Microparticles and cardiovascular diseases

References

• Conde-Vancells J, Rodriguez-Suarez E, Embade N, et al. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res. 2008;7:5157–5166.
   PubMed Web of Science ®Google Scholar
• van der Pol E, Böing AN, Harrison P, et al. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev. 2012;64:676–705.
   PubMed Web of Science ®Google Scholar
• Wu ZH, Ji CL, Li H, et al. Membrane microparticles and diseases. Eur Rev Med Pharmacol Sci. 2013;17:2420–2427.
   PubMed Web of Science ®Google Scholar
• Shantsila E, Kamphuisen PW, Lip G. Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis. J Thromb Haemost. 2010;8:2358–2368.
   PubMed Web of Science ®Google Scholar
• Dinkla S, Brock R, Joosten I, et al. Gateway to understanding microparticles: standardized isolation and identification of plasma membrane-derived vesicles. Nanomedicine (Lond). 2013;8:1657–1668.
   PubMed Web of Science ®Google Scholar
• Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750.
   PubMed Web of Science ®Google Scholar
• Pilzer D, Gasser O, Moskovich O, et al. Emission of membrane vesicles: roles in complement resistance, immunity and cancer. Springer Semin Immun. 2005;27:375–387.
   PubMed Web of Science ®Google Scholar
• The fourth international meeting of ISEV, ISEV2015. J Extracell vesicles. 2015;4:27783.
   PubMed Web of Science ®Google Scholar
• Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495–516.
   PubMed Web of Science ®Google Scholar
• Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907–1920.
   PubMed Web of Science ®Google Scholar
• van der Pol E, Böing AN, Gool EL, et al. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost. 2016;14(1):48–56.
   Web of Science ®Google Scholar
• Beyer C, Pisetsky DS. The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol. 2010;6:21–29.
   PubMed Web of Science ®Google Scholar
• Flaumenhaft R, Dilks JR, Richardson J, et al. Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood. 2008;113:1112–1121.
   PubMed Web of Science ®Google Scholar
• Moulin VJ, Mayrand D, Messier H, et al. Shedding of microparticles by myofibroblasts as mediator of cellular cross-talk during normal wound healing. J Cell Physiol. 2010;225:734–740.
   PubMed Web of Science ®Google Scholar
• Castellana D, Zobairi F, Martinez MC, et al. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res. 2009;69:785–793.
   PubMed Web of Science ®Google Scholar
• Beaudoin AR, Grondin G. Shedding of vesicular material from the cell surface of eukaryotic cells: different cellular phenomena. Biochim Biophys Acta. 1991;1071:203–219.
   PubMedGoogle Scholar
• Zhang HC, Liu XB, Huang S, et al. Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo. Stem Cells Dev. 2012;21:3289–3297.
   PubMed Web of Science ®Google Scholar
• Chen YW, Chen YC, Wang JS. Absolute hypoxic exercise training enhances in vitro thrombin generation by increasing procoagulant platelet-derived microparticles under high shear stress in sedentary men. Clin Sci. 2013;124:639–649.
   PubMed Web of Science ®Google Scholar
• Lee SK, Yang SH, Kwon I, et al. Role of tumour necrosis factor receptor-1 and nuclear factor-κB in production of TNF-α-induced pro-inflammatory microparticles in endothelial cells. Thromb Haemost. 2014;112:580–588.
   PubMed Web of Science ®Google Scholar
• Rautou PE, Vion AC, Amabile N, et al. Microparticles, vascular function, and atherothrombosis. Circ Res. 2011;109:593–606.
   PubMed Web of Science ®Google Scholar
• Burger D, Schock S, Thompson CS, et al. Microparticles: biomarkers and beyond. Clin Sci. 2013;124:423–441.
   PubMed Web of Science ®Google Scholar
• Ratajczak J, Wysoczynski M, Hayek F, et al. Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia. 2006;20:1487–1495.
   PubMed Web of Science ®Google Scholar
• Freyssinet JM, Toti F. Formation of procoagulant microparticles and properties. Thromb Res. 2010;125:S46–S48.
   PubMed Web of Science ®Google Scholar
• Manno S, Takakuwa Y, Mohandas N. Identification of a functional role for lipid asymmetry in biological membranes: phosphatidylserine-skeletal protein interactions modulate membrane stability. Proc Natl Acad Sci USA. 2002;99:1943–1948.
   PubMed Web of Science ®Google Scholar
• Daleke DL. Regulation of transbilayer plasma membrane phospholipid asymmetry. J Lipid Res. 2003;44:233–242.
   PubMed Web of Science ®Google Scholar
• Bevers EM, Williamson PL. Phospholipid scramblase: an update. FEBS Lett. 2010;584:2724–2730.
   PubMed Web of Science ®Google Scholar
• Raphael RM, Waugh RE, Svetina S, et al. Fractional occurrence of defects in membranes and mechanically driven interleaflet phospholipid transport. Phys Rev E Stat Nonlin Soft Matter Phys. 2001;64:051913.
   PubMed Web of Science ®Google Scholar
• Yan R, Wang Z, Yuan Y, et al. Role of cAMP-dependent protein kinase in the regulation of platelet procoagulant activity. Arch Biochem Biophys. 2009;485:41–48.
   PubMed Web of Science ®Google Scholar
• Miyoshi H, Umeshita K, Sakon M, et al. Calpain activation in plasma membrane bleb formation during tert-butyl hydroperoxide-induced rat hepatocyte injury. Gastroenterology. 1996;110:1897–1904.
   PubMed Web of Science ®Google Scholar
• Cauwenberghs S, Feijge MAH, Harper AGS, et al. Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton. FEBS Lett. 2006;580:5313–5320.
   PubMed Web of Science ®Google Scholar
• Sebbagh M, Renvoizé C, Hamelin J, et al. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol. 2001;3:346–352.
   PubMed Web of Science ®Google Scholar
• Sapet C, Simoncini S, Loriod B, et al. Thrombin-induced endothelial microparticle generation: identification of a novel pathway involving ROCK-II activation by caspase-2. Blood. 2006;108:1868–1876.
   PubMed Web of Science ®Google Scholar
• Coleman ML, Sahai EA, Yeo M, et al. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol. 2001;3:339–345.
   PubMed Web of Science ®Google Scholar
• Zwaal RFA, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci. 2005;62:971–988.
   PubMed Web of Science ®Google Scholar
• Hugel B, Martínez MC, Kunzelmann C, et al. Membrane microparticles: two sides of the coin. Physiology (Bethesda). 2005;20:22–27.
   PubMed Web of Science ®Google Scholar
• Hargett LA, Bauer NN. On the origin of microparticles: from “platelet dust” to mediators of intercellular communication. Pulm Circ. 2013;3:329–340.
   PubMed Web of Science ®Google Scholar
• Bucki R, Pastore JJ, Giraud F, et al. Involvement of the Na+/H + exchanger in membrane phosphatidylserine exposure during human platelet activation. Biochim Biophys Acta. 2006;1761:195–204.
   PubMed Web of Science ®Google Scholar
• Deregibus MC, Cantaluppi V, Calogero R, et al. Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood. 2007;110:2440–2448.
   PubMed Web of Science ®Google Scholar
• Fox JE, Austin CD, Boyles JK, et al. Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membrane. J Cell Biol. 1990;111:483–493.
   PubMed Web of Science ®Google Scholar
• Biró E, Akkerman JWN, Hoek FJ, et al. The phospholipid composition and cholesterol content of platelet-derived microparticles: a comparison with platelet membrane fractions. J Thromb Haemost. 2005;3:2754–2763.
   PubMed Web of Science ®Google Scholar
• György B, Szabó TG, Pásztói M, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68:2667–2688.
   PubMed Web of Science ®Google Scholar
• Raimondo F, Morosi L, Chinello C, et al. Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery. Proteomics. 2011;11:709–720.
   PubMed Web of Science ®Google Scholar
• Scanu A, Molnarfi N, Brandt KJ, et al. Stimulated T cells generate microparticles, which mimic cellular contact activation of human monocytes: differential regulation of pro- and anti-inflammatory cytokine production by high-density lipoproteins. J Leukoc Biol. 2008;83:921–927.
   PubMed Web of Science ®Google Scholar
• Bratton DL, Fadok VA, Richter DA, et al. Appearance of phosphatidylserine on apoptotic cells requires calcium-mediated nonspecific flip-flop and is enhanced by loss of the aminophospholipid translocase. J Biol Chem. 1997;272:26159–26165.
   PubMed Web of Science ®Google Scholar
• Weerheim AM, Kolb AM, Sturk A, et al. Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography. Anal Biochem. 2002;302:191–198.
   PubMed Web of Science ®Google Scholar
• Liu ML, Reilly MP, Casasanto P, et al. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles. Arterioscler Thromb Vasc Biol. 2007;27:430–435.
   PubMed Web of Science ®Google Scholar
• Heijnen HF, Schiel AE, Fijnheer R, et al. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood. 1999;94:3791–3799.
   PubMed Web of Science ®Google Scholar
• Del Conde I, Shrimpton CN, Thiagarajan P, et al. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood. 2005;106:1604–1611.
   PubMed Web of Science ®Google Scholar
• Sims PJ, Faioni EM, Wiedmer T, et al. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J Biol Chem. 1988;263:18205–18212.
   PubMed Web of Science ®Google Scholar
• Horstman LL, Jy W, Jimenez JJ, et al. New horizons in the analysis of circulating cell-derived microparticles. Keio J Med. 2004;53:210–230.
   PubMedGoogle Scholar
• Gasser O, Hess C, Miot S, et al. Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp Cell Res. 2003;285:243–257.
   PubMed Web of Science ®Google Scholar
• Jimenez JJ, Jy W, Mauro LM, et al. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res. 2003;109:175–180.
   PubMed Web of Science ®Google Scholar
• Teruel R, Corral J, Pérez-Andreu V, et al. Potential role of miRNAs in developmental haemostasis. PLoS One. 2011;6:e17648.
   PubMed Web of Science ®Google Scholar
• Jung KH, Chu K, Lee ST, et al. Risk of macrovascular complications in type 2 diabetes mellitus: endothelial microparticle profiles. Cerebrovasc Dis. 2011;31:485–493.
   PubMed Web of Science ®Google Scholar
• Feng B, Chen Y, Luo Y, et al. Circulating level of microparticles and their correlation with arterial elasticity and endothelium-dependent dilation in patients with type 2 diabetes mellitus. Atherosclerosis. 2010;208:264–269.
   PubMed Web of Science ®Google Scholar
• Berezin AE, Kremzer AA, Martovitskaya YV, et al. Pattern of endothelial progenitor cells and apoptotic endothelial cell-derived microparticles in chronic heart failure patients with preserved and reduced left ventricular ejection fraction. EBioMedicine. 2016;4:86–94.
   PubMed Web of Science ®Google Scholar
• Bernard S, Loffroy R, Sérusclat A, et al. Increased levels of endothelial microparticles CD144 (VE-Cadherin) positives in type 2 diabetic patients with coronary noncalcified plaques evaluated by multidetector computed tomography (MDCT). Atherosclerosis. 2009;203:429–435.
   PubMed Web of Science ®Google Scholar
• Stępień E, Stankiewicz E, Zalewski J, et al. Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation. Arch Med Res. 2012;43:31–35.
   PubMed Web of Science ®Google Scholar
• Sabatier F, Darmon P, Hugel B, et al. Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes. 2002;51:2840–2845.
   PubMed Web of Science ®Google Scholar
• Berezin AE, Kremzer AA, Berezina TA, et al. Pattern of circulating microparticles in chronic heart failure patients with metabolic syndrome: relevance to neurohumoral and inflammatory activation. BBA Clin. 2015;4:69–75.
   PubMed Web of Science ®Google Scholar
• Terrisse A, Puech N, Allart S, et al. Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow. J Thromb Haemost. 2010;8:2810–2819.
   PubMed Web of Science ®Google Scholar
• Sansone R, Stanske B, Keymel S, et al. Macrovascular and microvascular function after implantation of left ventricular assist devices in end-stage heart failure: role of microparticles. J Heart Lung Transplant. 2015;34:921–932.
   PubMed Web of Science ®Google Scholar
• Cheng V, Kashyap SR, Schauer PR, et al. Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles. Surg Obes Relat Dis. 2013;9:207–212.
   PubMed Web of Science ®Google Scholar
• Diamant M, Nieuwland R, Pablo RF, et al. Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus. Circulation. 2002;106:2442–2447.
   PubMed Web of Science ®Google Scholar
• Martínez MC, Larbret F, Zobairi F, et al. Transfer of differentiation signal by membrane microvesicles harboring hedgehog morphogens. Blood. 2006;108:3012–3020.
   PubMed Web of Science ®Google Scholar
• Pluskota E, Woody NM, Szpak D, et al. Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles. Blood. 2008;112:2327–2335.
   PubMed Web of Science ®Google Scholar
• Bernimoulin M, Waters EK, Foy M, et al. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009;7:1019–1028.
   PubMed Web of Science ®Google Scholar
• Reich CF, Pisetsky DS. The content of DNA and RNA in microparticles released by Jurkat and HL-60 cells undergoing in vitro apoptosis. Exp Cell Res. 2009;315:760–768.
   PubMed Web of Science ®Google Scholar
• Diehl P, Fricke A, Sander L, et al. Microparticles: major transport vehicles for distinct microRNAs in circulation. Cardiovasc Res. 2012;93:633–644.
   PubMed Web of Science ®Google Scholar
• Risitano A, Beaulieu LM, Vitseva O, et al. Platelets and platelet-like particles mediate intercellular RNA transfer. Blood. 2012;119:6288–6295.
   PubMed Web of Science ®Google Scholar
• Sommeijer D, Joop K, Leyte A, et al. Pravastatin reduces fibrinogen receptor gpIIIa on platelet-derived microparticles in patients with type 2 diabetes. J Thromb Haemost. 2005;3:1168–1171.
   PubMed Web of Science ®Google Scholar
• Mack M, Kleinschmidt A, Brühl H, et al. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med. 2000;6:769–775.
   PubMed Web of Science ®Google Scholar
• Rozmyslowicz T, Majka M, Kijowski J, et al. Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS. 2003;17:33–42.
   PubMed Web of Science ®Google Scholar
• Mause SF, Ritzel E, Liehn EA, et al. Platelet microparticles enhance the vasoregenerative potential of angiogenic early outgrowth cells after vascular injury. Circulation. 2010;122:495–506.
   PubMed Web of Science ®Google Scholar
• Salanova B, Choi M, Rolle S, et al. Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils. J Biol Chem. 2007;282:27960–27969.
   PubMed Web of Science ®Google Scholar
• Al-Nedawi K, Meehan B, Micallef J, et al. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol. 2008;10:619–624.
   PubMed Web of Science ®Google Scholar
• Whale TA, Wilson HL, Tikoo SK, et al. Passively acquired membrane proteins alter the functional capacity of bovine polymorphonuclear cells. J Leukoc Biol. 2006;80:481–491.
   PubMed Web of Science ®Google Scholar
• Ray DM, Spinelli SL, Pollock SJ, et al. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008;99:86–95.
   PubMed Web of Science ®Google Scholar
• MacKenzie A, Wilson HL, Kiss-Toth E, et al. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity. 2001 ;15:825–835.
   PubMed Web of Science ®Google Scholar
• Bianco F, Pravettoni E, Colombo A, et al. Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol. 2005;174:7268–7277.
   PubMed Web of Science ®Google Scholar
• Pizzirani C, Ferrari D, Chiozzi P, et al. Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood. 2007;109:3856–3864.
   PubMed Web of Science ®Google Scholar
• Lindemann S, Tolley ND, Dixon DA, et al. Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol. 2001;154:485–490.
   PubMed Web of Science ®Google Scholar
• Mause SF, von Hundelshausen P, Zernecke A, et al. Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol. 2005;25:1512–1518.
   PubMed Web of Science ®Google Scholar
• Kim HK, Song KS, Chung JH, et al. Platelet microparticles induce angiogenesis in vitro. Br J Haematol. 2004;124:376–384.
   PubMed Web of Science ®Google Scholar
• Taraboletti G, D’Ascenzo S, Giusti I, et al. Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH. Neoplasia. 2006;8:96–103.
   PubMed Web of Science ®Google Scholar
• Brill A, Dashevsky O, Rivo J, et al. Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovasc Res. 2005;67:30–38.
   PubMed Web of Science ®Google Scholar
• Sidhu SS, Mengistab AT, Tauscher AN, et al. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene. 2004;23:956–963.
   PubMed Web of Science ®Google Scholar
• Sarkar A, Mitra S, Mehta S, et al. Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. Unutmaz D, editor. PLoS One. 2009;4:e7140.
   Google Scholar
• Barry OP, Pratico D, Lawson JA, et al. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J Clin Invest. 1997;99:2118–2127.
   PubMed Web of Science ®Google Scholar
• Barry OP, Kazanietz MG, Praticò D, et al. Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. J Biol Chem. 1999;274:7545–7556.
   PubMed Web of Science ®Google Scholar
• Barry OP, Praticò D, Savani RC, et al. Modulation of monocyte-endothelial cell interactions by platelet microparticles. J Clin Invest. 1998;102:136–144.
   PubMed Web of Science ®Google Scholar
• Lorant DE, Zimmerman GA, McIntyre TM, et al. Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. Semin Cell Biol. 1995;6:295–303.
   PubMedGoogle Scholar
• Watanabe J, Marathe GK, Neilsen PO, et al. Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. J Biol Chem. 2003;278:33161–33168.
   PubMed Web of Science ®Google Scholar
• Ratajczak J, Miekus K, Kucia M, et al. Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia. 2006;20:847–856.
   PubMed Web of Science ®Google Scholar
• Hunter MP, Ismail N, Zhang X, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One. 2008;3:e3694.
   PubMed Web of Science ®Google Scholar
• Collino F, Deregibus MC, Bruno S, et al. Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS One. 2010;5:e11803.
   PubMed Web of Science ®Google Scholar
• Yuan A, Farber EL, Rapoport AL, et al. Transfer of microRNAs by embryonic stem cell microvesicles. PLoS One. 2009;4:e4722.
   PubMed Web of Science ®Google Scholar
• Obregon C, Rothen-Rutishauser B, Gitahi SK, et al. Exovesicles from human activated dendritic cells fuse with resting dendritic cells, allowing them to present alloantigens. Am J Pathol. 2006;169:2127–2136.
   PubMed Web of Science ®Google Scholar
• Chen CZ, Li L, Lodish HF, et al. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83–86.
   PubMed Web of Science ®Google Scholar
• Aliotta JM, Pereira M, Johnson KW, et al. Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription. Exp Hematol. 2010;38:233–245.
   PubMed Web of Science ®Google Scholar
• English D, Garcia JG, Brindley DN. Platelet-released phospholipids link haemostasis and angiogenesis. Cardiovasc Res. 2001;49:588–599.
   PubMed Web of Science ®Google Scholar
• Chargaff E, West R. The biological significance of the thromboplastic protein of blood. J Biol Chem. 1946;166:189–197.
   PubMed Web of Science ®Google Scholar
• Owens AP, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res. 2011;108:1284–1297.
   PubMed Web of Science ®Google Scholar
• Mackman N, Tilley RE, Key NS. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:1687–1693.
   PubMed Web of Science ®Google Scholar
• Polgar J, Matuskova J, Wagner DD. The P-selectin, tissue factor, coagulation triad. J Thromb Haemost. 2005;3:1590–1596.
   PubMed Web of Science ®Google Scholar
• Somajo S, Koshiar RL, Norström E, et al. Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C. Thromb Res. 2014;134:144–152.
   PubMed Web of Science ®Google Scholar
• Alexandru N, Andrei E, Dragan E, et al. Interaction of platelets with endothelial progenitor cells in the experimental atherosclerosis: role of transplanted endothelial progenitor cells and platelet microparticles. Biol Cell. 2015;107:189–204.
   PubMed Web of Science ®Google Scholar
• Tual-Chalot S, Guibert C, Muller B, et al. Circulating microparticles from pulmonary hypertensive rats induce endothelial dysfunction. Am J Respir Crit Care Med. 2010;182:261–268.
   PubMed Web of Science ®Google Scholar
• Turiák L, Misják P, Szabó TG, et al. Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice. J Proteomics. 2011;74:2025–2033.
   PubMed Web of Science ®Google Scholar
• Robbins PD, Dorronsoro A, Booker CN. Regulation of chronic inflammatory and immune processes by extracellular vesicles. J Clin Invest. 2016;126:1173.
   PubMed Web of Science ®Google Scholar
• Mohning MP, Thomas SM, Barthel L, et al. Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK. Am J Physiol Cell Mol Physiol. 2018;314:L69–L82.
   PubMed Web of Science ®Google Scholar
• Ma J, Wei K, Zhang H, et al. Mechanisms by which dendritic cells present tumor microparticle antigens to CD8 + T cells. Cancer Immunol Res. 2018;6:1057–1068.
   PubMed Web of Science ®Google Scholar
• Buesing KL, Densmore JC, Kaul S, et al. Endothelial microparticles induce inflammation in acute lung injury. J Surg Res. 2011;166:32–39.
   PubMed Web of Science ®Google Scholar
• Mesri M, Altieri DC. Leukocyte microparticles stimulate endothelial cell cytokine release and tissue factor induction in a JNK1 signaling pathway. J Biol Chem. 1999;274:23111–23118.
   PubMed Web of Science ®Google Scholar
• Neri T, Armani C, Pegoli A, et al. Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles. Eur Respir J. 2011;37:1494–1502.
   PubMed Web of Science ®Google Scholar
• Wang JG, Williams JC, Davis BK, et al. Monocytic microparticles activate endothelial cells in an IL-1β-dependent manner. Blood. 2011;118:2366–2374.
   PubMed Web of Science ®Google Scholar
• Gasser O, Schifferli JA. Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood. 2004;104:2543–2548.
   PubMed Web of Science ®Google Scholar
• Dalli J, Norling LV, Renshaw D, et al. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood. 2008;112:2512–2519.
   PubMed Web of Science ®Google Scholar
• Bardelli C, Amoruso A, Federici Canova D, et al. Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPARγ ligands. Br J Pharmacol. 2012;165:716–728.
   PubMed Web of Science ®Google Scholar
• Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10:826–837.
   PubMed Web of Science ®Google Scholar
• Radziwon-Balicka A, Moncada de la Rosa C, Jurasz P. Platelet-associated angiogenesis regulating factors: a pharmacological perspective. Can J Physiol Pharmacol. 2012;90:679–688.
   PubMed Web of Science ®Google Scholar
• Collier MEW, Ettelaie C. Induction of endothelial cell proliferation by recombinant and microparticle-tissue factor involves 1-integrin and extracellular signal regulated kinase activation. Arterioscler Thromb Vasc Biol. 2010;30:1810–1817.
   PubMed Web of Science ®Google Scholar
• Benameur T, Soleti R, Porro C, et al. Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. PLoS One. 2010;5:e12688.
   PubMed Web of Science ®Google Scholar
• Soleti R, Benameur T, Porro C, et al. Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors. Carcinogenesis. 2009;30:580–588.
   PubMed Web of Science ®Google Scholar
• Lacroix R, Sabatier F, Mialhe A, et al. Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood. 2007;110:2432–2439.
   PubMed Web of Science ®Google Scholar
• Taraboletti G, D'Ascenzo S, Borsotti P, et al. Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am J Pathol. 2002;160:673–680.
   PubMed Web of Science ®Google Scholar
• Leroyer AS, Ebrahimian TG, Cochain C, et al. Microparticles from ischemic muscle promotes postnatal vasculogenesis. Circulation. 2009;119:2808–2817.
   PubMed Web of Science ®Google Scholar
• Aoki N, Yokoyama R, Asai N, et al. Adipocyte-derived microvesicles are associated with multiple angiogenic factors and induce angiogenesis in vivo and in vitro. Endocrinology. 2010;151:2567–2576.
   PubMed Web of Science ®Google Scholar
• Yang C, Mwaikambo BR, Zhu T, et al. Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways. Am J Physiol Regul Integr Comp Physiol. 2008;294:R467–R476.
   PubMed Web of Science ®Google Scholar
• Shai E, Varon D. Development, cell differentiation, angiogenesis—microparticles and their roles in angiogenesis. Arterioscler Thromb Vasc Biol. 2010;31:10–14.
   Web of Science ®Google Scholar
• Varon D, Haion Y, Brill A, et al. Cell-driven angiogenesis and neurogenesis after stroke is regulated by platelet’s microparticles. Blood. 2015;112:1899.
   Google Scholar
• Mezentsev A, Merks RMH, O’Riordan E, et al. Endothelial microparticles affect angiogenesis in vitro: role of oxidative stress. Am J Physiol Heart Circ Physiol. 2005;289:H1106–H1114.
   PubMed Web of Science ®Google Scholar
• Klinkner DB, Densmore JC, Kaul S, et al. Endothelium-derived microparticles inhibit human cardiac valve endothelial cell function. Shock. 2006;25:575–580.
   PubMed Web of Science ®Google Scholar
• Brodsky SV, Zhang F, Nasjletti A, et al. Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Hear Circ Physiol. 2004;286:H1910–H1915.
   PubMed Web of Science ®Google Scholar
• Amabile N, Guérin AP, Leroyer A, et al. Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol. 2005;16:3381–3388.
   PubMed Web of Science ®Google Scholar
• Boulanger CM, Scoazec A, Ebrahimian T, et al. Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation. 2001;104:2649–2652.
   PubMed Web of Science ®Google Scholar
• Mostefai HA, Agouni A, Carusio N, et al. Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. J Immunol. 2008;180:5028–5035.
   PubMed Web of Science ®Google Scholar
• Martin S, Tesse A, Hugel B, et al. Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation. 2004;109:1653–1659.
   PubMed Web of Science ®Google Scholar
• Horn P, Cortese-Krott MM, Amabile N, et al. Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction. J Am Heart Assoc. 2012;2:e003764.
   PubMed Web of Science ®Google Scholar
• Pfister SL. Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery. Hypertension. 2004;43:428–433.
   PubMed Web of Science ®Google Scholar
• Agouni A, Ducluzeau P-H, Benameur T, et al. Microparticles from patients with metabolic syndrome induce vascular hypo-reactivity via fas/fas-ligand pathway in mice. PLoS One. 2011;6:e27809.
   PubMed Web of Science ®Google Scholar
• Gregory CD, Pound JD. Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues. J Pathol. 2011;223:178–195.
   Web of Science ®Google Scholar
• Aupeix K, Hugel B, Martin T, et al. The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J Clin Invest. 1997;99:1546.
   PubMed Web of Science ®Google Scholar
• Segundo C, Medina F, Rodríguez C, et al. Surface molecule loss and bleb formation by human germinal center B cells undergoing apoptosis: role of apoptotic blebs in monocyte chemotaxis. Blood. 1999;94:1012–1020.
   PubMed Web of Science ®Google Scholar
• Distler JHW, Akhmetshina A, Dees C, et al. Induction of apoptosis in circulating angiogenic cells by microparticles. Arthritis Rheum. 2011;63:2067–2077.
   PubMed Web of Science ®Google Scholar
• Huber LC, Jüngel A, Distler JHW, et al. The role of membrane lipids in the induction of macrophage apoptosis by microparticles. Apoptosis. 2007;12:363–374.
   PubMed Web of Science ®Google Scholar
• Abid Hussein MN, Böing AN, Sturk A, et al. Inhibition of microparticle release triggers endothelial cell apoptosis and detachment. Thromb Haemost. 2007;98:1096–1107.
   PubMed Web of Science ®Google Scholar
• Abid Hussein MN, Nieuwland R, Hau CM, et al. Cell-derived microparticles contain caspase 3 in vitro and in vivo. J Thromb Haemost. 2005;3:888–896.
   PubMed Web of Science ®Google Scholar
• Böing AN, Hau CM, Sturk A, et al. Platelet microparticles contain active caspase 3. Platelets. 2008;19:96–103.
   PubMed Web of Science ®Google Scholar
• Albanese J, Meterissian S, Kontogiannea M, et al. Biologically active FAS antigen and its cognate ligand are expressed on plasma membrane-derived extracellular vesicles. Blood. 1998;91:3862–3874.
   PubMed Web of Science ®Google Scholar
• Juránek I, Bezek S. Controversy of free radical hypothesis: reactive oxygen species-cause or consequence of tissue injury? Gen Physiol Biophys. 2005;24:263–278.
   PubMed Web of Science ®Google Scholar
• Dröge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47–95.
   PubMed Web of Science ®Google Scholar
• Essayagh S, Xuereb JM, Terrisse AD, et al. Microparticles from apoptotic monocytes induce transient platelet recruitment and tissue factor expression by cultured human vascular endothelial cells via a redox-sensitive mechanism. Thromb Haemost. 2007;98:831–837.
   PubMed Web of Science ®Google Scholar
• Mastronardi ML, Mostefai HA, Soleti R, et al. Microparticles from apoptotic monocytes enhance nitrosative stress in human endothelial cells. Fundam Clin Pharmacol. 2011;25:653–660.
   PubMed Web of Science ®Google Scholar
• Touyz RM. Reactive oxygen species, vascular oxidative stress, and redox signaling in hypertension: what is the clinical significance? Hypertension. 2004;44:248–252.
   PubMed Web of Science ®Google Scholar
• Rodrigo R, Prat H, Passalacqua W, et al. Relationship between oxidative stress and essential hypertension. Hypertens Res. 2007;30:1159–1167.
   PubMed Web of Science ®Google Scholar
• Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol. 2002;89:3–9A.
   PubMed Web of Science ®Google Scholar
• Cordazzo C, Neri T, Petrini S, et al. Angiotensin II induces the generation of procoagulant microparticles by human mononuclear cells via an angiotensin type 2 receptor-mediated pathway. Thromb Res. 2013;131:e168–e174.
   PubMed Web of Science ®Google Scholar
• Preston RA, Jy W, Jimenez JJ, et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertens. 2003;41:211–217.
   PubMed Web of Science ®Google Scholar
• Hsu CY, Huang PH, Chiang CH, et al. Increased circulating endothelial apoptotic microparticle to endothelial progenitor cell ratio is associated with subsequent decline in glomerular filtration rate in hypertensive patients. PLoS One. 2013;8:e68644.
   PubMed Web of Science ®Google Scholar
• Huang PH, Huang SS, Chen YH, et al. Increased circulating CD31+/annexin V + apoptotic microparticles and decreased circulating endothelial progenitor cell levels in hypertensive patients with microalbuminuria. J Hypertens. 2010;28:1655–1665.
   PubMed Web of Science ®Google Scholar
• Giannella A, Radu CM, Franco L, et al. Circulating levels and characterization of microparticles in patients with different degrees of glucose tolerance. Cardiovasc Diabetol. 2017;16:118.
   PubMed Web of Science ®Google Scholar
• Kurtzman N, Zhang L, French B, et al. Personalized cytomic assessment of vascular health: evaluation of the vascular health profile in diabetes mellitus. Cytometry. 2013;84B:255–266.
   Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. 5-HT2A receptor antagonist increases circulating adiponectin in patients with type 2 diabetes. Blood Coagul Fibrinolysis. 2005;16:423–428.
   PubMed Web of Science ®Google Scholar
• Omoto S, Nomura S, Shouzu A, et al. Detection of monocyte-derived microparticles in patients with Type II diabetes mellitus. Diabetologia. 2002;45:550–555.
   PubMed Web of Science ®Google Scholar
• Alkhatatbeh MJ, Enjeti AK, Acharya S, et al. The origin of circulating CD36 in type 2 diabetes. Nutr Diabetes. 2013;3:e59.
   PubMed Web of Science ®Google Scholar
• Tsimerman G, Roguin A, Bachar A, et al. Involvement of microparticles in diabetic vascular complications. Thromb Haemost. 2011;106:310–321.
   PubMed Web of Science ®Google Scholar
• Burger D, Turner M, Xiao F, et al. High glucose increases the formation and pro-oxidative activity of endothelial microparticles. Diabetologia. 2017;60:1791–1800.
   PubMed Web of Science ®Google Scholar
• Tripodi A, Branchi A, Chantarangkul V, et al. Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay. J Thromb Thrombolysis. 2011;31:165–172.
   PubMed Web of Science ®Google Scholar
• Berezin AE, Kremzer AA, Berezina TA, et al. The pattern of circulating microparticles in patients with diabetes mellitus with asymptomatic atherosclerosis. Acta Clin Belg. 2016;71:38–45.
   PubMed Web of Science ®Google Scholar
• Jansen F, Yang X, Franklin BS, et al. High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovasc Res. 2013;98:94–106.
   PubMed Web of Science ®Google Scholar
• Omoto S, Nomura S, Shouzu A, et al. Significance of platelet-derived microparticles and activated platelets in diabetic nephropathy. Nephron. 1999;81:271–277.
   PubMed Web of Science ®Google Scholar
• Ettelaie C, Su S, Li C, et al. Tissue factor-containing microparticles released from mesangial cells in response to high glucose and AGE induce tube formation in microvascular cells. Microvasc Res. 2008;76:152–160.
   PubMed Web of Science ®Google Scholar
• Zampetaki A, Kiechl S, Drozdov I, et al. Plasma microRNA profiling reveals loss of endothelial MiR-126 and other microRNAs in type 2 diabetes. Circ Res. 2010;107:810–817.
   PubMed Web of Science ®Google Scholar
• Li S, Wei J, Zhang C, et al. Cell-derived microparticles in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Cell Physiol Biochem. 2016;39:2439–2450.
   PubMedGoogle Scholar
• Rodrigues KF, Pietrani NT, Fernandes AP, et al. Circulating microparticles levels are increased in patients with diabetic kidney disease: a case-control research. Clin Chim Acta. 2018;479:48–55.
   PubMed Web of Science ®Google Scholar
• Cimmino G, D’Amico C, Vaccaro V, et al. The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor? Expert Rev Cardiovasc Ther. 2011;9:517–523.
   PubMedGoogle Scholar
• Domingueti CP, Dusse LMS, Carvalho MDG, et al. Diabetes mellitus: the linkage between oxidative stress, inflammation, hypercoagulability and vascular complications. J Diabetes Complications. 2016;30:738–745.
   PubMed Web of Science ®Google Scholar
• Fish JE, Santoro MM, Morton SU, et al. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008;15:272–284.
   PubMed Web of Science ®Google Scholar
• Jansen F, Stumpf T, Proebsting S, et al. Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6. J Mol Cell Cardiol. 2017;104:43–52.
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen L, Liu M. Microvesicles and diabetic complications – novel mediators, potential biomarkers and therapeutic targets. Acta Pharmacol Sin. 2014;35:433–443.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Effect of cilostazol on soluble adhesion molecules and platelet-derived microparticles in patients with diabetes. Thromb Haemost. 1998;80:388–392.
   PubMed Web of Science ®Google Scholar
• Nomura S, Takahashi N, Inami N, et al. Probucol and ticlopidine: effect on platelet and monocyte activation markers in hyperlipidemic patients with and without type 2 diabetes. Atherosclerosis. 2004;174:329–335.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Significance of chemokines and activated platelets in patients with diabetes. Clin Exp Immunol. 2000;121:437–443.
   PubMed Web of Science ®Google Scholar
• Shouzu A, Nomura S, Omoto S, et al. Effect of ticlopidine on monocyte-derived microparticles and activated platelet markers in diabetes mellitus. Clin Appl Thromb Hemost. 2004;10:167–173.
   PubMed Web of Science ®Google Scholar
• Shouzu A, Nomura S, Hayakawa T, et al. Effect of sarpogrelate hydrochloride on platelet-derived microparticles and various soluble adhesion molecules in diabetes mellitus. Clin Appl Thromb Hemost. 2000;6:139–143.
   PubMed Web of Science ®Google Scholar
• Serebruany VL, Malinin AI, Pokov AN, et al. Antiplatelet profiles of the fixed-dose combination of extended-release dipyridamole and low-dose aspirin compared with clopidogrel with or without aspirin in patients with type 2 diabetes and a history of transient ischemic attack: a randomized, single-blind, 30-day trial. Clin Ther. 2008;30:249–259.
   PubMed Web of Science ®Google Scholar
• Nomura S, Kanazawa S, Fukuhara S. Effects of efonidipine on platelet and monocyte activation markers in hypertensive patients with and without type 2 diabetes mellitus. J Hum Hypertens. 2002;16:539–547.
   PubMed Web of Science ®Google Scholar
• Nomura S, Inami N, Kimura Y, et al. Effect of nifedipine on adiponectin in hypertensive patients with type 2 diabetes mellitus. J Hum Hypertens. 2007;21:38–44.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Long-term treatment with nifedipine modulates procoagulant marker and C-C chemokine in hypertensive patients with type 2 diabetes mellitus. Thromb Res. 2005;115:277–285.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Losartan and simvastatin inhibit platelet activation in hypertensive patients. J Thromb Thrombolysis. 2004;18:177–185.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Effects of losartan and simvastatin on monocyte-derived microparticles in hypertensive patients with and without type 2 diabetes mellitus. Clin Appl Thromb Hemost. 2004;10:133–141.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Effect of valsartan on monocyte/endothelial cell activation markers and adiponectin in hypertensive patients with type 2 diabetes mellitus. Thromb Res. 2006;117:385–392.
   PubMed Web of Science ®Google Scholar
• Nomura S, Inami N, Shouzu A, et al. The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients. Platelets. 2009;20:16–22.
   PubMed Web of Science ®Google Scholar
• Tehrani S, Mobarrez F, Antovic A, et al. Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia. Thromb Res. 2010;126:e225–e231.
   PubMed Web of Science ®Google Scholar
• Koga H, Sugiyama S, Kugiyama K, et al. Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease. Eur Heart J. 2006;27:817–823.
   PubMed Web of Science ®Google Scholar
• Nomura S, Kanazawa S, Fukuhara S. Effects of eicosapentaenoic acid on platelet activation markers and cell adhesion molecules in hyperlipidemic patients with Type 2 diabetes mellitus. J Diabetes Complications. 2003;17:153–159.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Effects of eicosapentaenoic acid on endothelial cell-derived microparticles, angiopoietins and adiponectin in patients with type 2 diabetes. J Atheroscler Thromb. 2009;16:83–90.
   PubMed Web of Science ®Google Scholar
• Morel O, Jesel L, Hugel B, et al. Protective effects of vitamin C on endothelium damage and platelet activation during myocardial infarction in patients with sustained generation of circulating microparticles. J Thromb Haemost. 2003;1:171–177.
   PubMed Web of Science ®Google Scholar
• Shimazu T, Inami N, Satoh D, et al. Effect of acarbose on platelet-derived microparticles, soluble selectins, and adiponectin in diabetic patients. J Thromb Thrombolysis. 2009;28:429–435.
   PubMed Web of Science ®Google Scholar
• Nomura S, Omoto S, Yokoi T, et al. Effects of miglitol in platelet-derived microparticle, adiponectin, and selectin level in patients with type 2 diabetes mellitus. Int J Gen Med. 2011;4:539–545.
   PubMedGoogle Scholar
• Esposito K, Maiorino MI, Di Palo C, et al. Effects of pioglitazone versus metformin on circulating endothelial microparticles and progenitor cells in patients with newly diagnosed type 2 diabetes–a randomized controlled trial. Diabetes Obes Metab. 2011;13:439–445.
   PubMed Web of Science ®Google Scholar
• Sambola A, Osende J, Hathcock J, et al. Role of risk factors in the modulation of tissue factor activity and blood thrombogenicity. Circulation. 2003;107:973–977.
   PubMed Web of Science ®Google Scholar
• Li M, Yu D, Williams KJ, et al. Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages. Arterioscler Thromb Vasc Biol. 2010;30:1818–1824.
   PubMed Web of Science ®Google Scholar
• Gordon C, Gudi K, Krause A, et al. Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. Am J Respir Crit Care Med. 2011;184:224–232.
   PubMed Web of Science ®Google Scholar
• Li CJ, Liu Y, Chen Y, et al. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. Am J Pathol. 2013;182:1552–1562.
   PubMed Web of Science ®Google Scholar
• Heiss C, Amabile N, Lee AC, et al. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function. J Am Coll Cardiol. 2008;51:1760–1771.
   PubMed Web of Science ®Google Scholar
• Tushuizen ME, Nieuwland R, Rustemeijer C, et al. Elevated endothelial microparticles following consecutive meals are associated with vascular endothelial dysfunction in type 2 diabetes. Diabetes Care. 2007;30:728–730.
   PubMed Web of Science ®Google Scholar
• Ou ZJ, Chang FJ, Luo D, et al. Endothelium-derived microparticles inhibit angiogenesis in the heart and enhance the inhibitory effects of hypercholesterolemia on angiogenesis. Am J Physiol Endocrinol Metab. 2011;300:E661–E668.
   PubMed Web of Science ®Google Scholar
• Llorente-Cortes V. Aggregated low-density lipoprotein uptake induces membrane tissue factor procoagulant activity and microparticle release in human vascular smooth muscle cells. Circulation. 2004;110:452–459.
   PubMed Web of Science ®Google Scholar
• Nomura S, Shouzu A, Omoto S, et al. Activated platelet and oxidized LDL induce endothelial membrane vesiculation: clinical significance of endothelial cell-derived microparticles in patients with type 2 diabetes. Clin Appl Thromb Hemost. 2004;10:205–215.
   PubMed Web of Science ®Google Scholar
• Carpintero R, Gruaz L, Brandt KJ, et al. HDL interfere with the binding of T cell microparticles to human monocytes to inhibit pro-inflammatory cytokine production. PLoS One. 2010;5:e11869.
   PubMed Web of Science ®Google Scholar
• Tramontano AF, O’Leary J, Black AD, et al. Statin decreases endothelial microparticle release from human coronary artery endothelial cells: implication for the Rho-kinase pathway. Biochem Biophys Res Commun. 2004;320:34–38.
   PubMed Web of Science ®Google Scholar
• Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med. 2006;119:812–819.
   PubMed Web of Science ®Google Scholar
• Arteaga RB, Chirinos JA, Soriano AO, et al. Endothelial microparticles and platelet and leukocyte activation in patients with the metabolic syndrome. Am J Cardiol. 2006;98(1):70–74.
   PubMed Web of Science ®Google Scholar
• Ueba T, Haze T, Sugiyama M, et al. Level, distribution and correlates of platelet-derived microparticles in healthy individuals with special reference to the metabolic syndrome. Thromb Haemost. 2008;100:280–285.
   PubMed Web of Science ®Google Scholar
• Chironi G, Simon A, Hugel B, et al. Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects. Arterioscler Thromb Vasc Biol. 2006;26:2775–2780.
   PubMed Web of Science ®Google Scholar
• Helal O, Defoort C, Robert S, et al. Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: relationship with oxidative stress. Nutr Metab Cardiovasc Dis. 2011;21:665–671.
   PubMed Web of Science ®Google Scholar
• Tricot O, Mallat Z, Heymes C, et al. Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation. 2000;101:2450–2453.
   PubMed Web of Science ®Google Scholar
• Boulanger CM, Amabile N, Guérin AP, et al. In vivo shear stress determines circulating levels of endothelial microparticles in end-stage renal disease. Hypertension. 2007;49:902–908.
   PubMed Web of Science ®Google Scholar
• Mundi S, Massaro M, Scoditti E, et al. Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review. Cardiovasc Res. 2018;114:35–52.
   PubMed Web of Science ®Google Scholar
• Densmore JC, Signorino PR, Ou J, et al. Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury. Shock. 2006;26:464–471.
   PubMed Web of Science ®Google Scholar
• Jy W, Minagar A, Jimenez JJ, et al. Endothelial microparticles (EMP) bind and activate monocytes: elevated EMP-monocyte conjugates in multiple sclerosis. Front Biosci. 2004;9:3137–3144.
   PubMed Web of Science ®Google Scholar
• Dean WL, Lee MJ, Cummins TD, et al. Proteomic and functional characterization of platelet microparticle size classes. Thromb Haemost. 2009;102:711–718.
   PubMed Web of Science ®Google Scholar
• Lusis AJ. Atherosclerosis. Nature. 2000;407:233–241.
   PubMed Web of Science ®Google Scholar
• Mesri M, Altieri DC. Endothelial cell activation by leukocyte microparticles. J Immunol. 1998;161:4382–4387.
   PubMed Web of Science ®Google Scholar
• Curtis A, Wilkinson P, Gui M, et al. p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles. J Thromb Haemost. 2009;7:701–709.
   PubMed Web of Science ®Google Scholar
• Rautou PE, Leroyer AS, Ramkhelawon B, et al. Microparticles from human atherosclerotic plaques promote endothelial ICAM-1-dependent monocyte adhesion and transendothelial migration. Circ Res. 2011;108:335–343.
   PubMed Web of Science ®Google Scholar
• Leroyer AS, Isobe H, Lesèche G, et al. Cellular origins and thrombogenic activity of microparticles isolated from human atherosclerotic plaques. J Am Coll Cardiol. 2007;49:772–777.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Hugel B, Ohan J, et al. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation. 1999;99:348–353.
   PubMed Web of Science ®Google Scholar
• Mayr M, Grainger D, Mayr U, et al. Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. Circ Cardiovasc Genet. 2009;2:379–388.
   PubMed Web of Science ®Google Scholar
• Kolodgie FD, Narula J, Burke AP, et al. Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death. Am J Pathol. 2000;157:1259–1268.
   PubMed Web of Science ®Google Scholar
• Tabas I. Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol. 2005;25:2255–2264.
   PubMed Web of Science ®Google Scholar
• Antwi-Baffour S, Kholia S, Aryee YD, et al. Human plasma membrane-derived vesicles inhibit the phagocytosis of apoptotic cells – possible role in SLE. Biochem Biophys Res Commun. 2010;398:278–283.
   PubMed Web of Science ®Google Scholar
• Hanayama R, Tanaka M, Miwa K, et al. Identification of a factor that links apoptotic cells to phagocytes. Nature. 2002;417:182–187.
   PubMed Web of Science ®Google Scholar
• Ait-Oufella H, Kinugawa K, Zoll J, et al. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation. 2007;115:2168–2177.
   PubMed Web of Science ®Google Scholar
• Dasgupta SK, Abdel-Monem H, Niravath P, et al. Lactadherin and clearance of platelet-derived microvesicles. Blood. 2009;113:1332–1339.
   PubMed Web of Science ®Google Scholar
• Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev. 2006;86:515–581.
   PubMed Web of Science ®Google Scholar
• Angelot F, Seilles E, Biichle S, et al. Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases. Haematologica. 2009;94:1502–1512.
   PubMed Web of Science ®Google Scholar
• Eken C, Gasser O, Zenhaeusern G, et al. Polymorphonuclear neutrophil-derived ectosomes interfere with the maturation of monocyte-derived dendritic cells. J Immunol. 2008;180:817–824.
   PubMed Web of Science ®Google Scholar
• Shefler I, Salamon P, Reshef T, et al. T cell-induced mast cell activation: a role for microparticles released from activated T cells. J Immunol. 2010;185:4206–4212.
   PubMed Web of Science ®Google Scholar
• Weber A, Köppen HO, Schrör K. Platelet-derived microparticles stimulate coronary artery smooth muscle cell mitogenesis by a PDGF-independent mechanism. Thromb Res. 2000;98:461–466.
   PubMed Web of Science ®Google Scholar
• Pakala R. Serotonin and thromboxane A2 stimulate platelet-derived microparticle-induced smooth muscle cell proliferation. Cardiovasc Radiat Med. 2004;5:20–26.
   PubMedGoogle Scholar
• Sato Y, Asada Y, Marutsuka K, et al. Tissue factor induces migration of cultured aortic smooth muscle cells. Thromb Haemost. 1996;75:389–392.
   PubMed Web of Science ®Google Scholar
• Marutsuka K, Hatakeyama K, Sato Y, et al. Protease-activated receptor 2 (PAR2) mediates vascular smooth muscle cell migration induced by tissue factor/factor VIIa complex. Thromb Res. 2002;107:271–276.
   PubMed Web of Science ®Google Scholar
• Moreno PR, Purushothaman KR, Zias E, et al. Neovascularization in human atherosclerosis. Curr Mol Med. 2006;6:457–477.
   PubMed Web of Science ®Google Scholar
• Kolodgie FD, Gold HK, Burke AP, et al. Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med. 2003;349:2316–2325.
   PubMed Web of Science ®Google Scholar
• Canault M, Leroyer AS, Peiretti F, et al. Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am J Pathol. 2007;171:1713–1723.
   PubMed Web of Science ®Google Scholar
• Distler JHW, Jungel A, Huber LC, et al. The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. Proc Natl Acad Sci. 2005;102:2892–2897.
   PubMed Web of Science ®Google Scholar
• Dashevsky O, Varon D, Brill A. Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production. Int J Cancer. 2009;124:1773–1777.
   PubMed Web of Science ®Google Scholar
• Leroyer AS, Rautou PE, Silvestre JS, et al. CD40 ligand + microparticles from human atherosclerotic plaques stimulate endothelial proliferation and angiogenesis. J Am Coll Cardiol. 2008;52:1302–1311.
   PubMed Web of Science ®Google Scholar
• Philippova M, Suter Y, Toggweiler S, et al. T-cadherin is present on endothelial microparticles and is elevated in plasma in early atherosclerosis. Eur Heart J. 2011;32:760–771.
   PubMed Web of Science ®Google Scholar
• Koga H, Sugiyama S, Kugiyama K, et al. Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol. 2005;45:1622–1630.
   PubMed Web of Science ®Google Scholar
• Mallat Z, Benamer H, Hugel B, et al. Elevated levels of shed membrane microparticles with pocoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation. 2000;101:841–843.
   PubMed Web of Science ®Google Scholar
• Bernal-Mizrachi L, Jy W, Jimenez JJ, et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Am Heart J. 2003;145:962–970.
   PubMed Web of Science ®Google Scholar
• Morel O, Hugel B, Jesel L, et al. Circulating procoagulant microparticles and soluble GPV in myocardial infarction treated by primary percutaneous transluminal coronary angioplasty. A possible role for GPIIb-IIIa antagonists. J Thromb Haemost. 2004;2:1118–1126.
   PubMed Web of Science ®Google Scholar
• Radecke CE, Warrick AE, Singh GD, et al. Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction. Thromb Haemost. 2015;113:605–616.
   PubMed Web of Science ®Google Scholar
• Montoro-García S, Shantsila E, Tapp LD, et al. Small-size circulating microparticles in acute coronary syndromes: relevance to fibrinolytic status, reparative markers and outcomes. Atherosclerosis. 2013;227:313–322.
   PubMed Web of Science ®Google Scholar
• Zhou B, Li J, Chen S, et al. Time course of various cell origin circulating microparticles in ST-segment elevation myocardial infarction patients undergoing percutaneous transluminal coronary intervention. Exp Ther Med. 2016;11:1481–1486.
   PubMed Web of Science ®Google Scholar
• Min PK, Kim JY, Chung KH, et al. Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction. Atherosclerosis. 2013;227:323–328.
   PubMed Web of Science ®Google Scholar
• Suades R, Padró T, Crespo J, et al. Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time. Int J Cardiol. 2016;202:378–387.
   PubMed Web of Science ®Google Scholar
• Biasucci LM, Porto I, Di Vito L, et al. Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circ J. 2012;76:2174–2182.
   PubMed Web of Science ®Google Scholar
• Huisse MG, Ajzenberg N, Feldman L, et al. Microparticle-linked tissue factor activity and increased thrombin activity play a potential role in fibrinolysis failure in ST-segment elevation myocardial infarction. Thromb Haemost. 2009;101:734–740.
   PubMed Web of Science ®Google Scholar
• Maly M, Hrachovinova I, Tomasov P, et al. Patients with acute coronary syndromes have low tissue factor activity and microparticle count, but normal concentration of tissue factor antigen in platelet free plasma: a pilot study. Eur J Haematol. 2009;82:148–153.
   PubMed Web of Science ®Google Scholar
• Jung C, Sörensson P, Saleh N, et al. Circulating endothelial and platelet derived microparticles reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction. Atherosclerosis. 2012;221:226–231.
   PubMed Web of Science ®Google Scholar
• Crawford JR, Trial J, Nambi V, et al. Plasma levels of endothelial microparticles bearing monomeric C-reactive protein are increased in peripheral artery disease. J Cardiovasc Trans Res. 2016;9:184–193.
   PubMed Web of Science ®Google Scholar
• Chironi GN, Simon A, Boulanger CM, et al. Circulating microparticles may influence early carotid artery remodeling. J Hypertens. 2010;28:789–796.
   PubMed Web of Science ®Google Scholar
• van der Zee PM, Biró E, Ko Y, et al. P-Selectin- and CD63-exposing platelet microparticles reflect platelet activation in peripheral arterial disease and myocardial infarction. Clin Chem. 2006;52:657–664.
   PubMed Web of Science ®Google Scholar
• Nomura S, Imamura A, Okuno M, et al. Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines. Thromb Res. 2000;98:257–268.
   PubMed Web of Science ®Google Scholar
• Jung KH, Chu K, Lee ST, et al. Circulating endothelial microparticles as a marker of cerebrovascular disease. Ann Neurol. 2009;66:191–199.
   PubMed Web of Science ®Google Scholar
• Simak J, Gelderman MP, Yu H, et al. Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. J Thromb Haemost. 2006;4:1296–1302.
   PubMed Web of Science ®Google Scholar
• Cherian P, Hankey GJ, Eikelboom JW, et al. Endothelial and platelet activation in acute ischemic stroke and its etiological subtypes. Stroke. 2003;34:2132–2137.
   PubMed Web of Science ®Google Scholar
• Montoro-García S, Shantsila E, Wrigley BJ, et al. Small-size microparticles as indicators of acute decompensated state in ischemic heart failure. Rev Española Cardiol (Engl Ed). 2015;68:951–958.
   PubMed Web of Science ®Google Scholar
• Bulut D, Maier K, Bulut-Streich N, et al. Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction. J Card Fail. 2008;14:336–340.
   PubMed Web of Science ®Google Scholar
• Berezin AE, Kremzer AA. Impaired phenotype of circulating endothelial microparticles in chronic heart failure patients: relevance to body mass index. Diabetes Metab Syndr Clin Res Rev. 2015;9:230–236.
   PubMed Web of Science ®Google Scholar
• Garcia S, Chirinos J, Jimenez J, et al. Phenotypic assessment of endothelial microparticles in patients with heart failure and after heart transplantation: switch from cell activation to apoptosis. J Hear Lung Transplant. 2005;24:2184–2189.
   PubMed Web of Science ®Google Scholar
• Ivak P, Pitha J, Wohlfahrt P, et al. Endothelial dysfunction expressed as endothelial microparticles in patients with end-stage heart failure. Physiol Res. 2014;63:S369–S373.
   PubMed Web of Science ®Google Scholar
• Walenta K, Schwarz V, Schirmer SH, et al. Circulating microparticles as indicators of peripartum cardiomyopathy. Eur Heart J. 2012;33:1469–1479.
   PubMed Web of Science ®Google Scholar
• Choudhury A, Chung I, Blann AD, et al. Elevated platelet microparticle levels in nonvalvular atrial fibrillation: relationship to p-selectin and antithrombotic therapy. Chest. 2007;131:809–815.
   PubMed Web of Science ®Google Scholar
• Ederhy S, Di Angelantonio E, Mallat Z, et al. Levels of circulating procoagulant microparticles in nonvalvular atrial fibrillation. Am J Cardiol. 2007;100:989–994.
   PubMed Web of Science ®Google Scholar
• Azzam H, Zagloul M. Elevated platelet microparticle levels in valvular atrial fibrillation. Hematology. 2009;14:357–360.
   PubMed Web of Science ®Google Scholar
• Hayashi M, Takeshita K, Inden Y, et al. Platelet activation and induction of tissue factor in acute and chronic atrial fibrillation: involvement of mononuclear cell-platelet interaction. Thromb Res. 2011;128:e113–e118.
   PubMed Web of Science ®Google Scholar
• Diehl P, Aleker M, Helbing T, et al. Increased platelet, leukocyte and endothelial microparticles predict enhanced coagulation and vascular inflammation in pulmonary hypertension. J Thromb Thrombolysis. 2011;31:173–179.
   PubMed Web of Science ®Google Scholar
• Amabile N, Heiss C, Real WM, et al. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med. 2008;177:1268–1275.
   PubMed Web of Science ®Google Scholar
• Narin N, Yilmaz E, Pamukcu O, et al. Are endothelial microparticles early markers of pulmonary hypertension? Biomarkers. 2014;19:319–325.
   PubMed Web of Science ®Google Scholar
• Lin ZB, Ci HB, Li Y, et al. Endothelial microparticles are increased in congenital heart diseases and contribute to endothelial dysfunction. J Transl Med. 2017;15:4.
   PubMed Web of Science ®Google Scholar
• Blair LA, Haven AK, Bauer NN. Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium. Respir Res. 2016;17:133.
   PubMed Web of Science ®Google Scholar
• Belik D, Tsang H, Wharton J, et al. Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis. J Biomed Sci. 2016;23:4.
   PubMed Web of Science ®Google Scholar
• Sinning JM, Losch J, Walenta K, et al. Circulating CD31+/Annexin V + microparticles correlate with cardiovascular outcomes. Eur Heart J. 2011;32:2034.
   PubMed Web of Science ®Google Scholar
• Chiva-Blanch G, Bratseth V, Ritschel V, et al. Monocyte-derived circulating microparticles (CD14+, CD14+/CD11b + and CD14+/CD142+) are related to long-term prognosis for cardiovascular mortality in STEMI patients. Int J Cardiol. 2017;227:876–881.
   PubMed Web of Science ®Google Scholar
• Giannopoulos G, Oudatzis G, Paterakis G, et al. Red blood cell and platelet microparticles in myocardial infarction patients treated with primary angioplasty. Int J Cardiol. 2014;176:145–150.
   PubMed Web of Science ®Google Scholar
• Steppich BA, Braun SL, Stein A, et al. Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction. Thrombosis J. 2009;7:11.
   PubMedGoogle Scholar
• Fan Y, Wang L, Li Y, et al. Quantification of endothelial microparticles on modified cytometric bead assay and prognosis in chest pain patients. Circ J. 2014;78:206–214.
   PubMed Web of Science ®Google Scholar
• Berezin AE, Kremzer AA, Samura TA, et al. Circulating endothelial-derived apoptotic microparticles in the patients with ischemic symptomatic chronic heart failure: relevance of pro-inflammatory activation and outcomes. Int Cardiovasc Res J. 2014;8:116–123.
   PubMedGoogle Scholar
• Nascimbene A, Hernandez R, George JK, et al. Association between cell-derived microparticles and adverse events in patients with nonpulsatile left ventricular assist devices. J Heart Lung Transplant. 2014;33:470–477.
   PubMed Web of Science ®Google Scholar
• Amabile N, Heiss C, Chang V, et al. Increased CD62e + endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. J Hear Lung Transplant. 2009;28:1081–1086.
   PubMed Web of Science ®Google Scholar