Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials

References

• Ayala DE, Hermida RC, Mojón A, Fernández JR. 2013. Cardiovascular risk of resistant hypertension: Dependence on treatment-time regimen of blood pressure-lowering medications. Chronobiol Int. 30:340–352. doi:10.3109/07420528.2012.701455.
   PubMed Web of Science ®Google Scholar
• Bowles NP, Thosar SS, Herzig MX, Shea SA. 2018. Chronotherapy for hypertension. Curr Hypertens Rep. 20:97. doi:10.1007/s11906-018-0897-4.
   PubMed Web of Science ®Google Scholar
• De Giorgi A, Menegatti AM, Fabbian F, Portaluppi F, Manfredini R. 2013. Circadian rhythms and medical diseases: Does it matter when drugs are taken? Eur J Intern Med. 24(8):698–706. doi:10.1016/j.ejim.2013.03.019.
   PubMed Web of Science ®Google Scholar
• Fernández JR, Mojón A, Hermida RC. 2020. Chronotherapy of hypertension: Advantages of 48h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. In press
   Web of Science ®Google Scholar
• Hermida RC. 2007. Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy: Rationale and design of the MAPEC study. Chronobiol Int. 24(4):749–775. doi:10.1080/07420520701535837.
   PubMed Web of Science ®Google Scholar
• Hermida RC. 2016. Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: Rationale and design of the Hygia Project. Chronobiol Int. 33(7):906–936. doi:10.1080/07420528.2016.1181078.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Fernández JR, Mojón A, Smolensky MH, Fabbian F, Portaluppi F. 2013a. Administration-time-differences in effects of hypertension medications on ambulatory blood pressure regulation. Chronobiol Int. 30(1–2):280–314. doi:10.3109/07420528.2012.709448.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Fernández JR, Portaluppi F, Fabbian F, Smolensky MH. 2011a. Circadian rhythms in blood pressure regulation and optimization of hypertension treatment with ACE inhibitor and ARB medications. Am J Hypertens. 24(4):383–391. doi:10.1038/ajh.2010.217.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Fontao MJ, Mojón A, Fernández JR. 2013b. Ambulatory blood pressure monitoring: Importance of sampling rate and duration – 48 versus 24 hours – on the accurate assessment of cardiovascular risk. Chronobiol Int. 30(1–2):55–67. doi:10.3109/07420528.2012.701457.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2010. Influence of circadian time of hypertension treatment on cardiovascular risk: Results of the MAPEC study. Chronobiol Int. 27(8):1629–1651. doi:10.3109/07420528.2010.510230.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2011b. Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk. J Am Coll Cardiol. 58(11):1165–1173. doi:10.1016/j.jacc.2011.04.043.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2011c. Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes. Diabetes Care. 34(6):1270–1276. doi:10.2337/dc11-0297/-/DC1.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2011d. Bedtime dosing of antihypertensive medications reduces cardiovascular risk in CKD. J Am Soc Nephrol. 22(12):2313–2321. doi:10.1681/ASN.2011040361.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2013c. Cardiovascular risk of essential hypertension: Influence of class, number, and treatment-time regimen of hypertension medications. Chronobiol Int. 30(1–2):315–327. doi:10.3109/07420528.2012.701534.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2016a. Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes: A randomised controlled trial. Diabetologia. 59(2):255–265. doi:10.1007/s00125-015-3749-7.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2016b. Sleep-time BP: prognostic marker of type 2 diabetes and therapeutic target for prevention. Diabetologia. 59:244–254. doi:10.1007/s00125-015-3748-8.
   Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernández JR. 2017. Sleep-time ambulatory BP is an independent prognostic marker of CKD. J Am Soc Nephrol. 28(9):2802–2811. doi:10.1681/ASN.2016111186.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Fernánez JR. 2018a. Risk of incident chronic kidney disease is better reduced by bedtime than upon awakening ingestion of hypertension medications. Hypertens Res. 41(5):342–353. doi:10.1038/s41440-018-0029-1.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Mojón A, Smolensky MH, Fernández JR. 2019a. Diagnosis and management of hypertension: Around-the-clock ambulatory blood pressure monitoring is substantially more effective and less costly than daytime office blood pressure measurements. Chronobiol Int. 36(11):1515–1527. doi:10.1080/07420528.2019.1658201.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Ayala DE, Smolensky MH, Fernández JR, Mojón A, Portaluppi F. 2016c. Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks. Hypertens Res. 39(5):277–292. doi:10.1007/s00125-015-3748-8.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Crespo JJ, Domínguez-Sardiña M, for the Hygia Chronotherapy Trial Investigators. 2020a. Improved reduction of cardiovascular risk by bedtime ingestion of ARB and ACEI medication class therapies. Eur Heart J. doi:10.1093/eurheartj/ehaa214.
   Web of Science ®Google Scholar
• Hermida RC, Crespo JJ, Domínguez-Sardiña M, Otero A, Moyá A, Ríos MT, Sineiro E, Castiñeira MC, Callejas PA, Pousa L, et al. 2019b. Bedtime hypertension treatment improves cardiovascular risk reduction: The Hygia Chronotherapy Trial. Eur Heart J. Epub ahead of print. doi:10.1093/eurheartj/ehy754
   Google Scholar
• Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, et al. 2018b. Asleep blood pressure: Significant prognostic marker of vascular risk and therapeutic target for prevention. Eur Heart J. 39(47):4159–4171. doi:10.1093/eurheartj/ehy475.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Fernández JR, Ayala DE, Mojón A, Alonso I, Calvo C. 2004. Circadian time-qualified tolerance intervals for ambulatory blood pressure monitoring in the diagnosis of hypertension. Chronobiol Int. 21(1):147–160. doi: 10.1081/CBI-120027988.
   Google Scholar
• Hermida RC, Fernández JR, Mojón A. 2020b. Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. In press
   Web of Science ®Google Scholar
• Hermida RC, Mojón A, Fernández JR, Alonso I, Ayala DE. 2002. The tolerance-hyperbaric test: A chronobiologic approach for improved diagnosis of hypertension. Chronobiol Int. 19(6):1183–1211. doi:10.1081/cbi-120015960.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Smolensky MH, Ayala DE, Portaluppi F. 2015. Ambulatory blood pressure monitoring (ABPM) as the reference standard for diagnosis of hypertension and assessment of vascular risk in adults. Chronobiol Int. 32(10):1329–1342. doi:10.3109/07420528.2015.1113804.
   PubMed Web of Science ®Google Scholar
• Hermida RC, Smolensky MH, Ayala DE, Portaluppi F, Crespo JJ, Fabbian F, Haus E, Manfredini R, Mojón A, Moyá A, et al. 2013d. 2013 Ambulatory blood pressure monitoring recommendations for the diagnosis of adult hypertension, assessment of cardiovascular and other hypertension-associated risk, and attainment of therapeutic goals. Joint recommendations from the International Society for Chronobiology (ISC), American Association of Medical Chronobiology and Chronotherapeutics (AAMCC), Spanish Society of Applied Chronobiology, Chronotherapy, and Vascular Risk (SECAC), Spanish Society of Atherosclerosis (SEA), and Romanian Society of Internal Medicine (RSIM). Chronobiol Int. 30:355–410. doi:10.3109/07420528.2013.750490.
   PubMed Web of Science ®Google Scholar
• Law MR, Morris JK, Wald NJ. 2009. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: Meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 338(may19 1):b1665. doi:10.1136/bmj.b1665.
   PubMed Web of Science ®Google Scholar
• Lemmer B, Middeke M. 2020. A commentary of the Spanish hypertension studies MAPEC and Hygia. Chronobiol Int. In press. 1–3. doi:10.1080/07420528.2020.1761374.
   PubMed Web of Science ®Google Scholar
• Piper MA, Evans CV, Burda BU, Margolis KL, O’Connor E, Whitlock EP. 2015. Diagnosis and predictive accuracy of blood pressure screening methods with consideration of rescreening intervals: A systematic review for the U.S. Preventive services task force. Ann Intern Med. 162(3):192–204. doi:10.7326/M14-1539.
   PubMed Web of Science ®Google Scholar
• Roush GC, Fapohunda J, Kostis JB. 2014. Evening dosing of antihypertensive therapy to reduce cardiovascular events: A third type of evidence based on a systematic review and meta-analysis of randomized trials. J Clin Hypertens (Greenwich). 16(8):561–568. doi:10.1111/jch.12354.
   PubMed Web of Science ®Google Scholar
• Schillaci G, Battista F, Settimi L, Schillaci L, Pucci G. 2015. Antihypertensive drug treatment and circadian blood pressure rhythm: A review of the role of chronotherapy in hypertension. Curr Pharm Des. 21(6):756–772. doi:10.2174/1381612820666141024130013.
   PubMed Web of Science ®Google Scholar
• Smolensky MH, Hermida RC, Ayala DE, Portaluppi F. 2015. Bedtime hypertension chronotherapy: Concepts and patient outcomes. Curr Pharm Des. 21(6):773–790. doi:10.2174/1381612820666141024150542.
   PubMed Web of Science ®Google Scholar
• Smolensky MH, Hermida RC, Ayala DE, Tiseo R, Portaluppi F. 2010. Administration-time-dependent effect of blood pressure-lowering medications: Basis for the chronotherapy of hypertension. Blood Press Monit. 15(4):173–180. doi:10.1097/MBP.0b013e32833c7308.
   PubMed Web of Science ®Google Scholar
• Smolensky MH, Hermida RC, Portaluppi F. 2017. Circadian mechanisms of 24-hour blood pressure regulation and patterning. Sleep Med Rev. 33:4–16. doi:10.1016/j.smrv.2016.02.003.
   PubMed Web of Science ®Google Scholar
• Sobiczewski W, Wirthwein M, Gruchala M, Kocic I. 2014. Mortality in hypertensive patients with coronary heart disease depends on chronopharmacotherapy and dipping status. Pharmacol Rep. 66(3):448–452. doi:10.1016/j.pharep.2013.12.009.
   PubMed Web of Science ®Google Scholar
• Stranges PM, Drew AM, Rafferty P, Shuster JE, Brooks AD. 2015. Treatment of hypertension with chronotherapy: Is it time? Ann Pharmacother. 49(3):323–334. doi:10.1177/1060028014563535.
   PubMed Web of Science ®Google Scholar
• Williams B, Mancia G, Spiering W, Rosei EA, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, et al. 2018. 2018 ESC/ESH guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 39:3021–3104. doi:10.1093/eaurheartj/ehy339.
   PubMed Web of Science ®Google Scholar
• Zhao P, Xu P, Wan C, Wang Z. 2011. Evening versus morning dosing regimen drug therapy for hypertension. Cochrane Database Syst Rev. 10:CD004184. doi:10.1002/14651858.CD004184.pub2.
   Google Scholar