950
Views
0
CrossRef citations to date
0
Altmetric
Immunology

Is there a rationale for supplementing with vitamin D patients under treatment with allergen immunotherapy?

, , , &
Article: 2230864 | Received 06 Apr 2023, Accepted 24 Jun 2023, Published online: 30 Jun 2023

References

  • Umar M, Sastry KS, Chouchane AI. Role of vitamin D Beyond the skeletal function: a review of the molecular and clinical studies. Int J Mol Sci. 2018;19(6):1. doi: 10.3390/ijms19061618.
  • Bivona G, Agnello L, Ciaccio M. The immunological implication of the new vitamin D metabolism. Cent Eur J Immunol. 2018;43(3):331–7. doi: 10.5114/ceji.2018.80053.
  • Chambers ES, Suwannasaen D, Mann EH, et al. 1alpha,25-dihydroxyvitamin D3 in combination with transforming growth factor-beta increases the frequency of Foxp3(+) regulatory T cells through preferential expansion and usage of interleukin-2. Immunology. 2014;143(1):52–60. doi: 10.1111/imm.12289.
  • Sassi F, Tamone C, D’Amelio P. Vitamin D: nutrient, hormone, and immunomodulator. Nutrients. 2018;10(11):1656. doi: 10.3390/nu10111656.
  • Ruiter B, Patil SU, Shreffler WG. Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells. Clin Exp Allergy. 2015;45(7):1214–1225. doi: 10.1111/cea.12568.
  • Pelst MP, Höbart C, Wallaeys C, et al. Adjuvanting allergen extracts for sublingual immunotherapy: calcitriol downregulates CXCL8 production in primary sublingual epithelial cells. Front Immunol. 2020;11:1033. doi: 10.3389/fimmu.2020.01033.
  • Pfeffer PE, Mann EH, Hornsby E, et al. Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Annals ATS. 2014;11(Supplement 5):S314–S321. doi: 10.1513/AnnalsATS.201405-204AW.
  • Hufnagl K, Jensen-Jarolim E. Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease. Allergo J Int. 2018;27(3):72–78. doi: 10.1007/s40629-018-0054-2.
  • Fabri M, Stenger S, Shin DM, et al. Vitamin D is required for IFN-γ-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011;3(104):104ra2. doi: 10.1126/scitranslmed.3003045.
  • Yuk JM, Shin DM, Lee HM, et al. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009;6(3):231–243. doi: 10.1016/j.chom.2009.08.004.
  • Campbell GR, Spector SA. Autophagy induction by vitamin D inhibits both Mycobacterium tuberculosis and human immunodeficiency virus type 1. Autophagy. 2012;8(10):1523–1525. doi: 10.4161/auto.21154.
  • Chambers ES, Vukmanovic-Stejic M, Turner CT, et al. Vitamin D3 replacement enhances antigen-specific immunity in older adults. Immunother Adv. 2021;1:ltaa008. doi: 10.1093/immadv/ltaa008.
  • Wu X, Hu W, Lu L, et al. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment. Acta Pharm Sin B. 2019;9(2):203–219. doi: 10.1016/j.apsb.2018.09.002.
  • Min D, Lv XB, Wang X, et al. Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity. Br J Cancer. 2013;109(3):723–730. doi: 10.1038/bjc.2013.337.
  • Palmer MT, Lee YK, Maynard CL, et al. Lineage-specific effects of 1,25-dihydroxyvitamin D3 on the development of effector CD4 T cells. J Biol Chem. 2011;286(2):997–1004. doi: 10.1074/jbc.M110.163790.
  • Xie Z, Chen J, Zheng C, et al. 1,25-dihydroxyvitamin D3-induced dendritic cells suppress experimental autoimmune encephalomyelitis by increasing proportions of the regulatory lymphocytes and reducing T helper type 1 and type 17 cells. Immunology. 2017;152(3):414–424. doi: 10.1111/imm.12776.
  • Guan Y, Hao Y, Guan Y, et al. The effect of vitamin D supplementation on rheumatoid arthritis patients: a systematic review and Meta-Analysis. Front Med (Lausanne). 2020;7:596007. doi: 10.3389/fmed.2020.596007.
  • Illescas-Montes R, Melguizo-Rodríguez L, Ruiz C, et al. Vitamin D and autoimmune diseases. Life Sci. 2019;233:116744. doi: 10.1016/j.lfs.2019.116744.
  • Sîrbe C, Rednic S, Grama A, et al. An update on the effects of vitamin D on the immune system and autoimmune diseases. Int J Mol Sci. 2022;23(17):9784. doi: 10.3390/ijms23179784.
  • Heine G, Francuzik W, Doelle-Bierke S, et al. Immunomodulation of high-dose vitamin D supplementation during allergen-specific immunotherapy. Allergy. 2021;76(3):930–933. doi: 10.1111/all.14541.
  • Durham SR, Shamji MH. Allergen immunotherapy: past, present and future. Nat Rev Immunol. 2023;23(5):317–328. doi: 10.1038/s41577-022-00786-1.
  • Petrarca C, Lanuti P, Petrosino MIMI, et al. Peripheral effector memory regulatory T cells are incremented and functionally enhanced in successful mite monomeric allergoid sublingual immunotherapy. Allergy. 2021;76(7):2208–2211. doi: 10.1111/all.14692.
  • Taher YA, van Esch BC, Hofman GA, et al. 1alpha,25-dihydroxyvitamin D3 potentiates the beneficial effects of allergen immunotherapy in a mouse model of allergic asthma: role for IL-10 and TGF-beta. J Immunol. 2008;180(8):5211–5221. doi: 10.4049/jimmunol.180.8.5211.
  • Grundström J, Neimert-Andersson T, Kemi C, et al. Covalent coupling of vitamin D3 to the major cat allergen fel d 1 improves the effects of allergen-specific immunotherapy in a mouse model for cat allergy. Int Arch Allergy Immunol. 2012;157(2):136–146. doi: 10.1159/000327546.
  • Van Overtvelt L, Lombardi V, Razafindratsita A, et al. IL-10-inducing adjuvants enhance sublingual immunotherapy efficacy in a murine asthma model. Int Arch Allergy Immunol. 2008;145(2):152–162. doi: 10.1159/000108140.
  • Hesse L, van Ieperen N, Petersen AH, et al. High dose vitamin D3 empowers effects of subcutaneous immunotherapy in a grass pollen-driven mouse model of asthma. Sci Rep. 2020;10(1):20876. doi: 10.1038/s41598-020-77947-6.
  • Ma JX, Xia JB, Cheng XM, et al. 1,25-dihydroxyvitamin D3 pretreatment enhances the efficacy of allergen immunotherapy in a mouse allergic asthma model. Chin Med J (Engl). 2010;123:3591–3596.
  • Heine G, Tabeling C, Hartmann B, et al. 25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model. J Immunol. 2014;193(3):1017–1023. doi: 10.4049/jimmunol.1301656.
  • Petrarca C, Clemente E, Amato V, et al. Vitamin D3 improves the effects of low dose der p 2 allergoid treatment in der p 2 sensitized BALB/c mice. Clin Mol Allergy. 2016;14:7. doi: 10.1186/s12948-016-0044-1.
  • Hesse L, Petersen AH, Oude Elberink JNG, et al. 1,25(OH)2VitD3 supplementation enhances suppression of grass pollen-induced allergic asthma by subcutaneous and sublingual immunotherapy in a mouse model. Sci Rep. 2020;10(1):8960. doi: 10.1038/s41598-020-65946-6.
  • Jerzynska J, Stelmach W, Rychlik B, et al. The clinical effect of vitamin D supplementation combined with grass-specific sublingual immunotherapy in children with allergic rhinitis. Allergy Asthma Proc. 2016;37(2):105–114. doi: 10.2500/aap.2016.37.3921.
  • Jerzyńska J, Stelmach W, Rychlik B, et al. Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis. Arch Med Sci. 2018;14(1):122–131. doi: 10.5114/aoms.2016.61978.
  • Yu ZJ, Zeng L, Luo XQ, et al. Vitamin D3 inhibits micro RNA-17-92 to promote specific immunotherapy in allergic rhinitis. Sci Rep. 2017;7(1):546. doi: 10.1038/s41598-017-00431-1.
  • Baris S, Kiykim A, Ozen O, et al. Vitamin D as an adjunct to subcutaneous allergen immunotherapy in asthmatic children sensitized to house dust mite. Allergy. 2014;69(2):246–253. doi: 10.1111/all.12278.
  • Lombardi C, Passalacqua G. Italian vitamin D allergy group vitamin D levels and allergic diseases. An italian cross-sectional multicenter survey. Eur Ann Allergy Clin Immunol. 2017;49:75–79.
  • Hypponen E, Berry DJ, Wjst M, et al. Serum 25-hydroxyvitamin D and IgE—a significant but nonlinear relationship. Allergy. 2009;64(4):613–620. doi: 10.1111/j.1398-9995.2008.01865.x.
  • Licari A, Marseglia GL, Ciprandi G. Vitamin D3 in children with allergic asthma in clinical practice. Pediatr Pulmonol. 2019;54(3):225–227. doi: 10.1002/ppul.24229.
  • Hennessy A, Hourihane JO, Malvisi L, et al. Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease-specific Cork BASELINE birth cohort study. Allergy. 2018;73(11):2182–2191. doi: 10.1111/all.13590.
  • Jia X, Zheng H, Yan X, et al. Effect of baseline serum vitamin D level on symptom and medication scores of subcutaneous immunotherapy in children with mite allergy. Front Pediatr. 2022;10:1018549. doi: 10.3389/fped.2022.1018549.
  • Joudi M, Farid Hosseini R, Khoshkhui M, et al. Effects of serum vitamin D and efficacy of subcutaneous immunotherapy in adult patients With allergic rhinitis. Allergy Asthma Immunol Res. 2019;11(6):885–893. doi: 10.4168/aair.2019.11.6.885.
  • Majak P, Jerzyńska J, Smejda K, et al. Correlation of vitamin D with Foxp3 induction and steroid-sparing effect of immunotherapy in asthmatic children. Ann Allergy Asthma Immunol. 2012;109(5):329–335. doi: 10.1016/j.anai.2012.08.002.
  • Reinholz M, Ruzicka T, Schauber J. Vitamin D and its role in allergic disease. Clin Exp Allergy. 2012;42(6):817–826. doi: 10.1111/j.1365-2222.2011.03923.x.
  • Yepes-Nunez JJ, Brozek JL, Fiocchi A, et al. Vitamin D supplementation in primary allergy prevention: systematic review of randomized and nonrandomized studies. Allergy. 2018;73(1):37–49. doi: 10.1111/all.13241.
  • Grant CC, Crane J, Mitchell EA, et al. Vitamin D supplementation during pregnancy and infancy reduces aeroallergen sensitization: a randomized controlled trial. Allergy. 2016;71(9):1325–1334. doi: 10.1111/all.12909.
  • Chawes BL, Bonnelykke K, Stokholm J, et al. Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA. 2016;315(4):353–361. doi: 10.1001/jama.2015.18318.
  • Litonjua AA, Carey VJ, Laranjo N, et al. Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA. 2016;315(4):362–370. doi: 10.1001/jama.2015.18589.
  • Mirzakhani H, Carey VJ, Zeiger R, et al. Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children. Clin Exp Allergy. 2019;49(4):419–429. doi: 10.1111/cea.13320.
  • Kim YH, Kim KW, Kim MJ, et al. Vitamin D levels in allergic rhinitis: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2016;27(6):580–590. doi: 10.1111/pai.12599.
  • Li Q, Zhou Q, Zhang G, et al. Vitamin D supplementation and allergic diseases during childhood: a systematic review and Meta-Analysis. Nutrients. 2022;14(19):3947. doi: 10.3390/nu14193947.
  • Luo C, Sun Y, Zeng Z, et al. Vitamin D supplementation in pregnant women or infants for preventing allergic diseases: a systematic review and meta-analysis of randomized controlled trials. Chin Med J (Engl). 2022;135(3):276–284. doi: 10.1097/CM9.0000000000001951.
  • Zeng R, Li Y, Shen S, et al. Is antenatal or early-life vitamin D associated with eczema or food allergy in childhood? A systematic review. Clin Experimental Allergy. 2023;53(5):511–525. doi: 10.1111/cea.14281.
  • Di T, Chen L. A narrative review of vitamin D and food allergy in infants and children. Transl Pediatr. 2021;10(10):2614–2620. doi: 10.21037/tp-21-396.
  • Moingeon P, Lombardi V, Baron-Bodo V, et al. Enhancing allergen-presentation platforms for sublingual immunotherapy. J Allergy Clin Immunol Pract. 2017;5(1):23–31. doi: 10.1016/j.jaip.2016.07.020.
  • Rajakulendran M, Tham EH, Soh JY, et al. Novel strategies in immunotherapy for allergic diseases. Asia Pac Allergy. 2018;8(2):e14. doi: 10.5415/apallergy.2018.8.e14.
  • Nelson HS. Allergy immunotherapy: future directions for the 2020s. Allergy Asthma Proc. 2020;41(5):314–325. doi: 10.2500/aap.2020.41.200041.
  • Sadeghi M, Keshavarz Shahbaz S, Dehnavi S, et al. Current possibilities and future perspectives for improving efficacy of allergen-specific sublingual immunotherapy. Int Immunopharmacol. 2021;101(Pt B):108350. doi: 10.1016/j.intimp.2021.108350.