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Chronobiology International
The Journal of Biological and Medical Rhythm Research
Volume 40, 2023 - Issue 9
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Original article

Melatonin secretion patterns are associated with cognitive vulnerability and brain structure in bipolar depression

, , , , , , , , & show all
Pages 1279-1290 | Received 09 Nov 2022, Accepted 18 Sep 2023, Published online: 02 Oct 2023

References

  • Abé C, Ching CR, Liberg B, Lebedev AV, Agartz I, Akudjedu TN, Alda M, Alnæs D, Alonso-Lana S, Benedetti F. 2022. Longitudinal structural brain changes in bipolar disorder: a multicenter neuroimaging study of 1232 individuals by the ENIGMA bipolar disorder working group. Biol Psychiatry. 91:582–592. doi:10.1016/j.biopsych.2021.09.008.
  • Adan A, Natale V. 2002. Gender differences in morningness-eveningness preference. Chronobiol Int. 19:709–20. doi:10.1081/cbi-120005390.
  • Agresti A. 1996. An introduction to categorical data analysis. New York: wiley.
  • Alghamdi BS. 2018. The neuroprotective role of melatonin in neurological disorders. J Neurosci Res. 96:1136–1149. doi:10.1002/jnr.24220.
  • Amaral FGD, Cipolla-Neto J. 2018. A brief review about melatonin, a pineal hormone. Arch Endocrinol Metab. 62:472–479. doi:10.20945/2359-3997000000066.
  • Arendt J. 2005. Melatonin: Characteristics, concerns, and prospects. J Biol Rhythms. 20:291–303. doi:10.1177/0748730405277492.
  • Barichello T, Giridharan VV, Bhatti G, Sayana P, Doifode T, Macedo D, Quevedo J. 2021. Inflammation as a mechanism of bipolar disorder neuroprogression. Curr Top Behav Neurosci. 48:215–237.
  • Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. 1961. An inventory for measuring depression. Arch Gen Psychiatry. 4:561–571. doi:10.1001/archpsyc.1961.01710120031004.
  • Benedetti F, Colombo C, Pontiggia A, Bernasconi A, Florita M, Smeraldi E. 2003. Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J Clin Psychiatry. 64:648–653. doi:10.4088/JCP.v64n0605.
  • Benedetti F, Melloni EMT, Dallaspezia S, Bollettini I, Locatelli C, Poletti S, Colombo C. 2017. Night sleep influences white matter microstructure in bipolar depression. J Affect Disord. 218:380–387. doi:10.1016/j.jad.2017.05.008.
  • Benedetti F, Radaelli D, Bernasconi A, Dallaspezia S, Falini A, Scotti G, Lorenzi C, Colombo C, Smeraldi E. 2008. Clock genes beyond the clock: CLOCK genotype biases neural correlates of moral valence decision in depressed patients. Genes Brain Behav. 7:20–25. doi:10.1111/j.1601-183X.2007.00312.x.
  • Beyer JL, Kuchibhatla M, Payne M, Moo-Young M, Cassidy F, MacFall J, Krishnan KR. 2004. Caudate volume measurement in older adults with bipolar disorder. Int J Geriatr Psychiatry. 19:109–114. doi:10.1002/gps.1030.
  • Bollettini I, Melloni EM, Aggio V, Poletti S, Lorenzi C, Pirovano A, Vai B, Dallaspezia S, Colombo C, Benedetti F. 2017. Clock genes associate with white matter integrity in depressed bipolar patients. Chronobiol Int. 34:212–224. doi:10.1080/07420528.2016.1260026.
  • Bora E, Fornito A, Yucel M, Pantelis C. 2010. Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry. 67:1097–1105. doi:10.1016/j.biopsych.2010.01.020.
  • Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. 2016. Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Mov Disord. 31:1062–1066. doi:10.1002/mds.26592.
  • Burkhalter H, De Geest S, Wirz-Justice A, Cajochen C. 2016. Melatonin rhythms in renal transplant recipients with sleep-wake disturbances. Chronobiol Int. 33:810–820. doi:10.3109/07420528.2016.1169192.
  • Carpenter JS, Abelmann AC, Hatton SN, Robillard R, Hermens DF, Bennett MR, Lagopoulos J, Hickie IB. 2017. Pineal volume and evening melatonin in young people with affective disorders. Brain Imaging Behav. 11:1741–1750. doi:10.1007/s11682-016-9650-2.
  • Castro-Fornieles J, Bargallo N, Calvo A, Arango C, Baeza I, Gonzalez-Pinto A, Parellada M, Graell M, Moreno C, Otero S, et al. 2018. Gray matter changes and cognitive predictors of 2-year follow-up abnormalities in early-onset first-episode psychosis. Eur Child Adolesc Psychiatry. 27:113–126. doi:10.1007/s00787-017-1013-z.
  • Dallaspezia S, Benedetti F. 2009. Melatonin, circadian rhythms, and the clock genes in bipolar disorder. Curr Psychiatry Rep. 11:488–493. doi:10.1007/s11920-009-0074-1.
  • Dobson AJ. 1990. An introduction to generalized linear models. New York: chapman & Hall. doi:10.1007/978-1-4899-7252-1.
  • Emens J, Lewy A, Kinzie JM, Arntz D, Rough J. 2009. Circadian misalignment in major depressive disorder. Psychiatry Res. 168:259–261. doi:10.1016/j.psychres.2009.04.009.
  • Fang L, Yu Q, Yin F, Yu J, Zhang Y, Zhang Y, Zhu D, Qin X. 2021. Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients. Brain Behav. 11:e02186. doi:10.1002/brb3.2186.
  • Favrais G, Saliba E, Savary L, Bodard S, Gulhan Z, Gressens P, Chalon S. 2021. Partial protective effects of melatonin on developing brain in a rat model of chorioamnionitis. Sci Rep. 11:22167. doi:10.1038/s41598-021-01746-w.
  • Fennell MJ, Campbell EA. 1984. The cognitions questionnaire: Specific thinking errors in depression. Br J Clin Psychol. 23:81–92. doi:10.1111/j.2044-8260.1984.tb00631.x.
  • Hajek T, Carrey N, Alda M. 2005. Neuroanatomical abnormalities as risk factors for bipolar disorder. Bipolar Disord. 7:393–403. doi:10.1111/j.1399-5618.2005.00238.x.
  • Hajek T, Gunde E, Slaney C, Propper L, MacQueen G, Duffy A, Alda M. 2009. Striatal volumes in affected and unaffected relatives of bipolar patients–high-risk study. J Psychiatr Res. 43:724–729. doi:10.1016/j.jpsychires.2008.10.008.
  • Hallam KT, Olver JS, Horgan JE, McGrath C, Norman TR. 2005a. Low doses of lithium carbonate reduce melatonin light sensitivity in healthy volunteers. Int J Neuropsychopharmacol. 8:255–259. doi:10.1017/S1461145704004894.
  • Hallam KT, Olver JS, Norman TR. 2005b. Effect of sodium valproate on nocturnal melatonin sensitivity to light in healthy volunteers. Neuropsychopharmacology. 30:1400–1404. doi:10.1038/sj.npp.1300739.
  • Hamilton M. 1967. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 6:278–296. doi:10.1111/j.2044-8260.1967.tb00530.x.
  • Hatton SN, Lagopoulos J, Hermens DF, Scott E, Hickie IB, Bennett MR. 2013. Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits. Int J Bipolar Disord. 1:3. doi:10.1186/2194-7511-1-3.
  • Haukvik UK, Gurholt TP, Nerland S, Elvsåshagen T, Akudjedu TN, Alda M, Alnæs D, Alonso‐Lana S, Bauer J, Baune BT. 2022. In vivo hippocampal subfield volumes in bipolar disorder—A mega‐analysis from the enhancing neuro Imaging genetics through meta‐analysis bipolar disorder working group. Hum Brain Mapp. 43:385–398. doi:10.1002/hbm.25249.
  • Hibar D, Westlye LT, Doan NT, Jahanshad N, Cheung J, Ching CR, Versace A, Bilderbeck A, Uhlmann A, Mwangi B. 2018. Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA bipolar disorder working group. Mol Psychiatr. 23:932–942. doi:10.1038/mp.2017.73.
  • Hibar DP, Westlye LT, Doan NT, Jahanshad N, Cheung JW, Ching CRK, Versace A, Bilderbeck AC, Uhlmann A, Mwangi B, et al. 2018. Cortical abnormalities in bipolar disorder: An MRI analysis of 6503 individuals from the ENIGMA bipolar disorder working group. Mol Psychiatry. 23:932–942. doi:10.1038/mp.2017.73.
  • Hill T, Lewicki P. 2006. Chapter 18: General linear models. In: Statistics: methods and applications. A comprehensive reference for science, industry, and data mining. Tulsa (OK): StatSoft. p. 245–276.
  • Horne JA, Ostberg O. 1976. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int J Chronobiol. 4:97–110.
  • Jean-Louis G, Kripke DF, Mason WJ, Elliott JA, Youngstedt SD. 2001. Sleep estimation from wrist movement quantified by different actigraphic modalities. J Neurosci Methods. 105:185–191. doi:10.1016/S0165-0270(00)00364-2.
  • Ketchesin KD, Zong W, Hildebrand MA, Seney ML, Cahill KM, Scott MR, Shankar VG, Glausier JR, Lewis DA, Tseng GC. 2021. Diurnal rhythms across the human dorsal and ventral striatum. Proc Natl Acad Sci USA. 118:e2016150118. doi:10.1073/pnas.2016150118.
  • Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. 2002. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 17:181–193. doi:10.1177/074873002129002474.
  • Lancaster TM. 2018. Evidence for association between familial bipolar risk and ventral striatal volume. J Affect Disord. 232:69–72. doi:10.1016/j.jad.2018.02.015.
  • Langer AI, Cangas AJ, Serper M. 2011. Analysis of the multidimensionality of hallucination-like experiences in clinical and nonclinical Spanish samples and their relation to clinical symptoms: implications for the model of continuity. Int J Psychol. 46:46–54. doi:10.1080/00207594.2010.503760.
  • Lee EJ, Lee MY, Chen HY, Hsu YS, Wu TS, Chen ST, Chang GL. 2005. Melatonin attenuates gray and white matter damage in a mouse model of transient focal cerebral ischemia. J Pineal Res. 38:42–52. doi:10.1111/j.1600-079X.2004.00173.x.
  • Lewy AJ. 2009. Circadian misalignment in mood disturbances. Curr Psychiatry Rep. 11:459–465. doi:10.1007/s11920-009-0070-5.
  • Lewy AJ, Lefler BJ, Emens JS, Bauer VK. 2006. The circadian basis of winter depression. Proc Natl Acad Sci USA. 103:7414–7419. doi:10.1073/pnas.0602425103.
  • Lewy AJ, Sack RL. 1989. The dim light melatonin onset as a marker for circadian phase position. Chronobiol Int. 6:93–102. doi:10.3109/07420528909059144.
  • Lyall LM, Wyse CA, Graham N, Ferguson A, Lyall DM, Cullen B, Celis Morales CA, Biello SM, Mackay D, Ward J, et al. 2018. Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank. Lancet Psychiatry. 5:507–514. doi:10.1016/S2215-0366(18)30139-1.
  • McClung CA. 2011. Circadian rhythms and mood regulation: Insights from pre-clinical models. Eur Neuropsychopharmacol. 21:S683–93. doi:10.1016/j.euroneuro.2011.07.008.
  • McClung CA. 2013. How might circadian rhythms control mood? Let me count the ways. Biol Psychiatry. 74:242–249. doi:10.1016/j.biopsych.2013.02.019.
  • McCullagh P, Nelder JA. 1989. Generalized linear models. New York: Chapman and Hall/CRC. doi:10.1201/9780203753736.
  • McKenna BS, Drummond SP, Eyler LT. 2014. Associations between circadian activity rhythms and functional brain abnormalities among euthymic bipolar patients: a preliminary study. J Affect Disord. 164:101–106. doi:10.1016/j.jad.2014.04.034.
  • Meck WH, Penney TB, Pouthas V. 2008. Cortico-striatal representation of time in animals and humans. Curr Opin Neurobiol. 18:145–152. doi:10.1016/j.conb.2008.08.002.
  • Morris G, Stubbs B, Kohler CA, Walder K, Slyepchenko A, Berk M, Carvalho AF. 2018. The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis. Sleep Med Rev. 41:255–265. doi:10.1016/j.smrv.2018.03.007.
  • Murray G, Gottlieb J, Hidalgo MP, Etain B, Ritter P, Skene DJ, Garbazza C, Bullock B, Merikangas K, Zipunnikov V, et al. 2020. Measuring circadian function in bipolar disorders: empirical and conceptual review of physiological, actigraphic, and self-report approaches. Bipolar Disord. 22:693–710. doi:10.1111/bdi.12963.
  • Ng TH, Chung KF, Ho FY, Yeung WF, Yung KP, Lam TH. 2015. Sleep-wake disturbance in interepisode bipolar disorder and high-risk individuals: a systematic review and meta-analysis. Sleep Med Rev. 20:46–58. doi:10.1016/j.smrv.2014.06.006.
  • Nolte I, Lutkhoff AT, Stuck BA, Lemmer B, Schredl M, Findeisen P, Groden C. 2009. Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approach. J Magn Reson Imaging. 30:499–505. doi:10.1002/jmri.21872.
  • Novakova M, Prasko J, Latalova K, Sladek M, Sumova A. 2015. The circadian system of patients with bipolar disorder differs in episodes of mania and depression. Bipolar Disord. 17:303–314. doi:10.1111/bdi.12270.
  • Nurnberger JI Jr., Adkins S, Lahiri DK, Mayeda A, Hu K, Lewy A, Miller A, Bowman ES, Miller MJ, Rau L, et al. 2000. Melatonin suppression by light in euthymic bipolar and unipolar patients. Arch Gen Psychiatry. 57:572–579. doi:10.1001/archpsyc.57.6.572.
  • Palomba M, Bentivoglio M. 2008. Chronic inflammation affects the photic response of the suprachiasmatic nucleus. J Neuroimmunol. 193:24–27. doi:10.1016/j.jneuroim.2007.09.002.
  • Reiter RJ, Tan DX, Galano A. 2014. Melatonin: Exceeding expectations. Physiol (Bethesda). 29:325–333. doi:10.1152/physiol.00011.2014.
  • Robillard R, Carpenter JS, Rogers NL, Fares S, Grierson AB, Hermens DF, Naismith SL, Mullin SJ, Feilds KL, Glozier N, et al. 2018. Circadian rhythms and psychiatric profiles in young adults with unipolar depressive disorders. Transl Psychiatry. 8:213. doi:10.1038/s41398-018-0255-y.
  • Robillard R, Naismith SL, Rogers NL, Scott EM, Ip TK, Hermens DF, Hickie IB. 2013b. Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. Eur Psychiatry. 28:412–416. doi:10.1016/j.eurpsy.2013.04.001.
  • Robillard R, Naismith S, Rogers N, Scott E, Ip T, Hermens DF, Hickie I. 2013a. Sleep-wake cycle and melatonin rhythms in adolescents and young adults with mood disorders: comparison of unipolar and bipolar phenotypes. Eur Psychiatr. 28:412–416. doi:10.1016/j.eurpsy.2013.04.001.
  • Sarlak G, Jenwitheesuk A, Chetsawang B, Govitrapong P. 2013. Effects of melatonin on nervous system aging: neurogenesis and neurodegeneration. J Pharmacol Sci. 123:9–24. doi:10.1254/jphs.13R01SR.
  • Srinivasan V, Smits M, Spence W, Lowe AD, Kayumov L, Pandi-Perumal SR, Parry B, Cardinali DP. 2006. Melatonin in mood disorders. World J Biol Psychiatry. 7:138–151. doi:10.1080/15622970600571822.
  • Stevens MC, Kiehl KA, Pearlson G, Calhoun VD. 2007. Functional neural circuits for mental timekeeping. Hum Brain Mapp. 28:394–408. doi:10.1002/hbm.20285.
  • Terman M, Terman JS. 2005. Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects. CNS Spectr. 10:647–710. doi:10.1017/s1092852900019611.
  • Terman JS, Terman M, Lo ES, Cooper TB. 2001. Circadian time of morning light administration and therapeutic response in winter depression. Arch Gen Psychiatry. 58:69–75. doi:10.1001/archpsyc.58.1.69.
  • Tsai SY, Gildengers AG, Hsu JL, Chung KH, Chen PH, Huang YJ. 2019. Inflammation associated with volume reduction in the gray matter and hippocampus of older patients with bipolar disorder. J Affect Disord. 244:60–66. doi:10.1016/j.jad.2018.10.093.
  • Voultsios A, Kennaway DJ, Dawson D. 1997. Salivary melatonin as a circadian phase marker: validation and comparison to plasma melatonin. J Biol Rhythms. 12:457–466. doi:10.1177/074873049701200507.
  • Wang YP, Gorenstein C. 2013. Psychometric properties of the beck depression inventory-II: a comprehensive review. Braz J Psychiatry. 35:416–431. doi:10.1590/1516-4446-2012-1048.
  • Welsh DK, Takahashi JS, Kay SA. 2010. Suprachiasmatic nucleus: Cell autonomy and network properties. Annu Rev Physiol. 72:551–577. doi:10.1146/annurev-physiol-021909-135919.
  • Wirz-Justice A, Benedetti F, Terman M. 2009. Chronotherapeutics for affective disorders. A clinician’s manual for light and wake therapy. Basel: karger. doi:10.1159/isbn.978-3-8055-9121-8.
  • Wirz-Justice A, Benedetti F, Terman M. 2013. Chronotherapeutics for affective disorders. A clinician’s manual for light and wake therapy. 2nd ed. Karger: basel. doi:10.1159/isbn.978-3-318-02091-5.
  • Wise T, Radua J, Via E, Cardoner N, Abe O, Adams T, Amico F, Cheng Y, Cole J, Périco CDAM. 2017. Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. Mol Psychiatr. 22:1455–1463. doi:10.1038/mp.2016.72.

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