Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression

References

• Lesch K. P. Gene‐environment interaction and the genetics of depression. J Psychiatry Neurosci 2004; 29: 174–84
   PubMed Web of Science ®Google Scholar
• Rosenthal N. E., Sack D. A., Gillin J. C., Lewy A. J., Goodwin F. K., Davenport Y., et al. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984; 41: 72–80
   PubMed Web of Science ®Google Scholar
• Lewy A. J., Lefler B. J., Emens J. S., Bauer V. K. The circadian basis of winter depression. Proc Natl Acad Sci U S A 2006; 103: 7414–9
   PubMed Web of Science ®Google Scholar
• Partonen T., Lönnqvist J. Seasonal affective disorder. Lancet 1998; 352: 1369–74
   PubMed Web of Science ®Google Scholar
• Lam R. W., Tam E. M., Yatham L. N., Shiah I. S., Zis A. P. Seasonal depression: the dual vulnerability hypothesis revisited. J Affect Disord 2001; 63: 123–32
   PubMed Web of Science ®Google Scholar
• Lewy A. J., Sack R. L., Miller L. S., Hoban T. M. Antidepressant and circadian phase‐shifting effects of light. Science 1987; 235: 352–4
   PubMed Web of Science ®Google Scholar
• Czeisler C. A., Kronauer R. E., Mooney J. J., Anderson J. L., Allan J. S. Biologic rhythm disorders, depression, and phototherapy: a new hypothesis. Psychiatr Clin North Am 1987; 10: 687–709
   PubMed Web of Science ®Google Scholar
• Teicher M. H., Glod C. A., Magnus E., Harper D., Benson G., Krueger K., et al. Circadian rest‐activity disturbances in seasonal affective disorder. Arch Gen Psychiatry 1997; 54: 124–30
   PubMed Web of Science ®Google Scholar
• Huang Z. J., Edery I., Rosbash M. PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature 1993; 364: 259–62
   PubMed Web of Science ®Google Scholar
• Crews S. T. Control of cell lineage‐specific development and transcription by bHLH‐PAS proteins. Genes Dev 1998; 12: 607–20
   PubMed Web of Science ®Google Scholar
• Shearman L. P., Sriram S., Weaver D. R., Maywood E. S., Chaves I., Zheng B., et al. Interacting molecular loops in the mammalian circadian clock. Science 2000; 288: 1013–9
   PubMed Web of Science ®Google Scholar
• Kaasik K., Lee C. C. Reciprocal regulation of haem biosynthesis and the circadian clock in mammals. Nature 2004; 430: 467–71
   PubMed Web of Science ®Google Scholar
• Bunney W. E., Bunney B. G. Molecular clock genes in man and lower animals: possible implications for circadian abnormalities in depression. Neuropsychopharmacology 2000; 22: 335–45
   PubMed Web of Science ®Google Scholar
• Zheng B., Larkin D. W., Albrecht U., Sun Z. S., Sage M., Eichele G., et al. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 1999; 400: 169–73
   PubMed Web of Science ®Google Scholar
• Bae K., Jin X., Maywood E. S., Hastings M. H., Reppert S. M., Weaver D. R. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 2001; 30: 525–36
   PubMed Web of Science ®Google Scholar
• Xu Y., Toh K. L., Jones C. R., Shin J. Y., Fu Y. H., Ptáček L. J. Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 2007; 128: 59–70
   PubMed Web of Science ®Google Scholar
• Bunger M. K., Wilsbacher L. D., Moran S. M., Clendenin C., Radcliffe L. A., Hogenesch J. B., et al. Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 2000; 103: 1009–17
   PubMed Web of Science ®Google Scholar
• Dudley C. A., Erbel‐Sieler C., Estill S. J., Reick M., Franken P., Pitts S., et al. Altered patterns of sleep and behavioral adaptability in NPAS2‐deficient mice. Science 2003; 301: 379–83
   PubMed Web of Science ®Google Scholar
• Franken P., Dudley C. A., Estill S. J., Barakat M., Thomason R., O'Hara B. F., et al. NPAS2 as a transcriptional regulator of non‐rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A 2006; 103: 7118–23
   PubMed Web of Science ®Google Scholar
• Desan P. H., Oren D. A. Is seasonal affective disorder a disorder of circadian rhythms?. CNS Spectr 2001; 6: 487–94
   PubMedGoogle Scholar
• Lincoln G. A., Andersson H., Loudon A. Clock genes in calendar cells as the basis of annual timekeeping in mammals—a unifying hypothesis. J Endocrinol 2003; 179: 1–13
   PubMed Web of Science ®Google Scholar
• Pando M. P., Pinchak A. B., Cermakian N., Sassone‐Corsi P. A cell‐based system that recapitulates the dynamic light‐dependent regulation of the vertebrate clock. Proc Natl Acad Sci U S A 2001; 98: 10178–83
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Press, Washington, DC 1994, 4th ed
   Google Scholar
• Rosenthal N. E., Bradt G. H., Wehr T. A. Seasonal Pattern Assessment Questionnaire. National Institute of Mental Health, Bethesda, Md 1984
   Google Scholar
• Horne J. A., Östberg O. A self‐assessment questionnaire to determine morningness‐eveningness in human circadian rhythms. Int J Chronobiol 1976; 4: 97–110
   PubMedGoogle Scholar
• Duffy J. F., Rimmer D. W., Czeisler C. A. Association of intrinsic circadian period with morningness‐eveningness, usual wake time, and circadian phase. Behav Neurosci 2001; 115: 895–9
   PubMed Web of Science ®Google Scholar
• François P., Hakim V. Design of genetic networks with specified functions by evolution in silico. Proc Natl Acad Sci U S A 2004; 101: 580–5
   PubMed Web of Science ®Google Scholar
• Di Ventura B., Lemerle C., Michalodimitrakis K., Serrano L. From in vivo to in silico biology and back. Nature 2006; 443: 527–33
   PubMed Web of Science ®Google Scholar
• Sherry S. T., Ward M. H., Kholodov M., Baker J., Phan L., Smigielski E. M., et al. dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 2001; 29: 308–11
   PubMed Web of Science ®Google Scholar
• Riva A., Kohane I. S. SNPper: retrieval and analysis of human SNPs. Bioinformatics 2002; 18: 1681–5
   PubMed Web of Science ®Google Scholar
• Schug J., Overton G. C. TESS: Transcription Element Search Software on the WWW. Technical Report CBIL‐TR‐1997‐1001‐v0.0. Computational Biology and Informatics Laboratory at the University of Pennsylvania, Philadelphia, Pa 1997
   Google Scholar
• Long F., Liu H., Hahn C., Sumazin P., Zhang M. Q., Zilberstein A. Genome‐wide prediction and analysis of function‐specific transcription factor binding sites. In Silico Biology 2004; 4: 395–410
   PubMedGoogle Scholar
• Duan J., Wainwright M. S., Comeron J. M., Saitou N., Sanders A. R., Gelernter J., et al. Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet 2003; 12: 205–16
   PubMed Web of Science ®Google Scholar
• Wang D., Johnson A. D., Papp A. C., Kroetz D. L., Sadee W. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics 2005; 15: 693–704
   PubMed Web of Science ®Google Scholar
• Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 2003; 31: 3406–15
   PubMed Web of Science ®Google Scholar
• Xia X. Maximizing transcription efficiency causes codon usage bias. Genetics 1996; 144: 1309–20
   PubMed Web of Science ®Google Scholar
• Oresic M., Shalloway D. Specific correlations between relative synonymous codon usage and protein secondary structure. J Mol Biol 1998; 281: 31–48
   PubMed Web of Science ®Google Scholar
• Xie T., Ding D. The relationship between synonymous codon usage and protein structure. FEBS Lett 1998; 434: 93–6
   PubMed Web of Science ®Google Scholar
• Cartegni L., Wang J., Zhu Z., Zhang M. Q., Krainer A. R. ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Res 2003; 31: 3568–71
   PubMed Web of Science ®Google Scholar
• Blencowe B. J. Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci 2000; 25: 106–10
   PubMed Web of Science ®Google Scholar
• Caceres J. F., Kornblihtt A. R. Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet 2002; 18: 186–93
   PubMed Web of Science ®Google Scholar
• Pesole G., Liuni S., Grillo G., Licciulli F., Mignone F., Gissi C., et al. UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002. Nucleic Acids Res 2002; 30: 335–40
   PubMed Web of Science ®Google Scholar
• Mignone F., Grillo G., Licciulli F., Iacono M., Liuni S., Kersey P. J., et al. UTRdb and UTRsite: a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res 2005; 33((Database issue))D141–6
   PubMed Web of Science ®Google Scholar
• de Bakker P. I., Yelensky R., Peter I., Gabriel S. B., Daly M. J., Altshuler D. Efficiency and power in genetic association studies. Nat Genet 2005; 37: 1217–23
   PubMed Web of Science ®Google Scholar
• Johansson C., Willeit M., Smedh C., Ekholm J., Paunio T., Kieseppä T., et al. Circadian clock‐related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. Neuropsychopharmacology 2003; 28: 734–9
   PubMed Web of Science ®Google Scholar
• Hattersley A. T., McCarthy M. I. What makes a good genetic association study?. Lancet 2005; 366: 1315–23
   PubMed Web of Science ®Google Scholar
• Cermakian N., Boivin D. B. A molecular perspective of human circadian rhythm disorders. Brain Res Rev 2003; 42: 204–20
   PubMedGoogle Scholar
• Johansson C., Smedh C., Partonen T., Pekkarinen P., Paunio T., Ekholm J., et al. Seasonal affective disorder and serotonin‐related polymorphisms. Neurobiol Dis 2001; 8: 351–7
   PubMed Web of Science ®Google Scholar
• Johansson C., Willeit M., Levitan R., Partonen T., Smedh C., Del Favero J., et al. The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality. Psychol Med 2003; 33: 785–92
   PubMed Web of Science ®Google Scholar
• Marchini J., Donelly P., Cardon L. Genome‐wide strategies for detecting multiple loci that influence complex diseases. Nat Genet 2005; 37: 413–7
   PubMed Web of Science ®Google Scholar
• Faedda G. L., Tondo L., Teicher M. H., Baldessarini R. J., Gelbard H. A., Floris G. H. Seasonal mood disorders: patterns of seasonal recurrence in mania and depression. Arch Gen Psychiatry 1993; 50: 17–23
   PubMed Web of Science ®Google Scholar
• Spanagel R., Pendyala G., Abarca C., Zghoul T., Sanchis‐Segura C., Magnone M. C., et al. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 2005; 11: 35–42
   PubMed Web of Science ®Google Scholar
• Spanagel R., Rosenwasser A. M., Schumann G., Sarkar D. K. Alcohol consumption and the body's biological clock. Alcohol Clin Exp Res 2005; 29: 1550–7
   PubMed Web of Science ®Google Scholar
• Lecomte M. J., Basseville M., Fauquet M. Involvement of intronic sequences in cell‐specific expression of the peripherin gene. J Neurochem 1999; 73: 1806–15
   PubMed Web of Science ®Google Scholar
• van Haasteren G., Li S., Ryser S., Schlegel W. Essential contribution of intron sequences to Ca(2+)‐dependent activation of c‐fos transcription in pituitary cells. Neuroendocrinology 2000; 72: 368–78
   PubMed Web of Science ®Google Scholar
• Mastrangelo I. A., Courey A. J., Wall J. S., Jackson S. P., Hough P. V. DNA looping and Sp1 multimer links: a mechanism for transcriptional synergism and enhancement. Proc Natl Acad Sci U S A 1991; 88: 5670–4
   PubMed Web of Science ®Google Scholar
• Su W., Jackson S., Tjian R., Echols H. DNA looping between sites for transcriptional activation: self‐association of DNA‐bound Sp1. Genes Dev 1991; 5: 820–6
   PubMed Web of Science ®Google Scholar
• Lamont E. W., Robinson B., Stewart J., Amir S. The central and basolateral nuclei of the amygdala exhibit opposite diurnal rhythms of expression of the clock protein Period2. Proc Natl Acad Sci U S A 2005; 102: 4180–4
   PubMed Web of Science ®Google Scholar
• Ueda H. R., Hayashi S., Chen W., Sano M., Machida M., Shigeyoshi Y., et al. System‐level identification of transcriptional circuits underlying mammalian circadian clocks. Nat Genet 2005; 37: 187–92
   PubMed Web of Science ®Google Scholar
• Akashi M., Ichise T., Mamine T., Takumi T. Molecular mechanism of cell‐autonomous circadian gene expression of Period2, a crucial regulator of the mammalian circadian clock. Mol Biol Cell 2006; 17: 555–65
   PubMed Web of Science ®Google Scholar
• Yamamoto Y., Yagita K., Okamura H. Role of cyclic mPer2 expression in the mammalian cellular clock. Mol Cell Biol 2005; 25: 1912–21
   PubMed Web of Science ®Google Scholar
• Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y. Z., Pray‐Grant M., et al. Characterization of a subset of the basic‐helix‐loop‐helix‐PAS superfamily that interacts with components of the dioxin signaling pathway. J Biol Chem 1997; 272: 8581–93
   PubMed Web of Science ®Google Scholar
• Sato T. K., Yamada R. G., Ukai H., Baggs J. E., Miraglia L. J., Kobayashi T. J., et al. Feedback repression is required for mammalian circadian clock function. Nat Genet 2006; 38: 312–9
   PubMed Web of Science ®Google Scholar
• Akashi M., Takumi T. The orphan nuclear receptor ROR( regulates circadian transcription of the mammalian core‐clock Bmal1. Nat Struct Mol Biol 2005; 12: 441–8
   PubMed Web of Science ®Google Scholar
• Sato T. K., Panda S., Miraglia L. J., Reyes T. M., Rudic R. D., McNamara P., et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 2004; 43: 527–37
   PubMed Web of Science ®Google Scholar
• Wiesenberg I., Missbach M., Kahlen J‐P., Schräder M., Carlberg C. Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand. Nucleic Acids Res 1995; 23: 327–33
   PubMed Web of Science ®Google Scholar
• Wehr T. A., Duncan W. C., Jr., Sher L., Aeschbach D., Schwartz P. J., Turner E. H., et al. A circadian signal of change of season in patients with seasonal affective disorder. Arch Gen Psychiatry 2001; 58: 1108–14
   PubMed Web of Science ®Google Scholar
• Tu B. P., McKnight S. L. Metabolic cycles as an underlying basis of biological oscillations. Nat Rev Mol Cell Biol 2006; 7: 696–701
   PubMed Web of Science ®Google Scholar
• Zhang J., Kaasik K., Blackburn M. R., Lee C. C. Constant darkness is a circadian metabolic signal in mammals. Nature 2006; 439: 340–3
   PubMed Web of Science ®Google Scholar
• Colwell C. S., Michel S., Itri J., Rodriguez W., Tam J., Lelièvre V., et al. Selective deficits in the circadian light response in mice lacking PACAP. Am J Physiol Regul Integr Comp Physiol 2004; 287: R1194–201
   PubMed Web of Science ®Google Scholar
• Yujnovsky I., Hirayama J., Doi M., Borrelli E., Sassone‐Corsi P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A 2006; 103: 6386–91
   PubMed Web of Science ®Google Scholar
• Lincoln G. A., Clarke I. J., Hut R. A., Hazlerigg D. G. Characterizing a mammalian circannual pacemaker. Science 2006; 314: 1941–4
   PubMed Web of Science ®Google Scholar
• Prosser H. M., Bradley A., Chesham J. E., Ebling F. J. P., Hastings M. H., Maywood E. S. Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A 2007; 104: 648–53
   PubMed Web of Science ®Google Scholar
• Gaist P. A., Obarzanek E., Skwerer R. G., Duncan C. C., Shultz P. M., Rosenthal N. E. Effects of bright light on resting metabolic rate in patients with seasonal affective disorder and control subjects. Biol Psychiatry 1990; 28: 989–96
   PubMed Web of Science ®Google Scholar
• Thompson C., Stinson D., Smith A. Seasonal affective disorder and season‐dependent abnormalities of melatonin suppression by light. Lancet 1990; 336: 703–6
   PubMed Web of Science ®Google Scholar
• Depue R. A., Arbisi P., Spoont M. R., Krauss S., Leon A., Ainsworth B. Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder. Am J Psychiatry 1989; 146: 989–95
   PubMed Web of Science ®Google Scholar
• Partonen T. The molecular basis for winter depression. Ann Med 1994; 26: 239–43
   PubMed Web of Science ®Google Scholar