Cardiorespiratory fitness and morbidity and mortality in patients with non-small cell lung cancer: a prospective study with propensity score weighting

References

• Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):1–12. doi: 10.3322/caac.21708.
   Web of Science ®Google Scholar
• Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 2019;94(8):1623–1640. doi: 10.1016/j.mayocp.2019.01.013.
   PubMed Web of Science ®Google Scholar
• Brioude G, Gust L, Thomas PA, et al. Postoperative complications after major lung resection. Rev Mal Respir. 2019;36(6):720–737. doi: 10.1016/j.rmr.2018.09.004.
   PubMed Web of Science ®Google Scholar
• Albouaini K, Egred M, Alahmar A, et al. Cardiopulmonary exercise testing and its application. Postgrad Med J. 2007;83(985):675–682. doi: 10.1136/hrt.2007.121558.
   PubMed Web of Science ®Google Scholar
• ATS/ACCP statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003;167:211–277.
   PubMed Web of Science ®Google Scholar
• Radtke T, Crook S, Kaltsakas G, et al. ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases. Eur Respir Rev. 2019;28(154):180101. doi: 10.1183/16000617.0101-2018.
   PubMed Web of Science ®Google Scholar
• Ross R, Blair SN, Arena R, et al. Importance of assessing cardiorespiratory fitness in clinical practice: a case for fitness as a clinical vital sign: a scientific statement from the American heart association. Circulation. 2016;134(24):e653–e99. doi: 10.1161/CIR.0000000000000461.
   PubMed Web of Science ®Google Scholar
• Guazzi M, Arena R, Halle M, et al. 2016 Focused update: clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Eur Heart J. 2018;39(14):1144–1161. doi: 10.1093/eurheartj/ehw180.
   PubMed Web of Science ®Google Scholar
• Begum S, Papagiannopoulos K, Falcoz P, et al. Outcome after video-assisted thoracoscopic surgery and open pulmonary lobectomy in patients with low VO2 max: a case-matched analysis from the ESTS database. Eur J Cardiothorac Surg. 2016;49(4):1054–1058; discussion 1058. doi: 10.1093/ejcts/ezv378.
   PubMed Web of Science ®Google Scholar
• Miyazaki T, Callister MEJ, Franks K, et al. Minute ventilation-to-carbon dioxide slope is associated with postoperative survival after anatomical lung resection. Lung Cancer. 2018;125:218–222. doi: 10.1016/j.lungcan.2018.10.003.
   PubMed Web of Science ®Google Scholar
• Rodrigues F, Grafino M, Faria I, et al. Surgical risk evaluation of lung cancer in COPD patients - a cohort observational study. Rev Port Pneumol (2006). 2016;22(5):266–272. doi: 10.1016/j.rppnen.2016.02.010.
   PubMedGoogle Scholar
• Mao YS, He J, Yan SP, et al. Cardiopulmonary exercise testing in the evaluation of high risk patients with lung cancer. Chin Med J. 2010;123:3089–3094.
   PubMed Web of Science ®Google Scholar
• Bobbio A, Chetta A, Internullo E, et al. Exercise capacity assessment in patients undergoing lung resection. Eur J Cardiothorac Surg. 2009;35(3):419–422. doi: 10.1016/j.ejcts.2008.11.004.
   PubMed Web of Science ®Google Scholar
• Imboden MT, Harber MP, Whaley MH, et al. Cardiorespiratory fitness and mortality in healthy men and women. J Am Coll Cardiol. 2018;72(19):2283–2292. doi: 10.1016/j.jacc.2018.08.2166.
   PubMed Web of Science ®Google Scholar
• Brunelli A, Pompili C, Salati M, et al. Preoperative maximum oxygen consumption is associated with prognosis after pulmonary resection in stage I non-small cell lung cancer. Ann Thorac Surg. 2014;98(1):238–242. doi: 10.1016/j.athoracsur.2014.04.029.
   PubMed Web of Science ®Google Scholar
• Jones LW, Watson D, Herndon Ii JE, et al. Peak oxygen consumption and long-term all-cause mortality in nonsmall cell lung cancer. Cancer. 2010;116(20):4825–4832. doi: 10.1002/cncr.25396.
   PubMed Web of Science ®Google Scholar
• Lindenmann J, Fink-Neuboeck N, Fediuk M, et al. Preoperative peak oxygen consumption: a predictor of survival in resected lung cancer. Cancers (Basel). 2020;12(4):836. doi: 10.3390/cancers12040836.
   PubMed Web of Science ®Google Scholar
• Dun Y, Olson TP, Li C, et al. Characteristics and reference values for cardiopulmonary exercise testing in the adult chinese population - the xiangya hospital exercise testing project (the X-ET project). Int J Cardiol. 2021;332:15–21. doi: 10.1016/j.ijcard.2021.03.013.
   PubMed Web of Science ®Google Scholar
• Dun Y, Olson TP, Ripley-Gonzalez JW, et al. Safety of ­exercise testing in the clinical chinese population. Front Cardiovasc Med. 2021;8:638682. doi: 10.3389/fcvm.2021.638682.
   PubMed Web of Science ®Google Scholar
• Gould MK, Donington J, Lynch WR, et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e93S–e120S. doi: 10.1378/chest.12-2351.
   PubMed Web of Science ®Google Scholar
• Brunelli A, Kim AW, Berger KI, et al. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: american college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e166S–ee90S. doi: 10.1378/chest.12-2395.
   PubMed Web of Science ®Google Scholar
• Fletcher GF, Ades PA, Kligfield P,., et al. Exercise standards for testing and training: a scientific statement from the American heart association. Circulation. 2013;128(8):873–934. doi: 10.1161/CIR.0b013e31829b5b44.
   PubMed Web of Science ®Google Scholar
• Fluss R, Faraggi D, Reiser B. Estimation of the Youden index and its associated cutoff point. Biom J. 2005;47(4):458–472. doi: 10.1002/bimj.200410135.
   PubMed Web of Science ®Google Scholar
• Peduzzi P, Concato J, Feinstein AR, et al. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol. 1995;48(12):1503–1510. doi: 10.1016/0895-4356(95)00048-8.
   PubMed Web of Science ®Google Scholar
• Normand ST, Landrum MB, Guadagnoli E, et al. Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores. J Clin Epidemiol. 2001;54(4):387–398. doi: 10.1016/s0895-4356(00)00321-8.
   PubMed Web of Science ®Google Scholar
• Thomas LE, Li F, Pencina MJ. Overlap weighting: a propensity score method that mimics attributes of a randomized clinical trial. JAMA. 2020;323(23):2417–2418. doi: 10.1001/jama.2020.7819.
   PubMed Web of Science ®Google Scholar
• Orkaby AR, Driver JA, Ho YL, et al. Association of statin use with all-cause and cardiovascular mortality in us veterans 75 years and older. JAMA. 2020;324(1):68–78. doi: 10.1001/jama.2020.7848.
   PubMed Web of Science ®Google Scholar
• Steyerberg EW, Harrell FE, Jr., Borsboom GJ, et al. Internal validation of predictive models: efficiency of some procedures for logistic regression analysis. J Clin Epidemiol. 2001;54(8):774–781. doi: 10.1016/s0895-4356(01)00341-9.
   PubMed Web of Science ®Google Scholar
• Sauerbrei W, Schumacher M. A bootstrap resampling procedure for model building: application to the cox regression model. Stat Med. 1992;11(16):2093–2109. doi: 10.1002/sim.4780111607.
   PubMed Web of Science ®Google Scholar
• Steyerberg EW, Vickers AJ, Cook NR, et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology. 2010;21(1):128–138. doi: 10.1097/EDE.0b013e3181c30fb2.
   PubMed Web of Science ®Google Scholar
• Haneuse S, VanderWeele TJ, Arterburn D. Using the E-value to assess the potential effect of unmeasured confounding in observational studies. JAMA. 2019;321(6):602–603. doi: 10.1001/jama.2018.21554.
   PubMed Web of Science ®Google Scholar
• Ochman B, Kiczmer P, Ziora P, et al. Incidence of concomitant neoplastic diseases, tumor characteristics, and the survival of patients with lung adenocarcinoma or squamous cell lung carcinoma in tobacco smokers and non-smokers-10-year retrospective single-Centre cohort study. Cancers (Basel). 2023;15(6):1896. doi: 10.3390/cancers15061896.
   PubMed Web of Science ®Google Scholar
• Vainshelboim B, Lima RM, Kokkinos P, et al. Cardiorespiratory fitness, lung cancer incidence, and cancer mortality in male smokers. Am J Prev Med. 2019;57(5):659–666. doi: 10.1016/j.amepre.2019.04.020.
   PubMed Web of Science ®Google Scholar
• Boidin M, Lip GY, Thijssen D. Role of cardiorespiratory fitness in cancer development: time for an update. Eur J Prev Cardiol. 2021;28(17):e14–e16. doi: 10.1177/2047487320935228.
   PubMed Web of Science ®Google Scholar
• Mazur A, Brat K, Homolka P, et al. Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications. PLoS One. 2022;17(8):e0272984. doi: 10.1371/journal.pone.0272984.
   PubMed Web of Science ®Google Scholar
• Dun Y, Wu S, Cui N, et al. Prognostic role of minute ventilation/carbon dioxide production slope for perioperative morbidity and long-term survival in resectable patients with nonsmall-cell lung cancer: a prospective study using propensity score overlap weighting. Int J Surg. 2023;109(9):2650–2659. doi: 10.1097/JS9.0000000000000509.
   PubMed Web of Science ®Google Scholar
• Bolliger CT, Jordan P, Solèr M, et al. Exercise capacity as a predictor of postoperative complications in lung resection candidates. Am J Respir Crit Care Med. 1995;151(5):1472–1480. doi: 10.1164/ajrccm.151.5.7735602.
   PubMed Web of Science ®Google Scholar
• Brutsche MH, Spiliopoulos A, Bolliger CT, et al. Exercise capacity and extent of resection as predictors of surgical risk in lung cancer. Eur Respir J. 2000;15(5):828–832. doi: 10.1034/j.1399-3003.2000.15e03.x.
   PubMed Web of Science ®Google Scholar
• Li Q, Cao M, Zhang G, et al. Evaluation of cardiopulmonary exercise test on predicting post-operative respiratory failure in patients with lung cancer. Chin J Lung Cancer. 2003;6:367–370.
   Google Scholar
• Licker M, Schnyder JM, Frey JG, et al. Impact of aerobic exercise capacity and procedure-related factors in lung cancer surgery. Eur Respir J. 2011;37(5):1189–1198. doi: 10.1183/09031936.00069910.
   PubMed Web of Science ®Google Scholar
• Wang JS, Abboud RT, Evans KG, et al. Role of CO diffusing capacity during exercise in the preoperative evaluation for lung resection. Am J Respir Crit Care Med. 2000;162(4 Pt 1):1435–1444. doi: 10.1164/ajrccm.162.4.2001117.
   PubMed Web of Science ®Google Scholar
• Bayram A, Candan T, Gebitekin C. Preoperative maximal exercise oxygen consumption test predicts postoperative pulmonary morbidity following major lung resection. Respirology. 2007;12(4):505–510. doi: 10.1111/j.1440-1843.2007.01097.x.
   PubMed Web of Science ®Google Scholar
• Bechard D, Wetstein L. Assessment of exercise oxygen consumption as preoperative criterion for lung resection. Ann Thorac Surg. 1987;44(4):344–349. doi: 10.1016/s0003-4975(10)63787-3.
   PubMed Web of Science ®Google Scholar
• Markos J, Mullan BP, Hillman DR, et al. Preoperative assessment as a predictor of mortality and morbidity after lung resection. Am Rev Respir Dis. 1989;139(4):902–910. doi: 10.1164/ajrccm/139.4.902.
   PubMed Web of Science ®Google Scholar
• Wang J, Olak J, Ultmann RE, et al. Assessment of pulmonary complications after lung resection. Ann Thorac Surg. 1999;67(5):1444–1447. doi: 10.1016/s0003-4975(99)00255-6.
   PubMed Web of Science ®Google Scholar
• Mancini DM, Eisen H, Kussmaul W, et al. Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure. Circulation. 1991;83(3):778–786. doi: 10.1161/01.cir.83.3.778.
   PubMed Web of Science ®Google Scholar
• Kaminsky LA, Arena R, Myers J, et al. Updated reference standards for cardiorespiratory fitness measured with cardiopulmonary exercise testing: data from the fitness registry and the importance of exercise national database (FRIEND). Mayo Clin Proc. 2022;97(2):285–293. doi: 10.1016/j.mayocp.2021.08.020.
   PubMed Web of Science ®Google Scholar
• Larsen FJ, Schiffer TA, Zinner C, et al. Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. Acta Physiol (Oxf). 2020;229:e13463.
   PubMed Web of Science ®Google Scholar
• Xie M, Jiang L, Dun Y, et al. Trimetazidine combined with exercise improves exercise capacity and anti-fatal stress ability through enhancing mitochondrial quality control. Life Sci. 2019;224:157–168. doi: 10.1016/j.lfs.2019.03.027.
   PubMed Web of Science ®Google Scholar
• Dun Y, Liu S, Zhang W, et al. Exercise combined with rhodiola sacra supplementation improves exercise capacity and ameliorates exhaustive exercise-induced muscle damage through enhancement of mitochondrial quality control. Oxid Med Cell Longev. 2017;2017:8024857–8024818. doi: 10.1155/2017/8024857.
   PubMed Web of Science ®Google Scholar
• Jiang L, Shen X, Dun Y, et al. Exercise combined with trimetazidine improves anti-fatal stress capacity through enhancing autophagy and heat shock protein 70 of myocardium in mice. Int J Med Sci. 2021;18(7):1680–1686. doi: 10.7150/ijms.53899.
   PubMed Web of Science ®Google Scholar
• Bilimoria KY, Liu Y, Paruch JL, et al. Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. J Am Coll Surg. 2013;217(5):833–842.e1-3. doi: 10.1016/j.jamcollsurg.2013.07.385.
   PubMed Web of Science ®Google Scholar
• O’Brien SM, Feng L, He X, et al. The society of thoracic surgeons 2018 adult cardiac surgery risk models: part 2-statistical methods and results. Ann Thorac Surg. 2018;105(5):1419–1428. doi: 10.1016/j.athoracsur.2018.03.003.
   PubMed Web of Science ®Google Scholar
• Brunelli A, Charloux A, Bolliger CT, et al. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J. 2009;34(1):17–41. doi: 10.1183/09031936.00184308.
   PubMed Web of Science ®Google Scholar
• Ha D, Mazzone PJ, Ries AL, et al. The utility of exercise testing in patients with lung cancer. J Thorac Oncol. 2016;11(9):1397–1410. doi: 10.1016/j.jtho.2016.04.021.
   PubMed Web of Science ®Google Scholar