Dysregulation of metallothionein and circadian genes in human hepatocellular carcinoma

References

• Buhr ED, Takahashi JS. (2013). Molecular components of the mammalian circadian clock. Handb Exp Pharmacol. 217:3–27.
   PubMedGoogle Scholar
• Chen H, Shen ZY, Xu W, et al. (2014). Expression of P450 and nuclear receptors in normal and end-stage Chinese livers. World J Gastroenterol. 20:8681–90.
   PubMed Web of Science ®Google Scholar
• Cheng ML, Lu YF, Chen H, et al. (2015). Liver expression of Nrf2-related genes in different liver diseases. Hepatobiliary Pancreat Dis Int. 14:485–91.
   PubMed Web of Science ®Google Scholar
• Cherian MG, Jayasurya A, Bay BH. (2003). Metallothioneins in human tumors and potential roles in carcinogenesis. Mutat Res. 533:201–9.
   PubMed Web of Science ®Google Scholar
• Cui M, Zheng M, Sun B, et al. (2015). A long noncoding RNA perturbs the circadian rhythm of hepatoma cells to facilitate hepatocarcinogenesis. Neoplasia. 17:79–88.
   PubMed Web of Science ®Google Scholar
• Dallmann R, Brown SA, Gachon F. (2014). Chronopharmacology: New insights and therapeutic implications. Annu Rev Pharmacol Toxicol. 54:339–61.
   PubMed Web of Science ®Google Scholar
• Dziegiel P, PulaB, Kobierzycki C, et al. (2016). Metallothioneins in normal and cancer cells. Adv Anat Embryol Cell Biol. 2:117.
   Google Scholar
• Ercolani L, Ferrari A, De Mei C, et al. (2015). Circadian clock: Time for novel anticancer strategies? Pharmacol Res. 100:288–95.
   PubMed Web of Science ®Google Scholar
• Filipski E, Subramanian P, Carrière J, et al. (2009). Circadian disruption accelerates liver carcinogenesis in mice. Mutat Res. 680:95–105.
   PubMed Web of Science ®Google Scholar
• Frank E, Sidor MM, Gamble KL, et al. (2013). Circadian clocks, brain function, and development. Ann N Y Acad Sci. 1306:43–67.
   PubMed Web of Science ®Google Scholar
• Fu L, Kettner NM. (2013). The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci. 119:221–82.
   PubMed Web of Science ®Google Scholar
• Fuhr L, Abreu M, Pett P, Relogio A. (2015). Circadian systems biology: When time matters. Comput Struct Biotechnol J. 13:417–26.
   PubMed Web of Science ®Google Scholar
• Fujie T, Segawa Y, Yoshida E, et al. (2016). Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J Toxicol Sci. 41:225–32.
   PubMed Web of Science ®Google Scholar
• Gachon F, Olela FF, Schaad O, et al. (2006). The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification. Cell Metab. 4:25–36.
   PubMed Web of Science ®Google Scholar
• Ghoshal K, Datta J, Majumder S, Bai S, Dong X, Parthun M, Jacob ST. (2002). Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol. 22:8302–19.
   PubMed Web of Science ®Google Scholar
• Houessinon A, Francois C, Sauzay C, Louandre C, Mongelard G, Godin C, Bodeau S, Takahashi S, Saidak Z, Gutierrez L, Regimbeau JM, Barget N, Barbare JC, Ganne N, Chauffert B, Coriat R, Galmiche A. (2016). Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib. Mol Cancer 15:38.
   Web of Science ®Google Scholar
• Huang XL, Fu CJ, Bu RF. (2011). Role of circadian clocks in the development and therapeutics of cancer. J Int Med Res. 39:2061–66.
   PubMed Web of Science ®Google Scholar
• Innominato PF, Roche VP, Palesh OG, et al. (2014). The circadian timing system in clinical oncology. Ann Med. 46:191–207.
   PubMed Web of Science ®Google Scholar
• Janevska D, Chaloska-Ivanova V, Janevski V. (2015). Hepatocellular carcinoma: Risk factors, diagnosis and treatment. Open Access Maced J Med Sci. 3:732–6.
   PubMedGoogle Scholar
• Jemal A, Siegel R, Ward E, et al. (2008). Cancer statistics. CA Cancer J Clin. 58:71–96.
   PubMed Web of Science ®Google Scholar
• Jin T, Wen GR, Jin H, et al. (2013). DEN-introduced hepatocellular carcinoma is associated with aberrant expression of clock gene in mice Chengdu Yi Xue Yuan Xue Bao. 8:156–9.
   Google Scholar
• Kelleher FC, Rao A, Maguire A. (2014). Circadian molecular clocks and cancer. Cancer Lett. 342:9–18.
   PubMed Web of Science ®Google Scholar
• Kettner NM, Katchy CA, Fu L. (2014). Circadian gene variants in cancer. Ann Med. 46:208–20
   PubMed Web of Science ®Google Scholar
• Klaassen CD, Liu J, Choudhury S. (1999). Metallothionein: An intercellular protein to protect against cadmium toxicity. Ann Rev Pharmacol Toxicol. 39:267–94.
   PubMed Web of Science ®Google Scholar
• Kourtidis A, Jain R, Carkner RD, et al. (2010). An RNA interference screen identifies metabolic regulators NR1D1 and PBP as novel survival factors for breast cancer cells with the ERBB2 signature. Cancer Res. 70:1783–92.
   PubMed Web of Science ®Google Scholar
• Krizkova S, Kepinska M, Emri G, et al. (2016). Microarray analysis of metallothioneins in human diseases––a review. J Pharm Biomed Anal. 117:464–73.
   PubMed Web of Science ®Google Scholar
• Levi F, Okyar A, Dulong S, et al. (2014). Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 377–421.
   Google Scholar
• Lin DW, FitzGerald LM, Fu R, et al. (2011). Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality. Cancer Epidemiol Biomarkers Prev. 20:1928–36.
   PubMed Web of Science ®Google Scholar
• Lin YM, Chang JH, Yeh KT, et al. (2008). Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog. 47:925–33.
   PubMed Web of Science ®Google Scholar
• Lu YF, Jin T, Xu Y, et al. (2013). Sex differences in the circadian variation of cytochrome p450 genes and corresponding nuclear receptors in mouse liver. Chronobiol Int. 30:1135–43.
   PubMed Web of Science ®Google Scholar
• Majumder S, Roy S, Kaffenberger T, et al. (2010). Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes. Cancer Res. 70:10265–76.
   PubMed Web of Science ®Google Scholar
• Mao J, Yu H, Wang C, et al. (2012). Metallothionein MT1M is a tumor suppressor of human hepatocellular carcinomas. Carcinogenesis. 33:2568–77.
   PubMed Web of Science ®Google Scholar
• Mohawk JA, Green CB, Takahashi JS. (2012). Central and peripheral circadian clocks in mammals. Annu Rev Neurosci. 1: 445–62.
   Web of Science ®Google Scholar
• Musiek ES, Fitzgerald GA. (2013). Molecular clocks in pharmacology. Handb Exp Pharmacol. 243–60.
   PubMedGoogle Scholar
• Park Y, Yu E. (2013). Expression of metallothionein-1 and metallothionein-2 as a prognostic marker in hepatocellular carcinoma. J Gastroenterol Hepatol 28:1565–72.
   PubMed Web of Science ®Google Scholar
• Partch CL, Green CB, Takahashi JS. (2014). Molecular architecture of the mammalian circadian clock. Trends Cell Biol. 24:90–9.
   PubMed Web of Science ®Google Scholar
• Pedersen MO, Larsen A, Stoltenberg M, Penkowa M. (2009). The role of metallothionein in oncogenesis and cancer prognosis. Prog Histochem Cytochem 44:29–64.
   PubMed Web of Science ®Google Scholar
• Raudenska M, Gumulec J, Podlaha O, et al. (2014). Metallothionein polymorphisms in pathological processes. Metallomics 6:55–68.
   PubMed Web of Science ®Google Scholar
• Salavaty A. (2015). Carcinogenic effects of circadian disruption: An epigenetic viewpoint. Chin J Cancer.34:375–83.
   Google Scholar
• Sato F, Nagata C, Liu Y, et al. (2009). PERIOD1 is an anti-apoptotic factor in human pancreatic and hepatic cancer cells. J Biochem. 146:833–8.
   PubMed Web of Science ®Google Scholar
• Savvidis C, Koutsilieris M. (2012). Circadian rhythm disruption in cancer biology. Mol Med. 18:1249–60.
   PubMed Web of Science ®Google Scholar
• Subramanian P, Mirunalini S, Dakshayani KB, et al. (2007). Prevention by melatonin of hepatocarcinogenesis in rats injected with N-nitrosodiethylamine. J Pineal Res. 43:305–12.
   PubMed Web of Science ®Google Scholar
• Tahara Y, Shibata S. (2016). Circadian rhythms of liver physiology and disease: Experimental and clinical evidence. Nat Rev Gastroenterol Hepatol. 13:217–26.
   PubMed Web of Science ®Google Scholar
• Tao X, Zheng JM, Xu AM, et al. (2007). Downregulated expression of metallothionein and its clinicopathological significance in hepatocellular carcinoma. Hepatol Res. 37:820–7.
   PubMed Web of Science ®Google Scholar
• Fujie T, Segawa Y, Yoshida E, et al. (2016). Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells. J Toxicol Sci. 41:225–32.
   PubMed Web of Science ®Google Scholar
• Wong RH, Huang CH, Yeh CB, et al. (2013). Effects of metallothionein-1 genetic polymorphism and cigarette smoking on the development of hepatocellular carcinoma. Ann Surg Oncol. 20:2088–95.
   PubMed Web of Science ®Google Scholar
• Xiangji L, Feng X, Qingbao C, et al. (2011). Knockdown of HBV surface antigen gene expression by a lentiviral microRNA-based system inhibits HBV replication and HCC growth. J Viral Hepat. 18:653–60.
   PubMed Web of Science ®Google Scholar
• Xu YQ, Zhang D, Jin T, et al. (2012). Diurnal variation of hepatic antioxidant gene expression in mice. PloS One. 7:e44237.
   PubMed Web of Science ®Google Scholar
• Yang SL, Yu C, Jiang JX, et al. (2014). Hepatitis B virus X protein disrupts the balance of the expression of circadian rhythm genes in hepatocellular carcinoma. Oncol Lett. 8:2715–20.
   PubMed Web of Science ®Google Scholar
• Zhang D, Jin T, Xu YQ, et al. (2012). Diurnal-and sex-related difference of metallothionein expression in mice. J Circadian Rhythms. 10:5.
   Google Scholar
• Zhou D, Wang Y, Chen L, et al. (2016). Evolving roles of circadian rhythms in liver homeostasis and pathology. Oncotarget. 7:8625–39.
   PubMed Web of Science ®Google Scholar
• Zhang L, Ptacek LJ, Fu YH. (2013). Diversity of human clock genotypes and consequences. Prog Mol Biol Transl Sci. 119:51–81.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Ma F, Zhou F, et al. (2014). Functional polymorphisms of circadian negative feedback regulation genes are associated with clinical outcome in hepatocellular carcinoma patients receiving radical resection. Med Oncol. 31:179.
   PubMed Web of Science ®Google Scholar
• Zhao B, Lu J, Yin J, et al. (2012). A functional polymorphism in PER3 gene is associated with prognosis in hepatocellular carcinoma. Liver Int. 32:1451–59.
   Google Scholar