Are We Only Detecting the Tip of the Iceberg? A Nationwide Study on Primary Aldosteronism with up to 8-Year Follow-up

References

• Rossi GP, Bernini G, Fabris B, et al. Primary aldosteronism (PA) prevalence in Italy (PAPY) study: results of a nationwide survey. Am J Hypertens. May 2005;18(5):235a–235a.
   PubMed Web of Science ®Google Scholar
• Mulatero P, Stowasser M, Loh KC, et al. Extensive personal experience - increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents. J Clin Endocrinol Metab. Mar 2004;89(3):1045–1050. doi:10.1210/jc.2003-031337.
   PubMed Web of Science ®Google Scholar
• Kayser SC, Dekkers T, Groenewoud HJ, et al. Study heterogeneity and estimation of prevalence of primary aldosteronism: a systematic review and meta-regression analysis. J Clin Endocrinol Metab. Jul 2016;101(7):2826–2835. doi:10.1210/jc.2016-1472.
   PubMed Web of Science ®Google Scholar
• Sigurjonsdottir HA, Gronowitz M, Andersson O, et al. Unilateral adrenal hyperplasia is a usual cause of primary hyperaldosteronism. Results from a Swedish screening study. BMC Endocrinol Disord. Sep 8, 2012;12:17. doi:10.1186/1472-6823-12-17.
   PubMed Web of Science ®Google Scholar
• Gordon RD, Stowasser M, Tunny TJ, Klemm SA, Rutherford JC. High incidence of primary aldosteronism in 199 patients referred with hypertension. Clin Exp Pharmacol Physiol. Apr 1994;21(4):315–318. doi:10.1111/j.1440-1681.1994.tb02519.x.
   PubMed Web of Science ®Google Scholar
• Milliez P, Girerd X, Plouin PF, Blacher J, Safar ME, Mourad JJ. Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism. J Am Coll Cardiol. Apr 19, 2005;45(8):1243–1248. doi:10.1016/j.jacc.2005.01.015.
   PubMed Web of Science ®Google Scholar
• Rossi GP, Bernini G, Desideri G, et al. Renal damage in primary aldosteronism: results of the PAPY study. Hypertension. Aug 2006;48(2):232–238. doi:10.1161/01.HYP.0000230444.01215.6a.
   PubMed Web of Science ®Google Scholar
• Born-Frontsberg E, Reincke M, Rump LC, et al. Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic primary aldosteronism: results of the German Conn’s registry. J Clin Endocrinol Metab. Apr 2009;94(4):1125–1130. doi:10.1210/jc.2008-2116.
   PubMed Web of Science ®Google Scholar
• Hung CS, Sung SH, Liao CW, et al. Aldosterone induces vascular damage a wave reflection analysis study. Hypertension. Sep 2019;74(3):623–629. doi:10.1161/Hypertensionaha.118.12342.
   PubMed Web of Science ®Google Scholar
• Schwartz GL. Screening for adrenal-endocrine hypertension: overview of accuracy and cost-effectiveness. Endocrinol Metab Clin North Am. Jun 2011;40(2):279–94, vii. doi:10.1016/j.ecl.2011.02.001.
   PubMed Web of Science ®Google Scholar
• Rutherford JC, Taylor WL, Stowasser M, Gordon RD. Success of surgery for primary aldosteronism judged by residual autonomous aldosterone production. World J Surg. Dec 1998;22(12):1243–1245. doi:10.1007/s002689900552.
   PubMed Web of Science ®Google Scholar
• Sukor N, Kogovsek C, Gordon RD, Robson D, Stowasser M. Improved quality of life, blood pressure, and biochemical status following laparoscopic adrenalectomy for unilateral primary aldosteronism. J Clin Endocrinol Metab. Mar 2010;95(3):1360–1364. doi:10.1210/jc.2009-1763.
   PubMed Web of Science ®Google Scholar
• Rossi GP, Cesari M, Cuspidi C, et al. Long-term control of arterial hypertension and regression of left ventricular hypertrophy with treatment of primary aldosteronism. Hypertension. Jul 2013;62(1):62–69. doi:10.1161/HYPERTENSIONAHA.113.01316.
   PubMed Web of Science ®Google Scholar
• Funder JW, Carey RM, Mantero F, et al. The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. May 2016;101(5):1889–1916. doi:10.1210/jc.2015-4061.
   PubMed Web of Science ®Google Scholar
• Wu VC, Wang SM, Chang CH, et al. Long term outcome of aldosteronism after target treatments. Sci Rep-UK. Sep 2, 2016;6:ARTN 32103. doi:10.1038/srep32103.
   Web of Science ®Google Scholar
• Chen YY, Lin YHH, Huang WC, et al. Adrenalectomy improves the long-term risk of end-stage renal disease and mortality of primary aldosteronism. J Endocrinol Soc. Jun 2019;3(6):1110–1126. doi:10.1210/js.2019-00019.
   PubMed Web of Science ®Google Scholar
• Velema M, Dekkers T, Hermus A, et al. Quality of life in primary aldosteronism: a comparative effectiveness study of adrenalectomy and medical treatment. J Clin Endocrinol Metab. Jan 1, 2018;103(1):16–24. doi: 10.1210/jc.2017-01442.
   PubMed Web of Science ®Google Scholar
• Ahmed AH, Gordon RD, Sukor N, Pimenta E, Stowasser M. Quality of life in patients with bilateral primary aldosteronism before and during treatment with spironolactone and/or amiloride, including a comparison with our previously published results in those with unilateral disease treated surgically. J Clin Endocrinol Metab. Sep 2011;96(9):2904–2911. doi:10.1210/jc.2011-0138.
   PubMed Web of Science ®Google Scholar
• Vorselaars WMCM, Nell S, Postma EL, et al. Clinical outcomes after unilateral adrenalectomy for primary aldosteronism. JAMA Surg. Apr 2019;154(4):ARTN e185842. doi:10.1001/jamasurg.2018.5842.
   Web of Science ®Google Scholar
• Steichen O, Zinzindohoue F, Plouin PF, Amar L. Outcomes of adrenalectomy in patients with unilateral primary aldosteronism: a review. Hormone Metab Res. Mar 2012;44(3):221–227. doi:10.1055/s-0031-1299681.
   PubMed Web of Science ®Google Scholar
• Muth A, Ragnarsson O, Johannsson G, Wangberg B. Systematic review of surgery and outcomes in patients with primary aldosteronism. Br J Surg. Mar 2015;102(4):307–317. doi:10.1002/bjs.9744.
   PubMed Web of Science ®Google Scholar
• Grytaas MA, Stromsoy SS, Rorvik JT, et al. Clinical characteristics and long-term outcome of primary aldosteronism in a Norwegian population. Hormone Metab Res. Nov 2017;49(11):838–846. doi:10.1055/s-0043-118909.
   PubMed Web of Science ®Google Scholar
• Bernini G, Bacca A, Carli V, et al. Cardiovascular changes in patients with primary aldosteronism after surgical or medical treatment. J Endocrinol Invest. Mar 2012;35(3):274–280. doi:10.3275/7611.
   PubMed Web of Science ®Google Scholar
• Park KS, Kim JH, Yang YS, et al. Outcomes analysis of surgical and medical treatments for patients with primary aldosteronism. Endocrinol J. Jun 2017;64(6):623–632. doi:10.1507/endocrj.EJ16-0530.
   PubMed Web of Science ®Google Scholar
• Jonsdottir G, Gudmundsson J, Birgisson G, Sigurjonsdottir HA. Primary aldosteronism: from case detection to histopathology with up to 6 years of follow-up. J Clin Hypertens (Greenwich). Nov 23, 2016. doi:10.1111/jch.12947.
   PubMed Web of Science ®Google Scholar
• Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. Sep 2008;93(9):3266–3281. doi:10.1210/jc.2008-0104.
   PubMed Web of Science ®Google Scholar
• Umakoshi H, Tanase-Nakao K, Wada N, et al. Importance of contralateral aldosterone suppression during adrenal vein sampling in the subtype evaluation of primary aldosteronism. Clin Endocrinol. Oct 2015;83(4):462–467. doi:10.1111/cen.12761.
   PubMed Web of Science ®Google Scholar
• Jakobsson H, Farmaki K, Sakinis A, Ehn O, Johannsson G, Ragnarsson O. Adrenal venous sampling: the learning curve of a single interventionalist with 282 consecutive procedures. Diagn Interv Radiol. Mar–Apr 2018;24(2):89–93. doi:10.5152/dir.2018.17397.
   PubMed Web of Science ®Google Scholar
• Williams TA, Lenders JWM, Mulatero P, et al. Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol. Sep 2017;5(9):689–699. doi:10.1016/S2213-8587(17)30135-3.
   PubMed Web of Science ®Google Scholar
• Rossi GP, Bolognesi M, Rizzoni D, et al. Vascular remodeling and duration of hypertension predict outcome of adrenalectomy in primary aldosteronism patients. Hypertension. May 2008;51(5):1366–1371. doi:10.1161/Hypertensionaha.108.111369.
   PubMed Web of Science ®Google Scholar
• Hung A, Ahmed S, Gupta A, et al. Performance of the aldosterone to renin ratio as a screening test for primary aldosteronism. J Clin Endocrinol Metab. Aug 2021;106(8):2423–2435. doi:10.1210/clinem/dgab348.
   PubMed Web of Science ®Google Scholar
• Stowasser M, Ahmed AH, Pimenta E, Taylor PJ, Gordon RD. Factors affecting the aldosterone/renin ratio. Hormone Metab Res. Mar 2012;44(3):170–176. doi:10.1055/s-0031-1295460.
   PubMed Web of Science ®Google Scholar
• Sawka AM, Young WF, Thompson GB, et al. Primary aldosteronism: factors associated with normalization of blood pressure after surgery. Ann Intern Med. Aug 21, 2001;135(4):258–261. doi: 10.7326/0003-4819-135-4-200108210-00010.
   PubMed Web of Science ®Google Scholar
• Weigel M, Riester A, Hanslik G, et al. Post-saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism. Eur J Endocrinol. Apr 2015;172(4):443–450. doi:10.1530/Eje-14-1013.
   PubMed Web of Science ®Google Scholar
• Nanba AT, Nanba K, Byrd JB, et al. Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism. Clin Endocrinol. Dec 2017;87(6):665–672. doi:10.1111/cen.13442.
   PubMed Web of Science ®Google Scholar
• Young WF, Stanson AW, Thompson GB, Grant CS, Farley DR, van Heerden JA. Role for adrenal venous sampling in primary aldosteronism. Surgery. Dec 2004;136(6):1227–1235. doi:10.1016/j.surg.2004.06.051.
   PubMed Web of Science ®Google Scholar
• Mills KT, Bundy JD, Kelly TN, et al. Global disparities of hypertension prevalence and control: a systematic analysis of population-based studies from 90 countries. Circulation. Aug 9, 2016;134(6):441–450. doi:10.1161/CIRCULATIONAHA.115.018912.
   PubMed Web of Science ®Google Scholar
• Hundemer GL, Curhan GC, Yozamp N, Wang ML, Vaidya A. Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study. Lancet Diabetes Endocrinol. Jan 2018;6(1):51–59. doi:10.1016/S2213-8587(17)30367-4.
   PubMed Web of Science ®Google Scholar