A randomized, double-blind and placebo-controlled crossover trial on the effect of l-ornithine ingestion on the human circadian clock

References

• Albrecht U. 2012. Timing to perfection: The biology of central and peripheral circadian clocks. Neuron. 74:246–60.
   PubMed Web of Science ®Google Scholar
• Bass J, Takahashi JS. 2010. Circadian integration of metabolism and energetics. Science. 330:1349–54.
   PubMed Web of Science ®Google Scholar
• Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, Parry BL, Revell VL. 2008. Measuring melatonin in humans. Journal Clinical Sleep Medicine: JCSM: Official Publication American Academy Sleep Medicine. 4:66–69.
   PubMed Web of Science ®Google Scholar
• Burgess HJ, Sharkey KM, Eastman CI. 2002. Bright light, dark and melatonin can promote circadian adaptation in night shift workers. Sleep Med Rev. 6:407–20.
   PubMed Web of Science ®Google Scholar
• Burke TM, Markwald RR, McHill AW, Chinoy ED, Snider JA, Bessman SC, Jung CM, O’Neill JS, Wright KP Jr. 2015. Effects of caffeine on the human circadian clock in vivo and in vitro. Sci Transl Med. 7: 305ra146 doi: 10.1126/scitranslmed.aad3106.
   Web of Science ®Google Scholar
• Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. 1989. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res. 28:193–213.
   PubMed Web of Science ®Google Scholar
• Campbell SS, Kripke DF, Gillin JC, Hrubovcak JC. 1988. Exposure to light in healthy elderly subjects and Alzheimer’s patients. Physiol Behav. 42:141–44.
   PubMed Web of Science ®Google Scholar
• Doi YMM, Okawa M, Uchiyama M. 1998. Development of the Japanese version of the Pittsburgh Sleep Quality Index. J. Jpn J Psychiatry Treat. 13(6):755–63.
   Google Scholar
• Doi YMM, Uchiyama M, Okawa M, Kim K, Shibui K, Kamei Y. 2000. Psychometric assessment of subjective sleep quality using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J) in psychiatric disordered and control subjects.. Psychiatry Res. 97(2–3):165–72.
   PubMed Web of Science ®Google Scholar
• Figueiro MG. 2016. Delayed sleep phase disorder: Clinical perspective with a focus on light therapy. Nat Sci Sleep. 8:91–106.
   PubMed Web of Science ®Google Scholar
• Fukuda T, Haraguchi A, Kuwahara M, Nakamura K, Hamaguchi Y, Ikeda Y, Ishida Y, Wang G, Shirakawa C, Tanihata Y, et al. 2016. l-Ornithine affects peripheral clock gene expression in mice. Sci Rep. 6:34665.
   PubMed Web of Science ®Google Scholar
• Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, Kamagata M, Yang ZH, Hirasawa A, Tahara Y, et al. 2015. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PloS One. 10:e0132472.
   PubMed Web of Science ®Google Scholar
• Gachon F, Nagoshi E, Brown SA, Ripperger J, Schibler U. 2004. The mammalian circadian timing system: From gene expression to physiology. Chromosoma. 113:103–12.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Pietrocola F, Kroemer G. 2015. Molecular Regulation of Circadian Rhythms by Polyamines. Cell Metab. 22:757–58.
   PubMed Web of Science ®Google Scholar
• Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, Herer P, Tzischinsky O, Lavie P. 1994. Sleep disorders and melatonin rhythms in elderly people. BMJ. 309:167.
   PubMed Web of Science ®Google Scholar
• He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, et al. 2016. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 23:610–21.
   PubMed Web of Science ®Google Scholar
• Hida A, Kitamura S, Enomoto M, Nozaki K, Moriguchi Y, Echizenya M, Kusanagi H, Mishima K. 2012. Individual traits and environmental factors influencing sleep timing: A study of 225 Japanese couples. Chronobiol Int. 29:220–26.
   PubMed Web of Science ®Google Scholar
• Horne JA, Ostberg O. 1976. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 4:97–110.
   PubMedGoogle Scholar
• Ishihara K, Miyashita A, Inugami M, Fukuda K, Yamazaki K, Miyata Y. 1986. [The results of investigation by the Japanese version of Morningness-Eveningness Questionnaire]. Shinrigaku Kenkyu: Japanese Journal Psychology. 57:87–91.
   PubMedGoogle Scholar
• Kalsbeek A, Cutrera RA, Van Heerikhuize JJ, Van Der Vliet J, Buijs RM. 1999. GABA release from suprachiasmatic nucleus terminals is necessary for the light-induced inhibition of nocturnal melatonin release in the rat. Neuroscience. 91:453–61.
   PubMed Web of Science ®Google Scholar
• Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. 2002. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 17:181–93.
   PubMed Web of Science ®Google Scholar
• Kokubo T, Ikeshima E, Kirisako T, Miura Y, Horiuchi M, Tsuda A. 2013. A randomized, double-masked, placebo-controlled crossover trial on the effects of L-ornithine on salivary cortisol and feelings of fatigue of flushers the morning after alcohol consumption. Biopsychosoc Med. 7:6.
   PubMedGoogle Scholar
• Kurata K, Shigemi K, Tomonaga S, Aoki M, Morishita K, Denbow DM, Furuse M. 2011. L-ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks. Neuroscience. 172:226–31.
   PubMed Web of Science ®Google Scholar
• Kurauchi I, Shigemi K, Kabuki Y, Hamasu K, Yamane H, Aoki M, Kawada Y, Morishita K, Denbow DM, Furuse M. 2010. Central L-ornithine, but not polyamines, induces a hypnotic effect in neonatal chicks under acute stress. Nutr Neurosci. 13:17–20.
   PubMed Web of Science ®Google Scholar
• Kuroda H, Tahara Y, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, et al. 2012. Meal frequency patterns determine the phase of mouse peripheral circadian clocks. Sci Rep. 2:711.
   PubMed Web of Science ®Google Scholar
• Lack L, Wright H. 1993. The effect of evening bright light in delaying the circadian rhythms and lengthening the sleep of early morning awakening insomniacs. Sleep. 16:436–43.
   PubMed Web of Science ®Google Scholar
• Lewy AJ, Bauer VK, Ahmed S, Thomas KH, Cutler NL, Singer CM, Moffit MT, Sack RL. 1998. The human phase response curve (PRC) to melatonin is about 12 hours out of phase with the PRC to light. Chronobiol Int. 15:71–83.
   PubMed Web of Science ®Google Scholar
• Lewy AJ, Cutler NL, Sack RL. 1999. The endogenous melatonin profile as a marker for circadian phase position. J Biol Rhythms. 14:227–36.
   PubMed Web of Science ®Google Scholar
• Lockley SW, Brainard GC, Czeisler CA. 2003. High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light. J Clin Endocrinol Metab. 88:4502–05.
   PubMed Web of Science ®Google Scholar
• Matsuo H, Iwamoto A, Otsuka T, Hishida Y, Akiduki S, Aoki M, Furuse M, Yasuo S. 2015. Effects of time of L-ornithine administration on the diurnal rhythms of plasma growth hormone, melatonin, and corticosterone levels in mice. Chronobiol Int. 32:225–34.
   PubMed Web of Science ®Google Scholar
• Minors DS, Waterhouse JM, Wirz-Justice A. 1991. A human phase-response curve to light. Neurosci Lett. 133:36–40.
   PubMed Web of Science ®Google Scholar
• Minowa M, Okawa MUchiyama M. (1998). Development of the japanese version of the pittsburgh sleep quality index (in japanese). Japanese Journal Of Psychiatry Treatment. 13 (6):755–763
   Google Scholar
• Minowa M, Uchiyama M, Okawa M, Kim K, Shibui K, (2000). Psychometric assessment of subjective sleep quality using the japanese version of the pittsburgh sleep quality index (psqi-j) in psychiatric disordered and control subjects. Psychiatry Res. 97:165-172
   PubMed Web of Science ®Google Scholar
• Mishima K, Hishikawa Y, Okawa M. 1998. Randomized, dim light controlled, crossover test of morning bright light therapy for rest-activity rhythm disorders in patients with vascular dementia and dementia of Alzheimer’s type. Chronobiol Int. 15:647–54.
   PubMed Web of Science ®Google Scholar
• Miyake M, Kirisako T, Kokubo T, Miura Y, Morishita K, Okamura H, Tsuda A. 2014. Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers. Nutrition Journal. 13:53.
   PubMed Web of Science ®Google Scholar
• O’Kane RL, Vina JR, Simpson I, Zaragoza R, Mokashi A, Hawkins RA. 2006. Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+. American Journal of Physiology Endocrinology and Metabolism. 291:E412–419.
   PubMed Web of Science ®Google Scholar
• Oike H. 2017. Modulation of circadian clocks by nutrients and food factors. Biosci Biotechnol Biochem. 81:863–70.
   PubMed Web of Science ®Google Scholar
• Omori K, Kagami Y, Yokoyama C, Moriyama T, Matsumoto N, Masaki M, Nakamura H, Kamasaka H, Shiraishi K, Kometani T, Kuriki T, Huang ZUrade Y. 2012. Promotion of non-rapid eye movement sleep in mice after oral administration of ornithine. Sleep and Biological Rhythms. 10:38-45.
   Web of Science ®Google Scholar
• Potter GD, Skene DJ, Arendt J, Cade JE, Grant PJ, Hardie LJ. 2016. Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocr Rev. 37:584–608.
   PubMed Web of Science ®Google Scholar
• Roenneberg T, Merrow M. 2016. The Circadian Clock and Human Health. Current Biology: CB. 26:R432–443.
   PubMed Web of Science ®Google Scholar
• Stoll J, Wadhwani KC, Smith QR. 1993. Identification of the cationic amino acid transporter (System y+) of the rat blood-brain barrier. J Neurochem. 60:1956–59.
   PubMed Web of Science ®Google Scholar
• Tozawa T, Mishima K, Satoh K, Echizenya M, Shimizu T, Hishikawa Y. 2003. Stability of sleep timing against the melatonin secretion rhythm with advancing age: clinical implications. J Clin Endocrinol Metab. 88:4689–95.
   PubMed Web of Science ®Google Scholar
• Wehrens SMT, Christou S, Isherwood C, Middleton B, Gibbs MA, Archer SN, Skene DJ, Johnston JD. 2017. Meal Timing Regulates the Human Circadian System. Current Biology: CB. 27(1768–1775):e1763.
   Google Scholar
• Zwighaft Z, Aviram R, Shalev M, Rousso-Noori L, Kraut-Cohen J, Golik M, Brandis A, Reinke H, Aharoni A, Kahana C, et al. 2015. Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age. Cell Metab. 22:874–85.
   PubMed Web of Science ®Google Scholar