SPP1, a potential therapeutic target and biomarker for lung cancer: functional insights through computational studies

References

• Ahmad, S., Pasha Km, M., Raza, K., Rafeeq, M. M., Habib, A. H., Eswaran, M., & Yadav, M. K. (2022). Reporting dinaciclib and theodrenaline as a multitargeted inhibitor against SARS-CoV-2: an in-silico study. Journal of Biomolecular Structure and Dynamics, 0, 1–11. https://doi.org/10.1080/07391102.2022.2060308
   PubMedGoogle Scholar
• Chang, A. Y., Devore, R., Gu, C., et al. (1997). In vitro and clinical studies: Paclitaxel and vinorelbine in non-small-cell lung cancer. Oncology, 11, 31–34.
   Google Scholar
• Chen, Y. T., Xie, J. Y., Sun, Q., & Mo, W. J. (2019). Novel drug candidates for treating esophageal carcinoma: A study on differentially expressed genes, using connectivity mapping and molecular docking. International Journal of Oncology, 54(1), 152–166. https://doi.org/10.3892/ijo.2018.4618
   PubMed Web of Science ®Google Scholar
• Cheung, C. H. Y., & Juan, H.-F. (2017). Quantitative proteomics in lung cancer. Journal of Biomedical Science, 24(1), 37. https://doi.org/10.1186/s12929-017-0343-y
   PubMedGoogle Scholar
• Clough, E., & Barrett, T. (2016). The gene expression omnibus database. Methods in Molecular Biology (Clifton, N.J.), 1418, 93–110. https://doi.org/10.1007/978-1-4939-3578-9_5
   PubMedGoogle Scholar
• Cragg, G. M., & Newman, D. J. (2013). Natural products: A continuing source of novel drug leads. Biochimica et Biophysica Acta, 1830(6), 3670–3695. https://doi.org/10.1016/j.bbagen.2013.02.008
   PubMed Web of Science ®Google Scholar
• Das, S. K., Mahanta, S., Tanti, B., Tag, H., & Hui, P. K. (2022). Identification of phytocompounds from Houttuynia cordata Thunb. as potential inhibitors for SARS-CoV-2 replication proteins through GC-MS/LC-MS characterization, molecular docking and molecular dynamics simulation. Molecular Diversity, 26(1), 365–388. https://doi.org/10.1007/s11030-021-10226-2
   PubMed Web of Science ®Google Scholar
• Desai, A. G., Qazi, G. N., Ganju, R. K., El-Tamer, M., Singh, J., Saxena, A. K., Bedi, Y. S., Taneja, S. C., & Bhat, H. K. (2008). Medicinal plants and cancer chemoprevention. Current Drug Metabolism, 9(7), 581–591. https://doi.org/10.2174/138920008785821657
   PubMed Web of Science ®Google Scholar
• Dhar, M. L., Dhar, M. M., Dhawan, B. N., et al. (1968). Screening of Indian plants for biological activity: I. Indian Journal of Experimental Biology, 6, 232–247.
   PubMed Web of Science ®Google Scholar
• Ding, F., Luo, X., Tu, Y., Duan, X., Liu, J., Jia, L., & Zheng, P. (2021). Alpk1 sensitizes pancreatic beta cells to cytokine-induced apoptosis via upregulating TNF-α signaling pathway. Frontiers in Immunology, 12, 705751. https://doi.org/10.3389/fimmu.2021.705751
   PubMed Web of Science ®Google Scholar
• Dutta, S., Kharkar, P. S., Sahu, N. U., & Khanna, A. (2017). Molecular docking prediction and in vitro studies elucidate anti-cancer activity of phytoestrogens. Life Sciences, 185, 73–84. https://doi.org/10.1016/j.lfs.2017.07.015
   PubMed Web of Science ®Google Scholar
• Emig, D., Ivliev, A., Pustovalova, O., Lancashire, L., Bureeva, S., Nikolsky, Y., & Bessarabova, M. (2013). Drug target prediction and repositioning using an integrated network-based approach. PLoS One, 8(4), e60618. https://doi.org/10.1371/journal.pone.0060618
   PubMed Web of Science ®Google Scholar
• Fang, W.-Y., Dahiya, R., Qin, H.-L., Mourya, R., & Maharaj, S. (2016). Natural proline-rich cyclopolypeptides from marine organisms: Chemistry, synthetic methodologies and biological status. Marine Drugs, 14(11), 194. https://doi.org/10.3390/md14110194
   PubMed Web of Science ®Google Scholar
• Ford, J. D., Huang, K. S., Wang, H. B., Davin, L. B., & Lewis, N. G. (2001). Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucoside - Hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed. Journal of Natural Products, 64(11), 1388–1397. https://doi.org/10.1021/np010367x
   PubMed Web of Science ®Google Scholar
• Frezzetti, D., Gallo, M., Maiello, M. R., D'Alessio, A., Esposito, C., Chicchinelli, N., Normanno, N., & De Luca, A. (2017). VEGF as a potential target in lung cancer. Expert Opinion on Therapeutic Targets, 21(10), 959–966. https://doi.org/10.1080/14728222.2017.1371137
   PubMed Web of Science ®Google Scholar
• Fujii, T., Hirakata, T., Kurozumi, S., Tokuda, S., Nakazawa, Y., Obayashi, S., Yajima, R., Oyama, T., & Shirabe, K. (2020). VEGF-A is associated with the degree of TILs and PD-L1 expression in primary breast cancer. In Vivo (Athens, Greece), 34(5), 2641–2646. https://doi.org/10.21873/invivo.12082
   PubMed Web of Science ®Google Scholar
• Furukawa, C., Daigo, Y., Ishikawa, N., Kato, T., Ito, T., Tsuchiya, E., Sone, S., & Nakamura, Y. (2005). Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. Cancer Research, 65(16), 7102–7110. https://doi.org/10.1158/0008-5472.CAN-04-1877
   PubMed Web of Science ®Google Scholar
• Germanos, M., Gao, A., Taper, M., Yau, B., & Kebede, M. A. (2021). Inside the insulin secretory granule. Metabolites, 11(8), 515. https://doi.org/10.3390/metabo11080515
   PubMed Web of Science ®Google Scholar
• Ghosh, C., Luong, G., & Sun, Y. (2021). A snapshot of the PD-1/PD-L1 pathway. Journal of Cancer, 12(9), 2735–2746. https://doi.org/10.7150/JCA.57334
   PubMed Web of Science ®Google Scholar
• Göthlin Eremo, A., Lagergren, K., Othman, L., Montgomery, S., Andersson, G., & Tina, E. (2020). Evaluation of SPP1/osteopontin expression as predictor of recurrence in tamoxifen treated breast cancer. Scientific Reports, 10(1), 1451. https://doi.org/10.1038/s41598-020-58323-w
   PubMed Web of Science ®Google Scholar
• Gracia-Cazaña, T., Padgett, E., Calderero, V., & Oncins, R. (2021). Nivolumab-associated Stevens-Johnson syndrome in a patient with lung cancer. Dermatology Online Journal, 27(3), 13030/qt2897t6dq.
   Google Scholar
• Guan, L., Yang, H., Cai, Y., Sun, L., Di, P., Li, W., Liu, G., & Tang, Y. (2019). ADMET-score—A comprehensive scoring function for evaluation of chemical drug-likeness. Medchemcomm, 10(1), 148–157. https://doi.org/10.1039/c8md00472b
   PubMed Web of Science ®Google Scholar
• Haratani, K., Hayashi, H., Chiba, Y., Kudo, K., Yonesaka, K., Kato, R., Kaneda, H., Hasegawa, Y., Tanaka, K., Takeda, M., & Nakagawa, K. (2018). Association of immune-related adverse events with nivolumab efficacy in non-small-cell lung cancer. JAMA Oncology, 4(3), 374–378. https://doi.org/10.1001/jamaoncol.2017.2925
   PubMed Web of Science ®Google Scholar
• Hsu, P.-C., Jablons, D. M., Yang, C.-T., & You, L. (2019). Epidermal growth factor receptor (EGFR) pathway, yes-associated protein (YAP) and the regulation of programmed death-ligand 1 (PD-L1) in non-small cell lung cancer (NSCLC). International Journal of Molecular Sciences, 20(15), 3821. https://doi.org/10.3390/ijms20153821
   PubMed Web of Science ®Google Scholar
• Jiang, Y., Zhang, Z., Wang, X., Feng, Z., Hong, B., Yu, D., & Wang, Y. (2022). A novel prognostic factor TIPE2 in bladder cancer. Pathology Oncology Research, 28, 1610282. https://doi.org/10.3389/pore.2022.1610282
   PubMed Web of Science ®Google Scholar
• Kenfield, S. A., Wei, E. K., Stampfer, M. J., Rosner, B. A., & Colditz, G. A. (2008). Comparison of aspects of smoking among the four histological types of lung cancer. Tobacco Control, 17(3), 198–204. https://doi.org/10.1136/tc.2007.022582
   PubMed Web of Science ®Google Scholar
• Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., Celis, E., Abrams, S. I., Ozato, K., & Liu, K. (2018). An osteopontin/CD44 immune checkpoint controls CD8 + T cell activation and tumor immune evasion. The Journal of Clinical Investigation, 128(12), 5549–5560. https://doi.org/10.1172/JCI123360
   PubMed Web of Science ®Google Scholar
• Kudoh, S. (2009). Chemotherapy for lung cancer. Respiration and Circulation, 57, 587–595.
   Google Scholar
• Li, H., Li, M., Guo, H., Lin, G., Huang, Q., & Qiu, M. (2022). Integrative analyses of circulating mRNA and lncRNA expression profile in plasma of lung cancer patients. Frontiers in Oncology, 12, 843054. https://doi.org/10.3389/fonc.2022.843054
   PubMedGoogle Scholar
• Li, L., Ameri, A. H., Wang, S., Jansson, K. H., Casey, O. M., Yang, Q., Beshiri, M. L., Fang, L., Lake, R. G., Agarwal, S., Alilin, A. N., Xu, W., Yin, J., & Kelly, K. (2019). EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis. Oncogene, 38(35), 6241–6255. https://doi.org/10.1038/s41388-019-0873-8
   PubMed Web of Science ®Google Scholar
• Li, X., Zhang, Q., Chen, G., & Luo, D. (2021). Multi-omics analysis showed the clinical value of gene signatures of C1QC(+) and SPP1(+) TAMs in cervical cancer. Frontiers in Immunology, 12, 694801. https://doi.org/10.3389/fimmu.2021.694801
   PubMed Web of Science ®Google Scholar
• Liang, L., Lu, G., Pan, G., Deng, Y., Liang, J., Liang, L., Liu, J., Tang, Y., & Wei, G. (2019). A case-control study of the association between the SPP1 gene SNPs and the susceptibility to breast cancer in Guangxi, China. Frontiers in Oncology, 9, 1415. https://doi.org/10.3389/fonc.2019.01415
   PubMed Web of Science ®Google Scholar
• Liu, Y., Tu, M., & Wang, L. (2022). Pan-cancer analysis predicts FOXS1 as a key target in prognosis and tumor immunotherapy. International Journal of General Medicine, 15, 2171–2185. https://doi.org/10.2147/IJGM.S354195
   PubMed Web of Science ®Google Scholar
• Ma, Y., Ren, Y., Dai, Z.-J., Wu, C.-J., Ji, Y.-H., & Xu, J. (2017). IL-6, IL-8 and TNF-α levels correlate with disease stage in breast cancer patients. Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University, 26(3), 421–426. https://doi.org/10.17219/acem/62120
   PubMed Web of Science ®Google Scholar
• Maia, E. H. B., Assis, L. C., de Oliveira, T. A., da Silva, A. M., & Taranto, A. G. (2020). Structure-based virtual screening: From classical to artificial intelligence. Frontiers in Chemistry, 8, 343. https://doi.org/10.3389/fchem.2020.00343
   PubMed Web of Science ®Google Scholar
• Neidle, S. (2012). Design principles for quadruplex-binding small molecules. pp 151–174.
   Google Scholar
• Niu, Z., Zhang, W., Shi, J., Li, X., & Wu, H. (2021). Effect of silencing C-erbB-2 on esophageal carcinoma cell biological behaviors by inhibiting IGF-1 pathway activation. Journal of Cardiothoracic Surgery, 16(1), 1–16. https://doi.org/10.1186/s13019-021-01540-9
   PubMed Web of Science ®Google Scholar
• Ohe, Y., Ohashi, Y., Kubota, K., Tamura, T., Nakagawa, K., Negoro, S., Nishiwaki, Y., Saijo, N., Ariyoshi, Y., & Fukuoka, M. (2007). Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan. Annals of Oncology: Official Journal of the European Society for Medical Oncology, 18(2), 317–323. https://doi.org/10.1093/annonc/mdl377
   PubMed Web of Science ®Google Scholar
• Okda, T. M., Atwa, G. M. K., Eldehn, A. F., Dahran, N., Alsharif, K. F., & Elmahallawy, E. K. (2022). A novel role of galectin-3 and thyroglobulin in prognosis and differentiation of different stages of thyroid cancer and elucidation of the potential contribution of Bcl-2, IL-8 and TNF-α. Biomedicines, 10(2), 352. https://doi.org/10.3390/biomedicines10020352
   PubMed Web of Science ®Google Scholar
• Osman, M. S., Baleanu, D., Tariq, K. U.-H., Kaplan, M., Younis, M., & Rizvi, S. T. R. (2020). Different types of progressive wave solutions via the 2D-chiral nonlinear Schrödinger equation. Frontiers in Physics, 8:215. https://doi.org/10.3389/fphy.2020.00215
   Web of Science ®Google Scholar
• Pattar, S. V., Adhoni, S. A., Kamanavalli, C. M., & Kumbar, S. S. (2020). In silico molecular docking studies and MM/GBSA analysis of coumarin-carbonodithioate hybrid derivatives divulge the anticancer potential against breast cancer. Beni-Suef University Journal of Basic and Applied Sciences, 9(36). https://doi.org/10.1186/s43088-020-00059-7
   Google Scholar
• Porta, C., Paglino, C., & Mosca, A. (2014). Targeting PI3K/Akt/mTOR signaling in cancer. Frontiers in Oncology, 4, 64. https://doi.org/10.3389/fonc.2014.00064
   PubMedGoogle Scholar
• Qu, M., Han, T., Chen, X., Sun, Q., Li, Q., & Zhao, M. (2022). Exploring potential targets of Actinidia Chinensis Planch root against hepatocellular carcinoma based on network pharmacology and molecular docking and development and verification of immune-associated prognosis features for hepatocellular carcinoma. Journal of Gastrointestinal Oncology, 13(3), 1289–1307. https://doi.org/10.21037/jgo-22-398
   PubMed Web of Science ®Google Scholar
• Raudvere, U., Kolberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H., & Vilo, J. (2019). g:Profiler: A web server for functional enrichment analysis and conversions of gene lists (2019 update). Nucleic Acids Research, 47(W1), W191–W198. https://doi.org/10.1093/nar/gkz369
   PubMed Web of Science ®Google Scholar
• Ray, I., Meira, L. B., Michael, A., & Ellis, P. E. (2022). Adipocytokines and disease progression in endometrial cancer: A systematic review. Cancer Metastasis Reviews, 41(1), 211–242. https://doi.org/10.1007/s10555-021-10002-6
   PubMed Web of Science ®Google Scholar
• Rodriguez Lanzi, C., Wei, R., Luo, D., & Mackenzie, G. G. (2022). Phospho-aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan. Neoplasia (New York, N.Y.), 24(2), 133–144. https://doi.org/10.1016/j.neo.2021.12.004
   PubMed Web of Science ®Google Scholar
• Shree, P., Mishra, P., Selvaraj, C., Singh, S. K., Chaube, R., Garg, N., & Tripathi, Y. B. (2022). Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants—Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)—A molecular docking study. Journal of Biomolecular Structure & Dynamics, 40(1), 190–203. https://doi.org/10.1080/07391102.2020.1810778
   PubMed Web of Science ®Google Scholar
• Siegel, R. L., Miller, K. D., Fuchs, H. E., & Jemal, A. (2022). Cancer statistics, 2022. CA: A Cancer Journal for Clinicians, 72(1), 7–33. https://doi.org/10.3322/caac.21708
   PubMed Web of Science ®Google Scholar
• Sigismund, S., Avanzato, D., & Lanzetti, L. (2018). Emerging functions of the EGFR in cancer. Molecular Oncology, 12(1), 3–20. https://doi.org/10.1002/1878-0261.12155
   PubMed Web of Science ®Google Scholar
• Silva, A. P. S., Coelho, P. V., Anazetti, M., & Simioni, P. U. (2017). Targeted therapies for the treatment of non-small-cell lung cancer: Monoclonal antibodies and biological inhibitors. Human Vaccines & Immunotherapeutics, 13(4), 843–853. https://doi.org/10.1080/21645515.2016.1249551
   PubMed Web of Science ®Google Scholar
• Sundar, S., Thangamani, L., Piramanayagam, S., Rahul, C. N., Aiswarya, N., Sekar, K., & Natarajan, J. (2021). Screening of FDA-approved compound library identifies potential small-molecule inhibitors of SARS-CoV-2 non-structural proteins NSP1, NSP4, NSP6 and NSP13: Molecular modeling and molecular dynamics studies. Journal of Proteins and Proteomics, 12(3), 161–175. https://doi.org/10.1007/s42485-021-00067-w
   PubMedGoogle Scholar
• Taghizadeh, M. S., Niazi, A., Moghadam, A., & Afsharifar, A. (2022). Experimental, molecular docking and molecular dynamic studies of natural products targeting overexpressed receptors in breast cancer. PLoS One, 17(5), e0267961. https://doi.org/10.1371/journal.pone.0267961
   PubMed Web of Science ®Google Scholar
• Tan, X., Fu, J., Yuan, Z., Zhu, L., & Fu, L. (2021). ACNPD: The database for elucidating the relationships between natural products, compounds, molecular mechanisms, and cancer Types. Frontiers in Pharmacology, 12, 746067. https://doi.org/10.3389/fphar.2021.746067
   PubMed Web of Science ®Google Scholar
• Tang, H., Chen, J., Han, X., Feng, Y., & Wang, F. (2021). Upregulation of SPP1 is a marker for poor lung cancer prognosis and contributes to cancer progression and cisplatin resistance. Frontiers in Cell and Developmental Biology, 9, 646390. https://doi.org/10.3389/fcell.2021.646390
   PubMed Web of Science ®Google Scholar
• van de Waterbeemd, H., & Gifford, E. (2003). ADMET in silico modelling: Towards prediction paradise? Nature Reviews. Drug Discovery, 2(3), 192–204. https://doi.org/10.1038/nrd1032
   PubMed Web of Science ®Google Scholar
• Verma, S. K., Huang, P., Yi, Y., et al. (2019). Role of radiology in diagnosis of lung adenocarciconoma: A review article. International Journal of Science Inventions Today, 8, 24–28.
   Google Scholar
• Vijayakumar, B., Parasuraman, S., Raveendran, R., & Velmurugan, D. (2014). Identification of natural inhibitors against angiotensin I converting enzyme for cardiac safety using induced fit docking and MM-GBSA studies. Pharmacognosy Magazine, 10(Suppl 3), S639–S44. https://doi.org/10.4103/0973-1296.139809
   PubMedGoogle Scholar
• Wang, Y., Hu, S., Bai, X., Zhang, K., Yu, R., Xia, X., & Zheng, X. (2021). Identification of significant genes in lung cancer of nonsmoking women via bioinformatics analysis. BioMed Research International, 2021, 5516218. https://doi.org/10.1155/2021/5516218
   PubMed Web of Science ®Google Scholar
• Wang, Z., Qi, F., Cui, Y., Zhao, L., Sun, X., Tang, W., & Cai, P. (2018). An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics. Bioscience Trends, 12(3), 220–239. https://doi.org/10.5582/bst.2018.01144
   PubMed Web of Science ®Google Scholar
• Wei, T., Bi, G., Bian, Y., Ruan, S., Yuan, G., Xie, H., Zhao, M., Shen, R., Zhu, Y., Wang, Q., Yang, Y., & Zhu, D. (2020). The significance of secreted phosphoprotein 1 in multiple human cancers. Frontiers in Molecular Biosciences, 7, 565383. https://doi.org/10.3389/fmolb.2020.565383
   PubMed Web of Science ®Google Scholar
• Wu, A. T. H., Lawal, B., Tzeng, Y.-M., Shih, C.-C., & Shih, C.-M. (2022). Identification of a novel theranostic signature of metabolic and immune-inflammatory dysregulation in myocardial infarction, and the potential therapeutic properties of ovatodiolide, a diterpenoid derivative. International Journal of Molecular Sciences, 23(3), 1281. https://doi.org/10.3390/ijms23031281
   PubMed Web of Science ®Google Scholar
• Xu, C., Sun, L., Jiang, C., Zhou, H., Gu, L., Liu, Y., & Xu, Q. (2017). SPP1, analyzed by bioinformatics methods, promotes the metastasis in colorectal cancer by activating EMT pathway. Biomedicine & Pharmacotherapy—Biomedecine & Pharmacotherapie, 91, 1167–1177. https://doi.org/10.1016/j.biopha.2017.05.056
   PubMed Web of Science ®Google Scholar
• Xu, L., Chen, Y., Li, Q., He, T., & Chen, X. (2020). Molecular cloning. Fish & Shellfish Immunology, 98, 981–987. https://doi.org/10.1016/j.fsi.2019.10.064
   PubMed Web of Science ®Google Scholar
• Ying, H.-Z., Yu, C.-H., Chen, H.-K., Zhang, H.-H., Fang, J., Wu, F., & Yu, W.-Y. (2020). Quinonoids: Therapeutic potential for lung cancer treatment. BioMed Research International, 2020, 2460565. https://doi.org/10.1155/2020/2460565
   PubMed Web of Science ®Google Scholar
• Zappa, C., & Mousa, S. A. (2016). Non-small cell lung cancer: Current treatment and future advances. Translational Lung Cancer Research, 5(3), 288–300. https://doi.org/10.21037/tlcr.2016.06.07
   PubMed Web of Science ®Google Scholar
• Zheng, Q., Min, S., & Zhou, Q. (2021). Identification of potential diagnostic and prognostic biomarkers for LUAD based on TCGA and GEO databases. Bioscience Reports, 41(6), 1–24. https://doi.org/10.1042/BSR20204370
   Google Scholar