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Original Article

Functional and expression analysis of ovine steroid 11ß-hydroxylase (Cytochrome P45011ß)

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Pages 325-347 | Published online: 07 Aug 2009

References

  • Boon W C, Roche P J, Hammond V E, Jeyaseelan K, Crawford R J, Coghlan J P. Cloning and expression analysis of a cytochrome P-45011ß cDNA in sheep. Biochim Biophys Acta 1995; 1260: 109–112
  • Müller J. Regulation of aldosterone synthesis: Physical and clinical aspects. Monographs on Endocrinology, Vol 29. Springer-Verlag. 1987
  • Kawamoto T, Mitsuuchi Y, Ohnishi T, Ichikawa Y, Yokoyama Y, Sumimoto H, Toda K, Miyahara K, Kuribayashi I, Nakao K, Hosoda K, Yamamoto Y, Imura H, Shizuta Y. Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism. Biochem Biophys Res Commun 1990; 173: 309–316
  • Curnow K M, Tusie-Luna M T, Pascoe L, Natarajan R, Gu J L, Nadler J L, White P C. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Mol Endocrinol 1991; 5: 1513–1522
  • Denner K, Doehmer J, Bernhardt R. Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 chinese hamster cells. Endocr Res 1995; 21: 443–448
  • Kawamoto T, Mitsuuchi Y, Toda K, Miyahara K, Yokoyama Y, Nakao K, Hosoda K, Yamamoto Y, Imura H, Shizuta Y. Cloning of cDNA and genomic DNA for human cytochrome P-45011ß. FEBS Lett 1990; 269: 345–349
  • Nonaka Y, Okamoto M. Functional expression of cDNAs encoding rat 11ß-hydroxylase [cytochrome P-450(11ß)] and aldosterone synthase [cytochrome P-450(11ß,aldo)]. Eur J Biochem 1991; 202: 897–902
  • Domalik L J, Chaplin D D, Kirkman S, Wu R C, Liu W, Howard T A, Seldin M F, Parker K L. Different isozymes of mouse 11ß-hydroxylase produce mineralocorticoids and glucocorticoids. Mol Endocrinol 1991; 5: 1853–1861
  • LeHoux J G, Martel D, Lehoux J, Ducharme L, Lefebvre A, Briére N. P450aldo in hamster adrenal cortex: Immunofluorescent and immuno-gold electron microscopic studies. Endocr Res 1995; 21: 275–280
  • Veronneau S, Bernard H, Cloutier M, Courtmanche J, Ducharme L, Lefebvre A, Mason J I, LeHoux J-G. The hamster adrenal cytochrome P450c11 has equipotent 11ß-hydroxylase and 19-hydroxylase activities but no aldosterone synthase activity. J Steroid Biochem Mol Biol 1996; 57: 125–139
  • Ogishima T, Mitani F, Ishimura Y. Isolation of two distinct cytochrome P-45011ß with aldosterone synthase activity from bovine adrenocortical mitochondria. J Biochem 1989; 105: 497–499
  • Nonaka Y, Okamoto M, Morohashi K, Kirita S, Hashimoto T, Omura T. Functional expression of cDNAs for bovine 11ß-hydroxylase-aldosterone synthases P450(11ß)-2 and -3 and their chimeras. J Steroid Biochem Mol Biol 1992; 41: 779–780
  • Sun T, Zhao Y, Nonaka Y, Okamoto M. Cloning and expression of cytochrome P450(11ß) of porcine adrenal cortex. J Steroid Biochem Mol Biol 1995; 52: 227–232
  • Nonaka Y, Takemori H, Halder S K, Sun T, Ohta M, Hatano O, Takakusu A, Okamoto M. Frog cytochrome P450(11ß,aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis. Eur J Biochem 1995; 229: 249–256
  • Müller J. 11-hydroxylation of 18-hydroxy-11-deoxycorticosterone by rat adrenal tissue: zone specific and effect of sodium and potassium restriction. J Steroid Biochem 1980; 13: 253–257
  • Erdmann B, Denner K, Gerst H, Lenz D, Bernhardt R. Human adrenal CYP11B1: Localization by in situ-hybridization and functional expression in cell cultures. Endocr Res 1995; 21: 425–435
  • Ogishima T, Suzuki H, Hata J-I, Mitani F, Ishimura Y. Zone-specific expression of aldosterone synthase cytochrome P-450 and cytochrome 11ß in rat adrenal cortex: histochemical basis for functional zonation. Endocrinology 1992; 130: 2971–2977
  • Yabu M, Senda T, Nonaka Y, Matsukawa N, Okamoto M, Fujita H. Localization of the gene transcripts of 11ß-hydroxylase and aldosterone synthase in the rat adrenal cortex by in situ hybridization. Histochemistry 1991; 96: 391–394
  • Yanagibashi K, Haniu M, Shively J E, Shen W H, Hall P. The synthesis of aldosterone by the adrenal cortex: two zones (fasciculata and glomerulosa) possess one enzyme for 11ß- 18-hydroxylation and aldehyde synthesis. J Biol Chem 1986; 261: 3556–3562
  • Gluzman Y. SV40-transformed simian cells support the replication of early SV40 mutants. Cell 1981; 23: 175–182
  • Zuber M X, Mason J I, Simpson E R, Waterman M R. Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: Incorporation of a steroidogenic pathway into nonsteroidogenic cells. Proc Natl Acad Sci U.S.A 1988; 85: 699–703
  • Geballe A P, Mocarski E S. Translational control of cytomegalovirus gene expression is mediated by upstream AUG codon. J Virol 1988; 62: 3334–3340
  • Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells. J Mol Biol 1987; 196: 947–950
  • Gauss G H, Lieber M R. DEAE-dextran enhances electroporation of mammalian cells. Nucleic Acids Res 1992; 20: 6739–6740
  • Coghlan J P, Wintour E M, Scoggins B A. The measurement of corticosteroids in adrenal vein blood of sheep. Aust J Exp Biol Med Sci 1966; 44: 639–664
  • Coghlan J P, Scoggins B A. Measurement of aldosterone on peripheral blood of man and sheep. J Clin Endocrinol Metab 1967; 27: 1470–1486
  • McDougall J G, Butkus A, Coghlan J P, Denton D A, Müller J, Oddie C J, Robinson P M, Scoggins B A. Biosynthetic and morphological evidence for inhibition of aldosterone production following administration of ACTH to sheep. Acta Endocr 1980; 94: 559–570
  • Coghlan J P, Aldred P, Haralambidis J, Niall H D, Penschow J D, Tregear G W. Hybridization Histochemistry. Anal Biochem 1985; 149: 1–28
  • Penschow J D. Hybridization histochemistry. Laboratory histopathology, A E Woods, R C Ellis. Churchill Livingstone. 1996; pp. 8.6-1–8.6-36
  • Tangalakis K, Coghlan J P, Connell J, Crawford R, Darling P, Hammond V E, Haralambidis J, Penschow J, Wintour E M. Tissue distribution and levels of gene expression of three steroid hydroxylases in fetal adrenal glands. Acta Endocr 1986; 120: 225–232
  • Curnow K M, Mulatero P, Emeric-Blanchouin N, Aupetit-Faisant B, Corvol P, Pascoe L. The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme [letter]. Nat Struct Biol 1997; 4: 32–35
  • Simpson S A, Tait J F, Wettstein A, Neher R, Euw J V, Reichstein T. Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel. Experientia 1953; 9: 333–335
  • Simpson S A, Tait J F. Secretion of a salt-retaining hormone by the mammalian adrenal cortex. Lancet 1953; 2: 226–228
  • Ohta M, Fujii S, Nonaka Y, Okamoto M. Metabolism of 11–deoxycortisol by cytochrome P450(11ß): Identification of reaction products by 1H-NMR and LC/MS-APCI method. Endocr Res 1995; 21: 477–481
  • Vinson G P, Teja R, Ho M M, Puddefoot J R. A two cell type theory for aldosterone biosynthesis: the roles of 11ß-hydroxylase and aldosterone synthase and a high capacity tightly binding steroid carrier for 18-hydroxydeoxycorticosterone in rat adrenals. J Endocrinol 1995; 144: 359–368
  • Müller J. The conversion of 18-hydroxycorticosterone and 18-hydroxy-11-deoxycorticosterone to aldosterone by rat adrenal tissue: evidence for an alternate biosynthetic pathway. J Steroid Biochem 1980; 13: 245–251
  • Damasco M C, Lantos C P. The existence of two inconvertible forms of 18-hydroxycorticosterone: is one of them the active precursor of aldosterone?. J Steroid Biochem 1975; 6: 69–74
  • Fraser R, Lantos C P. 18-Hydroxycorticosterone: A review. J Steroid Biochem 1978; 9: 273–286
  • Ulick S. Diagnosis and nomenclature of the disorders of the terminal portion of the aldosterone biosynthesis pathway. J Clin Endocrinol Metab 1976; 43: 92–96
  • Ikushiro S, Kominami S, Takemori S. Adrenal cytochrome P-450 11ß-proteoliposomes catalyzing aldosterone synthesis: preparation and characterization. Biochim Biophys Acta 1989; 984: 50–56
  • Maurer R, Reubi H R. Distribution and coregulation of three peptide receptors in adrenals. Eur J Pharmacol 1986; 125: 241–247
  • Bird I M, Zheng J, Corbin C J, Magness R R, Conley A J. Immunohistochemical analysis of AT1 receptor versus P450c17 and 3ßHSD expression in ovine adrenals. Endocr Res 1996; 22: 349–353
  • Ohnishi T, Wada A, Lauber M, Yamano T, Okamoto M. Aldosterone biosynthesis in mitochondria of isolated zones of adrenal cortex. J Steroid Biochem 1988; 31: 73–81
  • McDougall J G, Coghlan J P, McGarry E E, Scoggins B A. Aldosterone production by sheep adrenal glands in vitro. J Steroid Biochem 1976; 7: 421–428

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