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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 37, 2020 - Issue 8
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CHRONOBIOLOGY DISCUSSION FORUM: HYPERTENSION CHRONOBIOLOGY AND CHRONOTHERAPY

Ambulatory blood pressure-based inclusion criteria in the Hygia Chronotherapy Trial. Rebuttal to Lemmer and Middeke

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References

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  • Fernández JR, Mojón A, Hermida RC. 2020. Chronotherapy of hypertension: advantages of 48-h ambulatory blood pressure monitoring assessments in MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. 37(5):739–750. doi:10.1080/07420528.2020.1771355.
  • Hermida RC. 2007. Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy: Rationale and design of the MAPEC study. Chronobiol Int. 24(4):749–775. doi:10.1080/07420520701535837
  • Hermida RC. 2016. Sleep-time ambulatory blood pressure as a prognostic marker of vascular and other risks and therapeutic target for prevention by hypertension chronotherapy: rationale and design of the Hygia project. Chronobiol Int. 33(7):906–936. doi:10.1080/07420528.2016.1181078
  • Hermida RC, Ayala DE, Mojón A, Fernández JR. 2010. Influence of circadian time of hypertension treatment on cardiovascular risk: Results of the MAPEC study. Chronobiol Int. 27:1629–1651. doi:10.3109/07420528.2010.510230.
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  • Hermida RC, Crespo JJ, Otero A, Domínguez-Sardiña M, Moyá A, Ríos MT, Castiñeira MC, Callejas PA, Pousa L, Sineiro E, et al. 2018. Asleep blood pressure: Significant prognostic marker of vascular risk and therapeutic target for prevention. Eur Heart J. 39(47):4159–4171. doi:10.1093/eurheartj/ehy475.
  • Hermida RC, Fernández JR, Mojón A. 2020a. Current evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial. Chronobiol Int. 37(5):751–758. doi:10.1080/07420528.2020.1771356.
  • Hermida RC, Mojón A, Fernández JR; for the Hygia Project Investigators. 2020b. Bedtime hypertension chronotherapy best reduces cardiovascular disease risk as documented by MAPEC and Hygia Chronotherapy outcomes trials. Chronobiol Int. 37(5):731–738. doi:10.1080/07420528.2020.1771354.
  • Kreutz R, Kjeldsen SE, Burnier M, Narkiewicz K, Oparil S, Mancia G. 2020. Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the Hygia project. Blood Press. 29(3):135–136. doi:10.1080/08037051.2020.1747696
  • Lemmer B, Middeke M. 2020a. A commentary of the Spanish hypertension studies MAPEC and Hygia. Chronobiol Int. 37(5):728–730. doi:10.1080/07420528.2020.176374.
  • Lemmer B, Middeke M. 2020b. Insufficient reply by Hermida et al. to the critical comments to the MAPEC and HYGIA studies. Chronobiol Int. In press.
  • Machado AP. (2020). Blood pressure medication should be routinely dosed at bedtime. An Internist’s critical appraisal of the editorial by Rainhold Kreutz et al. (2020). Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Press. 29(3):135–136. doi:10.1080/07420528.2020.1781358.. Chronobiol Int.
  • Middeke M, Lemmer B, Kreutz R, Schrader J. 2020a. Keine generelle abendliche einnahme von antihypertensiva! Arzneiverordnung in der Praxis. 47:95–97.
  • Middeke M, Lemmer B, Kreutz R, Schrader J, Holzgreve H. 2020b. Antihypertensiva nicht generell abends nehmen. MMW Fortschr Med. 162(6):34–36. doi:10.1007/s15006-020-0331-0

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