Independent prognostic biomarker FERMT3 associated with immune infiltration and immunotherapy response in glioma

References

• Low JT, Ostrom QT, Cioffi G, et al. Primary brain and other central nervous system tumors in the United States (2014-2018): a summary of the CBTRUS statistical report for clinicians. Neurooncol Pract. 2022;9(3):1–15.
   PubMed Web of Science ®Google Scholar
• Rognoni E, Ruppert R, Fassler R. The kindlin family: functions, signaling properties and implications for human disease. J Cell Sci. 2016;129(1):17–27. doi: 10.1242/jcs.161190.
   PubMed Web of Science ®Google Scholar
• Zhan J, Zhang H. Kindlins: roles in development and cancer progression. Int J Biochem Cell Biol. 2018;98:93–103. doi: 10.1016/j.biocel.2018.03.008.
   PubMed Web of Science ®Google Scholar
• Sin S, Bonin F, Petit V, et al. Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst. 2011;103(17):1323–1337. doi: 10.1093/jnci/djr290.
   PubMedGoogle Scholar
• Sossey-Alaoui K, Pluskota E, Davuluri G, et al. Kindlin-3 enhances breast cancer progression and metastasis by activating twist-mediated angiogenesis. Faseb J. 2014;28(5):2260–2271. doi: 10.1096/fj.13-244004.
   PubMed Web of Science ®Google Scholar
• Ma L, Tian Y, Qian T, et al. Kindlin-2 promotes src-mediated tyrosine phosphorylation of androgen receptor and contributes to breast cancer progression. Cell Death Dis. 2022;13(5):482. doi: 10.1038/s41419-022-04945-z.
   PubMed Web of Science ®Google Scholar
• Zhan J, Zhu X, Guo Y, et al. Opposite role of kindlin-1 and kindlin-2 in lung cancers. PLoS One. 2012;7(11):e50313. doi: 10.1371/journal.pone.0050313.
   PubMed Web of Science ®Google Scholar
• Liu G, Bao Y, Liu C, et al. IKKε phosphorylates kindlin-2 to induce invadopodia formation and promote colorectal cancer metastasis. Theranostics. 2020;10(5):2358–2373. doi: 10.7150/thno.40397.
   PubMed Web of Science ®Google Scholar
• Tang Y, Nan N, Gui C, et al. Blockage of PD-L1 by FERMT3-mediated wnt/β-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells. Clin Exp Pharmacol Physiol. 2022;49(9):988–997. doi: 10.1111/1440-1681.13685.
   PubMed Web of Science ®Google Scholar
• Ou YW, Zhao ZT, Wu CY, et al. Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways. Acta Pharmacol Sin. 2014;35(9):1199–1206. doi: 10.1038/aps.2014.60.
   PubMed Web of Science ®Google Scholar
• Lu C, Cui C, Liu B, et al. FERMT3 contributes to glioblastoma cell proliferation and chemoresistance to temozolomide through integrin mediated wnt signaling. Neurosci Lett. 2017;657:77–83. doi: 10.1016/j.neulet.2017.07.057.
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–w102. doi: 10.1093/nar/gkx247.
   PubMed Web of Science ®Google Scholar
• Chandrashekar DS, Karthikeyan SK, Korla PK, et al. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18–27. doi: 10.1016/j.neo.2022.01.001.
   PubMed Web of Science ®Google Scholar
• Shen W, Song Z, Zhong X, et al. Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform. iMeta. 2022;1(3):e36. doi: 10.1002/imt2.36.
   Google Scholar
• Zhao Z, Zhang KN, Wang Q, et al. Chinese glioma genome atlas (CGGA): a comprehensive resource with functional genomic data from Chinese glioma patients. Genomics Proteomics Bioinformatics. 2021;19(1):1–12. doi: 10.1016/j.gpb.2020.10.005.
   PubMed Web of Science ®Google Scholar
• Bowman RL, Wang Q, Carro A, et al. GlioVis data portal for visualization and analysis of brain tumor expression datasets. Neuro Oncol. 2017;19(1):139–141. doi: 10.1093/neuonc/now247.
   PubMed Web of Science ®Google Scholar
• Li J, Miao B, Wang S, et al. Hiplot: a comprehensive and easy-to-use web service for boosting publication-ready biomedical data visualization. Brief Bioinform. 2022;23(4):bbac261.
   PubMed Web of Science ®Google Scholar
• Gao J, Aksoy BA, Dogrusoz U, et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 2013;6(269):pl1. doi: 10.1126/scisignal.2004088.
   PubMed Web of Science ®Google Scholar
• Lin A, Qi C, Wei T, et al. CAMOIP: a web server for comprehensive analysis on multi-omics of immunotherapy in pan-cancer. Brief Bioinform. 2022;23(3):bbac129. doi: 10.1093/bib/bbac129.
   PubMed Web of Science ®Google Scholar
• Ru B, Wong CN, Tong Y, et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics. 2019;35(20):4200–4202. doi: 10.1093/bioinformatics/btz210.
   PubMed Web of Science ®Google Scholar
• Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of Tumor-Infiltrating immune cells. Cancer Res. 2017;77(21):e108–e10. doi: 10.1158/0008-5472.CAN-17-0307.
   PubMed Web of Science ®Google Scholar
• He Y, Jiang Z, Chen C, et al. Classification of triple-negative breast cancers based on immunogenomic profiling. J Exp Clin Cancer Res. 2018;37(1):327. doi: 10.1186/s13046-018-1002-1.
   PubMedGoogle Scholar
• Yoshihara K, Shahmoradgoli M, Martínez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4(1):2612. doi: 10.1038/ncomms3612.
   PubMed Web of Science ®Google Scholar
• Bennett ML, Bennett FC, Liddelow SA, et al. New tools for studying microglia in the mouse and human CNS. Proc Natl Acad Sci U S A. 2016;113(12):E1738–46. doi: 10.1073/pnas.1525528113.
   PubMed Web of Science ®Google Scholar
• Darmanis S, Sloan SA, Croote D, et al. Single-Cell RNA-Seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma. Cell Rep. 2017;21(5):1399–1410. doi: 10.1016/j.celrep.2017.10.030.
   PubMed Web of Science ®Google Scholar
• Roesch S, Rapp C, Dettling S, et al. When immune cells turn Bad-Tumor-Associated microglia/macrophages in glioma. Int J Mol Sci. 2018;19(2):436. doi: 10.3390/ijms19020436.
   PubMed Web of Science ®Google Scholar
• McIvor Z, Hein S, Fiegler H, et al. Transient expression of PU.1 commits multipotent progenitors to a myeloid fate whereas continued expression favors macrophage over granulocyte differentiation. Exp Hematol. 2003;31(1):39–47. doi: 10.1016/s0301-472x(02)01017-2.
   PubMed Web of Science ®Google Scholar
• Sonn I, Honda-Ozaki F, Yoshimatsu S, et al. Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia. Inflamm Regen. 2022;42(1):20. doi: 10.1186/s41232-022-00201-1.
   PubMed Web of Science ®Google Scholar
• Zeng Z, Wong CJ, Yang L, et al. TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response. Nucleic Acids Res. 2022;50(D1):D1391–D1397. doi: 10.1093/nar/gkab804.
   PubMed Web of Science ®Google Scholar
• Hoshida Y, Brunet JP, Tamayo P, et al. Subclass mapping: identifying common subtypes in independent disease data sets. PLOS One. 2007;2(11):e1195. doi: 10.1371/journal.pone.0001195.
   PubMed Web of Science ®Google Scholar
• He G, Chen Z, Zhuo S, et al. Pyroptosis: a novel signature to predict prognosis and immunotherapy response in gliomas. Hum Cell. 2022;35(6):1976–1992. doi: 10.1007/s13577-022-00791-5.
   PubMed Web of Science ®Google Scholar
• Liu CJ, Hu FF, Xia MX, et al. GSCALite: a web server for gene set cancer analysis. Bioinformatics. 2018;34(21):3771–3772. doi: 10.1093/bioinformatics/bty411.
   PubMed Web of Science ®Google Scholar
• Bernstein MN, Ni Z, Collins M, et al. CHARTS: a web application for characterizing and comparing tumor subpopulations in publicly available single-cell RNA-seq data sets. BMC Bioinf. 2021;22(1):83. doi: 10.1186/s12859-021-04021-x.
   PubMed Web of Science ®Google Scholar
• Neftel C, Laffy J, Filbin MG, et al. An integrative model of cellular states, plasticity, and genetics for glioblastoma. Cell. 2019;178(4):835–849.e21. doi: 10.1016/j.cell.2019.06.024.
   PubMed Web of Science ®Google Scholar
• Moser M, Bauer M, Schmid S, et al. Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med. 2009;15(3):300–305. doi: 10.1038/nm.1921.
   PubMed Web of Science ®Google Scholar
• Svensson L, Howarth K, McDowall A, et al. Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med. 2009;15(3):306–312. doi: 10.1038/nm.1931.
   PubMed Web of Science ®Google Scholar
• Feng C, Wee WK, Chen H, et al. Expression of kindlin-3 in melanoma cells impedes cell migration and metastasis. Cell Adh Migr. 2017;11(5-6):419–433. doi: 10.1080/19336918.2016.1243645.
   PubMed Web of Science ®Google Scholar
• Buonfiglioli A, Hambardzumyan D. Macrophages and microglia: the cerberus of glioblastoma. Acta Neuropathol Commun. 2021;9(1):54. doi: 10.1186/s40478-021-01156-z.
   PubMed Web of Science ®Google Scholar
• Xuan W, Lesniak MS, James CD, et al. Context-Dependent Glioblastoma-Macrophage/microglia symbiosis and associated mechanisms. Trends Immunol. 2021;42(4):280–292. doi: 10.1016/j.it.2021.02.004.
   PubMed Web of Science ®Google Scholar
• Dudiki T, Meller J, Mahajan G, et al. Microglia control vascular architecture via a TGFβ1 dependent paracrine mechanism linked to tissue mechanics. Nat Commun. 2020;11(1):986. doi: 10.1038/s41467-020-14787-y.
   PubMed Web of Science ®Google Scholar
• Liu H, Sun Y, Zhang Q, et al. Pro-inflammatory and proliferative microglia drive progression of glioblastoma. Cell Rep. 2021;36(11):109718. doi: 10.1016/j.celrep.2021.109718.
   PubMed Web of Science ®Google Scholar
• Wang G, Zhong K, Wang Z, et al. Tumor-associated microglia and macrophages in glioblastoma: from basic insights to therapeutic opportunities. Front Immunol. 2022;13:964898. doi: 10.3389/fimmu.2022.964898.
   PubMed Web of Science ®Google Scholar
• Yu MW, Quail DF. Immunotherapy for glioblastoma: current progress and challenges. Front Immunol. 2021;12:676301. doi: 10.3389/fimmu.2021.676301.
   PubMed Web of Science ®Google Scholar
• Wang C, Yu M, Zhang W. Neoantigen discovery and applications in glioblastoma: an immunotherapy perspective. Cancer Lett. 2022;550:215945. doi: 10.1016/j.canlet.2022.215945.
   PubMed Web of Science ®Google Scholar
• Bian Y, Wang Y, Chen X, et al. Image-guided diagnosis and treatment of glioblastoma. View. 2023;4(3):20220069. doi: 10.1002/VIW.20220069.
   Google Scholar
• Zhu H, Yang C, Yan A, et al. Tumor-targeted nano-adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity. View. 2023;4(3):20220067. doi: 10.1002/VIW.20220067.
   Google Scholar
• Qu S, Huang C, Zhu T, et al. OLFML3, as a potential predictor of prognosis and therapeutic target for glioma, is closely related to immune cell infiltration. View. 2023;4(2):20220052. doi: 10.1002/VIW.20220052.
   Google Scholar
• Yang WB, Hsu CC, Hsu TI, et al. Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma. Neuro Oncol. 2020;22(10):1439–1451. doi: 10.1093/neuonc/noaa103.
   PubMed Web of Science ®Google Scholar
• Hanisch D, Krumm A, Diehl T, et al. Class I HDAC overexpression promotes temozolomide resistance in glioma cells by regulating RAD18 expression. Cell Death Dis. 2022;13(4):293. doi: 10.1038/s41419-022-04751-7.
   PubMed Web of Science ®Google Scholar
• Chen R, Zhang M, Zhou Y, et al. The application of histone deacetylases inhibitors in glioblastoma. J Exp Clin Cancer Res. 2020;39(1):138. doi: 10.1186/s13046-020-01643-6.
   PubMed Web of Science ®Google Scholar
• Qu S, Li S, Hu Z. Upregulation of Piezo1 is a novel prognostic indicator in glioma patients. Cancer Manag Res. 2020;12:3527–3536. doi: 10.2147/CMAR.S251776.
   PubMed Web of Science ®Google Scholar
• Mao C, Huang C, Hu Z, et al. Transcription factor CASZ1 increases an oncogenic transcriptional process in tumorigenesis and progression of glioma cells. MedComm. 2022;3(4):e182. doi: 10.1002/mco2.182.
   PubMedGoogle Scholar
• Qu S, Qiu O, Huang J, et al. Upregulation of hsa-miR-196a-5p is associated with MIR196A2 methylation and affects the malignant biological behaviors of glioma. Genomics. 2021;113(3):1001–1010. doi: 10.1016/j.ygeno.2021.02.012.
   PubMed Web of Science ®Google Scholar
• Hu Z, Qu S. EVA1C is a potential prognostic biomarker and correlated with immune infiltration levels in WHO grade II/III glioma. Front Immunol. 2021;12:683572. doi: 10.3389/fimmu.2021.683572.
   PubMed Web of Science ®Google Scholar
• Qu S, Liu S, Qiu W, et al. Screening of autophagy genes as prognostic indicators for glioma patients. Am J Transl Res. 2020;12(9):5320–5331.
   PubMed Web of Science ®Google Scholar
• Qu S, Qiu O, Hu Z. The prognostic factors and nomogram for patients with high-grade gliomas. Fundam Res. 2021;1(6):824–828. doi: 10.1016/j.fmre.2021.07.005.
   Google Scholar