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Pharmacology

Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity

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Pages 2009-2017 | Received 06 May 2021, Accepted 13 Oct 2021, Published online: 09 Nov 2021

References

  • Harwansh RK, Mukherjee K, Bhadra S, et al. Cytochrome P450 inhibitory potential and RP-HPLC standardization of Trikatu-a Rasayana from Indian Ayurveda. J Ethnopharmacol. 2014;153(3):674–681.
  • Ponnusankar S, Pandit S, Babu R, et al. Cytochrome P450 inhibitory potential of Triphala-a Rasayana from Ayurveda. J Ethnopharmacol. 2011;133(1):120–125.
  • Bahadur S, Mukherjee PK, Pandit S, et al. Herb-drug interaction potential of Berberis aristata through cytochrome P450 inhibition assay. Synergy. 2017;4:1–7.
  • Mukherjee PK, Bahadur S, Chaudhary SK, et al. 2015. Quality related safety issue—evidence based validation of herbal medicine farm to pharma. In: Mukherjee PK, editor. Evidence based validation of herbal medicine. Amsterdam (The Netherlands): Elsevier, p. 332.
  • Mukherjee PK, Banerjee S, Kar A, et al. Exploring synergy in Ayurveda and traditional Indian systems of medicine. Synergy. 2018;7:30–33.
  • Mukherjee PK. 2020. Safety-Related quality issues for the development of herbal drugs in: quality control and evaluation of herbal drugs. Amsterdam (The Netherlands): Elsevier, p. 660–664.
  • Amanat M, Reza MS, Shuvo MSR, et al. Zingiber roseum rosc. rhizome: a rich source of hepatoprotective polyphenols. Biomed Pharmacother. 2021;139:111673.
  • Xu Y, Li Y, Lu Y, et al. Antioxidative and hepatoprotective activities of a novel polysaccharide (LSAP) from Lepista sordida mycelia. Food Sci Hum Wellness. 2021;10(4):536–544.
  • Madrigal-Santillán E, Madrigal-Bujaidar E, Álvarez-González I, et al. Review of natural products with hepatoprotective effects. World J Gastroenterol. 2014;20(40):14787–14804.
  • Asadi-Samani M, Kafash-Farkhad N, Azimi N, et al. Medicinal plants with hepatoprotective activity in Iranian folk medicine. Asian Pacific J Trop Biomed. 2015;5(2):146–157.
  • Saha P, Talukdar AD, Nath R, et al. Role of natural phenolics in hepatoprotection: a mechanistic review and analysis of regulatory network of associated genes. Front Pharmacol. 2019;10:509
  • Katashima CK, Silva VR, Gomes TL, et al. Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review. Obes Rev. 2017;18(6):700–711.
  • López-Hortas L, Pérez-Larrán P, González-Muñoz MJ, et al. Recent developments on the extraction and application of ursolic acid. a review. Food Res Int. 2018;103:130–149.
  • Pironi AM, de Araújo PR, Fernandes MA, et al. Characteristics, biological properties and analytical methods of ursolic acid: a review. Crit Rev Anal Chem. 2018;48(1):86–93.
  • Chavarria D, Silva T, Magalhães e Silva D, et al. Lessons from black pepper: piperine and derivatives thereof. Expert Opin Ther Pat. 2016;26(2):245–264.
  • Ouyang D-y, Zeng L-h, Pan H, et al. Piperine inhibits the proliferation of human prostate cancer cells via induction of cell cycle arrest and autophagy. Food Chem Toxicol. 2013;60:424–430.
  • Bae G-S, Kim M-S, Jung W-S, et al. Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. Eur J Pharmacol. 2010;642(1–3):154–162.
  • Sabina EP, Souriyan ADH, Jackline D, et al. Piperine, an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice. Asian Pacific J Trop Biomed. 2010;3(12):971–976.
  • Li S, Wang C, Wang M, et al. Antidepressant like effects of piperine in chronic mild stress treated mice and its possible mechanisms. Life Sci. 2007;80(15):1373–1381.
  • Wang H, Liu J, Gao G, et al. Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury. Brain Res. 2016;1639:214–227.
  • Jinhua W. Ursolic acid: pharmacokinetics process in vitro and in vivo, a mini review. Arch Pharm. 2019;352(3):e1800222.
  • Manap ASA, Tan ACW, Leong WH, et al. Synergistic effects of curcumin and piperine as potent acetylcholine and amyloidogenic inhibitors with significant neuroprotective activity in SH-SY5Y cells via computational molecular modelling and in vitro assay. Front Aging Neurosci. 2019;11:206.
  • Patial V, Mahesh S, Sharma S, et al. Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environ Toxicol Pharmacol. 2015;40(2):445–452.
  • Ma J-Q, Ding J, Zhang L, et al. Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway. Clin Res Hepatol Gastroenterol. 2015;39(2):188–197.
  • Ma J-Q, Ding J, Zhang L, et al. Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway. Environ Toxicol Pharmacol. 2014;37(3):975–983.
  • Rinwa P, Kumar A. Piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice. Brain Res. 2012;1488:38–50.
  • Di X, Wang X, Di X, et al. Effect of piperine on the bioavailability and pharmacokinetics of emodin in rats. J Pharm Biomed Anal. 2015;115:144–149.
  • Matsuda H, Ninomiya K, Morikawa T, et al. Hepatoprotective amide constituents from the fruit of piper chaba: structural requirements, mode of action, and new amides. Bioorg Med Chem. 2009;17(20):7313–7323.
  • Bhattacharyya S, Ahammed SM, Saha BP, et al. The gallic acid phospholipid complex improved the antioxidant potential of gallic acid by enhancing its bioavailability. AAPS PharmSciTech. 2013;14(3):1025–1033.
  • Araya EM, Adamu BA, Periasamy G, et al. In vivo hepatoprotective and in vitro radical scavenging activities of cucumis ficifolius A. rich root extract. J Ethnopharmacol. 2019;242:112031.
  • Chou TC, Martin N. 2005. CompuSyn for drug combinations: PC software and user’s guide: a computer program for quantification of synergism and antagonism in drug combinations and the determination of IC50 and ED50 and LD50 values. Paramus (NJ): ComboSyn, Inc.
  • Dimmitt S, Stampfer H, Martin JH. When less is more - efficacy with less toxicity at the ED50. Br J Clin Pharmacol. 2017;83(7):1365–1368.
  • Motiwala MN, Rangari VD. Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: evidence of a synergistic interaction. Synergy. 2015;2(1):1–6.
  • Biswas S, Mukherjee PK, Harwansh RK, et al. Enhanced bioavailability and hepatoprotectivity of optimized ursolic acid-phospholipid complex. Drug Dev Ind Pharm. 2019;45(6):946–958.
  • De Paz-Campos MA, Ortiz MI, Chávez Piña AE, et al. Synergistic effect of the interaction between curcumin and diclofenac on the formalin test in rats. Phytomedicine. 2014;21(12):1543–1548.
  • Bi X, Yuan Z, Qu B, et al. Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2. Phytomedicine. 2019;54:98–108.
  • Jin Z-H, Qiu W, Liu H, et al. Enhancement of oral bioavailability and immune response of ginsenoside Rh2 by co-administration with piperine. Chin J Nat Med. 2018;16(2):143–149.
  • Bhutani MK, Bishnoi M, Kulkarni SK. Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes. Pharmacol Biochem Behav. 2009;92(1):39–43.
  • Cho J, Rho O, Junco J, et al. Effect of combined treatment with ursolic acid and resveratrol on skin tumor promotion by 12-O-Tetradecanoylphorbol-13-Acetate. Cancer Prev Res. 2015;8(9):817–825.
  • Zhang H, Zheng D, Ding J, et al. Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo. Int J Nanomedicine. 2015;10:1909–1920.
  • Poudel K, Gautam M, Maharjan S, et al. Dual stimuli-responsive ursolic acid-embedded nanophytoliposome for targeted antitumor therapy. Int J Pharm. 2020;582:119330,
  • Vargas de Oliveira EC, Carneiro ZA, de Albuquerque S, et al. Development and evaluation of a nanoemulsion containing ursolic acid: a promising trypanocidal agent: nanoemulsion with ursolic acid against T. cruzi. AAPS PharmSciTech. 2017;18(7):2551–2560.
  • Singh AK, Pandey H, Ramteke PW, et al. Nano - suspension of ursolic acid for improving oral bioavailability and attenuation of type II diabetes: a histopathological investigation. Biocatal Agric Biotechnol. 2019;22:101433.