i1.2
   Google Scholar
• Ali, M. (2001). Techniques in Terpenoid Identification. Birla Publications.
   Google Scholar
• AmeliMojarad, M., AmeliMojarad, M., & Pourmahdian, A. (2022). The inhibitory role of stigmasterol on tumor growth by inducing apoptosis in Balb/c mouse with spontaneous breast tumor (SMMT). BMC Pharmacology and Toxicology, 23(1). https://doi.org/10.1186/s40360-022-00578-2
   PubMed Web of Science ®Google Scholar
• Baell, J. B., & Holloway, G. A. (2010). New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. Journal of Medicinal Chemistry, 53(7), 2719–2740. https://doi.org/10.1021/jm901137j
   PubMed Web of Science ®Google Scholar
• Balogun, T. A., Iqbal, M. N., Saibu, O. A., Akintubosun, M. O., Lateef, O. M., Nneka, U. C., Abdullateef, O. T., & Omoboyowa, D. A. (2022). Discovery of potential HER2 inhibitors from Mangifera indica for the treatment of HER2-Positive breast cancer: An integrated computational Approach. Journal of Biomolecular Structure and Dynamics, 40(23), 12772–12784. https://doi.org/10.1080/07391102.2021.1975570
   PubMed Web of Science ®Google Scholar
• BIOVIA (2021). BIOVIA Discovery Studio Visualizer 21.1.0.0. Dassault Systèmes.
   Google Scholar
• Brenk, R., Schipani, A., James, D., Krasowski, A., Gilbert, I. H., Frearson, J., & Wyatt, P. G. (2008). Lessons learnt from assembling screening libraries for drug discovery for neglected diseases. ChemMedChem, 3(3), 435–444. https://doi.org/10.1002/cmdc.200700139
   PubMed Web of Science ®Google Scholar
• Burns, M. W., & Kim, E. S. (2015). Profile of ceritinib in the treatment of ALK + metastatic non-small-cell lung cancer. Lung Cancer (Auckland, N.Z.), 6, 35–42. https://doi.org/10.2147/LCTT.S69114
   PubMedGoogle Scholar
• Cantrell, C. L., Berhow, M. A., Phillips, B. S., Duval, S. M., Weisleder, D., & Vaughn, S. F. (2003). Bioactive crude plant seed extracts from the NCAUR oilseed repository. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 10(4), 325–333. https://doi.org/10.1078/094471103322004820
   PubMed Web of Science ®Google Scholar
• Chambers, M. C., Maclean, B., Burke, R., Amodei, D., Ruderman, D. L., Neumann, S., Gatto, L., Fischer, B., Pratt, B., Egertson, J., Hoff, K., Kessner, D., Tasman, N., Shulman, N., Frewen, B., Baker, T. A., Brusniak, M.-Y., Paulse, C., Creasy, D., … Mallick, P. (2012). A cross-platform toolkit for mass spectrometry and proteomics. Nature Biotechnology, 30(10), 918–920. https://doi.org/10.1038/nbt.2377
   PubMed Web of Science ®Google Scholar
• Chan, W. W., Wise, S. C., Kaufman, M. D., Ahn, Y. M., Ensinger, C. L., Haack, T., Hood, M. M., Jones, J., Lord, J. W., Lu, W. P., Miller, D., Patt, W. C., Smith, B. D., Petillo, P. A., Rutkoski, T. J., Telikepalli, H., Vogeti, L., Yao, T., Chun, L., … Flynn, D. L. (2011). Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Cancer Cell, 19(4), 556–568. https://doi.org/10.1016/j.ccr.2011.03.003
   PubMed Web of Science ®Google Scholar
• Chirumbolo, S., Bjorklund, G., Lysiuk, R., Vella, A., Lenchyk, L., & Upyr, T. (2018). Targeting cancer with phytochemicals via their fine tuning of the cell survival signaling pathways. International Journal of Molecular Sciences. 19, 3568. https://doi.org/10.3390/ijms19113568
   PubMed Web of Science ®Google Scholar
• Choudhary, M. I., Shaikh, M., Tul-Wahab, A., & Ur-Rahman, A. (2020). In silico identification of potential inhibitors of key SARS-CoV-2 3CL hydrolase (Mpro) via molecular docking, MMGBSA predictive binding energy calculations, and molecular dynamics simulation. PLoS One, 15(7), e0235030. https://doi.org/10.1371/journal.pone.0235030
   PubMed Web of Science ®Google Scholar
• Colombo, R., Batista, A. N. D. L., Bomfim, G. C. C., Burgos, R. C. R., Cavalheiro, A. J., Bolzani, V. D. S., Silva, D. H. S., & Reimberg, M. C. H. (2010). Validated high-performance liquid chromatographic method for the standardisation of Ptychopetalum olacoides Benth., Olacaceae, commercial extracts. Revista Brasileira de Farmacognosia, 20(5), 781–788. https://doi.org/10.1590/S0102-695X2010005000027
   Google Scholar
• Costa, R., Shah, A. N., Santa-Maria, C. A., Cruz, M. R., Mahalingam, D., Carneiro, B. A., Chae, Y. K., Cristofanilli, M., Gradishar, W. J., & Giles, F. J. (2017). Targeting epidermal growth factor receptor in triple negative breast cancer: New discoveries and practical insights for drug development. Cancer Treatment Reviews, 53, 111–119. https://doi.org/10.1016/j.ctrv.2016.12.010
   PubMed Web of Science ®Google Scholar
• Daina, A., Michielin, O., & Zoete, V. (2017). SwissADME: A free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Scientific Reports, 7(1), 42717. https://doi.org/10.1038/srep42717
   PubMed Web of Science ®Google Scholar
• DeSantis, C., Ma, J., Bryan, L., & Jemal, A. (2014). Breast cancer statistics, 2013. CA: A Cancer Journal for Clinicians, 64(1), 52–62. https://doi.org/10.3322/caac.21203
   PubMed Web of Science ®Google Scholar
• Doebele, R. C., Pilling, A. B., Aisner, D. L., Kutateladze, T. G., Le, A. T., Weickhardt, A. J., Kondo, K. L., Linderman, D. J., Heasley, L. E., Franklin, W. A., Varella-Garcia, M., & Camidge, D. R. (2012). Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. Clinical Cancer Research, 18(5), 1472–1482. https://doi.org/10.1158/1078-0432.ccr-11-2906
   PubMed Web of Science ®Google Scholar
• Ebajo Jr, V., Shen, C.-C., & Ragasa, C. (2015). Terpenoids and Sterols from Hoya multiflora Blume. Journal of Applied Pharmaceutical Science, 5(4), 033–039. https://doi.org/10.7324/JAPS.2015.50406
   Google Scholar
• Forgacs, P., & Provost, J. (1981). Olaxoside, a saponin from Olax andronensis, Olax glabriflora and Olax psittacorum. Phytochemistry, 20(7), 1689–1691. https://doi.org/10.1016/S0031-9422(00)98556-X
   Web of Science ®Google Scholar
• Fufa, M. F., Deressa, F., Deyou, T., & Abdisa, N. (2018). Isolation and characterization of compounds from the leaves of Melia azedarach and stem bark of Albizia schimperiana and evaluation for antimicrobial activities. Medicinal Chemistry, 08(06), 154-165. https://doi.org/10.4172/2161-0444.1000507
   Google Scholar
• García, G. M., López, C. E., García, N. J., & Nebro, A. (2016). Molecular docking optimization in the context of multi-drug resistant and sensitive EGFR mutants. Molecules, 21, 1575. https://doi.org/10.3390/molecules21111575
   PubMed Web of Science ®Google Scholar
• Gavrin, L. K., & Saiah, E. (2013). Approaches to discover non-ATP site kinase inhibitors. MedChemComm, 4(1), 41–51. https://doi.org/10.1039/C2MD20180A
   Web of Science ®Google Scholar
• Goodman, V. L., Rock, E. P., Dagher, R., Ramchandani, R. P., Abraham, S., Gobburu, J. V. S., Booth, B. P., Verbois, S. L., Morse, D. E., Liang, C. Y., Chidambaram, N., Jiang, J. X., Tang, S., Mahjoob, K., Justice, R., & Pazdur, R. (2007). Approval summary: Sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advanced renal cell carcinoma. Clinical Cancer Research, 13(5), 1367–1373. https://doi.org/10.1158/1078-0432.ccr-06-2328
   PubMed Web of Science ®Google Scholar
• Guan, X. (2015). Cancer metastases: challenges and opportunities. Acta Pharmaceutica Sinica. B, 5(5), 402–418. https://doi.org/10.1016/j.apsb.2015.07.005
   PubMed Web of Science ®Google Scholar
• Hollenberg, P. F. (2002). Characteristics and common properties of inhibitors, inducers, and activators of CYP enzymes. Drug Metabolism Reviews, 34(1-2), 17–35. https://doi.org/10.1081/dmr-120001387
   PubMed Web of Science ®Google Scholar
• Kumar, A., Shanthi, V., & Ramanathan, K. (2016). Discovery of potential ALK inhibitors by virtual screening approach. 3 Biotech, 6(1), 21. https://doi.org/10.1007/s13205-015-0336-z
   PubMedGoogle Scholar
• Lehne, G. (2000). P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Current Drug Targets, 1(1), 85–99. https://doi.org/10.2174/1389450003349443
   PubMedGoogle Scholar
• Masuda, H., Zhang, D., Bartholomeusz, C., Doihara, H., Hortobagyi, G. N., & Ueno, N. T. (2012). Role of epidermal growth factor receptor in breast cancer. Breast Cancer Research and Treatment, 136(2), 331–345. https://doi.org/10.1007/s10549-012-2289-9
   PubMed Web of Science ®Google Scholar
• Mishra, T., Arya, R. K., Meena, S., Joshi, P., Pal, M., Meena, B., Upreti, D. K., Rana, T. S., & Datta, D. (2016). Isolation, characterization, and anticancer potential of cytotoxic triterpenes from Betula utilis Bark. PLoS One, 11(7), e0159430. https://doi.org/10.1371/journal.pone.0159430
   PubMed Web of Science ®Google Scholar
• Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E., & Adjei, A. A. (2008). Non–small cell lung cancer: Epidemiology, risk factors, treatment, and survivorship. Mayo Clinic Proceedings, 83(5), 584–594. https://doi.org/10.4065/83.5.584
   PubMed Web of Science ®Google Scholar
• Moon, D. O., Kim, M. O., Choi, Y. H., & Kim, G. Y. (2008). beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Cancer Letters, 264(2), 181–191. https://doi.org/10.1016/j.canlet.2008.01.032
   PubMed Web of Science ®Google Scholar
• Morris, G. M., Huey, R., Lindstrom, W., Sanner, M. F., Belew, R. K., Goodsell, D. S., & Olson, A. J. (2009). AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30(16), 2785–2791. https://doi.org/10.1002/jcc.21256
   PubMed Web of Science ®Google Scholar
• Nagar, B., Bornmann, W. G., Pellicena, P., & Schindler, T. (2002). Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Research, 62, 4236–4243. https://doi.org/10.3410/f.1008668.109812
   PubMed Web of Science ®Google Scholar
• Okoye, F. B. C., Sawadogo, W. R., Sendker, J., Aly, A. H., Quandt, B., Wray, V., Hensel, A., Esimone, C. O., Debbab, A., Diederich, M., & Proksch, P. (2015). Flavonoid glycosides from Olax mannii: Structure elucidation and effect on nuclear factor kappa B pathway. Journal of Ethnopharmacology, 176, 27–34. https://doi.org/10.1016/j.jep.2015.10.019
   PubMed Web of Science ®Google Scholar
• Oladipupo, A. R. (2020). Toxin to medicine and bioisosterism in drug development: A study of the discovery and development of ACE inhibitors from snake venom. Macedonian Pharmaceutical Bulletin, 66(2), 15–33. https://doi.org/10.33320/maced.pharm.bull.2020.66.03.001
   Google Scholar
• Oladipupo, A. R., Alaribe, C. S., Ariyo, I. A., Coker, H. A., & Ogunlaja, A. S. (2019). Cytotoxic, anti-mitotic and cytogenetic effects of the leaves and stems of Olax subscorpioidea Oliv. (Olacaceae) against Artemia salina nauplii and Allium cepa meristematic cells. Macedonian Pharmaceutical Bulletin, 65(01), 3–10. https://doi.org/10.33320/maced.pharm.bull.2019.65.01.001
   Google Scholar
• Oladipupo, A., Alaribe, C., Balogun, O., Akere, H., Ayanda, F., Toye, E., & Coker, H. (2018). Investigation of chemical, genotoxic and haematological properties of secondary metabolites from n-Hexane extract of Olax subscorpioidea Oliv. (Olacaceae) Leaves. Tropical Journal of Natural Product Research, 2(12), 506–511. https://doi.org/10.26538/tjnpr/v2i12.3
   Google Scholar
• Oladipupo, A. R., Coker, H. A. B., Alaribe, C. S., & Okoko, O. D. (2019). Microbial metabolites and enzymes inhibition in drug discovery and development: A case study of the statins, a class of HMG-CoA reductase inhibitors. Tropical Journal of Natural Product Research, 3(4), 99–106. https://doi.org/10.26538/tjnpr/v3i4.1
   Google Scholar
• Omoboyowa, D. A., Singh, G., Fatoki, J. O., & Oyeneyin, O. E. (2022). Computational investigation of phytochemicals from Abrus precatorius seeds as modulators of peroxisome proliferator-activated receptor gamma (PPARγ). Journal of Biomolecular Structure and Dynamics, 30, 1–15. https://doi.org/10.1080/07391102.2022.2091657
   Google Scholar
• Opiyo, S. A., Manguro, L. O. A., Owuor, P. O., & Ateka, E. M. (2017). Triterpenes from Elaeodendron schweinfurthianum and their antimicrobial activities against crop pathogens. American Journal of Chemistry, 7(3), 97–104. https://doi.org/10.5923/j.chemistry.20170703.03
   Google Scholar
• Palanivel, S., Yli-Harja, O., & Kandhavelu, M. (2022). Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis. Journal of Biomolecular Structure & Dynamics, 40(16), 7545–7554. https://doi.org/10.1080/07391102.2021.1900917
   PubMed Web of Science ®Google Scholar
• Pertuit, D., Mitaine-Offer, A.-C., Miyamoto, T., Tanaka, C., Delaude, C., & Lacaille-Dubois, M.-A. (2018). Triterpene saponins of the root bark of Olax obtusifolia De Wild. Phytochemistry Letters, 28, 174–178. https://doi.org/10.1016/j.phytol.2018.09.018
   Web of Science ®Google Scholar
• Petit-Topin, I., Fay, M., Resche-Rigon, M., Ulmann, A., Gainer, E., Rafestin-Oblin, M.-E., & Fagart, J. (2014). Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors. Journal of Steroid Biochemistry and Molecular Biology. 144, 427–435. https://doi.org/10.1016/j.jsbmb.2014.08.008
   PubMed Web of Science ®Google Scholar
• Petrelli, A., & Giordano, S. (2008). From single- to multi-target drugs in cancer therapy: When aspecificity becomes an advantage. Current Medicinal Chemistry, 15(5), 422–432. https://doi.org/10.2174/092986708783503212
   PubMed Web of Science ®Google Scholar
• Popoola, T. D., Guetchueng, S. T., Ritchie, K. J., Awodele, O., Dempster, N. M., Akinloye, O., Sarker, S. D., & Fatokun, A. A. (2021). Potent Nrf2-inducing, antioxidant, and anti-inflammatory effects and identification of constituents validate the anti-cancer use of Uvaria chamae and Olax subscorpioidea. BMC Complementary Medicines and Therapies, 21, 234. https://doi.org/10.1186/s12906-021-03404-0
   PubMedGoogle Scholar
• Reher, R., Kim, H. W., Zhang, C., Mao, H. H., Wang, M., Nothias, L.-F., Caraballo-Rodriguez, A. M., Glukhov, E., Teke, B., Leao, T., Alexander, K. L., Duggan, B. M., Van Everbroeck, E. L., Dorrestein, P. C., Cottrell, G. W., & Gerwick, W. H. (2020). A convolutional neural network-based approach for the rapid annotation of molecularly diverse natural products. Journal of the American Chemical Society, 142(9), 4114–4120. https://doi.org/10.1021/jacs.9b13786
   PubMed Web of Science ®Google Scholar
• Rodríguez-García, C., Sánchez-Quesada, C., & Gaforio, J. J. (2019). Dietary flavonoids as cancer chemopreventive agents: An updated review of human studies. Antioxidants, 8(5), 137. https://doi.org/10.3390/antiox8050137
   Web of Science ®Google Scholar
• Safe, S. H., Prather, P. L., Brents, L. K., Chadalapaka, G., & Jutooru, I. (2012). Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry, 12(10), 1211–1220. https://doi.org/10.2174/187152012803833099
   PubMed Web of Science ®Google Scholar
• Salvador, J. A. R., Leal, A. S. M., & Santos, R. C. (2010). Pentacyclic Triterpenes as Promising Agents in Cancer. Nova Science Publishers, Inc.
   Google Scholar
• Seelig, A. (2020). P-Glycoprotein: One mechanism, many tasks and the consequences for pharmacotherapy of cancers. Frontiers in Oncology, 10, 576559. https://doi.org/10.3389/fonc.2020.576559
   PubMed Web of Science ®Google Scholar
• Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003). Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Research, 13(11), 2498–2504. https://doi.org/10.1101/gr.1239303
   PubMed Web of Science ®Google Scholar
• Sigismund, S., Avanzato, D., & Lanzetti, L. (2018). Emerging functions of the EGFR in cancer. Molecular Oncology, 12(1), 3–20. https://doi.org/10.1002/1878-0261.12155
   PubMed Web of Science ®Google Scholar
• Singh, V. K., Chang, H.-H., Kuo, C.-C., Shiao, H.-Y., Hsieh, H.-P., & Coumar, M. S. (2017). Drug repurposing for chronic myeloid leukemia: In silico and in vitro investigation of DrugBank database for allosteric Bcr-Abl inhibitors. Journal of Biomolecular Structure and Dynamics, 35(8), 1833–1848. https://doi.org/10.1080/07391102.2016.1196462
   PubMed Web of Science ®Google Scholar
• Soverini, S., Hochhaus, A., Nicolini, F. E., Gruber, F., Lange, T., Saglio, G., Pane, F., Müller, M. C., Ernst, T., Rosti, G., Porkka, K., Baccarani, M., Cross, N. C. P., & Martinelli, G. (2011). BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Recommendations from an expert panel on behalf of European LeukemiaNet. Blood, 118(5), 1208–1215. https://doi.org/10.1182/blood-2010-12-326405
   PubMed Web of Science ®Google Scholar
• Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
   PubMed Web of Science ®Google Scholar
• Tamiru, F., Adane, L., & Bekele, B. (2018). Phytochemical screening of root extract of Momordica boivinii and isolation of two steroids. Research Journal of Phytochemistry, 12, 21–34. https://doi.org/10.17311/rjphyto.2018.21.34
   Google Scholar
• Tian, X., Guo, S., He, K., Roller, M., Yang, M., Liu, Q., Zhang, L., Ho, C.-T., & Bai, N. (2018). Qualitative and quantitative analysis of chemical constituents of Ptychopetalum olacoides Benth. Natural Product Research, 32(3), 354–357. https://doi.org/10.1080/14786419.2017.1354187
   PubMed Web of Science ®Google Scholar
• Trott, O., & Olson, A. J. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31(2), 455–461. https://doi.org/10.1002/jcc.21334
   PubMed Web of Science ®Google Scholar
• Veber, D. F., Johnson, S. R., Cheng, H.-Y., Smith, B. R., Ward, K. W., & Kopple, K. D. (2002). Molecular properties that influence the oral bioavailability of drug candidates. Journal of Medicinal Chemistry, 45(12), 2615–2623. https://doi.org/10.1021/jm020017n
   PubMed Web of Science ®Google Scholar
• Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A. V., Meehan, M. J., Liu, W.-T., Crüsemann, M., Boudreau, P. D., Esquenazi, E., Sandoval-Calderón, M., … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with global natural products social molecular networking. Nature Biotechnology, 34(8), 828–837. https://doi.org/10.1038/nbt.3597
   PubMed Web of Science ®Google Scholar
• Westerweel, E. P., Te Boekhorst, P. A. W., Levin, M., & Cornelissen, J. J. (2019). New approaches and treatment combinations for the management of chronic myeloid leukemia. Frontiers in Oncology, 9, 665. https://doi.org/10.3389/fonc.2019.00665
   PubMed Web of Science ®Google Scholar
• Wild, C. P., Weiderpass, E., & Stewart, B. W. (2020). World Cancer Report: Cancer Research for Cancer Prevention. International Agency for Research on Cancer.
   Google Scholar
• Wirasathien, L., Pengsuparp, T., Moriyasu, M., Kawanishi, K., & Suttisri, R. (2006). Cytotoxic C-Benzylated Chalcone and Other Constituents of Ellipeiopsis cherrevensis Arch. Archives of Pharmacal Research, 29(6), 497–502. https://doi.org/10.1007/BF02969423
   PubMed Web of Science ®Google Scholar
• Wongboonma, W., Thongnoppakhun, W., & Auewarakul, C. U. (2011). A singletube allele specific-polymerase chain reaction to detect T315I resistant mutation in chronic myeloid leukemia patients. Journal of Hematology & Oncology, 4, 7. https://doi.org/10.1186/1756-8722-4-7
   PubMed Web of Science ®Google Scholar
• Yun, C.-H., Boggon, T. J., Li, Y., Woo, M. S., Greulich, H., Meyerson, M., & Eck, M. J. (2007). Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell, 11(3), 217–227. https://doi.org/10.1016/j.ccr.2006.12.017
   PubMed Web of Science ®Google Scholar