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TRENDS IN CLINICAL PRACTICE

Treatment of airway mucus hypersecretion

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Pages 116-125 | Published online: 26 Aug 2009

References

  • Del Donno M., Bittesnich D., Chetta A., Olivieri D., Lopez‐Vidriero M. T. The effect of inflammation on mucociliary clearance in asthma: an overview. Chest 2000; 118: 1142–9
  • Houtmeyers E., Gosselink R., Gayan‐Ramirez G., Decramer M. Regulation of mucociliary clearance in health and disease. Eur Respir J 1999; 13: 1177–88
  • Maestrelli P., Saetta M., Mapp C. E., Fabbri L. M. Remodeling in response to infection and injury. Airway inflammation and hypersecretion of mucus in smoking subjects with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 164: S76–S80
  • Davis P. B. Cystic fibrosis. Pediatr Rev 2001; 22: 257–64
  • Prescott E., Lange P., Vestbo J. Chronic mucus hypersecretion in COPD and death from pulmonary infection. Eur Respir J 1995; 8: 1333–8
  • Knowles M. R., Boucher R. C. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002; 109: 571–7
  • Davies J. R., Herrmann A., Russell W., Svitacheva N., Wickström C., Carlstedt I. Respiratory tract mucins: structure and expression patterns. Novartis Foundation Symposium 248. Mucus Hypersecretion in Respiratory Disease. John Wiley & Sons, Chichester 2002; pp. 76–93
  • Rogers D. F. The airway goblet cell. Int J Biochem Cell Biol 2003; 35: 1–6
  • Finkbeiner W. E. Physiology and pathology of tracheobronchial glands. Respir Physiol 1999; 118: 77–83
  • Moniaux N., Escande F., Porchet N., Aubert J. P., Batra S. K. Structural organization and classification of the human mucin genes. Front Biosci 2001; 6: D1192–D1206
  • Dekker J., Rossen J. W., Buller H. A., Einerhand A. W. The MUC family: an obituary. Trends Biochem Sci 2002; 27: 126–31
  • Gum J. R., Jr., Crawley S. C., Hicks J. W., Szymkowski D. E., Kim Y. S. MUC17, a novel membrane‐tethered mucin. Biochem Biophys Res Commun 2002; 291: 466–75
  • Wu G. J., Wu M. W., Wang S. W., Liu Z., Qu P., Peng Q., et al. Isolation and characterization of the major form of human MUC18 cDNA gene and correlation of MUC18 over‐expression in prostate cancer cell lines and tissues with malignant progression. Gene 2001; 279: 17–31
  • Chen Y., Zhao Y. H., Kalaslavadi T. B., Hamati E., Nehrke K., Le A. D., et al. Genome‐wide search and identification of a novel gel‐forming mucin MUC19/Muc19 in glandular tissues. Am J Respir Cell Mol Biol 2004; 30: 155–65
  • Higuchi T., Orita T., Nakanishi S., Katsuya K., Watanabe H., Yamasaki Y., et al. Molecular cloning, genomic structure, and expression analysis of MUC20, a novel mucin protein, up‐regulated in injured kidney. J Biol Chem 2004; 279: 1968–79
  • Eapen S. S., Busse W. W. Asthma. Clin Allergy Immunol 2002; 16: 325–53
  • Rogers D. F. Airway mucus hypersecretion in asthma: an undervalued pathology?. Curr Opin Pharmacol 2004; 241–50, 4
  • Houston J. C., De Navasquez S., Trounce J. R. A clinical and pathological study of fatal cases of status asthmaticus. Thorax 1953; 8: 207–13
  • Dunnill M. S. The pathology of asthma with special reference to changes in the bronchial mucosa. J Clin Pathol 1960; 13: 27–33
  • Saetta M., Di Stefano A., Rosina C., Thiene G., Fabbri L. M. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 1991; 143: 138–43
  • Aikawa T., Shimura S., Sasaki H., Ebina M., Takishima T. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest 1992; 101: 916–21
  • Ordonez C. L., Khashayar R., Wong H. H., Ferrando R., Wu R., Hyde D. M., et al. Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. Am J Respir Crit Care Med 2001; 163: 517–23
  • National Heart Lung and Blood Institute, World Health Organisation. Global initiative for chronic obstructive lung disease. Publication number 2701. Bethesda National Institutes of Health. 2001
  • Reid L. Pathology of chronic bronchitis. Lancet 1954; 266: 274–8
  • Aikawa T., Shimura S., Sasaki H., Takishima T., Yaegashi H., Takahashi T. Morphometric analysis of intraluminal mucus in airways in chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 140: 477–82
  • Steiger D., Fahy J., Boushey H., Finkbeiner W. E., Basbaum C. Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways. Am J Respir Cell Mol Biol 1994; 10: 538–45
  • Caramori G., Di Gregorio C., Carlstedt I., Casolari P., Guzzinati I., Adcock I. M., et al. Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease. Histopathology 2004; 45: 477–84
  • Saetta M., Turato G., Baraldo S., Zanin A., Braccioni F., Mapp C. E., et al. Goblet cell hyperplasia and epithelial inflammation in peripheral airways of smokers with both symptoms of chronic bronchitis and chronic airflow limitation. Am J Respir Crit Care Med 2000; 161: 1016–21
  • Mullen J. B., Wright J. L., Wiggs B. R., Pare P. D., Hogg J. C. Structure of central airways in current smokers and ex‐smokers with and without mucus hypersecretion: relationship to lung function. Thorax 1987; 42: 843–8
  • Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 1960; 15: 132–41
  • Restrepo G., Heard B. E. The size of the bronchial glands in chronic bronchitis. J Pathol Bacteriol 1963; 85: 305–10
  • Jeffery P. K. Differences and similarities between chronic obstructive pulmonary disease and asthma. Clin Exp Allergy 1999; 29 Suppl 2: 14–26
  • Saetta M., Turato G., Maestrelli P., Mapp C. E., Fabbri L. M. Cellular and structural bases of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2001; 163: 1304–9
  • Djukanovic R. Airway inflammation in asthma and its consequences: implications for treatment in children and adults. J Allergy Clin Immunol 2002; 109 Suppl 6: S539–S548
  • Barnes P. J. Mediators of chronic obstructive pulmonary disease. Pharmacol Rev 2004; 56: 515–48
  • Lopez‐Vidriero M. T., Reid L. Chemical markers of mucous and serum glycoproteins and their relation to viscosity in mucoid and purulent sputum from various hypersecretory diseases. Am Rev Respir Dis 1978; 117: 465–77
  • Charman J., Reid L. Sputum viscosity in chronic bronchitis, bronchiectasis, asthma and cystic fibrosis. Biorheology 1972; 9: 185–99
  • Shimura S., Sasaki T., Sasaki H., Takishima T., Umeya K. Viscoelastic properties of bronchorrhoea sputum in bronchial asthmatics. Biorheology 1988; 25: 173–9
  • Sheehan J. K., Richardson P. S., Fung D. C., Howard M., Thornton D. J. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol 1995; 13: 748–56
  • Rogers D. F., Evans T. W. Plasma exudation and oedema in asthma. Br Med Bull 1992; 48: 120–34
  • Shimura S., Andoh Y., Haraguchi M., Shirato K. Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. Eur Respir J 1996; 9: 1395–401
  • Thornton D. J., Carlstedt I., Howard M., Devine P. L., Price M. R., Sheehan J. K. Respiratory mucins: identification of core proteins and glycoforms. Biochem J 1996; 316: 967–75
  • Hovenberg H. W., Davies J. R., Herrmann A., Linden C. J., Carlstedt I. MUC5AC, but not MUC2, is a prominent mucin in respiratory secretions. Glycoconj J 1996; 13: 839–47
  • Wickstrom C., Davies J. R., Eriksen G. V., Veerman E. C., Carlstedt I. MUC5B is a major gel‐forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C‐terminal cleavage. Biochem J 1998; 334: 685–93
  • Sheehan J. K., Howard M., Richardson P. S., Longwill T., Thornton D. J. Physical characterization of a low‐charge glycoform of the MUC5B mucin comprising the gel‐phase of an asthmatic respiratory mucous plug. Biochem J 1999; 338: 507–13
  • Kirkham S., Sheehan J. K., Knight D., Richardson P. S., Thornton D. J. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J 2002; 361: 537–46
  • Chen Y., Zhao Y. H., Di Y. P., Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino‐terminal and 5′‐flanking region. Am J Respir Cell Mol Biol 2001; 25: 542–53
  • Davies J. R., Carlstedt I. Respiratory tract mucins. Cilia and Mucus: from Development to Respiratory Defense., M Salthe. Marcel Dekker, Inc., New York 2001; p. 167–78, In
  • Groneberg D. A., Eynott P. R., Lim S., Oates T., Wu R., Carlstedt I., et al. Expression of respiratory mucins in fatal status asthmaticus and mild asthma. Histopathology 2002; 40: 367–73
  • Groneberg D. A., Eynott P. R., Oates T., Lim S., Wu R., Carlstedt I., et al. Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med 2002; 96: 81–6
  • Davies J. R., Svitacheva N., Lannefors L., Kornfalt R., Carlstedt I. Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem J 1999; 344: 321–30
  • Glynn A. A., Michaels L. Bronchial biopsy in chronic bronchitis and asthma. Thorax 1960; 15: 142–53
  • Houtmeyers E., Gosselink R., Gayan‐Ramirez G., Decramer M. Effects of drugs on mucus clearance. Eur Respir J 1999; 14: 452–67
  • Rogers D. F. The role of airway secretions in COPD: pathophysiology, epidemiology and pharmacotherapeutic options. COPD: J Chron Obstructive Pulm Dis 2005; 2: 341–53
  • Rogers D. F. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulm Pharmacol Ther 2005; 18: 1–8
  • Rogers D. F. Mucoactive drugs for asthma and COPD: any place in therapy?. Expert Opin Investig Drugs 2002; 11: 15–35
  • National Institute for Clinical Excellence (NICE). Chronic obstructive pulmonary disease: national clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care. Thorax 2004; 59((Suppl 1))1–232
  • Li Y., Martin L. D., Spizz G., Adler K. B. MARCKS Protein Is a Key Molecule Regulating Mucin Secretion by Human Airway Epithelial Cells in Vitro. J Biol Chem 2001; 276: 40982–90
  • Singer M., Martin L. D., Vargaftig B. B., Park J., Gruber A. D., Li Y., et al. A MARCKS‐related peptide blocks mucus hypersecretion in a mouse model of asthma. Nat Med 2004; 10: 193–6
  • Evans C., Kheradmand F., Corry D., Tuvim M., Densmore C., Waldrep C., et al. Gene therapy of mucus hypersecretion in experimental asthma. Chest 2002; 121((3 Suppl))90S–91S
  • Foster K. A. A new wrinkle on pain relief: re‐engineering clostridial neurotoxins for analgesics. Drug Discov Today 2005; 10: 563–9
  • Ford E., Cruttwell C., Nute E., Chaddock J., Barnes P., Sutton J., et al. Inhibition of mucin secretion from A549 cells using a re‐targeted clostridial endopeptidase. Proc Am Thor Soc 2005; 2: A219
  • Burgel P. R., Nadel J. A. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 2004; 59: 992–6
  • O'Donnell R. A., Richter A., Ward J., Angco G., Mehta A., Rousseau K., et al. Expression of ErbB receptors and mucins in the airways of long term current smokers. Thorax 2004; 59: 1032–40
  • Longphre M., Li D., Li J., Matovinovic E., Gallup M., Samet J. M., et al. Lung mucin production is stimulated by the air pollutant residual oil fly ash. Toxicol Appl Pharmacol 2000; 162: 86–92
  • Shim J. J., Dabbagh K., Takeyama K., Burgel P. R., Dao‐Pick T. P., Ueki I. F., et al. Suplatast tosilate inhibits goblet‐cell metaplasia of airway epithelium in sensitized mice. J Allergy Clin Immunol 2000; 105: 739–45
  • Wang B., Lim D. J., Han J., Kim Y. S., Basbaum C. B., Li J. D. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up‐regulate human MUC5AC mucin transcription via a positive p38 mitogen‐activated protein kinase pathway and a negative phosphoinositide 3‐kinase‐Akt pathway. J Biol Chem 2002; 277: 949–57
  • Atherton H. C., Jones G., Danahay H. IL‐13‐induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3‐kinase regulation. Am J Physiol Lung Cell Mol Physiol 2003; 285: L730–L9
  • Zhou Y., Shapiro M., Dong Q., Louahed J., Weiss C., Wan S., et al. A calcium‐activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction. Mucus Hypersecretion in Respiratory Disease. Wiley, Chichester 2002; p. 150–65
  • Nakanishi A., Morita S., Iwashita H., Sagiya Y., Ashida Y., Shirafuji H., et al. Role of gob‐5 in mucus overproduction and airway hyperresponsiveness in asthma. Proc Natl Acad Sci U S A 2001; 98: 5175–80
  • Knight D. Talniflumate (Genaera). Curr Opin Investig Drugs 2004; 5: 557–62
  • Guzman K., Gray T. E., Yoon J. H., Nettesheim P. Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids. Am J Physiol 1996; 271: L1023–8
  • Yoon J. H., Gray T., Guzman K., Koo J. S., Nettesheim P. Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix. Am J Respir Cell Mol Biol 1997; 16: 724–31
  • Koo J. S., Jetten A. M., Belloni P., Yoon J. H., Kim Y. D., Nettesheim P. Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells. Biochem J 1999; 338: 351–7
  • Apfel C., Bauer F., Crettaz M., Forni L., Kamber M., Kaufmann F., et al. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A 1992; 89: 7129–33
  • Bhattacharyya S. N., Manna B., Smiley R., Ashbaugh P., Coutinho R., Kaufman B. Smoke‐induced inhalation injury: effects of retinoic acid and antisense oligodeoxynucleotide on stability and differentiated state of the mucociliary epithelium. Inflammation 1998; 22: 203–14
  • Tesfaigzi Y., Fischer M. J., Martin A. J., Seagrave J. Bcl‐2 in LPS‐ and allergen‐induced hyperplastic mucous cells in airway epithelia of Brown Norway rats. Am J Physiol Lung Cell Mol Physiol 2000; 279: L1210–17
  • Kellerman D. J. P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance. Chest 2002; 121((5 Suppl))201S–05S
  • Roger P., Gascard J. P., Bara J., de Montpreville V. T., Yeadon M., Brink C. ATP induced MUC5AC release from human airways in vitro. Mediators Inflamm 2000; 9: 277–84
  • Jackson A. D. Airway goblet‐cell mucus secretion. Trends Pharmacol Sci 2001; 22: 39–45

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