706
Views
0
CrossRef citations to date
0
Altmetric
Rheumatology

Platelet-to-lymphocyte ratios as a haematological marker of synovitis in rheumatoid arthritis with normal acute phase reactant level

, , , , , & show all
Article: 2346546 | Received 21 Dec 2023, Accepted 27 Mar 2024, Published online: 07 Jun 2024

References

  • Smolen JS, Aletaha D, McInnes IB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038. doi: 10.1016/S0140-6736(16)30173-8.
  • Pedrazzi AHP. Acute phase proteins: clinical and laboratory diagnosis. A review. Ann Pharm Fr. 1998;56(3):108–114.
  • Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340(6):448–454. doi: 10.1056/NEJM199902113400607.
  • Jansen LM, van der Horst-Bruinsma IE, van Schaardenburg D, et al. Predictors of radiographic joint damage in ­patients with early rheumatoid arthritis. Ann Rheum Dis. 2001;60(10):924–927. doi: 10.1136/ard.60.10.924.
  • Viatte S, Plant D, Lunt M, et al. Is it possible to predict radiological damage in early rheumatoid arthritis (RA)? A report on the occurrence, progression, and prognostic factors of radiological erosions over the first 3 years in 866 patients from the early RA study (ERAS). J Rheumatol. 2004;40(2):144–156. doi: 10.3899/jrheum.121034.
  • Crowson CS, Rahman MU, Matteson EL. Which measure of inflammation to use? A comparison of erythrocyte sedimentation rate and C-reactive protein measurements from randomized clinical trials of golimumab in rheumatoid arthritis. J Rheumatol. 2009;36(8):1606–1610. doi: 10.3899/jrheum.081188.
  • Kay J, Morgacheva O, Messing SP, et al. Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year. Arthritis Res Ther. 2014;16(1):R40. doi: 10.1186/ar4469.
  • Orr CK, Najm A, Young F, et al. The utility and limitations of CRP, ESR and DAS28-CRP in appraising disease activity in rheumatoid arthritis. Front Med. 2018;5:185. doi: 10.3389/fmed.2018.00185.
  • Rossaint J, Margraf A, Zarbock A. Role of platelets in leukocyte recruitment and resolution of inflammation. Front Immunol. 2018;9:2712. doi: 10.3389/fimmu.2018.02712.
  • Naszai M, Kurjan A, Maughan TS. The prognostic utility of pre-treatment neutrophil-to-lymphocyte-ratio (NLR) in colorectal cancer: a systematic review and meta-analysis. Cancer Med. 2021;10(17):5983–5997. doi: 10.1002/cam4.4143.
  • Jin Z, Cai G, Zhang P, et al. The value of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as complementary diagnostic tools in the diagnosis of rheumatoid arthritis: a multicenter retrospective study. J Clin Lab Anal. 2021;35:e23569.
  • Wu YL, Fulgenzi CAM, D'Alessio A, et al. Neutrophil-­to-lymphocyte and platelet-to-lymphocyte ratios as prognostic biomarkers in unresectable hepatocellular carcinoma treated with atezolizumab plus bevacizumab. Cancers. 2022;14(23):5834.
  • Fu W, Ye W, Liu X, et al. Meta-analysis of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in Henoch-Schonlein purpura and its complications. Int Immunopharmacol. 2021:94:107454.
  • Ceylan OM, Yılmaz M, Yilmaz H, et al. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as inflammation markers in patients with papilledema due to idiopathic intracranial hypertension. Indian J Ophthalmol. 2021;69(6):1499–1505. doi: 10.4103/ijo.IJO_2030_20.
  • D’Agostino M-A, Terslev L, Aegerter P, et al. Scoring ultrasound synovitis in rheumatoid arthritis: a EULAR-OMERACT ultrasound taskforce—part 1: definition and development of a standardised, consensus-based scoring system. RMD Open. 2017;3(1):e000428. doi: 10.1136/rmdopen-2016-000428.
  • Felson DT, Smolen JS, Wells G, et al. American College of Rheumatology/European League against rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Ann Rheum Dis. 2011;70(3):404–413. doi: 10.1136/ard.2011.149765.
  • Targońska-Stępniak B, Zwolak R, Piotrowski M, et al. The relationship between hematological markers of systemic inflammation (neutrophil-to-lymphocyte, platelet-to-­lymphocyte, lymphocyte-to-monocyte ratios) and ultrasound disease activity parameters in patients with rheumatoid arthritis. J Clin Med. 2020;9(9):2760. doi: 10.3390/jcm9092760.
  • Lee H-N, Kim Y-K, Kim G-T, et al. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio as predictors of 12-week treatment response and drug persistence of anti-tumor necrosis factor-α agents in patients with rheumatoid arthritis: a retrospective chart review analysis. Rheumatol Int. 2019;39(5):859–868. doi: 10.1007/s00296-019-04276-x.
  • Boulos D, Proudman SM, Metcalf RG, et al. The neutrophil–lymphocyte ratio in early rheumatoid arthritis and its ability to predict subsequent failure of triple therapy. Semin Arthritis Rheum. 2019;49(3):373–376. doi: 10.1016/j.semarthrit.2019.05.008.
  • Wang Z, Kong L, Zhang H, et al. Tumor necrosis factor alpha -308G/a gene polymorphisms combined with neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio predicts the efficacy and safety of anti-TNF-α therapy in patients with ankylosing spondylitis, rheumatoid arthritis, and psoriasis arthritis. Front Pharmacol. 2021;12:811719. doi: 10.3389/fphar.2021.811719.
  • Du J, Chen S, Shi J, et al. The association between the lymphocyte-monocyte ratio and disease activity in rheumatoid arthritis. Clin Rheumatol. 2017;36(12):2689–2695. doi: 10.1007/s10067-017-3815-2.
  • Targońska-Stępniak B, Grzechnik K, Kolarz K, et al. Systemic inflammatory parameters in patients with elderly-onset rheumatoid arthritis (EORA) and young-onset rheumatoid arthritis (YORA)—an observational study. J Clin Med. 2021;10(6):1204. doi: 10.3390/jcm10061204.
  • Montenont E, Rondina MT, Campbell RA. Altered functions of platelets during aging. Curr Opin Hematol. 2019;26(5):336–342. doi: 10.1097/MOH.0000000000000526.
  • Rundberg Nilsson A, Soneji S, Adolfsson S, et al. Human and murine hematopoietic stem cell aging is associated with functional impairments and intrinsic megakaryocytic/erythroid bias. PLOS One. 2016;11(7):e0158369. doi: 10.1371/journal.pone.0158369.
  • Farr M, Wainwright A, Salmon M, et al. Platelets in the synovial fluid of patients with rheumatoid arthritis. Rheumatol Int. 1984;4(1):13–17. doi: 10.1007/BF00683878.
  • Boilard E, Nigrovic PA, Larabee K, et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science. 2010;327(5965):580–583. doi: 10.1126/science.1181928.
  • Symmons DP, Farr M, Salmon M, et al. Lymphopenia in rheumatoid arthritis. J R Soc Med. 1989;82(8):462–463.
  • Zinellu A, Mangoni AA. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio and disease activity in rheumatoid arthritis: a systematic review and meta-analysis. Eur J Clin Invest. 2023;53(2):e13877. doi: 10.1111/eci.13877.