Robert I. Gregerman, MD (1930–2021). An Editorial Reminiscence

References

• Gregerman RI. Robert Isaac Gregerman. Harvard Class of 1951 25th Anniversary Report. Harvard University Alumni Publications: Boston, MA. 1976. 372–374.
   Google Scholar
• Gregerman RI, Gaffney GW, Shock NW. Thyroxine turnover in euthyroid man with special reference to changes with age. J Clin Invest. 1962;41(11):2065–2074. doi:10.1172/JCI104664. PMID: 13950233.
   PubMed Web of Science ®Google Scholar
• Gregerman RI. Mechanisms of age-related alterations of hormone secretion and action. An overview of 30 years of progress. Exp Gerontol. 1986;21(4–5):345–365. doi:10.1016/0531-5565(86)90042-2. PMID: 3028848.
   PubMed Web of Science ®Google Scholar
• Davis FB, LaMantia RX, Spaulding SW, Wehmann RE, Davis PJ. Estimation of a physiologic replacement dose of levothyroxine in elderly patients with hypothyroidism. Arch Intern Med. 1984;144(9):1752–1754. doi:10.1001/archinte.1984.00350210064009. PMID: 6433829.
   PubMedGoogle Scholar
• Jonklaas J, Bianco AC, Bauer AJ, et al. Guidelines for the treatment of hypothyroidism. Prepared by the American Thyroid Association Task Force on Thyroid Hormone Replacement. Thyroid. 2014;24(12):1670–1751. doi:10.1089/thy.2014.0028. PMID: 25266247.
   PubMed Web of Science ®Google Scholar
• Gregerman RI, Solomon N. Acceleration of thyroxine turnover during bacterial pulmonary infections and fever: implications for the functional state of the thyroid during stress and in senescence. J Clin Endocrinol Metab. 1967;27(1):93–105. doi:10.1210/jcem-27-1-93. PMID: 4163768.
   PubMed Web of Science ®Google Scholar
• Lutz JH, Gregerman RI, Spaulding SW, Hornick RB, Alberts AT. Thyroxine binding proteins, free thyroxine and thyroxine turnover interrelationships during acute infectious illness in man 1. J Clin Endocrinol Metab. 1972;35(2):230–249. doi:10.1210/jcem-35-2-230. PMID: 4627324.
   PubMed Web of Science ®Google Scholar
• Spaulding SW, Gregerman RI. Free thyroxine in serum by equilibrium dialysis: effects of dilution, specific ions and inhibitors of binding. J Clin Endocrinol Metab. 1972;34(6):974–982. doi:10.1210/jcem-34-6-974. PMID: 5020425.
   PubMed Web of Science ®Google Scholar
• Wehmann RE, Gregerman RI, Burns WH, Saral R, Santos GW. Suppression of thyrotropin in the low-thyroxine state of severe nonthyroidial illness. N Engl J Med. 1985;312(9):546–552. doi:10.1056/NEJM198502283120904. PMID: 3881675.
   PubMed Web of Science ®Google Scholar
• Boelen A, Langouche L, Wiersinga W, Van den Berghe G. Nonthyroidal illness syndrome. In: Braverman LE, Cooper DS, Kopp PA, eds. Werner & Ingbar’s The Thyroid. A Fundamental and Clinical Text. 11th ed. Baltimore, MD: Wolters Kluwer; 2021:214–229.
   Google Scholar
• Roca RP, Blackman MR, Ackerley MB, Harman SM, Gregerman RI. Thyroid hormone elevations during acute psychiatric illness: relationship to severity and distinction from hyperthyroidism. Endocr Res. 1990;16(4):415–447. doi:10.1080/07435809009107116. PMID: 2129342.
   PubMed Web of Science ®Google Scholar
• Davis PJ, Spaulding SW, Gregerman RI. The three thyroxine-binding proteins in rat serum: binding capacities and effects of binding inhibitors. J Clin Endocrinol Metab. 1970;87(5) :978–986. doi:10.1210/endo-87-5-978. PMID: 4991673.
   Google Scholar
• Davis PJ, Handwerger BS, Gregerman RI. Thyroid hormone binding by human serum prealbumin (TBPA). J Clin Invest. 1972;51(3):515–521. doi:10.1172/JCI106839. PMID: 4110898.
   PubMed Web of Science ®Google Scholar
• Davis PJ, Mousa SA, Lin H-Y. Nongenomic actions of thyroid hormone: the integrin component. Physiol Rev. 2021;101(1):319–352. doi:10.1152/physrev.00038.2019. PMID: 32584192.
   PubMed Web of Science ®Google Scholar
• Gregerman RI. Solitary thyroid nodules. N Engl J Med. 1993;329(5):360. doi:10.1056/NEJM199307293290514. PMID: 8321268
   PubMedGoogle Scholar
• Gregerman RI. Thyroid disorders. In: Barker LR, Burton JR, Zieve PD, eds. Principles of Ambulatory Medicine. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2003:1230–1263.
   Google Scholar
• Weissman PN, Shenkman L, Gregerman RI. Chlorpropamide hyponatremia. Drug-induced inappropriate antidiuretic-hormone activity. N Engl J Med. 1971;284(2):65–71. doi:10.1056/NEJM197101142840202. PMID: 5538636.
   Web of Science ®Google Scholar
• Helderman JH, Vestal RE, Rowe JE, Tobin JD, Andres R, Robertson GL. The response of arginine vasopressin to intravenous ethanol and hypertonic saline in man: the impact of aging. J Gerontol. 1978;33(1):39–47. doi:10.1093/geronj/33.1.39. PMID: 618965.
   PubMedGoogle Scholar
• Gregerman RI, Kowatch MA. Double isotope derivative assay for angiotensin I: use for renin measurement. J Clin Endocrinol Metab. 1971;32(1):110–114. doi:10.1210/jcem-32-1-110. PMID: 4321495.
   PubMed Web of Science ®Google Scholar
• Gregerman RI. Identification of histidylleucine and other histidyl peptides as normal constituents of human urine. Biochem Med. 1967;1(2):151–167. doi:10.1016/0006-2944(67)90004-X.
   Google Scholar
• Robert I. Gregerman. Advancing Gerontology Research. U.S. Medicine. 2000(Aug):38–39
   Google Scholar
• Salomon Y, Londos C, Rodbell M. A highly sensitive adenylate cyclase assay. Anal Biochem. 1974;58(2):541–548. doi:10.1016/0003-2697(74)90222-x. PMID: 4827395.
   PubMed Web of Science ®Google Scholar
• Cooper B, Partilla JS, Gregerman RI. Adenylate cyclase of human fat cells. Expression of epinephrine-sensitive activation revealed by 5’-guanylyl-imidodiphosphate. J Clin Invest. 1975;56(5):1350–1353. doi:10.1016/0005-2744(76)90177-7. PMID: 8140.
   PubMed Web of Science ®Google Scholar
• Cooper B, Gregerman RI. Hormone-sensitive fat cell adenylate cyclase in the rat. Influences of growth, cell size, and aging. J Clin Invest. 1976;57(1):161–168. doi:10.1172/JCI108256. PMID: 173740.
   PubMed Web of Science ®Google Scholar
• Dax EM, Partilla JS, Gregerman RI. Mechanism of the age-related decrease of epinephrine-stimulated lipolysis in isolated rat adipocytes: β-adrenergic receptor binding, adenylate cyclase activity, and cyclic AMP accumulation. J Lipid Res. 1981;22(6):934–943. doi:10.1016/S0022-2275(20)37331-4. PMID: 6268727.
   PubMed Web of Science ®Google Scholar
• Carraro R, Li Z-h, Gregerman RI. Catecholamine-sensitive lipolysis in the rat: different loci for effect of age on the lipolytic cascade in epididymal vs perirenal fat cells. J Gerontol. 1994;49(4):B140–B143. doi:10.1093/geronj/49.4.b140. PMID: 8014385.
   PubMedGoogle Scholar
• Gregerman RI. MINIREVIEW. Aging and hormone-sensitive lipolysis: reconciling the literature. J Gerontol. 1994;49(4):B135–B139. doi:10.1093/geronj/49.4.b135. PMID: 8014384.
   PubMedGoogle Scholar
• Lonnqvist F, Nyberg B, Wahrenberg H, Arner P. Catecholamine-induced lipolysis in adipose tissue of the elderly. J Clin Invest. 1990;85(5):1614–1621. doi:10.1172/JCI114612. PMID: 2159025.
   PubMed Web of Science ®Google Scholar
• Kalish MI, Katz MS, Pineyro MA, Gregerman RI. Epinephrine- and glucagon-sensitive adenylate cyclases of rat liver during aging. Evidence for membrane instability associated with increased enzymatic activity. Biochim Biophys Acta. 1977;483(2):452–466. doi:10.1016/0005-2744(77)90073-0. PMID: 889839.
   PubMedGoogle Scholar
• Dax EM, Partilla JS, Pineyro MA, Gregerman RI. β-Adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging. Endocrinology. 1987;120(4):1534–1541. doi:10.1016/0005-2744(77)90073-0. PMID: 889839.
   PubMed Web of Science ®Google Scholar
• Katz MS, Dax EM, Gregerman RI. Beta adrenergic regulation of rat liver glycogenolysis during aging. Exp Gerontol. 1993;28(4–5):329–340. doi:10.1016/0531-5565(93)90060-q. PMID: 8224032.
   PubMed Web of Science ®Google Scholar
• Shi Y, Pizzini J, Wang H, et al. β2 -Adrenergic receptor agonist induced hepatic steatosis in mice: modeling nonalcoholic fatty liver disease in hyperadrenergic states. Am J Physiol Endocrinol Metab. 2021;321(1):E90–E104. doi:10.1152/ajpendo.00651.2020. PMID: 34029162.
   PubMed Web of Science ®Google Scholar
• Li Z-H, Lu ZD, Kirkland JL, Gregerman RI. Preadipocyte stimulating factor in rat serum: evidence for a discrete 63 kDa protein that promotes cell differentiation of rat preadipocytes in primary cultures. J Cell Physiol. 1989;141(3):543–557. doi:10.1002/jcp.1041410313. PMID: 2687298.
   PubMed Web of Science ®Google Scholar
• Carraro R, Li Z-H, Johnson JE, Gregerman RI. Adipocytes of old rats produce a decreased amount of differentiation factor for preadipocytes derived from adipose tissue islets. J Gerontol. 1992;47(6):B195–B201. doi:10.1093/geronj/47.6.b198. PMID: 1430848.
   Google Scholar
• Sanchez-Hidalgo M, Lu Z, Tan D-X, Maldonado MD, Reiter RJ, Gregerman RI. Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis. Am J Physiol Regul Integr Comp Physiol. 2007;292(6):R2208–R2215. doi:10.1152/ajpregu.00013.2007. PMID: 17379847.
   PubMed Web of Science ®Google Scholar
• Haylett WL, Ferris WF. Adipocyte-progenitor cell communication that influences adipogenesis. Cell Mol Life Sci. 2020;77(1):115–128. doi:10.1007/s00018-019-03256-5. PMID: 31352534.
   PubMed Web of Science ®Google Scholar
• Obituary: Gregerman, Dr. Robert Isaac. The Baltimore Sun. Oct 9, 2021; 11.
   Google Scholar
• Hubbard R, Gregerman RI, Wald G. Geometrical isomers of retinene. J Gen Physiol. 1953;36(3):415–429. doi:10.1085/jgp.36.3.415. PMID: 13022935.
   PubMed Web of Science ®Google Scholar
• Rieland R. Giants of the genome field. Johns Hopkins Magazine. 2022; 74(Spring, No. 1):38–45.
   Google Scholar
• Rudick N. What Is Now Known Was Once Only Imagined: An (Auto)biography of Niki de Saint Phalle. Catskill, NY: siglio. 2022:9–14.
   Google Scholar
• Spiegelman A. Foolish questions. New York Rev Books. 2020; 67(No. 4):9–12.
   Google Scholar
• Davis PJ, Gregerman RI. Parse analysis: a new method for the evaluation of investigators’ bibliographies. N Engl J Med. 1969;281(18):989–990. doi:10.1056/NEJM196910302811805. PMID: 5824741.
   PubMed Web of Science ®Google Scholar
• Davis PJ, Gregerman RI. Parse analysis II. A revised model that accounts for phi. N Engl J Med. 1995;332(14):965–966. doi:10.1056/NEJM199504063321421. PMID: 7877668.
   PubMed Web of Science ®Google Scholar