Developmental Origins of Health and Disease – from a small body size at birth to epigenetics

References

• Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986;1:1077–81.
   PubMed Web of Science ®Google Scholar
• Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, et al. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991;303:1019–22.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Osmond C, Forsén TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med. 2005;353:1802–9.
   PubMed Web of Science ®Google Scholar
• Whincup PH, Kaye SJ, Owen CG, Huxley R, Cook DG, Anazawa S, et al. Birth weight and risk of type 2 diabetes: a systematic review. JAMA. 2008;300:2886–97.
   PubMed Web of Science ®Google Scholar
• Barker DJ. Fetal origins of coronary heart disease. BMJ. 1995;311:171–4.
   PubMed Web of Science ®Google Scholar
• Lucas AA. role of nutritional programming in determining adult morbidity. Arch Dis Child. 1994;71:288–90.
   PubMed Web of Science ®Google Scholar
• Barker DJ. Developmental origins of adult health and diseases. J Epidemiol Community Health. 2004;58:114–15.
   PubMed Web of Science ®Google Scholar
• Warner MJ, Ozanne SE. Mechanisms involved in the developmental programming of adulthood diseases. Biochem J. 2010;427:333–47.
   PubMed Web of Science ®Google Scholar
• Barraclough CA. Production of anovulatory, sterile rats by single injections of testosterone propionate. Endocrinology. 1961;68:62–7.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Osmond C, Kajantie E, Forsén T, Barker DJ. Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia. 2006;49:2853–8.
   PubMed Web of Science ®Google Scholar
• Osmond C, Kajantie E, Forsén TJ, Eriksson JG, Barker DJ. Infant growth and stroke in adult life: the Helsinki Birth Cohort Study. Stroke. 2007;38:264–70.
   PubMed Web of Science ®Google Scholar
• Ylihärsilä H, Kajantie E, Osmond C, Forsén T, Barker DJ, Eriksson JG. Body mass index during childhood and adult body composition in men and women aged 56–70 y. Am J Clin Nutr. 2008;87:1769–75.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsén T, Tuomilehto J, Winter PD, Osmond C, Barker DJ. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999;318:427–31.
   PubMed Web of Science ®Google Scholar
• Eriksson J, Forsén T, Tuomilehto J, Osmond C, Barker D. Size at birth, fat-free mass and resting metabolic rate in adult life. Horm Metab Res. 2002;34:72–6.
   PubMed Web of Science ®Google Scholar
• Keys A, Aravanis C, Blackburn HW, van Buchem FS, Buzina R, Djordjevic BD, et al. Epidemiological studies related to coronary heart disease: characteristics of men aged 40-59 in seven countries. Acta Med Scand Suppl. 1966;460:1–392.
   PubMedGoogle Scholar
• Eriksson JG, Forsén T, Tuomilehto J, Osmond C, Barker DJ. Early growth and coronary heart disease in later life: longitudinal study. BMJ. 2001;322:949–53.
   PubMed Web of Science ®Google Scholar
• Forsén T, Eriksson JG, Tuomilehto J, Osmond C, Barker DJ. Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ. 1999;319:1403–7.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Kajantie E, Thornburg K, Osmond C. Prenatal and maternal characteristics and later risk for coronary heart disease among women. Eur J Prev Cardiol. 2016;23:385–90.
   PubMed Web of Science ®Google Scholar
• Marmot M, McDowell ME. Mortality decline and widening social inequalities. Lancet. 1986;2(8501):274–6.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Forsén T, Uutela A, Osmond C, Eriksson JG. Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study. BMJ. 2001;323:1273–6.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989;2:577–80.
   PubMed Web of Science ®Google Scholar
• Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res. 2007;61:5R–10R.
   PubMed Web of Science ®Google Scholar
• Zaccardi F, Webb DR, Yates T, Davies MJ. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgrad Med J. 2016;92:63–9.
   PubMed Web of Science ®Google Scholar
• Baz B, Riveline JP, Gautier JF. Endocrinology of pregnancy: gestational diabetes mellitus: definition, aetiological and clinical aspects. Eur J Endocrinol. 2015;174:R43–51.
   PubMed Web of Science ®Google Scholar
• Forsén T, Eriksson J, Tuomilehto J, Reunanen A, Osmond C, Barker D. The fetal and childhood growth of persons who develop type 2 diabetes. Ann Intern Med. 2000;133:176–82.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsen TJ, Osmond C, Barker DJ. Pathways of infant and childhood growth that lead to type 2 diabetes. Diabetes Care. 2003;26:3006–10.
   PubMed Web of Science ®Google Scholar
• Rolland-Cachera MF, Deheeger M, Bellisle F, Sempé M, Guilloud-Bataille M, Patois E. Adiposity rebound in children: a simple indicator for predicting obesity. Am J Clin Nutr. 1984;39:129–35.
   PubMed Web of Science ®Google Scholar
• Rolland-Cachera MF, Deheeger M, Guilloud-Bataille M, Avons P, Patois E, Sempé M. Tracking the development of adiposity from one month of age to adulthood. Ann Hum Biol. 1987;14:219–29.
   PubMed Web of Science ®Google Scholar
• Rolland-Cachera MF. Rate of growth in early life: a predictor of later health? Adv Exp Med Biol. 2005;569:35–9.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsén T, Tuomilehto J, Osmond C, Barker DJ. Early adiposity rebound in childhood and risk of type 2 diabetes in adult life. Diabetologia. 2003;46:190–4.
   PubMed Web of Science ®Google Scholar
• McCance DR, Pettitt DJ, Hanson RL, Jacobsson LT, Knowler WC, Bennett PH. Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ. 1994;308:942–5.
   PubMed Web of Science ®Google Scholar
• Wei JN, Sung FC, Li CY, Chang CH, Lin RS, Lin CC, et al. Low birth weight and high birth weight infants are both at an increased risk to have type 2 diabetes among schoolchildren in Taiwan. Diabetes Care. 2003;26:343–8.
   PubMed Web of Science ®Google Scholar
• Eriksson J, Forsén T, Tuomilehto J, Osmond C, Barker D. Fetal and childhood growth and hypertension in adult life. Hypertension. 2000;36:790–4.
   PubMed Web of Science ®Google Scholar
• Ylihärsilä H, Eriksson JG, Forsén T, Kajantie E, Osmond C, Barker DJ. Self-perpetuating effects of birth size on blood pressure levels in elderly people. Hypertension. 2003;41:446–50.
   PubMed Web of Science ®Google Scholar
• Bruno RM, Faconti L, Taddei S, Ghiadoni L. Birth weight and arterial hypertension. Curr Opin Cardiol. 2015;30:398–402.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Eriksson JG, Forsén T, Osmond C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002;31:1235–9.
   PubMed Web of Science ®Google Scholar
• Barker DJ, Forsén T, Eriksson JG, Osmond C. Growth and living conditions in childhood and hypertension in adult life: a longitudinal study. J Hypertens. 2002;20:1951–6.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsén TJ, Kajantie E, Osmond C, Barker DJ. Childhood growth and hypertension in later life. Hypertension. 2007;49:1415–21.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Forsén T, Tuomilehto J, Osmond C, Barker DJ. Early growth, adult income, and risk of stroke. Stroke. 2000;31:869–74.
   PubMed Web of Science ®Google Scholar
• Bellentani S, Scaglioni F, Marino M, Bedogni G. Epidemiology of non-alcoholic fatty liver disease. Dig Dis. 2010;28:155–61.
   PubMed Web of Science ®Google Scholar
• Puri P, Sanyal AL. Nonalcoholic fatty liver disease: definitions, risk factors, and workup. Clin Liver Dis. 2012;1:98–102.
   Google Scholar
• Sandboge S, Perälä MM, Salonen MK, Blomstedt PA, Osmond C, Kajantie E, et al. Early growth and non-alcoholic fatty liver disease in adulthood – the NAFLD liver fat score and equation applied on the Helsinki Birth Cohort Study. Ann Med. 2013;45:430–7.
   PubMed Web of Science ®Google Scholar
• Hu FB. Diet and lifestyle influences on risk of coronary heart disease. Curr Atheroscler Rep. 2009;11:257–63.
   PubMed Web of Science ®Google Scholar
• Vickers MH, Sloboda DM. Leptin as mediator of the effects of developmental programming. Best Pract Res Clin Endocrinol Metab. 2012;26:677–87.
   PubMed Web of Science ®Google Scholar
• Ellis PJ, Morris TJ, Skinner BM, Sargent CA, Vickers MH, Gluckman PD, et al. Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming. BMC Genomics. 2014;15:49.
   PubMed Web of Science ®Google Scholar
• Salonen MK, Kajantie E, Osmond C, Forsén T, Ylihärsilä H, Paile-Hyvärinen M, et al. Prenatal and childhood growth and leisure time physical activity in adult life. Eur J Public Health. 2011;21:719–24.
   PubMed Web of Science ®Google Scholar
• Salonen MK, Kajantie E, Osmond C, Forsén T, Ylihärsilä H, Paile-Hyvärinen M, et al. Developmental origins of physical fitness: the Helsinki Birth Cohort Study. PLoS One. 2011;6:e22302.
   PubMed Web of Science ®Google Scholar
• Bellinger L, Lilley C, Langley-Evans SC. Prenatal exposure to a maternal low-protein diet programmes a preference for high-fat foods in the young adult rat. Br J Nutr. 2004;92:513–20.
   PubMed Web of Science ®Google Scholar
• Bellinger L, Langley-Evans SC. Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clin Sci. 2005;109:413–20.
   PubMed Web of Science ®Google Scholar
• Garcia AP, Palou M, Priego T, Sanchez J, Palou A, Pico C. Moderate caloric restriction during gestation results in lower arcuate nucleus NPY- and alfa-MSH-neurons and impairs hypothalamic response to fed/fasting conditions in weaned rats. Diabetes Obes Metab. 2010;12:403–13.
   PubMed Web of Science ®Google Scholar
• Lussana F, Painter RC, Ocke MC, Buller HR, Bossuyt PM, Roseboom TJ. Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. Am J Clin Nutr. 2008;88:1648–52.
   PubMed Web of Science ®Google Scholar
• Stein AD, Rundle A, Wada N, Goldbohm RA, Lumey LH. Associations of gestational exposure to famine with energy balance and macronutrient density of the diet at age 58 years differ according to the reference population used. J Nutr. 2009;139:1555–61.
   PubMed Web of Science ®Google Scholar
• Barbieri MA, Portella AK, Silveira PP, Bettiol H, Agranonik M, Silva AA, et al. Severe intrauterine growth restriction is associated with higher spontaneous carbohydrate intake in young women. Pediatr Res. 2009;65:215–20.
   PubMed Web of Science ®Google Scholar
• Perälä MM, Männistö S, Kaartinen NE, Kajantie E, Osmond C, Barker DJ, et al. Body size at birth is associated with food and nutrient intake in adulthood. PLoS One. 2012;7:e46139.
   Google Scholar
• Van Horn L. Dietary sodium and blood pressure: how low should we go? Prog Cardiovasc Dis. 2015;58:61–8.
   PubMed Web of Science ®Google Scholar
• Perälä MM, Moltchanova E, Kaartinen NE, Männistö S, Kajantie E, Osmond C, et al. The association between salt intake and adult systolic blood pressure is modified by birth weight. Am J Clin Nutr. 2011;93:422–6.
   PubMed Web of Science ®Google Scholar
• Räikkönen K, Pesonen AK, Roseboom TJ, Eriksson JG. Early determinants of mental health. Best Pract Res Clin Endocrinol Metab. 2012;26:599–611.
   PubMed Web of Science ®Google Scholar
• Wiesel R. Time does not heal all wounds: quality of life and psychological distress of people who survived the holocaust as children 55 years later. J Trauma Stress. 2003;16:295–9.
   PubMed Web of Science ®Google Scholar
• Afifi TO, Brownridge DA, Cox BJ, Sareen J. Physical punishment, childhood abuse and psychiatric disorders. Child Abuse Neglect. 2006;30:1093–103.
   PubMed Web of Science ®Google Scholar
• Eriksson M, Räikkönen K, Eriksson JG. Early life stress and later health outcomes – findings from the Helsinki Birth Cohort Study. Am J Hum Biol. 2014;26:111–16.
   PubMed Web of Science ®Google Scholar
• von Bonsdorff MB, Rantanen T, Sipilä S, Salonen MK, Kajantie E, Osmond C, et al. Birth size and childhood growth as determinants of physical functioning in older age: the Helsinki Birth Cohort Study. Am J Epidemiol. 2011;174:1336–44.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Osmond C, Perälä MM, Salonen MK, Simonen M, Pohjolainen P, et al. Prenatal and childhood growth and physical performance in old age-findings from the Helsinki Birth Cohort Study 1934–1944. Age (Dordr). 2015;37:108.
   PubMed Web of Science ®Google Scholar
• Heslehurst N, Rankin J, Wilkinson JR, Summerbell CD. A nationally representative study of maternal obesity in England, UK: trends in incidence and demographic inequalities in 619 323 births, 1989–2007. Int J Obes (Lond). 2010;34:420–8.
   PubMed Web of Science ®Google Scholar
• Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307:491–7.
   PubMed Web of Science ®Google Scholar
• Popkin BM, Adair LS, Ng SW. Global nutrition transition and the pandemic of obesity in developing countries. Nutr Rev. 2012;70:3–21.
   PubMed Web of Science ®Google Scholar
• Available at: http://www.worldobesity.org/what-we-do/policy-prevention/worldobesitypublications/reports/ (accessed 11 March 2016)
   Google Scholar
• Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115:e290–6.
   PubMed Web of Science ®Google Scholar
• Roman AS, Rebarber A, Fox NS, Klauser CK, Istwan N, Rhea D, et al. The effect of maternal obesity on pregnancy outcomes in women with gestational diabetes. J Matern Fetal Neonatal Med. 2011;24:723–7.
   PubMed Web of Science ®Google Scholar
• Reynolds RM, Allan KM, Raja EA, Bhattacharya S, McNeill G, Hannaford PC, et al. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years. BMJ. 2013;347:f4539.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Sandboge S, Salonen MK, Kajantie E, Osmond C. Long-term consequences of maternal overweight in pregnancy on offspring later health: findings from the Helsinki Birth Cohort Study. Ann Med. 2014;46:434–8.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Sandboge S, Salonen M, Kajantie E, Osmond C. Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS). Ann Med. 2015;47:94–9.
   PubMed Web of Science ®Google Scholar
• Pal A, McCarthy MI. The genetics of type 2 diabetes and its clinical relevance. Clin Genet. 2013;83:297–306.
   PubMed Web of Science ®Google Scholar
• Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet. 1998;20:282–7.
   Web of Science ®Google Scholar
• Altshuler D, Hirschorn JN, Klannemark M, Lindgreb CM, Vohl MC, Nemesh J, et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet. 2000;26:76–80.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Lindi V, Uusitupa M, Forsen TJ, Laakso M, Osmond C, et al. The effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes. 2002;51:2321–4.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Osmond C, Lindi V, Uusitupa M, Forsen T, Laakso M, et al. Interactions between peroxisome proliferator-activated receptor gene polymorphism and birth length influence risk for type 2 diabetes. Diabetes Care. 2003;26:2476–7.
   PubMed Web of Science ®Google Scholar
• Eriksson J, Lindi V, Uusitupa M, Forsén T, Laakso M, Osmond C, et al. The effects of the Pro12Ala polymorphism of the PPARgamma-2 gene on lipid metabolism interact with body size at birth. Clin Genet. 2003;64:366–70.
   PubMed Web of Science ®Google Scholar
• Pulizzi N, Lyssenko V, Jonsson A, Osmond C, Laakso M, Kajantie E, et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia. 2009;52:825–9.
   PubMed Web of Science ®Google Scholar
• Horikoshi M, Yaghootkar H, Mook-Kanamori DO, Sovio U, Taal HR, Hennig BJ, et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013;45:76–82.
   PubMed Web of Science ®Google Scholar
• Kajantie E, Barker DJ, Osmond C, Forsén T, Eriksson JG. Growth before 2 years of age and serum lipids 60 years later: the Helsinki Birth Cohort Study. Int J Epidemiol. 2008;37:280–9.
   PubMed Web of Science ®Google Scholar
• Perälä MM, Valsta LM, Kajantie E, Leiviskä J, Eriksson JG. Impact of early growth on postprandial responses in later life. PLoS One. 2011;6:e24070.
   Google Scholar
• Perälä MM, Eriksson JG. Early growth and postprandial glucose, insulin, lipid and inflammatory responses in adulthood. Curr Opin Lipidol. 2012;23:327–33.
   PubMed Web of Science ®Google Scholar
• Perälä MM, Kajantie E, Valsta LM, Holst JJ, Leiviskä J, Eriksson JG. Early growth and postprandial appetite regulatory hormone responses. Br J Nutr. 2013;110:1591–600.
   PubMed Web of Science ®Google Scholar
• Ylihärsilä H, Kajantie E, Osmond C, Forsén T, Barker DJ, Eriksson JG. Birth size, adult body composition and muscle strength in later life. Int J Obes (Lond). 2007;31:1392–9.
   PubMed Web of Science ®Google Scholar
• Desai M, Crowther NJ, Ozanne SE, Lucas A, Hales CN. Adult glucose and lipid metabolism may be programmed during fetal life. Biochem Soc Trans. 1995;23:331–5.
   PubMed Web of Science ®Google Scholar
• Luyckx VA, Bertram JF, Brenner BM, Fall C, Hoy WE, Ozanne SE, et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet. 2013;382:273–83.
   PubMed Web of Science ®Google Scholar
• Elezi S, Kastrati A, Neumann FJ, Hadamitzky M, Dirschinger J, Schömig A. Vessel size and long-term outcome after coronary stent placement. Circulation. 1998;98:1875–80.
   PubMed Web of Science ®Google Scholar
• Schunkert H, Harrell L, Palacios IF. Implications of small reference vessel diameter in patients undergoing percutaneous coronary revascularization. J Am Coll Cardiol. 1999;34:40–8.
   PubMed Web of Science ®Google Scholar
• Sheifer SE, Canos MR, Weinfurt KP, Arora UK, Mendelsohn FO, Gersh BJ, et al. Sex differences in coronary artery size assessed by intravascular ultrasound. Am Heart J. 2000;139:649–53.
   PubMed Web of Science ®Google Scholar
• Dodge JT, Jr, Brown BG, Bolson EL, et al. Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation. 1992;86:232–46.
   PubMed Web of Science ®Google Scholar
• Matthews SG. Early programming of the hypothalamo-pituitary-adrenal axis. Trends Endocrinol Metab. 2002;13:373–80.
   PubMed Web of Science ®Google Scholar
• Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci. 2004;1032:63–84.
   PubMed Web of Science ®Google Scholar
• Godfrey KM, Costello PM, Lillycrop KA. The developmental environment, epigenetic biomarkers and long-term health. J Dev Orig Health Dis. 2015;6:399–406.
   PubMed Web of Science ®Google Scholar
• Godfrey KM, Sheppard A, Gluckman PD, Lillycrop KA, Burdge GC, McLean C, et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes. 2011;60:1528–34.
   PubMed Web of Science ®Google Scholar
• Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, et al. Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state. Transl Psychiatry. 2014;4:e448.
   PubMed Web of Science ®Google Scholar
• Painter RC, Roseboom TJ, Bleker OP. Prenatal exposure to the Dutch famine and disease in later life: an overview. Reprod Toxicol. 2005;20:345–52.
   PubMed Web of Science ®Google Scholar
• Eriksson JG, Ylihärsilä H, Forsén T, Osmond C, Barker DJ. Exercise protects against glucose intolerance in individuals with a small body size at birth. Prev Med. 2004;39:164–7.
   PubMed Web of Science ®Google Scholar
• Bucci M, Huovinen V, Guzzardi MA, Koskinen S, Raiko JR, Lipponen H, et al. Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers. Diabetologia. 2016;59:77–86.
   PubMed Web of Science ®Google Scholar