Unexplained increases in serum carcinoembryonic antigen levels in colorectal cancer patients during the postoperative follow-up period: an analysis of its incidence and longitudinal pattern

References

• Park YA, Lee KY, Kim NK, et al. Prognostic effect of perioperative change of serum carcinoembryonic antigen level: a useful tool for detection of systemic recurrence in rectal cancer. Ann Surg Oncol. 2006;13(5):1–10. doi: 10.1245/ASO.2006.03.090.
   PubMed Web of Science ®Google Scholar
• Takagawa R, Fujii S, Ohta M, et al. Preoperative serum carcinoembryonic antigen level as a predictive factor of recurrence after curative resection of colorectal cancer. Ann Surg Oncol. 2008;15(12):3433–3439. doi: 10.1245/s10434-008-0168-8.
   PubMed Web of Science ®Google Scholar
• NCCN. Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer Version 2.2023. [Internet]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf
   Google Scholar
• NCCN. Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Rectal Cancer Version 3.2023. [Internet]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/rectal.pdf
   Google Scholar
• Argilés G, Tabernero J, Labianca R, et al. Localised colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(10):1291–1305. doi: 10.1016/j.annonc.2020.06.022.
   PubMed Web of Science ®Google Scholar
• Glynne-Jones R, Wyrwicz L, Tiret E, et al. Rectal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(suppl_4):iv22–iv40. doi: 10.1093/annonc/mdx224.
   PubMed Web of Science ®Google Scholar
• Vogel JD, Felder SI, Bhama AR, et al. The American Society of Colon and Rectal Surgeons clinical practice guidelines for the management of colon cancer. Dis Colon Rectum. 2022;65(2):148–177. doi: 10.1097/DCR.0000000000002323.
   PubMed Web of Science ®Google Scholar
• You YN, Hardiman KM, Bafford A, et al. The American Society of Colon and Rectal Surgeons clinical practice guidelines for the management of rectal cancer. Dis Colon Rectum. 2020;63(9):1191–1222. doi: 10.1097/DCR.0000000000001762.
   PubMed Web of Science ®Google Scholar
• Hashiguchi Y, Muro K, Saito Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020;25(1):1–42. doi: 10.1007/s10147-019-01485-z.
   PubMed Web of Science ®Google Scholar
• MacSween JM, Warner NL, Bankhurst AD, et al. Carcinoembryonic antigen in whole serum. Br J Cancer. 1972;26(5):356–360. doi: 10.1038/bjc.1972.46.
   PubMed Web of Science ®Google Scholar
• Reynoso G, Chu TM, Holyoke D, et al. Carcinoembryonic antigen in patients with different cancers. JAMA. 1972;220(3):361–365. doi: 10.1001/jama.1972.03200030021005.
   PubMed Web of Science ®Google Scholar
• Hao C, Zhang G, Zhang L. Serum CEA levels in 49 different types of cancer and noncancer diseases. Prog Mol Biol Transl Sci. 2019;162:213–227.
   PubMed Web of Science ®Google Scholar
• Khoo SK, Hunt PS, Mackay IR. Studies of carcinoembryonic antigen activity of whole and extracted serum in ulcerative colitis. Gut. 1973;14(7):545–548. doi: 10.1136/gut.14.7.545.
   PubMed Web of Science ®Google Scholar
• Stevens DP, Mackay IR, Busselton Population Studies Group. Increased carcinoembryonic antigen in heavy cigarette smokers. Lancet. 1973;2(7840):1238–1239.
   PubMed Web of Science ®Google Scholar
• Litvak A, Cercek A, Segal N, et al. False-positive elevations of carcinoembryonic antigen in patients with a history of resected colorectal cancer. J Natl Compr Canc Netw. 2014;12(6):907–913. doi: 10.6004/jnccn.2014.0085.
   PubMed Web of Science ®Google Scholar
• Barton MK. False elevations of carcinoembryonic antigen levels are common in patients under surveillance for colorectal cancer recurrence. CA Cancer J Clin. 2014;64(6):365–366. doi: 10.3322/caac.21247.
   PubMed Web of Science ®Google Scholar
• Sakuma T, Iwata Y, Ueda Y, et al. Annual periodic increases in serum carcinoembryonic antigen concurrent with ground-glass opacity in the lung: report of a case. Surg Today. 2005;35(10):883–885. doi: 10.1007/s00595-005-3010-y.
   PubMed Web of Science ®Google Scholar
• Yoshida A, Sekiya M, Naito M. A case of high serum carcinoembryonic antigen (CEA) level in summer season. Jpn J Med Tech. 2014;63:305–310.
   Google Scholar
• Brierley JD, Gospodarowicz MK, Wittekind CH, editors. TNM classification of malignant tumors. 8th ed. Oxford: Wiley-Blackwell; 2016.
   Google Scholar
• Epstein MM, Andrén O, Kasperzyk JL, et al. Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue. Cancer Causes Control. 2012;23(8):1359–1366. doi: 10.1007/s10552-012-0016-9.
   PubMed Web of Science ®Google Scholar
• Connolly D, van Leeuwen PJ, Bailie J, et al. Daily, monthly and seasonal variation in PSA levels and the association with weather parameters. Prostate Cancer Prostatic Dis. 2011;14(1):58–62. doi: 10.1038/pcan.2010.37.
   PubMed Web of Science ®Google Scholar
• Oremek GM, Seiffert UB. Physical activity releases prostate-specific antigen (PSA) from the prostate gland into blood and increases serum PSA concentrations. Clin Chem. 1996;42(5):691–695. doi: 10.1093/clinchem/42.5.691.
   PubMed Web of Science ®Google Scholar
• Giovannucci E. The epidemiology of vitamin D and cancer incidence and mortality: a review (United States). Cancer Causes Control. 2005;16(2):83–95. doi: 10.1007/s10552-004-1661-4.
   PubMed Web of Science ®Google Scholar
• Wong JY, Mivechi NF, Paxton RJ, et al. The effects of hyperthermia on tumor carcinoembryonic antigen expression. Int J Radiat Oncol Biol Phys. 1989;17(4):803–808. doi: 10.1016/0360-3016(89)90070-9.
   PubMed Web of Science ®Google Scholar
• Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol. 2006;35(2):217–220. doi: 10.1093/ije/dyi229.
   PubMed Web of Science ®Google Scholar
• Fakih MG, Padmanabhan A. CEA monitoring in colorectal cancer. What you should know. Oncology. 2006;20(6):579–587; discussion 588, 594, 596.
   PubMed Web of Science ®Google Scholar
• Chen Q, Kong H, Qi X, et al. Carcinoembryonic antigen: a potential biomarker to evaluate the severity and prognosis of COVID-19. Front Med. 2020;7:579543. doi: 10.3389/fmed.2020.579543.
   Web of Science ®Google Scholar
• Yang L, Tu L. Implications of gastrointestinal manifestations of COVID-19. Lancet Gastroenterol Hepatol. 2020;5(7):629–630. doi: 10.1016/S2468-1253(20)30132-1.
   PubMed Web of Science ®Google Scholar
• Yu J, Yang Z, Zhou X, et al. Prognostic value of carcinoembryonic antigen on outcome in patients with coronavirus disease 2019. J Infect. 2020;81(2):e170–e172. doi: 10.1016/j.jinf.2020.06.018.
   PubMed Web of Science ®Google Scholar
• Bañez LL, Hamilton RJ, Partin AW, et al. Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. JAMA. 2007;298(19):2275–2280. doi: 10.1001/jama.298.19.2275.
   PubMed Web of Science ®Google Scholar
• Chang IH, Ahn SH, Han JH, et al. The clinical significance in healthy men of the association between obesity related plasma hemodilution and tumor marker concentration. J Urol. 2009;181(2):567–573; discussion 572–573. doi: 10.1016/j.juro.2008.10.030.
   PubMed Web of Science ®Google Scholar
• Park JS, Choi GS, Jang YS, et al. Influence of obesity on the serum carcinoembryonic antigen value in patients with colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2461–2468. doi: 10.1158/1055-9965.EPI-10-0569.
   PubMed Web of Science ®Google Scholar
• Park CH, Lizarraga AD, Lee YT, et al. Increased carcinoembryonic antigen (CEA) level is highly associated with low skeletal muscle mass in asymptomatic adults: a population-based study. J Clin Med. 2022;11(17):5009. doi: 10.3390/jcm11175009.
   PubMed Web of Science ®Google Scholar
• Touitou Y, Proust J, Klinger E, et al. Cumulative effects of age and pathology on plasma carcinoembryonic antigen in an unselected elderly population. Eur J Cancer Clin Oncol. 1984;20(3):369–374. doi: 10.1016/0277-5379(84)90083-x.
   PubMedGoogle Scholar
• Bjornsson TD. Use of serum creatinine concentrations to determine renal function. Clin Pharmacokinet. 1979;4(3):200–222. doi: 10.2165/00003088-197904030-00003.
   PubMed Web of Science ®Google Scholar