References
- WHO. Estimate of influenza deaths due to respiratory disease [cited 2021 Oct 13]. Available from: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/ burden-of-disease.
- Keilman LJ. Seasonal influenza (flu). Nurs Clin North Am. 2019;54(2):1–9. doi: 10.1016/j.cnur.2019.02.009.
- Ozaki Y, Rui J, Tang Y, et al. Anti-inflammatory effect of forsythia suspensa vahl and its active fraction. Biol Pharm Bull. 1997;20(8):861–864. doi: 10.1248/bpb.20.861.
- Chinese Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China. Beijing: China Medical Science Press; 2015.
- Han Z, Lei X-L, Zhang H, et al. Evaluating the safety of forsythin from forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models. Asian Pac J Trop Med. 2017;10(1):47–51. doi: 10.1016/j.apjtm.2016.10.011.
- Wang L, Zhang W, Lu Z, et al. Functional gene module-based identification of phillyrin as an anticardiac fibrosis agent. Front Pharmacol. 2020;11(11):1077. doi: 10.3389/fphar.2020.01077.
- Wang J, Chen G, Zhang Q, et al. Phillyrin attenuates osteoclast formation and function and prevents LPS-induced osteolysis in mice. Front Pharmacol. 2019;10(10):1188. doi: 10.3389/fphar.2019.01188.
- Zhang D, Qi B, Li D, et al. Phillyrin relieves lipopolysaccharide-induced AKI by protecting against glycocalyx damage and inhibiting inflammatory responses. Inflammation. 2020;43(2):540–551. doi: 10.1007/s10753-019-01136-5.
- Zhong W-T, Wu Y-C, Xie X-X, et al. Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice. Fitoterapia. 2013;90:132–139. doi: 10.1016/j.fitote.2013.06.003.
- Jiang Q, Chen J, Long X, et al. Phillyrin protects mice from traumatic brain injury by inhibiting the inflammation of microglia via PPARγ signaling pathway. Int Immunopharmacol. 2020;79:106083. doi: 10.1016/j.intimp.2019.106083.
- Do MT, Kim HG, Choi JH, et al. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food Chem. 2013;136(2):415–425. doi: 10.1016/j.foodchem.2012.09.012.
- Xiao HB, Sui GG, Lu XY. Phillyrin lowers body weight in obese mice via the modulation of PPAR/-ANGPTL 4 pathway. Obes Res Clin Pract. 2018;12(1):71–79. doi: 10.1016/j.orcp.2017.02.002.
- Zou P, Yu Y, Zheng N, et al. Applications of human pharmacokinetic prediction in first-in-human dose estimation. AAPS J. 2012;14(2):262–281. doi: 10.1208/s12248-012-9332-y.
- Pan L-L, Yang Y, Hui M, et al. Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified. Acta Pharmacol Sin. 2021;42(2):311–322. doi: 10.1038/s41401-020-0481-8.
- Yoon E, et al. Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol. 2016;4(2):131–142.
- Organ-specific warnings: internal analgesic, antipyretic, and antirheumatic products for over-the-counter human use-labeling for products that contain acetaminophen; guidance for industry; availability. US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER). 2015.
- Świerczyńska M, Mirowska-Guzel DM, Pindelska E. Antiviral drugs in influenza. Int J Environ Res Public Health. 2022;19(5):3018. doi: 10.3390/ijerph19053018.
- Deng J, Zhu X, Chen Z, et al. A review of food–drug interactions on oral drug absorption. Drugs. 2017;77(17):1833–1855. doi: 10.1007/s40265-017-0832-z.
- Moon YJ, Wang X, Morris ME. Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Toxicol in Vitro. 2006;20(2):187–210. doi: 10.1016/j.tiv.2005.06.048.
- Sheng Y, He Y, Huang X, et al. Systematic evaluation of dose proportionality studies in clinical pharmacokinetics. Curr Drug Metab. 2010;11(6):526–537. doi: 10.2174/138920010791636185.