Development and Significance of Cysteamine and Propionitrile Models of Duodenal Ulcer

References

• Brooks F. O. The pathophysiology of peptic ulcer: an overview. Peptic Ulcer Disease, F. P. Brooks, S. Cohen, R. D. Soloway. Churchill Livingstone, New York 1985; 45–149
   Google Scholar
• Wormsley K. G. Duodenal ulcer: does pathophysiology equal aetiology?. Gut 1983; 24: 775–780
   PubMed Web of Science ®Google Scholar
• Szabo S. Biology of disease—pathogenesis of duodenal ulcer disease. Lab Invest 1984; 51: 121–147
   PubMed Web of Science ®Google Scholar
• Selye H. A syndrome produced by diverse nocuous agents. Nature 1936; 138: 32
   Web of Science ®Google Scholar
• Robert A. Experimental production of duodenal ulcers. Biol Gastroenterol 1974; 7: 145–161
   PubMedGoogle Scholar
• Seronde J., Jr. The pathogenesis of duodenal ulcer disease in the pantothenate-deficient rat. Yale J Biol Med 1963; 36: 141–156
   PubMedGoogle Scholar
• Robert A., Stout T. J., Dale J. E. Production by secretagogues of duodenal ulcers in the rat. Gastroenterology 1970; 59: 95–102
   PubMed Web of Science ®Google Scholar
• Okabe S., Pfeiffer C. J. The acetic acid ulcer model: a procedure for chronic duodenal or gastric ulcer. Peptic Ulcer, C. J. Pfeiffer. J. B. Lippincott, Philadelphia 1971; 13–20
   Google Scholar
• Szabo S. Acetanilide toxicity. Hormones and Resistance, H. Selye. Springer. 1971; 179, New York
   Google Scholar
• Szabo S., Selye H. Duodenal ulcers produced by propionitrile in rats. Arch Pathol 1972; 93: 389–390
   Google Scholar
• Selye H., Szabo S. Experimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature 1973; 244: 458–459
   PubMed Web of Science ®Google Scholar
• Selye H. Production of perforating duodenal ulcers by 3,4-toluenediamine in the rat. Proc Soc Exp Biol Med 1973; 142: 1192–119
   PubMed Web of Science ®Google Scholar
• Szabo S. New approach to experimental ulcerogenics production of duodenal ulcer by derivatives of propionitrile and cysteamine. Proc 5th World Congr Gastroenterol. Mexico City 1974
   Google Scholar
• Szabo S., Gallagher G. T. Acute and chronic duodenal ulcers produced by cysteamine or -butyronitrile in the rat. Advances. Experimental Ulcer, S. Umehara, H. Ito. Proc 4th Int Conf Exp Ulcer, TokyoJapan 1980; 116–128
   Google Scholar
• Szabo S., Reynolds E. S., Unger S. H. Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. J Pharmacol Exp Ther 1982; 223: 68–76
   PubMed Web of Science ®Google Scholar
• Szabo S., Horner H. C., Gallagher G. T. Drug-induced duodenal ulcer: structure-activity correlations and pathogenesis. Drugs and Peptic Ulcer, C. J. Pfeiffer. CRC Press, Boca Raton 1982; Vol. 2: 55–74
   Google Scholar
• Szabo S. Animal model of human disease: duodenal ulcer disease: animal model: cysteamine-induced acute and chronic duodenal ulcer in the rat. Am J Pathol 1978; 93: 273–276
   PubMed Web of Science ®Google Scholar
• Poulsen S. S., Olsen P. S., Kirkegaard P. Healing of cysteamine-induced duodenal ulcers in the rat. Dig Dis Sci 1985; 30: 161–167
   PubMed Web of Science ®Google Scholar
• Cahill M. C., Gallagher G. T., Szabo S. Cysteamine induces duodenal ulcer in the mouse. Digestion 1986; 34: 1–8
   PubMedGoogle Scholar
• Smith J. A. The effect of atropine, cimetidine and FPL 52694 on duodenal ulcers in mice. Eur J Pharmacol 1983; 88: 215–221
   PubMedGoogle Scholar
• Morson B. C., Dawson I. M. P. Gastrointestinal Pathology, edn 2. Blackwell, London 1979
   Google Scholar
• Robbins S. L., Cotran R. S. Pathologic Basis of Disease, edn 2. W. B. Saunders, Philadelphia 1979
   Google Scholar
• Sleisenger M. H., Fordtran J. S. Gastrointestinal Disease—Pathophysiology. Diagnosis. Management. W. B. Saunders, Philadelphia 1978
   Google Scholar
• Giampaolo C., Poulsen S. S., Szabo S., Reynolds E. S., Feldman D. Stereomicroscopic and ultrastructural characterization of propionitrile-induced duodenal ulcer in the rat. Lab Invest 1978; 38: 1–7
   PubMedGoogle Scholar
• Poulsen S. S., Szabo S. Mucosal surface morphology and histological changes in the duodenum of the rat following the administration of cysteamine. Br J Exp Pathol 1977; 58: 1–8
   PubMedGoogle Scholar
• Szabo S., Gallagher G. T. Natural history of duodenal ulceration in animal models with cysteamine, propionitrile or n-butyronitrile. Lab Invest 1982; 46: 95A
   Google Scholar
• Tsunoda S., Yabana T. Experimental studies on the pathogenesis of peptic ulcer. On duodenal ulcer caused by cysteamine administration. Sapporo Med J 1980; 49: 281–302
   Google Scholar
• Pfeiffer C. J., Pfeiffer D. C., Szabo S. Early ultrastructural changes in rat duodenal mucosa associated with cysteamine-induced ulcer. Exp Mol Pathol, (in press).
   Google Scholar
• Rotter J. I. Gastric and duodenal ulcer are each many different diseases. Dig Dis Sci 1981; 26: 154–160
   PubMed Web of Science ®Google Scholar
• Robert A., Nezamis J. E., Lancaster C. Duodenal ulcers produced in rats by propionitrile: factors inhibiting and aggravating such ulcers. Toxicol Appl Pharmacol 1975; 31: 201–207
   PubMedGoogle Scholar
• Groves W. G., Schlosser J. H., Mead F. D. Acid hypersecretion and duodenal ulcers produced by cysteamine in rats. Res Commun Chem Pathol Pharmacol 1974; 9: 523–533
   PubMedGoogle Scholar
• Ishii Y., Fujii Y., Homma M. Gastric acid stimulating action of cysteamine in the rat. Eur J Pharmacol 1976; 36: 331–336
   PubMed Web of Science ®Google Scholar
• Borella L. E., Setthaler K., Lippman W. The role of gastric acid and pepsin secretions in theformation of cysteamine-induced duodenal ulcers in rats. Progress in Peptic Ulcer, Gy Mozsik, T. Javor. Akademiai Kiado, Budapest 1976; 585–596
   Google Scholar
• Szabo S., Reynolds E. S., Lichtenberger L. M., Haith L. R., Jr, Dzau V. J. Pathogenesis of duodenal ulcer: gastric hyperacidity caused by propionitrile and cysteamine in rats. Res Commun Chem Pathol Pharmacol 1977; 16: 311–323
   PubMedGoogle Scholar
• Kirkegaard P., Poulsen S. S., Loud F. B., Halse C., Christiansen J. Cysteamine-induced duodenal ulcer and acid secretion in the rat. Scand J Gastroenterol 1980; 15: 621–624
   PubMed Web of Science ®Google Scholar
• Kirkegaard P., Petersen B., Skov Olsen P., Poulsen S. S., Christiansen J. The mechanism of gastrin release in cysteamine-induced duodenal ulcer. Scand J Gastroenterol 1982; 17: 609–612
   PubMed Web of Science ®Google Scholar
• Spina G., Fox U., Glasser A. Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat. Pharmacol Res Commun 1982; 14: 679–686
   PubMedGoogle Scholar
• Szabo S., Haith L. R., Jr, Reynolds E. S. Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile. Influence of vagotomy, sympathectomy, histamine depletion, H-2 receptor antagonists and hormones. Dig Dis Sci 1979; 24: 471–477
   PubMedGoogle Scholar
• Joffe S. N., Bapat R. D. The temporary effect of proximal gastric vagotomy on experimental duodenal ulcers and gastric secretion. Brit J Surg 1979; 66: 234–237
   PubMedGoogle Scholar
• Moraes M. F., Nyhus L. M., Kalahanis N. G., Bombeck C. T., Das Gupta T. K. Role of the sympathetic nervous system in peptic ulcer production in rats. Surgery 1978; 83: 194–199
   PubMed Web of Science ®Google Scholar
• Bickel M. Prevention of duodenal ulcers in the rat by a synthetic prostaglandin analogue and natural prostaglandin E2. IRCS J Med Sci 1979; 7: 409
   Google Scholar
• Borella L. E., Seethaler K., Lippman W. Sucralfate: antipeptic, antiulcer activities and antagonism of gastric emptying. Arzneimittelforsch 1979; 29: 793–798
   PubMedGoogle Scholar
• Hernandez D. E., Adcock J. W., Nemeroff C. B., Prange A. J., Jr. The effect of intracisternally administered bombesin on cysteamine-induced duodenal ulcers in rats. Eur J Pharmacol 1982; 84: 205–209
   PubMedGoogle Scholar
• Ishihara Y., Yamada Y., Hata Y., Okabe S. Species and strain differences in mepirizole-induced duodenal ulcers in rats. Digestion 1983; 27: 29–35
   PubMed Web of Science ®Google Scholar
• Joffe S. N., Gaskin R. J., Barros D'Sa A. A. J., Baron J. H. Prevention of secretagogue-induced ulcers in the rat. Gastroenterology 1976; 70: 751–752
   PubMed Web of Science ®Google Scholar
• Leitold M., Engelhorn R., Schierok H.-J., Seidel H., Eliasson K. Pharmakologische Untersuchungen uber die antiulzerative Wirkung von 5,11-Dihydro-11-[(4-methyl-piperazin-l-yl)-acetyl]-6H-pyrido(2,3-b) (1,4) benzo-diazepin-6-on-dihydrochloride. Therapiewoche 1977; 27: 1532–1548
   Google Scholar
• Murakami M., Oketani K., Fujisaki H., Wakabayashi T., Ohgo T. Antiulcer effect of geranylgeranylacetone, a new acyclic polysoprenoid on experimentally induced gastric and duodenal ulcers in rats. Arzneimettelforsch 1981; 31: 799–804
   PubMed Web of Science ®Google Scholar
• Patricio J., Forgacs A., Germain M., Gremillet C. Influence de la vagotomie supra-selective sur les ulcers gastro-duodenaux par la cysteamine chez la rate. Gastroenterol Clin Biol 1977; 1: 467–471
   PubMedGoogle Scholar
• Rayford P. L., Miller T. A., Thompson J. C. Secretin, cholecystokinin and newer gastrointestinal hormones. N Engl J Med 1976; 294: 1093–1101
   PubMedGoogle Scholar
• Schwedes U., Usadel K., Szabo S. Somatostatin prevents cysteamine-induced duodenal ulcer. Eur J Pharmacol 1977; 44: 195–196
   PubMedGoogle Scholar
• Szabo S. Dopamine disorder in duodenal ulceration. Lancet 1979; 2: 880–882
   PubMedGoogle Scholar
• Szabo S., Neumeyer J. L. Dopamine agonists and antagonists in duodenal ulcer disease. ACS Symposium Series 224, Dopamine Receptors, C. Kaiser, J. W. Kebabian, 1983; 175–196
   Google Scholar
• Szabo S., Sandrock A. W., Nafradi J., Maull E. A., Gallagher G. T., Blyzniuk A. Dopamine and dopamine receptors in the gut—their possible role in duodenal ulceration. Advances in Dopamine Research, M. Kohsaka, T. Shohmori, Y. Tsukada, G. N. Woodruff. Pergamon Press, New York 1982; Vol. 37: 165–170
   Google Scholar
• Joffe S. N., Roberts N. B., Taylor W. H., Baron J. H. Exogenous and endogenous acid and pepsins in the pathogenesis of duodenal ulcers in the rat. Dig Dis Sci 1980; 25: 837–841
   PubMedGoogle Scholar
• Osumi Y., Muramatsu I., Fujiwara M. The effects of destruction of noradrenergic ascending ventral bundles and tetrabenazine on formation of stress-induced gastric ulcer. Eur J Pharmacol 1977; 41: 47–51
   PubMedGoogle Scholar
• Tamaki H., Onoda Y., Kashida T. Gastric secretion and duodenal ulcer formation by cysteamine in rats. Jap J Pharmacol 1978; 28: 647–649
   PubMedGoogle Scholar
• Mangla J. C., Pereira M. Duodenal pepsinogens in experimental duodenal ulcer in rats. Biochem Med 1982; 27: 82–85
   PubMedGoogle Scholar
• Adler R. S., Gallagher G. T., Szabo S. Duodenal ulcerogens cysteamine and propionitrile decrease duodenal neutralization of acid in the rat. Dig Dig Sci 1983; 28: 716–723
   PubMedGoogle Scholar
• Gallagher G. T., Szabo S. Direct measurement of duodenal acid-pepsin exposure at the site of ulceration in rats. Am J Physiol 1984; 246: G660–G665
   Google Scholar
• Ohe K., Okada Y., Fujiwara T., Inoue M., Miyoshi A. Cysteamine-induced inhibition of acid neutralization and the increase in hydrogen ion back-diffusion in duodenal mucosa. Dig Dis Sci 1982; 27: 250–256
   PubMedGoogle Scholar
• Briden S., Flemstrom G., Kivilaakso E. Effects of cysteamine on the duodenal mucosal alkaline response to luminal acid. Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A. Allen, G. Flemstrom, A. Garner, W. Silen, L. A. Turnberg. Raven Press, New York 1984; 189–194
   Google Scholar
• Briden S., Flemstrom G., Kivilaakso E. Cysteamine and propionitrile inhibit the rise of duodenal mucosal alkaline secretion in response to luminal acid in rats. Gastroenterology 1985; 88: 295–302
   PubMedGoogle Scholar
• Kirkegaard P., Poulsen S. S., Halse C., Loud F. B., Skov Olsen P., Christiansen J. The effect of cysteamine on the Brunner gland secretion in the rat. Scand J Gastroenterol 1981; 16: 93–96
   PubMed Web of Science ®Google Scholar
• Pihan G., Gallagher G. T., Szabo S. Biliary and pancreatic secretions influence experimental duodenal ulcer without affecting gastric secretion in the rat. Dig Dis Sci 1985; 30: 240–246
   PubMed Web of Science ®Google Scholar
• Flemstrom G., Garner A. Gastroduodenal HCO3-transport: characteristics and proposed role in acidity regulation and mucosal protection. Am J Physiol 1982; 242: G183–G193
   Google Scholar
• Simson J. N. L., Merhave A., Silen W. Alkaline secretion by amphibian duodenum—I. General characteristics. Am J Physiol 1981; 240: G401–G408
   Google Scholar
• Garner A., Flemstrom G., Heylings J. R., Hurst B. C., Hampson S. E., Hughes C. L. Factors regulating basal HCO3 transport by duodenal epithelia. Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A. Allen, G. Flemstrom, A. Garner, W. Silen, L. A. Turnberg. Raven Press, New York 1984; 153–158
   Google Scholar
• Isenberg J. I., Smedfors B., Johansson C. Effect of graded doses of intraluminal H+, prostaglandin E2, and inhibition of endogenous prostaglandin synthesis on proximal duodenal bicarbonate secretion in unanaesthetized rat. Gastroenterology 1985; 88: 303–307
   PubMed Web of Science ®Google Scholar
• Dieffenbach E., Pihan G., Szabo S. Effect of duodenal ulcerogens cysteamine (C), mepirizole (M), and 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on duodenal bicarbonate in conscious rats. Fed Proc 1986; 45: 338
   Google Scholar
• Peters T. J., Sharp G., Stiel D., Wilkes J. Biochemical basis of bicarbonate secretion by rat duodenal mucosa. Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A. Allen, G. Flemstrom, A. Garner, W. Silen, L. A. Turnberg. Raven Press, New York 1984; 181–187
   Google Scholar
• Simson J. N. L., Merhav A., Silen W. Alkaline secretion by amphibian duodenum—II. Short-circuit current and Na+ and CI− fluxes. Am J Physiol 1981; 240: G472–G479
   PubMedGoogle Scholar
• Dieffenbach E., Budrow J. A., Mainzer H. M., Brown A., Szabo S. Cysteamine decreases brush border enzymes in rat duodenum with possible indirect effect through gastric secretion. Dig Dis Sci 1985; 30: 373
   Google Scholar
• Hartiala K., Ivy A. C., Grossman M. I. Effect of feeding cinchophen on secretion of juice by duodenal glands in dog. Am J Physiol 1950; 162: 110–114
   PubMedGoogle Scholar
• Varro V. Z Inn Med 1975; 30: 624–628, Das experimentelle Ulkus.
   PubMedGoogle Scholar
• Poulsen S. S., Kirkegaard P., Skov Olsen P., Christiansen J. Brunner's glands of the rat during cysteamine ulceration. Scand J Gastroenterol 1981; 16: 459–464
   PubMed Web of Science ®Google Scholar
• Schulz I. Electrolyte and fluid secretion in the exocrine pancrease. Physiology of the Gastrointestinal Tract, L. R. Johnson, J. Christensen, E. D. Jacobson, M. I. Grossman, S. G. Schulta. Raven Press, New York 1981; Vol. 1: 795–820
   Google Scholar
• Konturek S. J. Control and regulation of duodenal acidity. Mechanisms of Mucosal Protection in the Upper Gastrointestinal Tract, A. Allen, G. Flemstrom, A. Garner, W. Wilen, L. A. Turnberg. Raven Press, New York 1984; 159–165
   Google Scholar
• Szabo S., Gallagher G. T. Effects of alkyl nitriles on the gastrointestinal tract. Surv Synth Pathol Res 1984; 3: 11–30
   PubMedGoogle Scholar
• Gallagher G. T., Szabo S. Secretory changes associated with chemically-induced duodenal ulceration: simultaneous measurements of acid, pepsin, base and pancreatic enzymes in rats with chronic gastric fistula. Digestion 1984; 29: 73–84
   PubMedGoogle Scholar
• Barbara L., Corinaldesi R., Baldi F., Stanghellini V. Motor factors: their pathogenetic role in peptic ulcer. Peptic Ulcer Disease—Advances in Pathogenesis and Treatment, G. B. Porro, K. D. Bardhan. Raven Press, New York 1982; 35–39
   Google Scholar
• Lichtenberger L. M., Szabo S., Reynolds E. S. Gastric emptying in the rat is inhibited by the duodenal ulcerogens, cysteamine and propionitrile. Gastroenterology 1977; 73: 1072–1076
   PubMed Web of Science ®Google Scholar
• Pihan G., Kline T. J., Szabo S. Biphasic effect of duodenal ulcerogens cysteamine (C), mepirizole (M) and 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MTPT) on gastric emptying in the rat. Fed Proc 1986; 45: 338
   Google Scholar
• Pihan G., Kline T. J., Neumeyer A. M., Hollenberg N. K., Szabo S. Duodenal ulcerogens, propionitrile (P) and cysteamine (C), influence myoelectric activity of the stomach and proximal duodenum in the rat: a possible role for dopamine. Fed Proc 1983; 42: 1368
   Google Scholar
• Pihan G., Kline T. J., Hollengerg N. K., Szabo S. Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Gastroenterology 1985; 88: 989–997
   PubMed Web of Science ®Google Scholar
• Malagelada J.-R., Larach J. R. Gastric emptying in duodenal ulcer. Scand J Gastroenterol [Suppl. 63] 1980; 15: 115–130
   Google Scholar
• Gallagher G. T., Blyzniuk A., Szabo S. Antisecretory and antiduodenal ulcerogenic actions of bromocriptine and lergotrile in the rat. Gastroenterology 1981; 80: 1152
   Google Scholar
• Szabo S., Gallagher G. T., Blyzniuk A., Maull E. A., Sandrock A. W. Duodenal ulcer and dopamine: new elements in pathogenesis and therapy. Advances in Pharmacology and Therapeutics II, H. Yoshida, Y. Hagihara, S. Ebashi. Pergamon Press, New York 1982; Vol. 5: 263–268, Toxicology and Experimental Models.
   Google Scholar
• Pihan G., Dupuy D., Brown A., Szabo S. Duodenal hypermotility impairs acid neutralization in experimental duodenal ulceration. Gastroenterology 1984; 86: 1210
   Google Scholar
• Szabo S., Pihan G., Gallagher G. T., Brown A. Role of local secretory and motility changes in the pathogenesis of experimental duodenal ulcer. Scand J Gastroenterol 1984; 19, [Suppl 92], 106–111
   Google Scholar
• Szabo S., Horner H. C., Gallagher G. T., Silver E., Hollenber N. K., Reichlin S. Pathogenesis of duodenal ulcer induced by cysteamine and propionitrile in the rat. Fed Proc 1980; 39: 326
   Google Scholar
• Yabana T., Yoshimura Y., Ohta M., Sekiyama N., Yachi A. Effect of cysteamine on the duodenal mucosal blood flow in rats. Defence Mechanism of Gastrointestinal Mucosa—Mucosal Blood Flow, K. Kawai. Kyoto, Japan 1981; 115–121, Proc 2nd Symp
   Google Scholar
• Oishi T., Gallagher G. T., Szabo S. Diurnal variation of duodenal ulcer induced by cysteamine. Gastroenterology 1982; 82: 1139
   Google Scholar
• Szabo S., Pfeiffer S., Oishi T. The chronopharmacology of drug-induced gastric and duodenal ulcers. Ann Rev Chronopharmacol 1986; 3: 383–384
   Google Scholar