MTHFR Polymorphisms in Girls with Anorexia Nervosa: Implications on Body Weight

References

• van Elburg AA, Eijkemans MJC, Kas MJH, et al. Predictors of recovery of ovarian function during weight gain in anorexia nervosa. Fertil Steril. Apr 01, 2007;87(4):902–908. doi:10.1016/j.fertnstert.2006.11.004.
   PubMed Web of Science ®Google Scholar
• Keski-Rahkonen A, Hoek HW, Susser ES, et al. Epidemiology and course of anorexia nervosa in the community. Am J Psychiatry. 2007;164(8):1259–1265. doi:10.1176/appi.ajp.2007.06081388.
   PubMed Web of Science ®Google Scholar
• Fitzpatrick KK, Lock J. Anorexia nervosa. BMJ Clin Evid. 2011;2011:1011.
   PubMedGoogle Scholar
• Schorr M, Miller KK. The endocrine manifestations of anorexia nervosa: mechanisms and management. Nat Rev Endocrinol. 2017;13(3):174–186. doi:10.1038/nrendo.2016.175.
   PubMed Web of Science ®Google Scholar
• Misra M, Golden NH, Katzman DK. State of the art systematic review of bone disease in anorexia nervosa. Int J Eat Disord. 2016;49(3):276–292. doi:10.1002/eat.22451.
   PubMed Web of Science ®Google Scholar
• Moskowitz L, Weiselberg E. Anorexia nervosa/atypical anorexia nervosa. Curr Probl Pediatr Adolesc Health Care. 2017;47(4):70–84. doi:10.1016/j.cppeds.2017.02.003.
   PubMed Web of Science ®Google Scholar
• Keel PK, Brown TA, Holm-Denoma J, Bodell LP. Comparison of DSM-IV versus proposed DSM-5 diagnostic criteria for eating disorders: reduction of eating disorder not otherwise specified and validity. Int J Eat Disord. 2011;44(6):553–560. doi:10.1002/eat.20892.
   PubMed Web of Science ®Google Scholar
• APA. DSM-5 criteria for the diagnosis of anorexia nervosa. http://www.dsm5.org/proposedrevisions/pages.
   Google Scholar
• Himmerich H, Bentley J, Kan C, Treasure J. Genetic risk factors for eating disorders: an update and insights into pathophysiology. Ther Adv Psychopharmacol. 2019;9: 2045125318814734-2045125318814734. doi:10.1177/2045125318814734.
   PubMed Web of Science ®Google Scholar
• Thornton LM, Munn-Chernoff MA, Baker JH, et al. The Anorexia Nervosa Genetics Initiative (ANGI): overview and methods. Contemp Clin Trials. 2018;74:61–69. doi:10.1016/j.cct.2018.09.015.
   PubMed Web of Science ®Google Scholar
• Anying L, Wei H, Qiong Y, Liping P, Qiang L. Expression of the C677T polymorphism of the 5, 10- methylenetetrahydrofolate reductase (MTHFR) gene in patients with carotid artery atherosclerosis. Med Sci Monit. 2020;26:e920320-1-e920320-8.
   Web of Science ®Google Scholar
• Long S. Goldblatt J MTHFR genetic testing: controversy and clinical implications. Aust Family Physician. 2016;45:237–240.
   PubMedGoogle Scholar
• Leal-Ugarte E, Peralta-Leal V, Meza-Espinoza JP, et al. Association of the MTHFR 677C>T polymorphism with obesity and biochemical variables in a young population of Mexico. J Med Biochem. 2019;38(4):461–467. doi:10.2478/jomb-2018-0046.
   PubMed Web of Science ®Google Scholar
• Ellis KJ, Shypailo RJ, Abrams SA, Wong WW . The reference child and adolescent models of body composition. A contemporary comparison. Ann N Y Acad Sci. 2000; 904: 374–382.
   Google Scholar
• Chidiac CW. An update on the medical consequences of anorexia nervosa. Curr Opin Pediatr. 2019;31(4):448–453. doi:10.1097/MOP.0000000000000755.
   PubMed Web of Science ®Google Scholar
• Bhatia P, Singh N. Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression. Fundam Clin Pharmacol. 2015;29(6):522–528. doi:10.1111/fcp.12145.
   PubMed Web of Science ®Google Scholar
• Di Renzo L, Rizzo M, Iacopino L, et al. Body composition phenotype: Italian mediterranean diet and C677T MTHFR gene polymorphism interaction. Eur Rev Med Pharmacol Sci. 2013;17(19):2555–2565.
   PubMed Web of Science ®Google Scholar
• Fan SJ, Yang BY, Zhi XY, et al. Are MTHFR C677T and MTRR A66G polymorphisms associated with overweight/obesity risk? From a case-control to a meta-analysis of 30,327 subjects. Int J Mol Sci. 2015;16(6):11849–11863. doi:10.3390/ijms160611849.
   PubMed Web of Science ®Google Scholar
• Di Renzo L, Bigioni M, Bottini FG, et al. Normal weight obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C–>T genes in the relationship between body composition and resting metabolic rate. Eur Rev Med Pharmacol Sci. 2006;10(5):235–245.
   PubMedGoogle Scholar
• Clifford AJ, Chen K, McWade L, et al. Gender and single nucleotide polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 are significant predictors of plasma homocysteine normalized by RBC folate in healthy adults. J Nutr. 2012;142(9):1764–1771. doi:10.3945/jn.112.160333.
   PubMed Web of Science ®Google Scholar
• Tremolizzo L, Conti E, Bomba M, et al. Decreased whole-blood global DNA methylation is related to serum hormones in anorexia nervosa adolescents. World J Biol Psychiatry. 2014;15(4):327–333. doi:10.3109/15622975.2013.860467.
   PubMed Web of Science ®Google Scholar
• Innis SM, Birmingham CL, Harbottle EJ. Are plasma homocysteine and methionine elevated when binging and purging behavior complicates anorexia nervosa? Evidence against the transdiagnostic theory of eating disorders. Eat Weight Disord. 2009;14(4):e184–189. doi:10.1007/BF03325115.
   PubMed Web of Science ®Google Scholar
• Wilhelm J, Muller E, de Zwaan M, et al. Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders. J Neural Transm. 2010;117(4):521–527. doi:10.1007/s00702-010-0379-6.
   PubMed Web of Science ®Google Scholar
• Rai V. Association of C677T polymorphism (rs1801133) in MTHFR gene with depression. Cell Mol Biol. 2017;63(6):60–67. doi:10.14715/cmb/2017.63.6.13.
   PubMed Web of Science ®Google Scholar
• Cho K, Amin ZM, An J, Rambaran KA, Johnson TB, Alzghari SK. Methylenetetrahydrofolate reductase A1298C polymorphism and major depressive disorder. Cureus. 2017;9(10):e1734.
   Web of Science ®Google Scholar