Increased blood CD226^- inflammatory monocytes with low antigen presenting potential correlate positively with severity of hemorrhagic fever with renal syndrome

References

• Avsic-Zupanc T, Saksida A, Korva M. Hantavirus infections. Clin Microbiol Infect. 2019;21S:1–12. doi: 10.1111/1469-0691.12291.
   Google Scholar
• Shen L, Sun M, Wei X, et al. Spatiotemporal association of rapid urbanization and water-body distribution on hemorrhagic fever with renal syndrome: a case study in the city of Xi’an, China. PLoS Negl Trop Dis. 2022;16(1):e0010094. doi: 10.1371/journal.pntd.0010094.
   PubMed Web of Science ®Google Scholar
• Tian H, Tie WF, Li H, et al. Orthohantaviruses infections in humans and rodents in Baoji, China. PLoS Negl Trop Dis. 2020;14(10):e0008778. doi: 10.1371/journal.pntd.0008778.
   PubMed Web of Science ®Google Scholar
• Knust B, Brown S, de St Maurice A, et al. Seoul virus infection and spread in United States home-based ratteries: rat and human testing results from a multistate outbreak investigation. J Infect Dis. 2020;222(8):1311–1319. doi: 10.1093/infdis/jiaa307.
   PubMed Web of Science ®Google Scholar
• Vaheri A, Strandin T, Hepojoki J, et al. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol. 2013;11(8):539–550. doi: 10.1038/nrmicro3066.
   PubMed Web of Science ®Google Scholar
• Outinen TK, Mäkelä S, Pörsti I, et al. Severity biomarkers in puumala hantavirus infection. Viruses. 2021;14(1):45. doi: 10.3390/v14010045.
   PubMed Web of Science ®Google Scholar
• De Smet MAJ, Bogaert S, Schauwvlieghe A, et al. Case report: hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis. Front Med (Lausanne). 2022;9:1096900. doi: 10.3389/fmed.2022.1096900.
   PubMed Web of Science ®Google Scholar
• Hooper J, Paolino KM, Mills K, et al. A phase 2a randomized, Double-Blind, Dose-Optimizing study to evaluate the immunogenicity and safety of a bivalent DNA vaccine for hemorrhagic fever with renal syndrome delivered by intramuscular electroporation. Vaccines. 2020;8(3):377. doi: 10.3390/vaccines8030377.
   Web of Science ®Google Scholar
• Yi J, Xu Z, Zhuang R, et al. Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity. J Infect Dis. 2013;207(9):1457–1461. doi: 10.1093/infdis/jis475.
   PubMed Web of Science ®Google Scholar
• Wang M, Wang J, Zhu Y, et al. Cellular immune response to Hantaan virus nucleocapsid protein in the acute phase of hemorrhagic fever with renal syndrome: correlation with disease severity. J Infect Dis. 2009;199(2):188–195. doi: 10.1086/595834.
   PubMed Web of Science ®Google Scholar
• Ma Y, Wang J, Yuan B, et al. HLA-A2 and B35 restricted Hantaan virus nucleoprotein CD8+ T-cell epitope-specific immune response correlates with milder disease in hemorrhagic fever with renal syndrome. PLoS Negl Trop Dis. 2013;7(2):e2076. doi: 10.1371/journal.pntd.0002076.
   PubMed Web of Science ®Google Scholar
• Ma Y, Yuan B, Zhuang R, et al. Hantaan virus infection induces both Th1 and ThGranzyme B + cell immune responses that associated with viral control and clinical outcome in humans. PLoS Pathog. 2015;11(4):e1004788. doi: 10.1371/journal.ppat.1004788.
   PubMed Web of Science ®Google Scholar
• Au RY, Jedlicka AE, Li W, et al. Seoul virus suppresses NF-kappaB-mediated inflammatory responses of antigen presenting cells from Norway rats. Virology. 2010;400(1):115–127. doi: 10.1016/j.virol.2010.01.027.
   PubMed Web of Science ®Google Scholar
• Matthys VS, Cimica V, Dalrymple NA, et al. Hantavirus GnT elements mediate TRAF3 binding and inhibit RIG-I/TBK1-directed beta interferon transcription by blocking IRF3 phosphorylation. J Virol. 2014;88(4):2246–2259. doi: 10.1128/JVI.02647-13.
   PubMed Web of Science ®Google Scholar
• Wong KL, Yeap WH, Tai JJ, et al. The three human monocyte subsets: implications for health and disease. Immunol Res. 2012;53(1-3):41–57. doi: 10.1007/s12026-012-8297-3.
   PubMed Web of Science ®Google Scholar
• Knoll R, Schultze JL, Schulte-Schrepping J. Monocytes and macrophages in COVID-19. Front Immunol. 2021;12:720109. doi: 10.3389/fimmu.2021.720109.
   PubMedGoogle Scholar
• Sampath P, Moideen K, Ranganathan UD, et al. Monocyte subsets: phenotypes and function in tuberculosis infection. Front Immunol. 2018;9:1726. doi: 10.3389/fimmu.2018.01726.
   PubMed Web of Science ®Google Scholar
• Ziegler-Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116(16):e74-80–e80. doi: 10.1182/blood-2010-02-258558.
   PubMed Web of Science ®Google Scholar
• Cros J, Cagnard N, Woollard K, et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity. 2010;33(3):375–386. doi: 10.1016/j.immuni.2010.08.012.
   PubMed Web of Science ®Google Scholar
• Schmidl C, Renner K, Peter K, et al. Transcription and enhancer profiling in human monocyte subsets. Blood. 2014;123(17):e90-99–e99. doi: 10.1182/blood-2013-02-484188.
   Web of Science ®Google Scholar
• Auffray C, Fogg D, Garfa M, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007;317(5838):666–670. doi: 10.1126/science.1142883.
   PubMed Web of Science ®Google Scholar
• Tang K, Zhang C, Zhang Y, et al. Elevated plasma soluble CD14 levels correlate with the monocyte response status during hantaan virus infection in humans. Viral Immunol. 2015;28(8):442–447. doi: 10.1089/vim.2015.0040.
   PubMed Web of Science ®Google Scholar
• Vangeti S, Strandin T, Liu S, et al. Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome. PLoS Pathog. 2021;17(3):e1009400. doi: 10.1371/journal.ppat.1009400.
   PubMed Web of Science ®Google Scholar
• Martinet L, Ferrari De Andrade L, Guillerey C, et al. DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 2015;11(1):85–97. doi: 10.1016/j.celrep.2015.03.006.
   PubMed Web of Science ®Google Scholar
• Scott JL, Dunn SM, Jin B, et al. Characterization of a novel membrane glycoprotein involved in platelet activation. J Biol Chem. 1989;264(23):13475–13482. doi: 10.1016/S0021-9258(18)80021-7.
   PubMed Web of Science ®Google Scholar
• Bi JC. CD226: a potent driver of antitumor immunity that needs to be maintained. Cell Mol Immunol. 2022;19(9):969–970. doi: 10.1038/s41423-020-00633-0.
   PubMed Web of Science ®Google Scholar
• Vo AV, Takenaka E, Shibuya A, et al. Expression of DNAM-1 (CD226) on inflammatory monocytes. Mol Immunol. 2016;69:70–76. doi: 10.1016/j.molimm.2015.11.009.
   PubMed Web of Science ®Google Scholar
• Lenac Rovis T, Kucan Brlic P, Kaynan N, et al. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. J Exp Med. 2016;213(9):1835–1850. doi: 10.1084/jem.20151899.
   PubMed Web of Science ®Google Scholar
• Liu B, Ma Y, Zhang Y, et al. CD8low CD100- T cells identify a novel CD8 T cell subset associated with viral control during human hantaan virus infection. J Virol. 2015;89(23):11834–11844. doi: 10.1128/JVI.01610-15.
   PubMed Web of Science ®Google Scholar
• Tang K, Zhang Y, Zhang C, et al. Hantaan virus-induced elevation of plasma osteoprotegerin and its clinical implications in hemorrhagic fever with renal syndrome. Int J Infect Dis. 2023;126:14–21. doi: 10.1016/j.ijid.2022.11.005.
   PubMed Web of Science ®Google Scholar
• Tang K, Zhang C, Zhang Y, et al. Elevated plasma interleukin 34 levels correlate with disease severity-reflecting parameters of patients with haemorrhagic fever with renal syndrome. Infect Dis. 2019;51(11-12):847–853. doi: 10.1080/23744235.2019.1672887.
   PubMed Web of Science ®Google Scholar
• Li Z, Shen Y, Song Y, et al. ER stress-related molecules induced by Hantaan virus infection in differentiated THP-1 cells. Cell Stress Chaperones. 2021;26(1):41–50. doi: 10.1007/s12192-020-01150-9.
   PubMed Web of Science ®Google Scholar
• Ye W, Lei Y, Yu M, et al. NLRP3 inflammasome is responsible for Hantavirus inducing interleukin-1beta in THP-1 cells. Int J Mol Med. 2015;35(6):1633–1640. doi: 10.3892/ijmm.2015.2162.
   PubMed Web of Science ®Google Scholar
• Xu-Yang Z, Pei-Yu B, Chuan-Tao Y, et al. Interferon-induced transmembrane protein 3 inhibits hantaan virus infection, and its single nucleotide polymorphism rs12252 influences the severity of hemorrhagic fever with renal syndrome. Front Immunol. 2016;7:535.
   PubMed Web of Science ®Google Scholar
• Jakubzick CV, Randolph GJ, Henson PM. Monocyte differentiation and antigen-presenting functions. Nat Rev Immunol. 2017;17(6):349–362. doi: 10.1038/nri.2017.28.
   PubMed Web of Science ®Google Scholar
• Hoffman D, Tevet Y, Trzebanski S, et al. A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella. Immunity. 2021;54(12):2712–2723 e2716. doi: 10.1016/j.immuni.2021.10.015.
   PubMed Web of Science ®Google Scholar
• Wang K, Ma H, Liu H, et al. The glycoprotein and nucleocapsid protein of hantaviruses manipulate autophagy flux to restrain host innate immune responses. Cell Rep. 2019;27(7):2075–2091.e5. e2075. doi: 10.1016/j.celrep.2019.04.061.
   PubMed Web of Science ®Google Scholar
• Brocato RL, Altamura LA, Carey BD, et al. Comparison of transcriptional responses between pathogenic and nonpathogenic hantavirus infections in Syrian hamsters using NanoString. PLoS Negl Trop Dis. 2021;15(8):e0009592. doi: 10.1371/journal.pntd.0009592.
   PubMed Web of Science ®Google Scholar
• Sola-Riera C, Gupta S, Maleki KT, et al. Hantavirus inhibits TRAIL-mediated killing of infected cells by downregulating death receptor 5. Cell Rep. 2019;28(8):2124–2139 e2126. doi: 10.1016/j.celrep.2019.07.066.
   PubMed Web of Science ®Google Scholar
• Sola-Riera C, Gupta S, Ljunggren HG, et al. Orthohantaviruses belonging to three phylogroups all inhibit apoptosis in infected target cells. Sci Rep. 2019;9(1):834. doi: 10.1038/s41598-018-37446-1.
   PubMedGoogle Scholar
• Nakano H, Lin KL, Yanagita M, et al. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat Immunol. 2009;10(4):394–402. doi: 10.1038/ni.1707.
   PubMed Web of Science ®Google Scholar
• Takenaka E, Van Vo A, Yamashita-Kanemaru Y, et al. Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4(+) T cell costimulation. Sci Rep. 2018;8(1):15180. doi: 10.1038/s41598-018-33437-4.
   PubMedGoogle Scholar
• Scholz S, Baharom F, Rankin G, et al. Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways. PLoS Pathog. 2017;13(6):e1006462. doi: 10.1371/journal.ppat.1006462.
   PubMed Web of Science ®Google Scholar
• Grossman L, Chang C, Dai J, et al. Epstein-Barr virus induces adhesion receptor CD226 (DNAM-1) expression during primary B-cell transformation into lymphoblastoid cell lines. Msphere. 2017;2(6):e00305. 00317. doi: 10.1128/mSphere.00305-17.
   PubMed Web of Science ®Google Scholar
• Braun M, Aguilera AR, Sundarrajan A, et al. CD155 on tumor cells drives resistance to immunotherapy by inducing the degradation of the activating receptor CD226 in CD8(+) T cells. Immunity. 2020;53(4):805–823 e815. doi: 10.1016/j.immuni.2020.09.010.
   PubMed Web of Science ®Google Scholar