Prognostic significance of downregulated BMAL1 and upregulated Ki-67 proteins in nasopharyngeal carcinoma

References

• Allegra CJ, Parr AL, Wold LE, Mahoney MR, Sargent DJ, Johnston P, Klein P, Behan K, O’Connell MJ, Levitt R, et al. 2002. Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer. J Clin Oncol: Official J Am Soc Clin Oncol. 20:1735–43. doi:10.1200/JCO.2002.07.080.
   PubMed Web of Science ®Google Scholar
• Balsalobre A. 2002. Clock genes in mammalian peripheral tissues. Cell Tissue Res. 309:193–99. doi:10.1007/s00441-002-0585-0.
   PubMed Web of Science ®Google Scholar
• Bass J, Takahashi JS. 2010. Circadian integration of metabolism and energetics. Science. 330:1349–54. doi:10.1126/science.1195027.
   PubMed Web of Science ®Google Scholar
• Cadenas C, Van De Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H, Hengstler JG. 2014. Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 13:3282–91. doi:10.4161/15384101.2014.954454.
   PubMed Web of Science ®Google Scholar
• Chicurel M. 2001. CIRCADIAN RHYTHMS: Mutant gene speeds up the human clock. Science. 291:226b–227. doi:10.1126/science.291.5502.226B.
   PubMed Web of Science ®Google Scholar
• Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, et al. 2012. The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleuralmesothelioma. Int J Cancer. 131:2820–31. doi:10.1002/ijc.27598.
   PubMed Web of Science ®Google Scholar
• Gao L, Xu GZ. 2007. Nasopharyngeal carcinoma. Beijing: Peking University Medical Press. 1–2.
   Google Scholar
• Gibbs J, Ince L, Matthews L, Mei J, Bell T, Yang N, Saer B, Begley N, Poolman T, Pariollaud M, et al. 2014. An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action. Nat Med. 20:919–26. doi:10.1038/nm.3599.
   PubMed Web of Science ®Google Scholar
• Hardin PE. 2011. Molecular genetic analysis of circadian timekeeping in Drosophila. Adv Genet. 74:141–73.
   PubMed Web of Science ®Google Scholar
• Hou X, Zhang L, Zhao C, Li S, Lu LX, Han F, Shao JY, Huang PY. 2006. Prognostic impact of plasma Epstein-Barr virus DNA concentration on distant metastasis in nasopharyngeal carcinoma. Ai Zheng. 25:785–92.
   PubMedGoogle Scholar
• Hsu C-M, Lin S-F, Lu C-T, Lin P-M, Yang M-Y. 2012. Altered expression of circadian clock genes in head and neck squamous cell carcinoma. Tumor Biol. 33:149–55. doi:10.1007/s13277-011-0258-2.
   PubMed Web of Science ®Google Scholar
• Hu ML, Yeh KT, Lin PM, Hsu CM, Hsiao HH, Liu YC, Lin HY, Lin SF, Yang MY. 2014. Deregulated expression of circadian clock genes in gastric cancer. BMC Gastroenterol. 14:67. doi:10.1186/1471-230X-14-67.
   PubMed Web of Science ®Google Scholar
• Ikeda M, Nomura M. 1997. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage. Biochem Biophys Res Commun. 233:258–64. doi:10.1006/bbrc.1997.6371.
   PubMed Web of Science ®Google Scholar
• Jiang F, Jin T, Feng X-L, Jin Q-F, Chen X-Z. 2015. Long-term outcomes and failure patterns of patients with nasopharyngeal carcinoma staged by magnetic resonance imaging in intensity-modulated radiotherapy era: The Zhejiang Cancer Hospital’s experience. J Cancer Res Ther. 11:179–84. doi:10.4103/0973-1482.168181.
   Web of Science ®Google Scholar
• Jiang W, Zhao S, Jiang X, Zhang E, Hu G, Hu B, Zheng P, Xiao J, Lu Z, Lu Y, et al. 2016. The circadian clock gene Bmal1 acts as a potential antioncogene in pancreatic cancer by activating the p53 tumor suppressor pathway. Cancer Lett. 371:314–25. doi:10.1016/j.canlet.2015.12.002.
   PubMed Web of Science ®Google Scholar
• Jung CH, Kim EM, Park JK, Hwang SG, Moon SK, Kim WJ, Um HD. 2013. Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway. Oncol Rep. 29:2109–13. doi:10.3892/or.2013.2381.
   PubMed Web of Science ®Google Scholar
• Kiessling S, Beaulieu-Laroche L, Blum ID, Landgraf D, Welsh DK, Storch K-F, Labrecque N, Cermakian N. 2017. Enhancing circadian clock function in cancer cells inhibits tumor growth. BMC Biol. 15:13. doi:10.1186/s12915-017-0349-7.
   PubMed Web of Science ®Google Scholar
• Lee CC. 2006. Tumor suppression by the mammalian period genes. Cancer Causes Control. 17:525–30. doi:10.1007/s10552-005-9003-8.
   PubMed Web of Science ®Google Scholar
• Li LT, Jiang G, Chen Q, Zheng JN. 2015. Ki67 is a promising molecular target in the diagnosis of cancer (Review). Melocular Med Rep. 11:1566–72.
   PubMed Web of Science ®Google Scholar
• Li W, Liu L, Liu D, Jin S, Yang Y, Tang W, Gong L. 2016. Decreased circadian component Bmal1 predicts tumor progression and poor prognosis in human pancreatic ductal adenocarcinoma. Biochem Biophys Res Commun. 472:156–62.
   PubMed Web of Science ®Google Scholar
• Logan RW, Zhang C, Murugan S, O’Connell S, Levitt D, Rosenwasser AM, Sarkar DK. 2012. Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. J Immunol. 188:2583–91. doi:10.4049/jimmunol.1102715.
   PubMed Web of Science ®Google Scholar
• Machowska M, Wachowicz K, Sopel M, Rzepecki R. 2014. Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells. BMC Cancer. 14:142. doi:10.1186/1471-2407-14-142.
   PubMedGoogle Scholar
• Mannic T, Meyer P, Triponez F, Pusztaszeri M, Le Martelot G, Mariani O, Schmitter D, Sage D, Philippe J, Dibner C. 2013. Circadian clock characteristics are altered in human thyroid malignant nodules. J Clin Endocrinol Metabolism. 98:4446–56. doi:10.1210/jc.2013-2568.
   PubMed Web of Science ®Google Scholar
• Mullenders J, Fabius AW, Madiredjo M, Bernards R, Beijersbergen RL. 2009. A large Scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. PLoS One. 4:e4798. doi:10.1371/journal.pone.0004798.
   PubMed Web of Science ®Google Scholar
• Narasimamurthy R, Virshup DM. 2017. A flick of the tail keeps the circadian clock in line. Mol Cell. 66:437–38. doi:10.1016/j.molcel.2017.05.008.
   PubMed Web of Science ®Google Scholar
• Nielsen PS, Riber-Hansen R, Jensen TO, Schmidt H, Steiniche T. 2013. Proliferation indices of phosphohistone H3 and Ki67: Strong prognostic markers in a consecutive cohort with stage I/II melanoma. Mod Pathol. 26:404–13. doi:10.1038/modpathol.2012.188.
   PubMed Web of Science ®Google Scholar
• Oshima T, Takenoshita S, Akaike M, Kunisaki C, Fujii S, Nozaki A, Numata K, Shiozawa M, Rino Y, Tanaka K, et al. 2011. Expression of circadian genes correlates with liver metastasis and outcomes in colorectal cancer. Oncol Rep. 25:1439–46. doi:10.3892/or.2011.1207.
   PubMed Web of Science ®Google Scholar
• Panda S, Hogenesch JB, Kay SA. 2002. Circadian rhythms from flies to human. Nature. 417:329–35. doi:10.1038/417329a.
   PubMed Web of Science ®Google Scholar
• Partch CL, Green CB, Takahashi JS. 2014. Molecular architecture of the mammalian circadian clock. Trends Cell Biol. 24:90–99.
   PubMed Web of Science ®Google Scholar
• Reppert SM, Weaver DR. 2002. Coordination of circadian timing in mammals. Nature. 418:935–41. doi:10.1038/nature00965.
   PubMed Web of Science ®Google Scholar
• Sakamoto W, Takenoshita S. 2015. Overexpression of both Clock and Bmal1 inhibits entry to S phase in human colon cancer cells. Fukushima J Med Sci. 61:111–24. doi:10.5387/fms.2015-11.
   PubMedGoogle Scholar
• Shi P, Zhong J, Hong J, Huang R, Wang K, Chen Y. 2016. Automated Ki-67 quantification of immunohistochemical staining image of human nasopharyngeal carcinoma xenografts. Sci Rep. 6:32127. doi:10.1038/srep32127.
   PubMed Web of Science ®Google Scholar
• Tang Q, Cheng B, Xie M, Chen Y, Zhao J, Zhou X1, Chen L. 2017. Circadian clock gene Bmal1 inhibits tumorigenesis and increases paclitaxel sensitivity in tongue squamous cell carcinoma. Cancer Res. 77:532–44. doi:10.1158/0008-5472.CAN-16-1322.
   PubMed Web of Science ®Google Scholar
• Xiong W, Li J, Zhang E, Huang H. 2016. BMAL1 regulates transcription initiation and activates circadian clock gene expression in mammals. Biochem Biophys Res Commun. 473:1019–25.
   PubMed Web of Science ®Google Scholar
• Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, et al. 2016. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Sci Transl Med. 8:324ra16.
   PubMed Web of Science ®Google Scholar
• Yeh CM, Shay J, Zeng TC, Chou JL, Huang TH, Lai HC, Chan MW. 2014. Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer. Int J Oncol. 45:210–17.
   Web of Science ®Google Scholar
• Young MW, Kay SA. 2001. Time zones: A comparative genetics of circadian clocks. Nat Rev Gen. 2:702–15. doi:10.1038/35088576.
   PubMed Web of Science ®Google Scholar
• Yu EA, Weaver DR. 2011. Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY). 3:479–93. doi:10.18632/aging.v3i5.
   PubMedGoogle Scholar
• Zeng ZL, Luo HY, Yang J, Wu WJ, Chen DL, Huang P, Xu RH. 2014. Overexpression of the circadian clock gene Bmal1 increases sensitivity to oxaliplatin incolorectal cancer. Clin Cancer Res. 20:1042–52.
   PubMed Web of Science ®Google Scholar
• Zeng Z-L, Wu M-W, Sun J, Sun Y-L, Cai Y-C, Huang Y-J, Xian L-J. 2010. Effects of the biological clock gene Bmal1 on tumour growth and anticancer drug activity. J Biochemistry. 148:319–26. doi:10.1093/jb/mvq069.
   PubMed Web of Science ®Google Scholar
• Zieker D, Jenne I, Koenigsrainer I, Zdichavsky M, Nieselt K, Buck K, Zieker J, Beckert S, Glatzle J, Spanagel R, et al. 2010. Circadian expression of clock- and tumor suppressor genes in human oral mucosa. Cell Physiol Biochem. 26:155–66. doi:10.1159/000320547.
   PubMed Web of Science ®Google Scholar