69
Views
1
CrossRef citations to date
0
Altmetric
Research Article

Analysis of the binding mechanism for a water-soluble Pd(II) complex containing β-amino alcohols with HSA applying experimental and computational methods

ORCID Icon, , &
Pages 3790-3801 | Received 07 Sep 2022, Accepted 12 May 2023, Published online: 27 May 2023

References

  • Abedanzadeh, S., Karami, K., Rahimi, M., Edalati, M., Abedanzadeh, M., Tamaddon, A. M., Jahromi, M. D., Amirghofran, Z., Lipkowski, J., & Lyczko, K. (2020). Potent cyclometallated Pd (II) antitumor complexes bearing α-amino acids: Synthesis, structural characterization, DNA/BSA binding, cytotoxicity and molecular dynamics simulation. Dalton Transactions (Cambridge, England : 2003), 49(42), 14891–14907. https://doi.org/10.1039/d0dt02304c
  • Alam, M. M., Abul Qais, F., Ahmad, I., Alam, P., Hasan Khan, R., & Naseem, I. (2018). Multi-spectroscopic and molecular modelling approach to investigate the interaction of riboflavin with human serum albumin. Journal of Biomolecular Structure & Dynamics, 36(3), 795–809. https://doi.org/10.1080/07391102.2017.1298470
  • Alam, M. N., & Huq, F. (2016). Comprehensive review on tumour active palladium compounds and structure–activity relationships. Coordination Chemistry Reviews, 316, 36–67. https://doi.org/10.1016/j.ccr.2016.02.001
  • Alinaghi, M., Karami, K., Shahpiri, A., Nasab, A. K., Momtazi-Borojeni, A. A., Abdollahi, E., & Lipkowski, J. (2020). A Pd (II) complex derived from pyridine-2-carbaldehyde oxime ligand: Synthesis, characterization, DNA and BSA interaction studies and in vitro anticancer activity. Journal of Molecular Structure, 1219, 128479. https://doi.org/10.1016/j.molstruc.2020.128479
  • Almutairi, F. M., Ajmal, M. R., Siddiqi, M. K., Amir, M., & Khan, R. H. (2020). Multi-spectroscopic and molecular docking technique study of the azelastine interaction with human serum albumin. Journal of Molecular Structure, 1201, 127147. https://doi.org/10.1016/j.molstruc.2019.127147
  • Anwer, R., AlQumaizi, K. I., Haque, S., Somvanshi, P., Ahmad, N., AlOsaimi, S. M., & Fatma, T. (2021). Unravelling the interaction of glipizide with human serum albumin using various spectroscopic techniques and molecular dynamics studies. Journal of Biomolecular Structure & Dynamics, 39(1), 336–347. https://doi.org/10.1080/07391102.2019.1711195
  • Aseman, M. D., Aryamanesh, S., Shojaeifard, Z., Hemmateenejad, B., & Nabavizadeh, S. M. (2019). Cycloplatinated (II) derivatives of mercaptopurine capable of binding Interactions with HSA/DNA. Inorganic Chemistry, 58(23), 16154–16170. https://doi.org/10.1021/acs.inorgchem.9b02696
  • Berman, H. M., Westbrook, J., Feng, Z., Gilliland, G., Bhat, T. N., Weissig, H., Shindyalov, I. N., & Bourne, P. E. (2000). The protein data bank. Nucleic Acids Research, 28(1), 235–242. https://doi.org/10.1093/nar/28.1.235
  • Biovia, D. S. (2020). BIOVIA workbook, release 2017; BIOVIA pipeline pilot, release 2017. Dassault Systèmes.
  • Carreira, M., Calvo-Sanjuán, R., Sanaú, M., Zhao, X., Magliozzo, R. S., Marzo, I., & Contel, M. (2012). Cytotoxic hydrophilic iminophosphorane coordination compounds of d8 metals. Studies of their interactions with DNA and HSA. Journal of Inorganic Biochemistry, 116, 204–214. https://doi.org/10.1016/j.jinorgbio.2012.06.017
  • Duhovny, D., Nussinov, R., & Wolfson, H. J. (2002). Efficient unbound docking of rigid molecules. International workshop on algorithms in bioinformatics (pp. 185–200). Springer.
  • Dustkami, M., Mansouri-Torshizi, H., Abdi, K., Dehghanian, E., Saeidifar, M., & Mohammadi, F. (2022). A couple of antitumor Pd(II) complexes make DNA-refolding and HSA-unfolding: Experimental and docking studies. Journal of Molecular Liquids, 349, 118450. https://doi.org/10.1016/j.molliq.2021.118450
  • Eswaran, R., Bertani, R., Sgarbossa, P., Karuppannan, N., & Nattamai S P, B. (2016). Synthesis, crystal structure, DNA and protein binding studies of novel binuclear Pd (II) complex of 6-methoxy-2-oxo-1, 2-dihydroquinoline-3-carbaldehyde-4 (N, N)-dimethylthiosemicarbazone. Journal of Inorganic Biochemistry, 155, 1–8. https://doi.org/10.1016/j.jinorgbio.2015.11.007
  • Fanelli, M., Formica, M., Fusi, V., Giorgi, L., Micheloni, M., & Paoli, P. (2016). New trends in platinum and palladium complexes as antineoplastic agents. Coordination Chemistry Reviews, 310, 41–79. https://doi.org/10.1016/j.ccr.2015.11.004
  • Feizi-Dehnayebi, M., Dehghanian, E., & Mansouri-Torshizi, H. (2021). A novel palladium (II) antitumor agent: Synthesis, characterization, DFT perspective, CT-DNA and BSA interaction studies via in-vitro and in-silico approaches. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 249, 119215. https://doi.org/10.1016/j.saa.2020.119215
  • Feizi-Dehnayebi, M., Dehghanian, E., & Mansouri-Torshizi, H. (2022). Probing the biomolecular (DNA/BSA) interaction by new Pd (II) complex via in-depth experimental and computational perspectives: Synthesis, characterization, cytotoxicity, and DFT approach. Journal of the Iranian Chemical Society, 19(7), 3155–3175. https://doi.org/10.1007/s13738-022-02519-6
  • Fu, X.-B., Lin, Z.-H., Liu, H.-F., & Le, X.-Y. (2014). A new ternary copper (II) complex derived from 2-(2′-pyridyl) benzimidazole and glycylglycine: Synthesis, characterization, DNA binding and cleavage, antioxidation and HSA interaction. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 122, 22–33. https://doi.org/10.1016/j.saa.2013.11.006
  • Hakimi, M., Mardani, Z., Moeini, K., Mohr, F., & Fernandes, M. A. (2014). Palladium, cadmium and mercury complexes of 2-((2-((2-hydroxyethyl) amino) ethyl) amino) cyclohexanol: Synthesis, structural, spectral and solution studies. Polyhedron, 67, 27–35. https://doi.org/10.1016/j.poly.2013.08.065
  • Hashempour, S., Shahabadi, N., Adewoye, A., Murphy, B., Rouse, C., Salvatore, B. A., Stratton, C., & Mahdavian, E. (2020). Binding studies of AICAR and human serum albumin by spectroscopic, theoretical, and computational methodologies. Molecules, 25(22), 5410. https://doi.org/10.3390/molecules25225410
  • Jiang, S., Ni, H., Liu, F., Gu, S., Yu, P., & Gou, Y. (2020). Binuclear Schiff base copper (II) complexes: Syntheses, crystal structures, HSA interaction and anti-cancer properties. Inorganica Chimica Acta, 499, 119186. https://doi.org/10.1016/j.ica.2019.119186
  • Jovanović, S., Obrenčević, K., Bugarčić, Ž. D., Popović, I., Žakula, J., & Petrović, B. (2016). New bimetallic palladium (II) and platinum (II) complexes: Studies of the nucleophilic substitution reactions, interactions with CT-DNA, bovine serum albumin and cytotoxic activity. Dalton Transactions (Cambridge, England : 2003), 45(31), 12444–12457. https://doi.org/10.1039/c6dt02226j
  • Karami, K., Alinaghi, M., Amirghofran, Z., & Lipkowski, J. (2018). Synthesis and characterization of two new trans palladium (II) complexes containing benzylamine ligand: DNA/BSA interactions, molecular docking and in vitro cytotoxic activity. Inorganica Chimica Acta, 471, 797–807. https://doi.org/10.1016/j.ica.2017.02.027
  • Karami, K., Rafiee, M., Lighvan, Z. M., Zakariazadeh, M., Faal, A. Y., Esmaeili, S.-A., & Momtazi-Borojeni, A. A. (2018). Synthesis, spectroscopic characterization and in vitro cytotoxicities of new organometallic palladium complexes with biologically active β-diketones; Biological evaluation probing of the interaction mechanism with DNA/Protein and molecular docking. Journal of Molecular Structure, 1154, 480–495. https://doi.org/10.1016/j.molstruc.2017.10.059
  • Kashanian, S., Heidary Zeidali, S., Omidfar, K., & Shahabadi, N. (2012). Multi-spectroscopic DNA interaction studies of sunset yellow food additive. Molecular Biology Reports, 39(12), 10045–10051. https://doi.org/10.1007/s11033-012-1873-8
  • Kashanian, S., Shariati, Z., Roshanfekr, H., & Ghobadi, S. (2012). DNA binding studies of 3, 5, 6-trichloro-2-pyridinol pesticide metabolite. DNA and Cell Biology, 31(7), 1341–1348. https://doi.org/10.1089/dna.2012.1662
  • Kooravand, M., Asadpour, S., Haddadi, H., & Farhadian, S. (2021). An insight into the interaction between malachite green oxalate with human serum albumin: Molecular dynamic simulation and spectroscopic approaches. Journal of Hazardous Materials, 407, 124878. https://doi.org/10.1016/j.jhazmat.2020.124878
  • Lazarević, T., Rilak, A., & Bugarčić, Ž. D. (2017). Platinum, palladium, gold and ruthenium complexes as anticancer agents: Current clinical uses, cytotoxicity studies and future perspectives. European Journal of Medicinal Chemistry, 142, 8–31. https://doi.org/10.1016/j.ejmech.2017.04.007
  • Liu, B., Guo, Y., Wang, J., Xu, R., Wang, X., Wang, D., Zhang, L., & Xu, Y. (2010). Spectroscopic studies on the interaction and sonodynamic damage of neutral red (NR) to bovine serum albumin (BSA). Journal of Luminescence, 130(6), 1036–1043. https://doi.org/10.1016/j.jlumin.2010.01.021
  • Liu, T., Liu, M., Guo, Q., Liu, Y., Zhao, Y., Wu, Y., Sun, B., Wang, Q., Liu, J., & Han, J. (2020). Investigation of binary and ternary systems of human serum albumin with oxyresveratrol/piceatannol and/or mitoxantrone by multipectroscopy, molecular docking and cytotoxicity evaluation. Journal of Molecular Liquids, 311, 113364. https://doi.org/10.1016/j.molliq.2020.113364
  • Manda, B., Prasad, A., Thatikonda, N., Lacerda Jr, V., Barbosa, L., Santos, H., Romão, W., Pavan, F., Ribeiro, C., dos Santos, E., Marques, M., de Lima, D., Micheletti, A., & Beatriz, A. (2017). Synthesis, antibacterial and antitubercular evaluation of cardanol and glycerol-based β-amino alcohol derivatives. Journal of the Brazilian Chemical Society, 29(3), 639–648. https://doi.org/10.21577/0103-5053.20170178
  • Mansouri-Torshizi, H., Khosravi, F., Ghahghaei, A., Shahraki, S., & Zareian-Jahromi, S. (2018). Investigation on the interaction of newly designed potential antibacterial Zn (II) complexes with CT-DNA and HSA. Journal of Biomolecular Structure & Dynamics, 36(10), 2713–2737. https://doi.org/10.1080/07391102.2017.1363086
  • Maurya, N., Maurya, J. K., Singh, U. K., Dohare, R., Zafaryab, M., Moshahid Alam Rizvi, M., Kumari, M., & Patel, R. (2019). In vitro cytotoxicity and interaction of noscapine with human serum albumin: Effect on structure and esterase activity of HSA. Molecular Pharmaceutics, 16(3), 952–966. https://doi.org/10.1021/acs.molpharmaceut.8b00864
  • Mohammadgholi, A., Leilabadi-Asl, A., Divsalar, A., & Eslami-Moghadam, M. (2021). Multi-spectroscopic studies of the interaction of new synthesized platin complex with human carrier protein of serum albumin. Journal of Biomolecular Structure & Dynamics, 39(4), 1506–1511. https://doi.org/10.1080/07391102.2020.1745690
  • Mohammadi, F., & Mansouri-Torshizi, H. (2020). Five novel palladium (II) complexes of 8-hydroxyquinoline and amino acids with hydrophobic side chains: Synthesis, characterization, cytotoxicity, DNA-and BSA-interaction studies. Journal of Biomolecular Structure & Dynamics, 38(10), 3059–3073. https://doi.org/10.1080/07391102.2019.1651219
  • Mrkalić, E., Jelić, R., Stojanović, S., & Sovrlić, M. (2021). Interaction between olanzapine and human serum albumin and effect of metal ions, caffeine and flavonoids on the binding: A spectroscopic study. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 249, 119295. https://doi.org/10.1016/j.saa.2020.119295
  • Najaran, A., Divsalar, A., Saboury, A. A., & Roodbari, N. H. (2019). Probing the interaction of newly synthesized Pt (II) complex on human serum albumin using competitive binding site markers. Journal of Fluorescence, 29(4), 827–835. https://doi.org/10.1007/s10895-019-02383-3
  • Ott, I., & Gust, R. (2007). Non platinum metal complexes as anti‐cancer drugs. Archiv Der Pharmazie, 340(3), 117–126. https://doi.org/10.1002/ardp.200600151
  • Patel, N. J., Bhatt, B. S., & Patel, M. N. (2019). Heteroleptic N, N-donor pyrazole based Pt (II) and Pd (II) complexes: DNA binding, molecular docking and cytotoxicity studies. Inorganica Chimica Acta, 498, 119130. https://doi.org/10.1016/j.ica.2019.119130
  • Pattanayak, R., Basak, P., Sen, S., & Bhattacharyya, M. (2017). An insight to the binding of ellagic acid with human serum albumin using spectroscopic and isothermal calorimetry studies. Biochemistry and Biophysics Reports, 10, 88–93. https://doi.org/10.1016/j.bbrep.2017.03.001
  • Rabbani, G., Lee, E. J., Ahmad, K., Baig, M. H., & Choi, I. (2018). Binding of tolperisone hydrochloride with human serum albumin: Effects on the conformation, thermodynamics, and activity of HSA. Molecular Pharmaceutics, 15(4), 1445–1456. https://doi.org/10.1021/acs.molpharmaceut.7b00976
  • Reddy, E. R., Trivedi, R., Sarma, A. V. S., Sridhar, B., Anantaraju, H. S., Sriram, D., Yogeeswari, P., & Nagesh, N. (2015). Sugar-boronate ester scaffold tethered pyridyl-imine palladium (II) complexes: Synthesis and their in vitro anticancer evaluation. Dalton Transactions (Cambridge, England : 2003), 44(40), 17600–17616. https://doi.org/10.1039/c5dt03266k
  • Saeidifar, M., Sabbaghzadeh, R., Torshizi, H. M., & Saboury, A. A. (2021). Binding evaluation of human serum albumin and a Pd(II) bischelate complex bearing N,O-alanine and O,O-malonate ligands: Synthesis, characterization, biological investigation and molecular docking. Journal of the Iranian Chemical Society, 18(1), 61–74. https://doi.org/10.1007/s13738-020-02005-x
  • Saswati, Mohanty, M., Banerjee, A., Biswal, S., Horn, A., Schenk, G., Brzezinski, K., Sinn, E., Reuter, H., & Dinda, R. (2020). Polynuclear zinc (II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation. Journal of Inorganic Biochemistry, 203, 110908., https://doi.org/10.1016/j.jinorgbio.2019.110908
  • Schneidman-Duhovny, D., Inbar, Y., Nussinov, R., & Wolfson, H. J. (2005). PatchDock and SymmDock: Servers for rigid and symmetric docking. Nucleic Acids Research, 33(Web Server issue), W363–W367. https://doi.org/10.1093/nar/gki481
  • Schneidman-Duhovny, D., Inbar, Y., Polak, V., Shatsky, M., Halperin, I., Benyamini, H., Barzilai, A., Dror, O., Haspel, N., Nussinov, R., & Wolfson, H. J. (2003). Taking geometry to its edge: Fast unbound rigid (and hinge‐bent) docking. Proteins, 52(1), 107–112. https://doi.org/10.1002/prot.10397
  • Shahabadi, N., & Hashempour, S. (2019). DNA binding studies of antibiotic drug cephalexin using spectroscopic and molecular docking techniques. Nucleosides, Nucleotides & Nucleic Acids, 38(6), 428–447. https://doi.org/10.1080/15257770.2018.1562071
  • Shahabadi, N., & Nemati, L. (2014). Multispectroscopic studies on the interaction of a platinum (II) complex containing l-histidine and 1, 10-phenanthroline ligands with bovine serum albumin. Applied Biochemistry and Biotechnology, 172(6), 2800–2814. https://doi.org/10.1007/s12010-013-0715-z
  • Shahabadi, N., & Razlansari, M. (2021). Exploring the binding mechanisms of inorganic magnetic nanocarrier containing L-Dopa with HSA protein utilizing multi spectroscopic techniques. Journal of Biomolecular Structure and Dynamics, 39(18), 7160–7167. https://doi.org/10.1080/07391102.2020.1806929
  • Shahabadi, N., & Razlansari, M. (2022). Insight into the binding mechanism of macrolide antibiotic; erythromycin to calf thymus DNA by multispectroscopic and computational approaches. Journal of Biomolecular Structure and Dynamics, 40(13), 6171–6182. https://doi.org/10.1080/07391102.2021.1877821
  • Shahabadi, N., & Shiri, F. (2017). Multispectroscopic studies on the interaction of a copper (ii) complex of ibuprofen drug with calf thymus DNA. Nucleosides, Nucleotides & Nucleic Acids, 36(2), 83–106. https://doi.org/10.1080/15257770.2016.1223305
  • Shahabadi, N., & Zendehcheshm, S. (2020). Evaluation of ct-DNA and HSA binding propensity of antibacterial drug chloroxine: Multi-spectroscopic analysis, atomic force microscopy and docking simulation. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 230, 118042. https://doi.org/10.1016/j.saa.2020.118042
  • Shahabadi, N., Akbari, A., Jamshidbeigi, M., & Fili, S. M. (2017). Interaction studies of copper complex containing food additive carmoisine dye with human serum albumin (HSA): Spectroscopic investigations. Luminescence : The Journal of Biological and Chemical Luminescence, 32(7), 1319–1327. https://doi.org/10.1002/bio.3328
  • Shahabadi, N., Falsafi, M., & Maghsudi, M. (2017). DNA-binding study of anticancer drug cytarabine by spectroscopic and molecular docking techniques. Nucleosides, Nucleotides & Nucleic Acids, 36(1), 49–65. https://doi.org/10.1080/15257770.2016.1218021
  • Shahabadi, N., Ghaffari, L., Mardani, Z., & Shiri, F. (2022). Experimental and molecular docking studies on the interaction of a water-soluble Pd (II) complex containing β-amino alcohol with calf thymus DNA. Biological Trace Element Research, 200(4), 1988–2000. https://doi.org/10.1007/s12011-021-02803-1
  • Shahabadi, N., Hadidi, S., & Kalar, Z. M. (2016). Biophysical studies on the interaction of platinum (II) complex containing antiviral drug ribavirin with human serum albumin. Journal of Photochemistry and Photobiology. B, Biology, 160, 376–382. https://doi.org/10.1016/j.jphotobiol.2016.05.006
  • Shahabadi, N., Zendehcheshm, S., Momeni, B. Z., & Abbasi, R. (2020). Antiproliferative activity and human serum albumin binding propensity of [SnMe2Cl2 (bu2bpy)]: multi-spectroscopic analysis, atomic force microscopy, and computational studies. Journal of Coordination Chemistry, 73(8), 1349–1376. https://doi.org/10.1080/00958972.2020.1775821
  • Shahraki, S., Heydari, A., Delarami, H. S., Oveisi Keikha, A., Azizi, Z., & Fathollahi Zonouz, A. (2020). Preparation, characterization and comparison of biological potency in two new Zn (II) and Pd (II) complexes of butanedione monoxime derivatives. Journal of Biomolecular Structure & Dynamics, 38(4), 997–1011. https://doi.org/10.1080/07391102.2019.1591305
  • Shahraki, S., Majd, M. H., & Heydari, A. (2019). Novel tetradentate Schiff base zinc (II) complex as a potential antioxidant and cancer chemotherapeutic agent: Insights from the photophysical and computational approach. Journal of Molecular Structure, 1177, 536–544. https://doi.org/10.1016/j.molstruc.2018.10.005
  • Sujayev, A., Taslimi, P., Garibov, E., Karaman, M., & Zangeneh, M. M. (2020). Novel cyclic thiourea derivatives of aminoalcohols at the presence of AlCl3 catalyst as potent α-glycosidase and α-amylase inhibitors: Synthesis, characterization, bioactivity investigation and molecular docking studies. Bioorganic Chemistry, 104, 104216. https://doi.org/10.1016/j.bioorg.2020.104216
  • Sun, X., Bi, S., Wu, J., Zhao, R., Shao, D., & Song, Z. (2020). Multispectral and molecular docking investigations on the interaction of primethamine/trimethoprim with BSA/HSA. Journal of Biomolecular Structure & Dynamics, 38(3), 934–942. https://doi.org/10.1080/07391102.2019.1588785
  • Tisoco, I., Donatoni, M. C., Victória, H. F. V., de Toledo, J. R., Krambrock, K., Chaves, O. A., de Oliveira, K. T., & Iglesias, B. A. (2022). Photophysical, photooxidation, and biomolecule-interaction of meso-tetra (thienyl) porphyrins containing peripheral Pt (ii) and Pd (ii) complexes. Insights for photodynamic therapy applications. Dalton Transactions (Cambridge, England : 2003), 51(4), 1646–1657. https://doi.org/10.1039/d1dt03565g
  • Vanguru, S., Jilla, L., Sajja, Y., Bantu, R., Nagarapu, L., Nanubolu, J. B., Bhaskar, B., Jain, N., Sivan, S., & Manga, V. (2017). A novel piperazine linked β-amino alcohols bearing a benzosuberone scaffolds as anti-proliferative agents. Bioorganic & Medicinal Chemistry Letters, 27(4), 792–796. https://doi.org/10.1016/j.bmcl.2017.01.031
  • Wani, T. A., Bakheit, A. H., Zargar, S., Alanazi, Z. S., & Al-Majed, A. A. (2021). Influence of antioxidant flavonoids quercetin and rutin on the in-vitro binding of neratinib to human serum albumin. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 246, 118977. https://doi.org/10.1016/j.saa.2020.118977
  • Wei, X., Yang, Y., Ge, J., Lin, X., Liu, D., Wang, S., Zhang, J., Zhou, G., & Li, S. (2020). Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium (II) complexes of hispolon derivatives. Journal of Inorganic Biochemistry, 202, 110857. https://doi.org/10.1016/j.jinorgbio.2019.110857
  • Yan, L., Wang, X., Wang, Y., Zhang, Y., Li, Y., & Guo, Z. (2012). Cytotoxic palladium (II) complexes of 8-aminoquinoline derivatives and the interaction with human serum albumin. Journal of Inorganic Biochemistry, 106(1), 46–51. https://doi.org/10.1016/j.jinorgbio.2011.09.032
  • Yasrebi, S. A., Takjoo, R., & Riazi, G. H. (2019). HSA-interaction studies of uranyl complexes of alkyl substituted isothiosemicarbazone. Journal of Molecular Structure, 1193, 53–61. https://doi.org/10.1016/j.molstruc.2019.04.126
  • Zhang, S., Gan, R., Zhao, L., Sun, Q., Xiang, H., Xiang, X., Zhao, G., & Li, H. (2021). Unveiling the interaction mechanism of alogliptin benzoate with human serum albumin: Insights from spectroscopy, microcalorimetry, and molecular docking and molecular dynamics analyses. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 246, 119040. https://doi.org/10.1016/j.saa.2020.119040
  • Zhou, Z., Hu, X., Hong, X., Zheng, J., Liu, X., Gong, D., & Zhang, G. (2020). Interaction characterization of 5− hydroxymethyl− 2− furaldehyde with human serum albumin: Binding characteristics, conformational change and mechanism. Journal of Molecular Liquids, 297, 111835. https://doi.org/10.1016/j.molliq.2019.111835

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.