Brucellosis: epidemiology, pathogenesis, diagnosis and treatment–a comprehensive review

References

• Pappas G, Papadimitriou P, Akritidis N, et al. The new global map of human brucellosis. Lancet Infect Dis. 2006;6(2):1–24. doi: 10.1016/S1473-3099(06)70382-6.
   PubMed Web of Science ®Google Scholar
• Atluri VL, Xavier MN, De Jong MF, et al. Interactions of the human pathogenic Brucella species with their hosts. Annu Rev Microbiol. 2011;65(1):523–541. doi: 10.1146/annurev-micro-090110-102905.
   PubMed Web of Science ®Google Scholar
• Franco MP, Mulder M, Gilman RH, et al. Human brucellosis. Lancet Infect Dis. 2007;7(12):775–786. doi: 10.1016/S1473-3099(07)70286-4.
   PubMed Web of Science ®Google Scholar
• Ariza J, Bosilkovski M, Cascio A, et al. Perspectives for the treatment of brucellosis in the 21st century: the Ioannina recommendations. PLoS Med. 2007;4(12):e317. doi: 10.1371/journal.pmed.0040317.
   PubMed Web of Science ®Google Scholar
• Schurig GG, Sriranganathan N, Corbel MJ. Brucellosis vaccines: past, present and future. Vet Microbiol. 2002;90(1–4):479–496. doi: 10.1016/S0378-1135(02)00255-9.
   PubMed Web of Science ®Google Scholar
• Goonaratna C. Brucellosis in humans and animals. Ceylon Med J. 2009;52(2):66. doi: 10.4038/cmj.v52i2.1028.
   Google Scholar
• Bennett NJ. Brucellosis. Medscape; 2023. Available from: https://emedicine.medscape.com/article/213430-overview?form=fpf
   Google Scholar
• Brucellosis; 2023 [cited 2023 Dec 8]. Available from: https://www.who.int/news-room/fact-sheets/detail/brucellosis
   Google Scholar
• Centers for Disease Control and Prevention. Estimates human Brucella infections could be four times higher than previously thought. Food Safety; 2023. Available from: https://www.food-safety.com/articles/8817-cdc-estimates-human-brucella-infections-could-be-four-times-higher-than-previously-thought.
   Google Scholar
• Laine CG, Johnson VE, Scott HM, et al. Global estimate of human brucellosis incidence. Emerg Infect Dis. 2023;29(9):1789–1797. doi: 10.3201/eid2909.230052.
   PubMed Web of Science ®Google Scholar
• Khurana SK, Sehrawat A, Tiwari R, et al. Bovine brucellosis–a comprehensive review. Vet Q. 2021;41(1):61–88. doi: 10.1080/01652176.2020.1868616.
   PubMed Web of Science ®Google Scholar
• Pal M, Gizaw F, Fekadu G, et al. Public health and economic importance of bovine brucellosis: an overview. Am J Epid Inf Dis. 2017;5(2):27–34. doi: 10.12691/ajeid-5-2-2.
   Google Scholar
• Bano Y, Ahmad Lone S. Brucellosis: an economically important infection. J Med Microb Diagn. 2015;4(4):208. doi: 10.4172/2161-0703.1000208.
   Google Scholar
• Fritz CL, Nguyen A, Vugia DJ. Epidemiology of brucellosis in California, 1993–2017: a continuing foodborne disease risk for older Latinos. Clin Infect Dis. 2021;73(11):2023–2030. doi: 10.1093/cid/ciab551.
   PubMed Web of Science ®Google Scholar
• Uzunović S, Skomorac M, Bašić F, et al. Human brucellosis as an epidemic zoonosis in Zenica-Doboj canton (Bosnia and Herzegovina) during 2008–2018. Open Infect Dis J. 2020;12(1):1–6. doi: 10.2174/1874279302012010001.
   Google Scholar
• Djokic V, Freddi L, de Massis F, et al. The emergence of Brucella canis as a public health threat in Europe: what we know and what we need to learn. Emerg Microb Infect. 2023;12(2):2249126. doi: 10.1080/22221751.2023.2249126.
   PubMed Web of Science ®Google Scholar
• Ali S, Nawaz Z, Akhtar A, et al. Epidemiological investigation of human brucellosis in Pakistan. Jundishapur J Microbiol. 2018;11(7):e61764. doi: 10.5812/jjm.61764.
   Web of Science ®Google Scholar
• Kalin R, Karahan M, Acik MN, et al. Mastitisli inek sütlerinde önemli patojenlerin direkt tespiti için bir multipleks PCR yönteminin geliştirilmesi. Kafkas Univ Vet Fak Derg. 2017;23(6):925–931. doi: 10.9775/kvfd.2017.17995.
   Google Scholar
• Yumuk Z, O’Callaghan D. Brucellosis in Turkey—an overview. Int J Infect Dis. 2012;16(4):e228–e235. doi: 10.1016/j.ijid.2011.12.011.
   PubMed Web of Science ®Google Scholar
• Alavi SM, Motlagh ME. A review of epidemiology, diagnosis and management of brucellosis for general physicians working in the Iranian Health Network. Jundishapur J Microbiol. 2012;5(2):384–387. doi: 10.5812/jjm.3248.
   Web of Science ®Google Scholar
• Bagheri H, Tapak L, Karami M, et al. Epidemiological features of human brucellosis in Iran (2011–2018) and prediction of brucellosis with data-mining models. J Res Health Sci. 2019;19(4):e00462. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183567/
   PubMed Web of Science ®Google Scholar
• Etemadi A, Moniri R, Saffari M, et al. Epidemiological, molecular characterization and risk factors of human brucellosis in Iran. Asian Pac J Trop Med. 2020;13(4):169. doi: 10.4103/1995-7645.280224.
   Web of Science ®Google Scholar
• Nematollahi S, Ayubi E, Karami M, et al. Epidemiological characteristics of human brucellosis in Hamadan province during 2009–2015: results from the national notifiable diseases surveillance system. Int J Infect Dis. 2017;61:56–61. doi: 10.1016/j.ijid.2017.06.002.
   PubMed Web of Science ®Google Scholar
• Norouzinezhad F, Erfani H, Norouzinejad A, et al. Epidemiological characteristics and trend in the incidence of human brucellosis in Iran from 2009 to 2017. J Res Health Sci. 2021;21(4):e00535. doi: 10.34172/jrhs.2021.70.
   PubMed Web of Science ®Google Scholar
• Al-Amr M, Abasi L, Khasawneh R, et al. Epidemiology of human brucellosis in military hospitals in Jordan: a five-year study. J Infect Dev Ctries. 2022;16(12):1870–1876. doi: 10.3855/jidc.16861.
   PubMed Web of Science ®Google Scholar
• Holt HR, Bedi JS, Kaur P, et al. Epidemiology of brucellosis in cattle and dairy farmers of rural Ludhiana, Punjab. PLoS Negl Trop Dis. 2021;15(3):e0009102. doi: 10.1371/journal.pntd.0009102.
   PubMed Web of Science ®Google Scholar
• Nawaz Z, Shafique M, Zahoor MA, et al. Sero-epidemiology and risk factor analysis of human brucellosis in Punjab, Pakistan: a cross sectional study. Trop Biomed. 2021;38(3):413–419. doi: 10.47665/tb.38.3.084.
   PubMed Web of Science ®Google Scholar
• Shi Y, Gao H, Pappas G, et al. Clinical features of 2041 human brucellosis cases in China. PLOS One. 2018;13(11):e0205500. doi: 10.1371/journal.pone.0205500.
   PubMed Web of Science ®Google Scholar
• Tao Z, Chen Q, Chen Y, et al. Epidemiological characteristics of human brucellosis—China. China CDC Wkly. 2021;3(6):114–119. doi: 10.46234/ccdcw2021.030.
   PubMedGoogle Scholar
• Liu Z G, Wang M, Ta N, et al. Seroprevalence of human brucellosis and molecular characteristics of Brucella strains in Inner Mongolia autonomous region of China, from 2012 to 2016. Emerg Microbes Infect. 2020;9(1):263–274. doi: 10.1080/22221751.2020.1720528.
   PubMed Web of Science ®Google Scholar
• Djangwani J, Ooko Abong’ G, Gicuku Njue L, et al. Brucellosis: prevalence with reference to East African community countries–a rapid review. Vet Med Sci. 2021;7(3):851–867. doi: 10.1002/vms3.425.
   PubMed Web of Science ®Google Scholar
• Vigeant P, Mendelson J, Miller MA. Human to human transmission of Brucella melitensis. Can J Infect Dis. 1995;6(3):153–155. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327908/ doi: 10.1155/1995/909404.
   PubMedGoogle Scholar
• Shakir R. Brucellosis. J Neurol Sci. 2021;420:117280. doi: 10.1016/j.jns.2020.117280.
   PubMed Web of Science ®Google Scholar
• Delam H, Keshtkaran Z, Rezaei B, et al. Changing patterns in epidemiology of brucellosis in the South of Iran (2015–2020): based on Cochran–Armitage trend test. Ann Glob Health. 2022;88(1):11. doi: 10.5334/aogh.3474.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. Treatment. Brucellosis. CDC; 2012. Available from: https://www.cdc.gov/brucellosis/treatment/index.html
   Google Scholar
• De Figueiredo P, Ficht TA, Rice-Ficht A, et al. Pathogenesis and immunobiology of brucellosis: review of Brucella–host interactions. Am J Pathol. 2015;185(6):1505–1517. doi: 10.1016/j.ajpath.2015.03.003.
   PubMed Web of Science ®Google Scholar
• Barbuddhe SB, Vergis J, Rawool DB. Immunodetection of bacteria causing brucellosis. In: Gurtler V, Patrauchan M, editors. Methods in microbiology. Vol. 47. Academic Press; 2020. p. 75–115. doi: 10.1016/bs.mim.2019.11.003.
   Google Scholar
• Matle I, Ledwaba B, Madiba K, et al. Characterisation of Brucella species and biovars in South Africa between 2008 and 2018 using laboratory diagnostic data. Vet Med Sci. 2021;7(4):1245–1253. doi: 10.1002/vms3.483.
   PubMed Web of Science ®Google Scholar
• Byndloss MX, Tsolis RM. Brucella spp. virulence factors and immunity. Annu Rev Anim Biosci. 2016;4(1):111–127. doi: 10.1146/annurev-animal-021815-111326.
   PubMedGoogle Scholar
• Elrashedy A, Gaafar M, Mousa W, et al. Immune response and recent advances in diagnosis and control of brucellosis. Ger J Vet Res. 2022;2(1):10–24. doi: 10.51585/gjvr.2022.1.0033.
   Google Scholar
• Głowacka P, Żakowska D, Naylor K, et al. Brucella–virulence factors, pathogenesis and treatment. Pol J Microbiol. 2018;67(2):151–161. doi: 10.21307/pjm-2018-029.
   PubMed Web of Science ®Google Scholar
• Wareth G, Melzer F, Neubauer H. In Brucella: selective pressure may turn some genes on instead of default off position. Med Hypotheses. 2017;103:29–31. doi: 10.1016/j.mehy.2017.04.006.
   PubMed Web of Science ®Google Scholar
• Ulu Kilic A, Metan G, Alp E. Clinical presentations and diagnosis of brucellosis. Recent Pat Antiinfect Drug Discov. 2013;8(1):34–41. doi: 10.2174/1574891X11308010007.
   PubMedGoogle Scholar
• Centers for Disease Control and Prevention (CDC). Brucellosis reference guide: exposures, testing, and prevention. Atlanta (GA): The Center for Food Security and Public Health; 2018. p. 1–40.
   Google Scholar
• Young EJ. An overview of human brucellosis. Clin Infect Dis. 1995;21(2):283–289; quiz 290. doi: 10.1093/clinids/21.2.283.
   PubMed Web of Science ®Google Scholar
• Rubach MP, Halliday JEB, Cleaveland S, et al. Brucellosis in low-income and middle-income countries. Curr Opin Infect Dis. 2013;26(5):404–412. doi: 10.1097/QCO.0b013e3283638104.
   PubMed Web of Science ®Google Scholar
• Heavey E. Brucellosis: a global concern. Nursing. 2019;49(5):14–16. doi: 10.1097/01.NURSE.0000554623.05347.a0.
   PubMedGoogle Scholar
• Çavuş B, Çaydaşı Ö, Aktan A, et al. Brucellosis as the cause of non-viral bacterial hepatitis: a case report. Open Access Maced J Med Sci. 2018;6(7):1260–1262. doi: 10.3889/oamjms.2018.198.
   PubMedGoogle Scholar
• Güçlü M, Yakar T, Habeoğlu MA. Spontaneous bacterial peritonitis and chylothorax related to Brucella infection in a cirrhotic patient. Electron J Gen Med. 2007;4(4):201–204. doi: 10.29333/ejgm/82530.
   Google Scholar
• Makaritsis KP, Liaskos C, Papadamou G, et al. Spontaneous bacterial peritonitis: an unusual manifestation of brucellosis in a previous healthy male patient. BMJ Case Rep. 2015;2015(1):bcr2015209387. doi: 10.1136/bcr-2015-209387.
   PubMedGoogle Scholar
• Qiu Z, Yang F, Zhang S. Immune thrombocytopenic purpura and its rare association with a Brucella infection: a case report. Cureus. 2022;14(10):e30049. doi: 10.7759/cureus.30049.
   PubMed Web of Science ®Google Scholar
• Yamashita H, Takahashi Y, Kaneko H, et al. Thrombotic thrombocytopenic purpura with an autoantibody to ADAMTS13 complicating Sjögren’s syndrome: two cases and a literature review. Mod Rheumatol. 2013;23(2):365–373. doi: 10.3109/s10165-012-0644-7.
   PubMed Web of Science ®Google Scholar
• Lambourne JR, Brooks T. Brucella and Coxiella; if you don’t look, you don’t find. Clin Med. 2015;15(2):212. doi: 10.7861/clinmedicine.15-2-212.
   Google Scholar
• Li Q, Liu J, Jiang W, et al. A case of brucellosis-induced Guillain–Barre syndrome. BMC Infect Dis. 2022;22(1):72. doi: 10.1186/s12879-021-07025-3.
   PubMed Web of Science ®Google Scholar
• Essrani R, Shnitser A. Brucella melitensis-induced transaminitis. Cureus. 2021;13(3):e13656. doi: 10.7759/cureus.13656.
   PubMed Web of Science ®Google Scholar
• Young EJ. Clinical manifestations of human brucellosis. In: Young EJ and Corbel MJ, editors. Brucellosis: clinical and laboratory aspects. CRC Press; 2020. p. 97–126. doi: 10.1201/9781003068518-10.
   Google Scholar
• Kaya F, Kocyigit A, Kaya C, et al. Brucellar testicular abscess presenting as a testicular mass: can color Doppler sonography be used in differentiation? Turk J Emerg Med. 2015;15(1):43–46. doi: 10.5505/1304.7361.2014.82698.
   PubMedGoogle Scholar
• Raju IT, Solanki R, Patnaik AN, et al. Brucella endocarditis—a series of five case reports. Indian Heart J. 2013;65(1):72–77. doi: 10.1016/j.ihj.2012.12.017.
   PubMedGoogle Scholar
• Bazzazi N, Yavarikia A, Keramat F. Ocular involvement of brucellosis. Middle East Afr J Ophthalmol. 2013;20(1):95–97. doi: 10.4103/0974-9233.106407.
   PubMedGoogle Scholar
• Karaali Z, Baysal B, Poturoglu S, et al. Cutaneous manifestations in brucellosis. Indian J Dermatol. 2011;56(3):339–340. doi: 10.4103/0019-5154.82505.
   PubMedGoogle Scholar
• Korkmaz P, Doyuk Kartal E. Skin manifestations associated with brucellosis. EMJ Dermatol. 2016;4:119–125. doi: 10.33590/emjdermatol/10312753.
   Google Scholar
• Wang W, Lu X, Li C, et al. A man with recurrent fever, arthritis, and rashes—brucellosis? A case report. BMC Infect Dis. 2020;20(1):18. doi: 10.1186/s12879-019-4746-0.
   PubMed Web of Science ®Google Scholar
• Spink WW. What is chronic brucellosis? Ann Intern Med. 1951;35(2):358–374. doi: 10.7326/0003-4819-35-2-358.
   PubMed Web of Science ®Google Scholar
• Ariza J, Corredoira J, Pallares R, et al. Characteristics of and risk factors for relapse of brucellosis in humans. Clin Infect Dis. 1995;20(5):1241–1249. doi: 10.1093/clinids/20.5.1241.
   PubMed Web of Science ®Google Scholar
• Solera J. Update on brucellosis: therapeutic challenges. Int J Antimicrob Agents. 2010;36(Suppl. 1):S18–S20. doi: 10.1016/j.ijantimicag.2010.06.015.
   PubMedGoogle Scholar
• Akkoc G, Tekerek S. Osteoarticular involvement in childhood brucellosis: evaluation of clinical, laboratory and radiologic features of 185 cases. Pediatr Infect Dis J. 2023;42(5):381–388. doi: 10.1097/INF.0000000000003844.
   PubMed Web of Science ®Google Scholar
• Whatmore AM, Koylass MS, Muchowski J, et al. Extended multilocus sequence analysis to describe the global population structure of the genus Brucella: phylogeography and relationship to biovars. Front Microbiol. 2016;7:2049. doi: 10.3389/fmicb.2016.02049.
   PubMed Web of Science ®Google Scholar
• Pappas G, Akritidis N, Bosilkovski M, et al. Medical progress brucellosis. N Engl J Med. 2005;352(22):2325–2336. doi: 10.1056/NEJMra050570.
   PubMed Web of Science ®Google Scholar
• Yagupsky P, Morat P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev. 2020;33(1):e00073-19. doi: 10.1128/CMR.00073-19.
   Web of Science ®Google Scholar
• Pappas G, Papadimitriou P. Challenges in Brucella bacteraemia. Int J Antimicrob Agents. 2007;30(Suppl. 1):29–31. doi: 10.1016/j.ijantimicag.2007.06.011.
   Google Scholar
• Olitzky AL. Laboratory techniques in brucellosis. Harefuah. 1976;91(11):408–409.
   PubMedGoogle Scholar
• Castaneda MR. A practical method for routine blood cultures in brucellosis. Proc Soc Exp Biol Med. 1947;64(1):114–115. doi: 10.3181/00379727-64-15717.
   PubMed Web of Science ®Google Scholar
• Al-Attas RA, Al-Khalifa M, Al-Qurashi AR, et al. Evaluation of PCR, culture and serology for the diagnosis of acute human brucellosis. Ann Saudi Med. 2000;20(3–4):224–228. doi: 10.5144/0256-4947.2000.224.
   PubMed Web of Science ®Google Scholar
• OIE-WOAH. Terrestrial code online access - WOAH - World organisation for animal health. 2023. https://www.woah.org/en/what-we-do/standards/codes-and-manuals/terrestrial-code-online-access/.
   Google Scholar
• Wareth G, Pletz MW, Neubauer H, et al. Proteomics of Brucella: technologies and their applications for basic research and medical microbiology. Microorganisms. 2020;8(5):766. doi: 10.3390/microorganisms8050766.
   PubMed Web of Science ®Google Scholar
• Di Bonaventura G, Angeletti S, Ianni A, et al. Microbiological laboratory diagnosis of human brucellosis: an overview. Pathogens. 2021;10(12):1623. doi: 10.3390/pathogens10121623.
   PubMed Web of Science ®Google Scholar
• El-Diasty M, El-Said R, Abdelkhalek A. Seroprevalence and molecular diagnosis of sheep brucellosis in Dakahlia Governorate, Egypt. Ger J Vet Res. 2021;1(1):34–39. doi: 10.51585/gjvr.2021.0006.
   Google Scholar
• Baddour MM, Alkhalifa DH. Evaluation of three polymerase chain reaction techniques for detection of Brucella DNA in peripheral human blood. Can J Microbiol. 2008;54(5):352–357. doi: 10.1139/W08-017.
   PubMed Web of Science ®Google Scholar
• Bounaadja L, Albert D, Chénais B, et al. Real-time PCR for identification of Brucella spp.: a comparative study of IS711, bcsp31 and per target genes. Vet Microbiol. 2009;137(1–2):156–164. doi: 10.1016/j.vetmic.2008.12.023.
   PubMed Web of Science ®Google Scholar
• Romero C, Gamazo C, Pardo M, et al. Specific detection of Brucella DNA by PCR. J Clin Microbiol. 1995;33(3):615–617. doi: 10.1128/jcm.33.3.615-617.1995.
   PubMed Web of Science ®Google Scholar
• Leal-Klevezas DS, Martinez-Vazquez IO, Lopez-Merino A, et al. Single-step PCR for detection of Brucella spp. from blood and milk of infected animals. J Clin Microbiol. 1995;33(12):3087–3090. doi: 10.1128/jcm.33.12.3087-3090.1995.
   PubMed Web of Science ®Google Scholar
• Kattar MM, Zalloua PA, Araj GF, et al. Development and evaluation of real-time polymerase chain reaction assays on whole blood and paraffin-embedded tissues for rapid diagnosis of human brucellosis. Diagn Microbiol Infect Dis. 2007;59(1):23–32. doi: 10.1016/j.diagmicrobio.2007.04.002.
   PubMed Web of Science ®Google Scholar
• Mitka S, Anetakis C, Souliou E, et al. Evaluation of different PCR assays for early detection of acute and relapsing brucellosis in humans in comparison with conventional methods. J Clin Microbiol. 2007;45(4):1211–1218. doi: 10.1128/JCM.00010-06.
   PubMed Web of Science ®Google Scholar
• Al Nakkas AF, Wright SG, Mustafa AS, et al. Single-tube, nested PCR for the diagnosis of human brucellosis in Kuwait. Ann Trop Med Parasitol. 2002;96(4):397–403. doi: 10.1179/000349802125001203.
   PubMed Web of Science ®Google Scholar
• Baily GG, Krahn JB, Drasar BS, et al. Detection of Brucella melitensis and Brucella abortus by DNA amplification. J Trop Med Hyg. 1992;95(4):271–275.
   PubMed Web of Science ®Google Scholar
• Navarro E, Escribano J, Fernández J, et al. Comparison of three different PCR methods for detection of Brucella spp. in human blood samples. FEMS Immunol Med Microbiol. 2002;34(2):147–151. doi: 10.1111/j.1574-695x.2002.tb00616.x.
   PubMedGoogle Scholar
• Zerva L, Bourantas K, Mitka S, et al. Serum is the preferred clinical specimen for diagnosis of human brucellosis by PCR. J Clin Microbiol. 2001;39(4):1661–1664. doi: 10.1128/JCM.39.4.1661-1664.2001.
   PubMed Web of Science ®Google Scholar
• Li M, Zhou X, Li J, et al. Real-time PCR assays for diagnosing brucellar spondylitis using formalin-fixed paraffin-embedded tissues. Medicine. 2018;97(9):e0062. doi: 10.1097/MD.0000000000010062.
   PubMed Web of Science ®Google Scholar
• Gopaul KK, Sells J, Lee R, et al. Development and assessment of multiplex high resolution melting assay as a tool for rapid single-tube identification of five Brucella species. BMC Res Notes. 2014;7(1):903. doi: 10.1186/1756-0500-7-903.
   PubMedGoogle Scholar
• Rajni Joshi NS. Clinical, serological and molecular diagnosis of brucellosis in domestic animals. Int J Curr Microbiol Appl Sci. 2021;10(4):368–385. doi: 10.20546/ijcmas.2021.1004.040.
   Google Scholar
• Bosilkovski M, Keramat F, Arapović J. The current therapeutical strategies in human brucellosis. Infection. 2021;49(5):823–832. doi: 10.1007/s15010-021-01586-w.
   PubMed Web of Science ®Google Scholar
• Patra S, Kalwaje Eshwara V, Pai AR, et al. Evaluation of clinical, diagnostic features and therapeutic outcome of neurobrucellosis: a case series and review of literature. Int J Neurosci. 2022;132(11):1080–1090. doi: 10.1080/00207454.2020.1860969.
   PubMed Web of Science ®Google Scholar
• Johansen TB, Scheffer L, Jensen VK, et al. Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective. Sci Rep. 2018;8(1):8538. doi: 10.1038/s41598-018-26906-3.
   PubMedGoogle Scholar
• Reza Irajian G, Masjedian Jazi F, Mirnejad R, et al. Species-specific PCR for the diagnosis and determination of antibiotic susceptibilities of Brucella strains isolated from Tehran, Iran. Iran J Pathol. 2016;11(3):238–247.
   PubMedGoogle Scholar
• Shevtsov A, Syzdykov M, Kuznetsov A, et al. Antimicrobial susceptibility of Brucella melitensis in Kazakhstan. Antimicrob Resist Infect Control. 2017;6(1):130. doi: 10.1186/s13756-017-0293-x.
   PubMedGoogle Scholar
• Doimari S, Singh V, Kumari R, et al. In vitro antimicrobial susceptibility of Brucella species isolated from human and animals in India. J Antibiot Res. 2019;3:1–6.
   Google Scholar
• Maves RC, Castillo R, Guillen A, et al. Antimicrobial susceptibility of Brucella melitensis isolates in Peru. Antimicrob Agents Chemother. 2011;55(3):1279–1281. doi: 10.1128/AAC.00979-10.
   PubMed Web of Science ®Google Scholar
• Cooke RPD, Perrett L. Antimicrobial susceptibility data for Brucella melitensis isolates cultured from UK patients. J Infect. 2014;68(4):401. doi: 10.1016/j.jinf.2014.01.002.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov. 2008;7(2):168–181. doi: 10.1038/nrd2467.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Kairys V, Rala S, et al. Mycobacterium tuberculosis β-carbonic anhydrases: novel targets for developing antituberculosis drugs. Int J Mol Sci. 2019;20(20):5153. doi: 10.3390/ijms20205153.
   PubMed Web of Science ®Google Scholar
• Köhler S, Ouahrani-Bettache S, Winum JY. Brucella suis carbonic anhydrases and their inhibitors: towards alternative antibiotics? J Enzym Inhib Med Chem. 2017;32(1):683–687. doi: 10.1080/14756366.2017.1295451.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Tolvanen MEE, Barker H, et al. Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology. Physiol Rev. 2022;102(3):1327–1383. doi: 10.1152/physrev.00018.2021.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Parvathaneni NK, Barker H, et al. Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series. J Enzyme Inhib Med Chem. 2020;35(1):109–117. doi: 10.1080/14756366.2019.1685510.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Supuran CT, Waheed A, et al. Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease. J Physiol. 2023;601(2):257–274. doi: 10.1113/JP283579.
   PubMed Web of Science ®Google Scholar
• Abdoli M, Bonardi A, Paoletti N, et al. Inhibition studies on human and mycobacterial carbonic anhydrases with N-((4-sulfamoylphenyl)carbamothioyl) amides. Molecules. 2023;28(10):4020. doi: 10.3390/molecules28104020.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Barker H, Aisala H, et al. Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth Gyrodactylus salaris. J Enzyme Inhib Med Chem. 2022;37(1):1577–1586. doi: 10.1080/14756366.2022.2080818.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Bonardi A, Aisala H, et al. Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris. J Enzyme Inhib Med Chem. 2023;38(1):2167988. doi: 10.1080/14756366.2023.2167988.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Hammaren M, Parikka M, et al. In vitro inhibition of Mycobacterium tuberculosis β-carbonic anhydrase 3 with mono- and dithiocarbamates and evaluation of their toxicity using zebrafish developing embryos. J Enzyme Inhib Med Chem. 2020;35(1):65–71. doi: 10.1080/14756366.2019.1683007.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Winum JY, Carta F, et al. Carbonic anhydrase inhibitors as novel drugs against mycobacterial β-carbonic anhydrases: an update on in vitro and in vivo studies. Molecules. 2018;23(11):2911. doi: 10.3390/molecules23112911.
   PubMed Web of Science ®Google Scholar
• Supuran CT. Bacterial carbonic anhydrases as drug targets: toward novel antibiotics? Front Pharmacol. 2011;2:34. doi: 10.3389/fphar.2011.00034.
   PubMed Web of Science ®Google Scholar
• Aspatwar A, Hammarén M, Koskinen S, et al. β-CA-specific inhibitor dithiocarbamate Fc14–584B: a novel antimycobacterial agent with potential to treat drug-resistant tuberculosis. J Enzyme Inhib Med Chem. 2017;32(1):832–840. doi: 10.1080/14756366.2017.1332056.
   PubMed Web of Science ®Google Scholar
• Maresca A, Scozzafava A, Köhler S, et al. Inhibition of beta-carbonic anhydrases from the bacterial pathogen Brucella suis with inorganic anions. J Inorg Biochem. 2012;110:36–39. doi: 10.1016/j.jinorgbio.2012.02.009.
   PubMed Web of Science ®Google Scholar
• Vullo D, Nishimori I, Scozzafava A, et al. Inhibition studies of a β-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides. Bioorg Med Chem Lett. 2010;20(7):2178–2182. doi: 10.1016/j.bmcl.2010.02.042.
   PubMed Web of Science ®Google Scholar
• Heidary M, Dashtbin S, Ghanavati R, et al. Evaluation of brucellosis vaccines: a comprehensive review. Front Vet Sci. 2022;9:925773. doi: 10.3389/fvets.2022.925773.
   PubMed Web of Science ®Google Scholar
• Montaraz JA, Winter AJ. Comparison of living and nonliving vaccines for Brucella abortus in BALB/c mice. Infect Immun. 1986;53(2):245–251. doi: 10.1128/iai.53.2.245-251.1986.
   PubMed Web of Science ®Google Scholar
• Yang X, Skyberg JA, Cao L, et al. Progress in Brucella vaccine development. Front Biol. 2013;8(1):60–77. doi: 10.1007/s11515-012-1196-0.
   Google Scholar
• Mansoori N, Pourmand MR. Vaccines and vaccine candidates against brucellosis. Infect Epidemiol Microbiol. 2016;2(4):32–36. doi: 10.18869/modares.iem.2.4.32.
   Google Scholar
• Li ZQ, Shi JX, Fu WD, et al. A Brucella melitensis M5-90 wboA deletion strain is attenuated and enhances vaccine efficacy. Mol Immunol. 2015a;66(2):276–283. doi: 10.1016/j.molimm.2015.04.004.
   PubMed Web of Science ®Google Scholar
• Truong QL, Cho Y, Kim K, et al. Booster vaccination with safe, modified, live-attenuated mutants of Brucella abortus strain RB51 vaccine confers protective immunity against virulent strains of B. abortus and Brucella canis in BALB/c mice. Microbiology. 2015;161(11):2137–2148. doi: 10.1099/mic.0.000170.
   PubMedGoogle Scholar
• Zhu L, Feng Y, Zhang G, et al. Brucella suis strain 2 vaccine is safe and protective against heterologous Brucella spp. infections. Vaccine. 2016;34(3):395–400. doi: 10.1016/j.vaccine.2015.09.116.
   PubMed Web of Science ®Google Scholar
• Verger JM, Grayon M, Zundel E, et al. Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes. Vaccine. 1995;13(2):191–196. doi: 10.1016/0264-410X(95)93135-V.
   PubMed Web of Science ®Google Scholar
• Gheibi A, Khanahmad H, Kashfi K, et al. Development of new generation of vaccines for Brucella abortus. Heliyon. 2018;4(12):e01079. doi: 10.1016/j.heliyon.2018.e01079.
   PubMed Web of Science ®Google Scholar
• Zhang J, Guo F, Chen C, et al. Brucella melitensis 16MΔhfq attenuation confers protection against wild-type challenge in BALB/c mice. Microbiol Immunol. 2013;57(7):502–510. doi: 10.1111/1348-0421.12065.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang J, Zhang K, et al. Brucella melitensis 16MΔTcfSR as a potential live vaccine allows for the differentiation between natural and vaccinated infection. Exp Ther Med. 2015b;10(3):1182–1188. doi: 10.3892/etm.2015.2619.
   PubMed Web of Science ®Google Scholar
• Wang Z, Niu JR, Ui Wang XLe, et al. Evaluation of a Brucella melitensis mutant deficient in O-polysaccharide export system ATP-binding protein as a rough vaccine candidate. Microbes Infect. 2014;16(8):633–639. doi: 10.1016/j.micinf.2014.06.013.
   PubMed Web of Science ®Google Scholar
• Costa LF, Cabello AL, Batista DFA, et al. The candidate vaccine strain Brucella ovis ΔabcBA is protective against Brucella melitensis infection in mice. Microbiol Immunol. 2020;64(11):730–736. doi: 10.1111/1348-0421.12850.
   PubMedGoogle Scholar
• Bao Y, Tian M, Li P, et al. Characterization of Brucella abortus mutant strain Δ22915, a potential vaccine candidate. Vet Res. 2017;48(1):17. doi: 10.1186/s13567-017-0422-9.
   PubMedGoogle Scholar
• Czibener C, Del Giudice MG, Spera JM, et al. Delta-pgm, a new live-attenuated vaccine against Brucella suis. Vaccine. 2016;34(13):1524–1530. doi: 10.1016/j.vaccine.2016.02.025.
   PubMed Web of Science ®Google Scholar
• Jain-Gupta N, Waldrop SG, Tenpenny NM, et al. Rough Brucella neotomae provides protection against Brucella suis challenge in mice. Vet Microbiol. 2019;239:108447. doi: 10.1016/j.vetmic.2019.108447.
   PubMed Web of Science ®Google Scholar
• Ficht TA, Kahl-McDonagh MM, Arenas-Gamboa AM, et al. Brucellosis: the case for live, attenuated vaccines. Vaccine. 2009;27(Suppl. 4):D40–D43. doi: 10.1016/j.vaccine.2009.08.058.
   PubMedGoogle Scholar
• Perkins SD, Smither SJ, Atkins HS. Towards a Brucella vaccine for humans. FEMS Microbiol Rev. 2010;34(3):379–394. doi: 10.1111/j.1574-6976.2010.00211.x.
   PubMed Web of Science ®Google Scholar
• Zimmermann P, Curtis N. Factors that influence the immune response to vaccination. Clin Microbiol Rev. 2019;32(2):e00084. doi: 10.1128/CMR.00084-18.
   PubMed Web of Science ®Google Scholar
• Abdollahi A, Mansouri S, Amani J, et al. A recombinant chimera protein as a novel Brucella subunit vaccine: protective efficacy and induced immune response in BALB/c mice. Jundishapur J Microbiol. 2018;11(1):1–9. doi: 10.5812/jjm.12776.
   Web of Science ®Google Scholar
• Ghasemi A, Jeddi-Tehrani M, Mautner J, et al. Immunization of mice with a novel recombinant molecular chaperon confers protection against Brucella melitensis infection. Vaccine. 2014;32(49):6659–6666. doi: 10.1016/j.vaccine.2014.09.013.
   PubMed Web of Science ®Google Scholar
• Sadeghi Z, Fasihi-Ramandi M, Bouzari S. Evaluation of immunogenicity of novel multi-epitope subunit vaccines in combination with poly I: c against Brucella melitensis and Brucella abortus infection. Int Immunopharmacol. 2019;75:105829. doi: 10.1016/j.intimp.2019.105829.
   PubMed Web of Science ®Google Scholar
• Delpino MV, Estein SM, Fossati CA, et al. Vaccination with Brucella recombinant DnaK and SurA proteins induces protection against Brucella abortus infection in BALB/c mice. Vaccine. 2007;25(37–38):6721–6729. doi: 10.1016/j.vaccine.2007.07.002.
   PubMed Web of Science ®Google Scholar
• Abkar M, Fasihi-Ramandi M, Kooshki H, et al. Oral immunization of mice with Omp31-loaded N-trimethyl chitosan nanoparticles induces high protection against Brucella melitensis infection. Int J Nanomedicine. 2017;12:8769–8778. doi: 10.2147/IJN.S149774.
   PubMed Web of Science ®Google Scholar
• Maleki M, Salouti M, Shafiee Ardestani M, et al. Preparation of a nanovaccine against Brucella melitensis M16 based on PLGA nanoparticles and oligopolysaccharide antigen. Artif Cells Nanomed Biotechnol. 2019;47(1):4248–4256. doi: 10.1080/21691401.2019.1687490.
   PubMed Web of Science ®Google Scholar
• Al-Halifa S, Gauthier L, Arpin D, et al. Nanoparticle-based vaccines against respiratory viruses. Front Immunol. 2019;10:22. doi: 10.3389/fimmu.2019.00022.
   PubMed Web of Science ®Google Scholar
• Leclerq S, Harms JS, Rosinha GMS, et al. Induction of a Th1-type of immune response but not protective immunity by intramuscular DNA immunisation with Brucella abortus GroEL heat-shock gene. J Med Microbiol. 2002;51(1):20–26. doi: 10.1099/0022-1317-51-1-20.
   PubMed Web of Science ®Google Scholar
• Afshari H, Maleki M, Salouti M. Immunological effects of two new nanovaccines against Brucella based on OPS and LPS antigens conjugated with PLGA nanoparticles. Eur Polym J. 2020;139:110021. doi: 10.1016/j.eurpolymj.2020.110021.
   Web of Science ®Google Scholar
• Hu XD, Yu DH, Chen ST, et al. A combined DNA vaccine provides protective immunity against Mycobacterium bovis and Brucella abortus in cattle. DNA Cell Biol. 2009;28(4):191–199. doi: 10.1089/dna.2008.0790.
   PubMed Web of Science ®Google Scholar
• Chen B, Liu B, Zhao Z, et al. Evaluation of a DNA vaccine encoding Brucella BvrR in BALB/c mice. Mol Med Rep. 2019;19(2):1302–1308. doi: 10.3892/mmr.2018.9735.
   PubMed Web of Science ®Google Scholar
• Jain S, Afley P, Dohre SK, et al. Evaluation of immunogenicity and protective efficacy of a plasmid DNA vaccine encoding ribosomal protein L9 of Brucella abortus in BALB/c mice. Vaccine. 2014;32(35):4537–4542. doi: 10.1016/j.vaccine.2014.06.012.
   PubMed Web of Science ®Google Scholar
• Velikovsky CA, Cassataro J, Sanchez M, et al. Single-shot plasmid DNA intrasplenic immunization for the production of monoclonal antibodies. Persistent expression of DNA. J Immunol Methods. 2000;244(1–2):1–7. doi: 10.1016/S0022-1759(00)00244-1.
   PubMed Web of Science ®Google Scholar
• Al-Mariri A, Tibor A, Lestrate P, et al. Yersinia enterocolitica as a vehicle for a naked DNA vaccine encoding Brucella abortus bacterioferritin or P39 antigen. Infect Immun. 2002;70(4):1915–1923. doi: 10.1128/IAI.70.4.1915-1923.2002.
   PubMed Web of Science ®Google Scholar
• Senevirathne A, Hewawaduge C, Lee JH. Attenuated Salmonella secreting Brucella protective antigens confer dual-faceted protection against brucellosis and salmonellosis in a mouse model. Vet Immunol Immunopathol. 2019;209:31–36. doi: 10.1016/j.vetimm.2019.02.001.
   PubMed Web of Science ®Google Scholar
• Bugybayeva D, Ryskeldinova S, Zinina N, et al. Development of human vectored brucellosis vaccine formulation: assessment of safety and protectiveness of influenza viral vectors expressing Brucella immunodominant proteins in mice and Guinea pigs. Biomed Res Int. 2020;2020:1438928. doi: 10.1155/2020/1438928.
   PubMed Web of Science ®Google Scholar
• Mohammadi E, Golchin M. High protection of mice against Brucella abortus by oral immunization with recombinant probiotic Lactobacillus casei vector vaccine, expressing the outer membrane protein OMP19 of Brucella species. Comp Immunol Microbiol Infect Dis. 2020;70:101470. doi: 10.1016/j.cimid.2020.101470.
   PubMed Web of Science ®Google Scholar
• Lin GZ, Liu YZ, Cai KZ, et al. Brucella abortus L7/L12 ve BCSP31 Proteinlerini Birlikte Eksprese Eden Rekombinant Adenovirusların immunojenitesi. Kafkas Univ Vet Fak Derg. 2018;24(2):211–217. doi: 10.9775/kvfd.2017.18644.
   Google Scholar
• Bugybayeva D, Kydyrbayev Z, Zinina N, et al. A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a Guinea pig model. Infect Dis Poverty. 2021;10(1):13. doi: 10.1186/s40249-021-00801-y.
   PubMed Web of Science ®Google Scholar
• Tabynov K, Sansyzbay A, Kydyrbayev Z, et al. Influenza viral vectors expressing the Brucella OMP16 or L7/L12 proteins as vaccines against B. abortus infection. Virol J. 2014;11(1):69. doi: 10.1186/1743-422X-11-69.
   PubMedGoogle Scholar
• Sáez D, Fernández P, Rivera A, et al. Oral immunization of mice with recombinant Lactococcus lactis expressing Cu, Zn superoxide dismutase of Brucella abortus triggers protective immunity. Vaccine. 2012;30(7):1283–1290. doi: 10.1016/j.vaccine.2011.12.088.
   PubMed Web of Science ®Google Scholar
• Cassataro J, Estein SM, Pasquevich KA, et al. Vaccination with the recombinant Brucella outer membrane protein 31 or a derived 27-amino-acid synthetic peptide elicits a CD4+ T helper 1 response that protects against Brucella melitensis infection. Infect Immun. 2005;73(12):8079–8088. doi: 10.1128/IAI.73.12.8079-8088.2005.
   PubMed Web of Science ®Google Scholar
• De la Rosa-Ramos MA, Arellano-Reynoso B, Hernández-Badillo E, et al. Evaluation of the goat cellular immune response to rBtuB-Hia-FlgK peptides from Brucella melitensis. Comp Immunol Microbiol Infect Dis. 2023;94:101944. doi: 10.1016/j.cimid.2023.101944.
   PubMed Web of Science ®Google Scholar
• Nejad RB, Krecek RC, Khalaf OH, et al. Brucellosis in the Middle East: current situation and a pathway forward. PLoS Negl Trop Dis. 2020;14(5):e0008071. doi: 10.1371/journal.pntd.0008071.
   PubMed Web of Science ®Google Scholar
• Addis M. Public health and economic importance of brucellosis: a review. Public Policy Admin Res. 2015;5(7):2225–2972.
   Google Scholar
• Islam MA, Khatun MM, Werre SR, et al. A review of Brucella seroprevalence among humans and animals in Bangladesh with special emphasis on epidemiology, risk factors and control opportunities. Vet Microbiol. 2013;166(3–4):317–326. doi: 10.1016/j.vetmic.2013.06.014.
   PubMed Web of Science ®Google Scholar
• Alewy Almashhadany D, Zefenkey ZF, Hassannejad S, et al. Milk borne brucellosis. In: Ibrahim SA, editor. Current issues and advances in the dairy industry. IntechOpen; 2023. doi: 10.5772/intechopen.109124.
   Google Scholar
• Di Bari C, Venkateswaran N, Bruce M, et al. Methodological choices in brucellosis burden of disease assessments: a systematic review. PLoS Negl Trop Dis. 2022;16(12):e0010468. doi: 10.1371/journal.pntd.0010468.
   PubMed Web of Science ®Google Scholar
• Herrera JAR, Thomsen ST, Jakobsen LS, et al. The burden of disease of three food-associated heavy metals in clusters in the Danish population–towards targeted public health strategies. Food Chem Toxicol. 2021;150:112072. doi: 10.1016/j.fct.2021.112072.
   PubMed Web of Science ®Google Scholar
• Golshani M, Buozari S. A review of brucellosis in Iran: epidemiology, risk factors, diagnosis, control, and prevention. Iran Biomed J. 2017;21(6):349–359. doi: 10.18869/acadpub.ibj.21.6.349.
   PubMedGoogle Scholar
• Franc KA, Krecek RC, Häsler BN, et al. Brucellosis remains a neglected disease in the developing world: a call for interdisciplinary action. BMC Public Health. 2018;18(1):125. doi: 10.1186/s12889-017-5016-y.
   PubMed Web of Science ®Google Scholar
• Dowdle WR. The principles of disease elimination and eradication. Bull World Health Org. 1998;76(Suppl. 2):22–25.
   PubMedGoogle Scholar
• Murray J, Cohen AL. Infectious disease surveillance. Int Encycloped Public Health. 2016;2016:222–229. doi: 10.1016/B978-0-12-803678-5.00517-8.
   Google Scholar
• Roth F, Zinsstag J, Orkhon D, et al. Human health benefits from livestock vaccination for brucellosis: case study. Bull World Health Organ. 2003;81(12):867–876.
   PubMed Web of Science ®Google Scholar
• Dalrymple-Champneys W. Undulant fever a neglected problem. The Lancet. 1950;255(6602):429–435. doi: 10.1016/S0140-6736(50)90361-8.
   Google Scholar
• Wyatt HV. Brucellosis and Maltese goats in the Mediterranean. J Malt Hist. 2009;1(2):4.
   Google Scholar
• Riedel S. Biological warfare and bioterrorism: a historical review. Proc (Bayl Univ Med Cent). 2004;17(4):400–406. doi: 10.1080/08998280.2004.11928002.
   PubMedGoogle Scholar
• Centers for Disease Control and Prevention. Risks from unpasteurized dairy products. Risk of exposure. Brucellosis. CDC; 2019. Available from: https://www.cdc.gov/brucellosis/exposure/unpasteurized-dairy-products.html
   Google Scholar
• Yuan W, Zhang M, Zou H, et al. Emergency response to occupational brucellosis in a pharmaceutical manufacturing enterprise. J Occup Health. 2018;60(5):404–409. doi: 10.1539/joh.2018-0089-CS.
   PubMed Web of Science ®Google Scholar
• Elbehiry A, Aldubaib M, Marzouk E, et al. The development of diagnostic and vaccine strategies for early detection and control of human brucellosis, particularly in endemic areas. Vaccines. 2023;11(3):654. doi: 10.3390/vaccines11030654.
   Web of Science ®Google Scholar
• Micoli F, Bagnoli F, Rappuoli R, et al. The role of vaccines in combatting antimicrobial resistance. Nat Rev Microbiol. 2021;19(5):287–302. doi: 10.1038/s41579-020-00506-3.
   PubMed Web of Science ®Google Scholar
• Behl T, Kaur I, Sehgal A, et al. Bioinformatics accelerates the major tetrad: a real boost for the pharmaceutical industry. Int J Mol Sci. 2021;22(12):6184. doi: 10.3390/ijms22126184.
   PubMed Web of Science ®Google Scholar
• Zhao C, Yang Y, Wu S, et al. Search trends and prediction of human brucellosis using Baidu index data from 2011 to 2018 in China. Sci Rep. 2020;10(1):5896. doi: 10.1038/s41598-020-62517-7.
   PubMed Web of Science ®Google Scholar
• World Bank. World Bank approves $82 million for prevention of zoonotic, endemic diseases in India. World Bank; 2023 [cited 2023 Aug 23]. Available from: https://www.worldbank.org/en/news/press-release/2023/05/10/world-bank-approves-82-million-for-prevention-of-zoonotic-endemic-diseases-in-india
   Google Scholar