Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence

References

• Douketis JD, Gu CS, Schulman S, et al. The risk for fatal pulmonary embolism after discontinuing anticoagulant therapy for venous thromboembolism. Ann Intern Med. 2007;147:766–774.
   PubMed Web of Science ®Google Scholar
• Fernandez MM, Hogue S, Preblick R, et al. Review of the cost of venous thromboembolism. Clinicoecon Outcomes Res. 2015;7:451–462.
   PubMed Web of Science ®Google Scholar
• Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet. 1999;353:1167–1173.
   PubMed Web of Science ®Google Scholar
• Cohen AT, Agnelli G, Anderson FA, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost. 2007;98:756–764.
   PubMed Web of Science ®Google Scholar
• Cushman M. Epidemiology and risk factors for venous thrombosis. Semin Hematol. 2007;44:62–69.
   PubMed Web of Science ®Google Scholar
• Rosendaal FR. Risk factors for venous thrombotic disease. Thromb Haemost. 1999;82:610–619.
   PubMed Web of Science ®Google Scholar
• Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol. 2015;12:464–474.
   PubMed Web of Science ®Google Scholar
• Rosengren A, Freden M, Hansson PO, et al. Psychosocial factors and venous thromboembolism: a long-term follow-up study of Swedish men. J Thromb Haemost. 2008;6:558–564.
   PubMed Web of Science ®Google Scholar
• Holst AG, Jensen G, Prescott E. Risk factors for venous thromboembolism: results from the Copenhagen City Heart Study. Circulation. 2010;121:1896–1903.
   PubMed Web of Science ®Google Scholar
• Zoller B, Li X, Sundquist J, et al. Socioeconomic and occupational risk factors for venous thromboembolism in Sweden: a nationwide epidemiological study. Thromb Res. 2012;129:577–582.
   PubMed Web of Science ®Google Scholar
• Enga KF, Brækkan SK, Hansen-Krone IJ, et al. Emotional states and future risk of venous thromboembolism: the Tromsø Study. Thromb Haemost. 2012;107:485–493.
   PubMed Web of Science ®Google Scholar
• Austin AW, Wissmann T, von Kanel R. Stress and hemostasis: an update. Semin Thromb Hemost. 2013;39:902–912.
   PubMed Web of Science ®Google Scholar
• Lee CW, Liao CH, Lin CL, et al. Depression and risk of venous thromboembolism: a population-based retrospective cohort study. Psychosom Med. 2015;77:591–598.
   PubMed Web of Science ®Google Scholar
• Wu CS, Chang CM, Chen CY, et al. Association between antidepressants and venous thromboembolism in Taiwan. J Clin Psychopharmacol. 2013;33:31–37.
   PubMed Web of Science ®Google Scholar
• Parkin L, Balkwill A, Sweetland S, et al. Antidepressants, depression, and venous thromboembolism risk: large prospective study of uk women. J Am Heart Assoc. 2017;6:e005316.
   PubMed Web of Science ®Google Scholar
• Parkin L, Skegg DC, Herbison GP, et al. Psychotropic drugs and fatal pulmonary embolism. Pharmacoepidemiol Drug Saf. 2003;12:647–652.
   PubMed Web of Science ®Google Scholar
• Jick SS, Li L. Antidepressant drug use and risk of venous thromboembolism. Pharmacotherapy 2008;28:144–150.
   PubMed Web of Science ®Google Scholar
• Ray JG, Mamdani MM, Yeo EL. Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism. Thromb Haemost. 2002;88:205–209.
   PubMed Web of Science ®Google Scholar
• Lacut K, Le Gal G, Couturaud F, et al. Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case-control study. Fundam Clin Pharmacol. 2007;21:643–650.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6:e1000097.
   PubMed Web of Science ®Google Scholar
• Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008–2012.
   PubMed Web of Science ®Google Scholar
• Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses 2011. Retrieved from www.ohri.ca/programs/clinical_epidemiology/oxford.asp
   Google Scholar
• Cornfield J. A method of estimating comparative rates from clinical data; applications to cancer of the lung, breast, and cervix. J Natl Cancer Inst. 1951;11:1269–1275.
   PubMed Web of Science ®Google Scholar
• DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–188.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–560.
   PubMed Web of Science ®Google Scholar
• Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011;342:d549.
   PubMed Web of Science ®Google Scholar
• Higgins JP, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 2009;172:137–159.
   PubMed Web of Science ®Google Scholar
• Thompson SG, Sharp SJ. Explaining heterogeneity in meta-analysis: a comparison of methods. Stat Med. 1999;18:2693–2708.
   PubMed Web of Science ®Google Scholar
• Reitsma PH, Rosendaal FR. Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study. J Thromb Haemost. 2004;2:619–622.
   PubMed Web of Science ®Google Scholar
• van Aken BE, Reitsma PH, Rosendaal FR. Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis. Br J Haematol. 2002;116:173–177.
   PubMed Web of Science ®Google Scholar
• Branchford BR. Venous thromboembolism risk with antidepressants: driven by disease or drugs?. J Am Heart Assoc. 2017;6:e006293.
   PubMed Web of Science ®Google Scholar
• Orr MW, Boullin DJ. The relationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine. Br J Clin Pharmacol. 1976;3:925–928.
   PubMed Web of Science ®Google Scholar
• Zornberg GL, Jick H. Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study. Lancet. 2000;356:1219–1223.
   PubMed Web of Science ®Google Scholar
• Arnone D, Hansen L, Davies G. Pulmonary embolism and severe depression. Am J Psychiatry. 2002;159:873–874.
   PubMed Web of Science ®Google Scholar
• Penninx BW, Guralnik JM, Ferrucci L, et al. Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry. 2000;157:715–721.
   PubMed Web of Science ®Google Scholar
• Ray JG. Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease. Arch Intern Med. 1998;158:2101–2106.
   PubMed Web of Science ®Google Scholar
• Musselman DL, Tomer A, Manatunga AK, et al. Exaggerated platelet reactivity in major depression. Am J Psychiatry. 1996;153:1313–1317.
   PubMed Web of Science ®Google Scholar
• Ferrari AJ, Charlson FJ, Norman RE, et al. Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med. 2013;10:e1001547.
   PubMed Web of Science ®Google Scholar
• Olfson M, Marcus SC. National patterns in antidepressant medication treatment. Arch Gen Psychiatry. 2009;66:848–856.
   PubMed Web of Science ®Google Scholar
• Ilyas S, Moncrieff J. Trends in prescriptions and costs of drugs for mental disorders in England, 1998-2010. Br J Psychiatry. 2012;200:393–398.
   PubMed Web of Science ®Google Scholar