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Research Article

Platelet–Lymphocyte Ratio, Neutrophil–Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China

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Pages 138-152 | Received 24 Jan 2022, Accepted 13 Sep 2022, Published online: 26 Sep 2022

References

  • Bragg F, Holmes MV, Iona A, et al. Association between diabetes and cause-specific mortality in rural and urban areas of China. JAMA. 2017;317(3):280–289. doi:10.1001/jama.2016.19720.
  • Jia W, Weng J, Zhu D, et al. Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev. 2019;35(6):e3158. doi:10.1002/dmrr.3158.
  • Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014;11(11):1185–1200. doi:10.7150/ijms.10001.
  • Marques-Vidal P, Schmid R, Bochud M, et al. Adipocytokines, hepatic and inflammatory biomarkers and incidence of type 2 diabetes. the CoLaus study. PLoS One. 2012;7(12):e51768. doi:10.1371/journal.pone.0051768.
  • Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. Curr Diab Rep. 2013;13(3):435–444. doi:10.1007/s11892-013-0375-y.
  • Matulewicz N, Karczewska-Kupczewska M. Insulin resistance and chronic inflammation. Postepy Hig Med Dosw (Online). 2016;70(10):1245–1258.
  • Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The platelet-to-lymphocyte ratio as an inflammatory marker in rheumatic diseases. Ann Lab Med. 2019;39(4):345–357. doi:10.3343/alm.2019.39.4.345.
  • Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S. Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 2012;5(1):2. doi:10.1186/1755-7682-5-2.
  • Mertoglu C, Gunay M. Neutrophil-Lymphocyte ratio and Platelet-Lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus. Diabetes Metab Syndr. 2017;11(Suppl 1):S127–S131. doi:10.1016/j.dsx.2016.12.021.
  • Atak B, Aktas G, Duman TT, Erkus E, Kocak MZ, Savli H. Diabetes control could through platelet-to-lymphocyte ratio in hemograms. Rev Assoc Med Bras (1992). 2019;65(1):38–42. doi:10.1590/1806-9282.65.1.38.
  • Mineoka Y, Ishii M, Hashimoto Y, Yamashita A, Nakamura N, Fukui M. Platelet to lymphocyte ratio correlates with diabetic foot risk and foot ulcer in patients with type 2 diabetes. Endocr J. 2019;66(10):905–913. doi:10.1507/endocrj.EJ18-0477.
  • Sefil F, Ulutas KT, Dokuyucu R, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus. J Int Med Res. 2014;42(2):581–588. doi:10.1177/0300060513516944.
  • Posul E, Yilmaz B, Aktas G, Kurt M. Does neutrophil-to-lymphocyte ratio predict active ulcerative colitis? Wien Klin Wochenschr. 2015;127(7–8):262–265. doi:10.1007/s00508-014-0683-5.
  • Polat N, Yildiz A, Yuksel M, et al. Association of neutrophil-lymphocyte ratio with the presence and severity of rheumatic mitral valve stenosis. Clin Appl Thromb Hemost. 2014;20(8):793–798. doi:10.1177/1076029613514131.
  • Aktas G, Sit M, Dikbas O, et al. Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto’s thyroiditis. Rev Assoc Med Bras (1992). 2017;63(12):1065–1068. doi:10.1590/1806-9282.63.12.1065.
  • Gao SQ, Huang LD, Dai RJ, Chen DD, Hu WJ, Shan YF. Neutrophil-lymphocyte ratio: a controversial marker in predicting Crohn’s disease severity. Int J Clin Exp Pathol. 2015;8:14779–14785.
  • Kosekli MA. Mean platelet volume and platelet to lymphocyte count ratio are associated with hepatitis B-related liver fibrosis. Eur J Gastroenterol Hepatol. 2022;34(3):324–327. doi:10.1097/MEG.0000000000002219.
  • Seyit M, Avci E, Nar R, et al. Neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio and platelet to lymphocyte ratio to predict the severity of COVID-19. Am J Emerg Med. 2021;45:569. doi:10.1016/j.ajem.2020.12.069.
  • Prodromidou A, Andreakos P, Kazakos C, Vlachos DE, Perrea D, Pergialiotis V. The diagnostic efficacy of platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in ovarian cancer. Inflamm Res. 2017;66(6):467–475. doi:10.1007/s00011-017-1026-6.
  • Maravilla Dominguez MA, Zermeno Gonzalez ML, Zavaleta Muniz ER, et al. Inflammation and atherogenic markers in patients with type 2 diabetes mellitus. Clin Investig Arterioscler. 2021;34(3):105–112. doi:10.1016/j.arteri.2021.03.006.
  • Vozarova B, Weyer C, Lindsay RS, Pratley RE, Bogardus C, Tataranni PA. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes. 2002;51(2):455–461. doi:10.2337/diabetes.51.2.455.
  • Onalan E, Gozel N, Donder E. Can hematological parameters in type 2 diabetes predict microvascular complication development? Pak J Med Sci. 2019;35(6):1511–1515. doi:10.12669/pjms.35.6.1150.
  • Ye T, Yang Y, Wang K, et al. [Neutrophil to lymphocyte ratio as a predictor for type 2 diabetes mellitus in patients with chronic obstructive pulmonary disease: a cohort study of 404 cases]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37(10):1308–1314.
  • World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. World Medical Association Declaration of Helsinki. Jama. 2013;310(20):2191–2194. doi:10.1001/jama.2013.281053.
  • Joint Committee for Guideline R. 2018 Chinese guidelines for prevention and treatment of hypertension-a report of the revision committee of Chinese guidelines for prevention and treatment of hypertension. J Geriatr Cardiol. 2019;16(3):182–241. doi:10.11909/j.1671-5411.2019.03.014.
  • American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013;36:S67–74.
  • Farrell GC, Chitturi S, Lau GK, Sollano JD. Asia-Pacific Working Party on N. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol. 2007;22(6):775–777. doi:10.1111/j.1440-1746.2007.05002.x.
  • Ramosaj B, Tulowietzki J, Pauly M. On the relation between prediction and imputation accuracy under missing covariates. Entropy (Basel). 2022;24(3):3.doi:10.3390/e24030386.
  • Shin G, Jang K, Kim M, Lee JH, Yoo HJ. Inflammatory markers and plasma fatty acids in predicting WBC level alterations in association with glucose-related markers: a cross-sectional study. Front Immunol. 2020;11:629. doi:10.3389/fimmu.2020.00629.
  • Luo H, He L, Zhang G, et al. Normal reference intervals of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and systemic immune inflammation index in healthy adults: a large multi-center study from Western China. Clin Lab. 2019;65(3):3. doi:10.7754/Clin.Lab.2018.180715.
  • Singh A, Boden G, Rao AK. Tissue factor and Toll-like receptor (TLR)4 in hyperglycaemia-hyperinsulinaemia. Effects in healthy subjects, and type 1 and type 2 diabetes mellitus. Thromb Haemost. 2015;113(4):750–758. doi:10.1160/TH14-10-0884.
  • Rao AK, Freishtat RJ, Jalagadugula G, et al. Alterations in insulin-signaling and coagulation pathways in platelets during hyperglycemia-hyperinsulinemia in healthy non-diabetic subject. Thromb Res. 2014;134(3):704–710. doi:10.1016/j.thromres.2014.06.029.
  • Ter Horst R, Jaeger M, Smeekens SP, et al. Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell. 2016;167(4):1111–1124.e1113. doi:10.1016/j.cell.2016.10.018.
  • Lasarte S, Samaniego R, Salinas-Munoz L, et al. Sex Hormones Coordinate Neutrophil Immunity in the Vagina by Controlling Chemokine Gradients. J Infect Dis. 2016;213(3):476–484. doi:10.1093/infdis/jiv402.
  • DeLoia JA, Stewart-Akers AM, Brekosky J, Kubik CJ. Effects of exogenous estrogen on uterine leukocyte recruitment. Fertil Steril. 2002;77(3):548–554. doi:10.1016/S0015-0282(01)03062-X.
  • Oertelt-Prigione S. The influence of sex and gender on the immune response. Autoimmun Rev. 2012;11(6–7):A479–485. doi:10.1016/j.autrev.2011.11.022.
  • Molloy EJ, O’Neill AJ, Grantham JJ, et al. Sex-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone. Blood. 2003;102(7):2653–2659. doi:10.1182/blood-2003-02-0649.
  • Barrachina MN, Morán LA, Izquierdo I, Casanueva FF, Pardo M, García Á. Analysis of platelets from a diet-induced obesity rat model: elucidating platelet dysfunction in obesity. Sci Rep. 2020;10(1):13104. doi:10.1038/s41598-020-70162-3.
  • Erdal E, İnanir M. Platelet-to-lymphocyte ratio (PLR) and Plateletcrit (PCT) in young patients with morbid obesity. Rev Assoc Med Bras (1992). 2019;65(9):1182–1187. doi:10.1590/1806-9282.65.9.1182.
  • Lou M, Luo P, Tang R, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15(1):9. doi:10.1186/s12902-015-0002-9.
  • Lee CT, Harris SB, Retnakaran R, et al. White blood cell subtypes, insulin resistance and beta-cell dysfunction in high-risk individuals–the PROMISE cohort. Clin Endocrinol (Oxf). 2014;81(4):536–541. doi:10.1111/cen.12390.
  • Yilmaz H, Ucan B, Sayki M, et al. Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity. Diabetes Metab Syndr. 2015;9(4):299–304. doi:10.1016/j.dsx.2014.04.009.
  • Yilmaz H, Celik HT, Namuslu M, et al. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Exp Clin Endocrinol Diabetes. 2014;122(1):39–43. doi:10.1055/s-0033-1361087.
  • Wang JR, Chen Z, Yang K, et al. Association between neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and diabetic retinopathy among diabetic patients without a related family history. Diabetol Metab Syndr. 2020;12(1):55. doi:10.1186/s13098-020-00562-y.
  • Liu S, Zheng H, Zhu X, et al. Neutrophil-to-lymphocyte ratio is associated with diabetic peripheral neuropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2017;130:90–97. doi:10.1016/j.diabres.2017.05.008.
  • Huang X, Qin Z, Xu M, et al. Neutrophil: lymphocyte ratio is positively associated with subclinical diabetic cardiomyopathy. BMC Endocr Disord. 2020;20(1):99. doi:10.1186/s12902-020-00571-y.
  • Guo X, Zhang S, Zhang Q, et al. Neutrophil:lymphocyte ratio is positively related to type 2 diabetes in a large-scale adult population: a Tianjin Chronic Low-Grade Systemic Inflammation and Health cohort study. Eur J Endocrinol. 2015;173(2):217–225. doi:10.1530/EJE-15-0176.
  • Azab B, Camacho-Rivera M, Taioli E. Average values and racial differences of neutrophil lymphocyte ratio among a nationally representative sample of United States subjects. PLoS One. 2014;9(11):e112361. doi:10.1371/journal.pone.0112361.

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