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Hematology

The value of platelet-rich plasma-derived extracellular vesicles in modern medicine

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Article: 2287705 | Received 17 May 2023, Accepted 20 Nov 2023, Published online: 08 Dec 2023

References

  • Alves R, Grimalt R. A review of platelet-rich plasma: history, biology, mechanism of action, and classification. Skin Appendage Disord. 2018;4(1):1–11. doi: 10.1159/000477353.
  • Qiao J, An N, Ouyang X. Quantification of growth factors in different platelet concentrates. Platelets. 2017;28(8):774–778. doi: 10.1080/09537104.2016.1267338.
  • Amable PR, Carias RB, Teixeira MV, et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors. Stem Cell Res Ther. 2013;4(3):67. doi: 10.1186/scrt218.
  • Katz JN. Platelet-Rich plasma for osteoarthritis and achilles tendinitis. JAMA. 2021;326(20):2012–2014. doi: 10.1001/jama.2021.19540.
  • Belk JW, Kraeutler MJ, Houck DA, et al. Platelet-Rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med. 2021;49(1):249–260. doi: 10.1177/0363546520909397.
  • Anitua E, Fernandez-de-Retana S, Alkhraisat MH. Platelet rich plasma in oral and maxillofacial surgery from the perspective of composition. Platelets. 2021;32(2):174–182. doi: 10.1080/09537104.2020.1856361.
  • Kang JS, Zheng Z, Choi MJ, et al. The effect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study. J Eur Acad Dermatol Venereol. 2014;28(1):72–79. doi: 10.1111/jdv.12062.
  • Alam M, Hughart R, Champlain A, et al. Effect of platelet-rich plasma injection for rejuvenation of photoaged facial skin: a randomized clinical trial. JAMA Dermatol. 2018;154(12):1447–1452. doi: 10.1001/jamadermatol.2018.3977.
  • Everts P, Onishi K, Jayaram P, et al. Platelet-Rich plasma: new performance understandings and therapeutic considerations in 2020. Int J Mol Sci. 2020;21(20):7794. doi: 10.3390/ijms21207794.
  • Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158–167. doi: 10.1016/j.tibtech.2008.11.009.
  • Kawase T. A strategic and worldwide cooperative challenge required for the next generation of platelet concentrates. Int J Mol Sci. 2022;23(7):3437. doi: 10.3390/ijms23073437.
  • Wu J, Piao Y, Liu Q, et al. Platelet-rich plasma-derived extracellular vesicles: a superior alternative in regenerative medicine? Cell Prolif. 2021;54:e13123.
  • Żmigrodzka M, Guzera M, Miśkiewicz A, et al. The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression. Tumour Biol. 2016;37(11):14391–14401. doi: 10.1007/s13277-016-5358-6.
  • Zhang B, Tian X, Hao J, et al. Mesenchymal stem cell-derived extracellular vesicles in tissue regeneration. Cell Transplant. 2020;29:963689720908500. doi: 10.1177/0963689720908500.
  • Veerman RE, Güçlüler Akpinar G, Eldh M, et al. Immune cell-derived extracellular Vesicles - Functions and therapeutic applications. Trends Mol Med. 2019;25(5):382–394. doi: 10.1016/j.molmed.2019.02.003.
  • Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200(4):373–383. doi: 10.1083/jcb.201211138.
  • Pisitkun T, Shen RF, Knepper MA. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci USA. 2004;101(36):13368–13373. doi: 10.1073/pnas.0403453101.
  • Dutta S, Hornung S, Kruayatidee A, et al. α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes parkinson’s disease from multiple system atrophy. Acta Neuropathol. 2021;142(3):511–513. doi: 10.1007/s00401-021-02332-0.
  • Yan C, Chen J, Wang C, et al. Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis. Drug Deliv. 2022;29(1):214–228. doi: 10.1080/10717544.2021.2023699.
  • Li K, Lin Y, Luo Y, et al. A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study. Mol Cancer. 2022;21(1):21. doi: 10.1186/s12943-022-01499-8.
  • Zhang Y, Kim MS, Jia B, et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. 2017;548(7665):52–57. doi: 10.1038/nature23282.
  • Gebara N, Scheel J, Skovronova R, et al. Single extracellular vesicle analysis in human amniotic fluid shows evidence of phenotype alterations in preeclampsia. J Extracell Vesicles. 2022;11(5):e12217. doi: 10.1002/jev2.12217.
  • Machtinger R, Laurent LC, Baccarelli AA. Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation. Hum Reprod Update. 2016;22(2):182–193. doi: 10.1093/humupd/dmv055.
  • Armstrong JPK, Stevens MM. Strategic design of extracellular vesicle drug delivery systems. Adv Drug Deliv Rev. 2018;130:12–16. doi: 10.1016/j.addr.2018.06.017.
  • Cocucci E, Meldolesi J. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. Trends Cell Biol. 2015;25(6):364–372. doi: 10.1016/j.tcb.2015.01.004.
  • Théry C, Witwer KW, Aikawa E, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7(1):1535750. doi: 10.1080/20013078.2018.1535750.
  • Valadi H, Ekström K, Bossios A, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–659. doi: 10.1038/ncb1596.
  • Cai J, Han Y, Ren H, et al. Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells. J Mol Cell Biol. 2013;5(4):227–238. doi: 10.1093/jmcb/mjt011.
  • Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367(6478) :eaau6977.doi: 10.1126/science.aau6977.
  • Wu Y, Wu M, Zhang Y, et al. Lyophilization is suitable for storage and shipment of fresh tissue samples without altering RNA and protein levels stored at room temperature. Amino Acids. 2012;43(3):1383–1388. doi: 10.1007/s00726-011-1212-8.
  • Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019;21(1):9–17. doi: 10.1038/s41556-018-0250-9.
  • Luan X, Sansanaphongpricha K, Myers I, et al. Engineering exosomes as refined biological nanoplatforms for drug delivery. Acta Pharmacol Sin. 2017;38(6):754–763. doi: 10.1038/aps.2017.12.
  • Xiong Y, Chen L, Yu T, et al. Inhibition of circulating exosomal microRNA-15a-3p accelerates diabetic wound repair. Aging (Albany NY). 2020;12(10):8968–8986. doi: 10.18632/aging.103143.
  • Wolf P. The nature and significance of platelet products in human plasma. Br J Haematol. 1967;13(3):269–288. doi: 10.1111/j.1365-2141.1967.tb08741.x.
  • Crawford N. The presence of contractile proteins in platelet microparticles isolated from human and animal platelet-free plasma. Br J Haematol. 1971;21(1):53–69. doi: 10.1111/j.1365-2141.1971.tb03416.x.
  • Berckmans RJ, Nieuwland R, Böing AN, et al. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost. 2001;85(04):639–649. doi: 10.1055/s-0037-1615646.
  • Zhang M, Hu W, Cai C, et al. Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment. Materials Today Bio. 2022;14:100223. doi: 10.1016/j.mtbio.2022.100223.
  • Haemmerle M, Stone RL, Menter DG, et al. The platelet lifeline to cancer: challenges and opportunities. Cancer Cell. 2018;33(6):965–983. doi: 10.1016/j.ccell.2018.03.002.
  • Gardin C, Ferroni L, Leo S, et al. Platelet-Derived exosomes in atherosclerosis. Int J Mol Sci. 2022;23(20):12546. doi: 10.3390/ijms232012546.
  • Nyam-Erdene A, Nebie O, Delila L, et al. Characterization and chromatographic isolation of platelet extracellular vesicles from human platelet lysates for applications in neuroregenerative medicine. ACS Biomater Sci Eng. 2021;7(12):5823–5835. doi: 10.1021/acsbiomaterials.1c01226.
  • Delila L, Nebie O, Le NTN, et al. Neuroprotective activity of a virus-safe nanofiltered human platelet lysate depleted of extracellular vesicles in parkinson’s disease and traumatic brain injury models. Bioeng Transl Med. 2023;8(1):e10360. doi: 10.1002/btm2.10360.
  • Zhang Y, Wang X, Chen J, et al. Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis. J Nanobiotechnology. 2022;20(1):56. doi: 10.1186/s12951-022-01245-8.
  • Qian Z, Wang H, Bai Y, et al. Improving chronic diabetic wound healing through an injectable and Self-Healing hydrogel with platelet-rich plasma release. ACS Appl Mater Interfaces. 2020;12(50):55659–55674. doi: 10.1021/acsami.0c17142.
  • Antich-Rosselló M, Forteza-Genestra MA, Monjo M, et al. Platelet-Derived extracellular vesicles for regenerative medicine. Int J Mol Sci. 2021;22(16):8580. doi: 10.3390/ijms22168580.
  • Tang Q, Lim T, Shen LY, et al. Well-dispersed platelet lysate entrapped nanoparticles incorporate with injectable PDLLA-PEG-PDLLA triblock for preferable cartilage engineering application. Biomaterials. 2021;268:120605. doi: 10.1016/j.biomaterials.2020.120605.
  • Harke H, Tanger D, Fürst-Denzer S[, et al. Effect of a preoperative separation of platelets on the postoperative blood loss subsequent to extracorporeal circulation in open heart surgery (author’s transl.). Anaesthesist. 1977;26(2):64–71.
  • Chen P, Huang L, Ma Y, et al. Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res. 2019;14(1):385. doi: 10.1186/s13018-019-1363-y.
  • Perez AG, Lana JF, Rodrigues AA, et al. Relevant aspects of centrifugation step in the preparation of platelet-rich plasma. ISRN Hematol. 2014;2014:176060–176068. doi: 10.1155/2014/176060.
  • Dashore S, Chouhan K, Nanda S, et al. Preparation of platelet-rich plasma: national IADVL PRP taskforce recommendations. Indian Dermatol Online J. 2021;12(Suppl 1):S12–s23. doi: 10.4103/idoj.idoj_269_21.
  • Li P, Kaslan M, Lee SH, et al. Progress in exosome isolation techniques. Theranostics. 2017;7(3):789–804. doi: 10.7150/thno.18133.
  • Antwi-Baffour S, Adjei J, Aryeh C, et al. Understanding the biosynthesis of platelets-derived extracellular vesicles. Immun Inflamm Dis. 2015;3(3):133–140. doi: 10.1002/iid3.66.
  • Štukelj R, Schara K, Bedina-Zavec A, et al. Effect of shear stress in the flow through the sampling needle on concentration of nanovesicles isolated from blood. Eur J Pharm Sci. 2017;98:17–29. doi: 10.1016/j.ejps.2016.10.007.
  • Fujioka Y, Ishikawa Y. Remnant lipoproteins as strong key particles to atherogenesis. J Atheroscler Thromb. 2009;16(3):145–154. doi: 10.5551/jat.e598.
  • Cervenakova L, Saá P, Yakovleva O, et al. Are prions transported by plasma exosomes? Transfus Apher Sci. 2016;55(1):70–83. doi: 10.1016/j.transci.2016.07.013.
  • Allan D, Tieu A, Lalu M, et al. Mesenchymal stromal cell-derived extracellular vesicles for regenerative therapy and immune modulation: progress and challenges toward clinical application. Stem Cells Transl Med. 2020;9(1):39–46. doi: 10.1002/sctm.19-0114.
  • Royo F, Théry C, Falcón-Pérez JM, et al. Methods for separation and characterization of extracellular vesicles: results of a worldwide survey performed by the ISEV rigor and standardization subcommittee. Cells. 2020;9(9):1955. doi: 10.3390/cells9091955.
  • Xu Y, Lin Z, He L, et al. Platelet-Rich plasma-derived exosomal USP15 promotes cutaneous wound healing via deubiquitinating EIF4A1. Oxid Med Cell Longev. 2021;2021:9674809–9674814. doi: 10.1155/2021/9674809.
  • Aatonen MT, Ohman T, Nyman TA, et al. Isolation and characterization of platelet-derived extracellular vesicles. J Extracell Vesicles. 2014;3(1):24692. doi: 10.3402/jev.v3.24692.
  • van der Meijden PEJ, Heemskerk JWM. Platelet biology and functions: new concepts and clinical perspectives. Nat Rev Cardiol. 2019;16(3):166–179. doi: 10.1038/s41569-018-0110-0.
  • Saumell-Esnaola M, Delgado D, García Del Caño G, et al. Isolation of platelet-derived exosomes from human platelet-rich plasma: biochemical and morphological characterization. Int J Mol Sci. 2022;23(5):2861. doi: 10.3390/ijms23052861.
  • Rui S, Yuan Y, Du C, et al. Comparison and investigation of exosomes derived from platelet-rich plasma activated by different agonists. Cell Transplant. 2021;30:9636897211017833. doi: 10.1177/09636897211017833.
  • Laffont B, Corduan A, Plé H, et al. Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles. Blood. 2013;122(2):253–261. doi: 10.1182/blood-2013-03-492801.
  • Goetzl EJ, Goetzl L, Karliner JS, et al. Human plasma platelet-derived exosomes: effects of aspirin. Faseb J. 2016;30(5):2058–2063. doi: 10.1096/fj.201500150R.
  • Spakova T, Janockova J, Rosocha J. Characterization and therapeutic use of extracellular vesicles derived from platelets. Int J Mol Sci. 2021;22(18):9701. doi: 10.3390/ijms22189701.
  • Gao M, Zhang B, Zhang Y, et al. The effects of apheresis, storage time, and leukofiltration on microparticle formation in apheresis platelet products. Transfusion. 2018;58(10):2388–2394. doi: 10.1111/trf.14890.
  • Ge Q, Zhou Y, Lu J, et al. miRNA in plasma exosome is stable under different storage conditions. Molecules. 2014;19(2):1568–1575. doi: 10.3390/molecules19021568.
  • Zhou H, Yuen PS, Pisitkun T, et al. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int. 2006;69(8):1471–1476. doi: 10.1038/sj.ki.5000273.
  • Johnson J, Wu YW, Blyth C, et al. Prospective therapeutic applications of platelet extracellular vesicles. Trends Biotechnol. 2021;39(6):598–612. doi: 10.1016/j.tibtech.2020.10.004.
  • Yin B, Ni J, Witherel CE, et al. Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics. Theranostics. 2022;12(1):207–231. doi: 10.7150/thno.62708.
  • Torreggiani E, Perut F, Roncuzzi L, et al. Exosomes: novel effectors of human platelet lysate activity. Eur Cell Mater. 2014;28:137–151; discussion 151. doi: 10.22203/ecm.v028a11.
  • Tao SC, Yuan T, Rui BY, et al. Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the akt/bad/bcl-2 signal pathway. Theranostics. 2017;7(3):733–750. doi: 10.7150/thno.17450.
  • Liu X, Wang L, Ma C, et al. Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via wnt/β-catenin signaling pathway. J Orthop Surg Res. 2019;14(1):470. doi: 10.1186/s13018-019-1529-7.
  • Wang S, Ding P, Xia X, et al. Bugan rongjin decoction alleviates inflammation and oxidative stress to treat the postmenopausal knee osteoarthritis through wnt signaling pathway. Biomed Eng Online. 2021;20(1):103. doi: 10.1186/s12938-021-00939-8.
  • Otahal A, Kramer K, Kuten-Pella O, et al. Characterization and chondroprotective effects of extracellular vesicles from plasma- and Serum-Based autologous blood-derived products for osteoarthritis therapy. Front Bioeng Biotechnol. 2020;8:584050. doi: 10.3389/fbioe.2020.584050.
  • Iyer SR, Scheiber AL, Yarowsky P, 3rd, et al. Exosomes isolated from platelet-rich plasma and mesenchymal stem cells promote recovery of function after muscle injury. Am J Sports Med. 2020;48(9):2277–2286. doi: 10.1177/0363546520926462.
  • Liu D, Jiang T, Cai W, et al. An in situ gelling drug delivery system for improved recovery after spinal cord injury. Adv Healthc Mater. 2016;5(12):1513–1521. doi: 10.1002/adhm.201600055.
  • Shi A, Li J, Qiu X, et al. TGF-β loaded exosome enhances ischemic wound healing in vitro and in vivo. Theranostics. 2021;11(13):6616–6631. doi: 10.7150/thno.57701.
  • Graça AL, Domingues RMA, Gomez-Florit M, et al. Platelet-Derived extracellular vesicles promote tenogenic differentiation of stem cells on bioengineered living fibers. Int J Mol Sci. 2023;24(4):3516. doi: 10.3390/ijms24043516.
  • Lu J, Yang X, He C, et al. Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1. Acta Biomater. 2023;161:80–99. doi: 10.1016/j.actbio.2023.02.018.
  • Curry N, Raja A, Beavis J, et al. Levels of procoagulant microvesicles are elevated after traumatic injury and platelet microvesicles are negatively correlated with mortality. J Extracell Vesicles. 2014;3(1):25625. doi: 10.3402/jev.v3.25625.
  • Zhang J, Guan J, Niu X, et al. Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis. J Transl Med. 2015;13(1):49. doi: 10.1186/s12967-015-0417-0.
  • Cho H, Blatchley MR, Duh EJ, et al. Acellular and cellular approaches to improve diabetic wound healing. Adv Drug Deliv Rev. 2019;146:267–288. doi: 10.1016/j.addr.2018.07.019.
  • Guo SC, Tao SC, Yin WJ, et al. Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of Yap in a diabetic rat model. Theranostics. 2017;7(1):81–96. doi: 10.7150/thno.16803.
  • Xu N, Wang L, Guan J, et al. Wound healing effects of a curcuma zedoaria polysaccharide with platelet-rich plasma exosomes assembled on chitosan/silk hydrogel sponge in a diabetic rat model. Int J Biol Macromol. 2018;117:102–107. doi: 10.1016/j.ijbiomac.2018.05.066.
  • Schlegelmilch K, Mohseni M, Kirak O, et al. Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell. 2011;144(5):782–795. doi: 10.1016/j.cell.2011.02.031.
  • Burnouf T, Chou ML, Lundy DJ, et al. Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery. J Biomed Sci. 2023;30(1):79. doi: 10.1186/s12929-023-00972-w.