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Research Article

Inhibition of NO Biosynthesis, but not Elevated Blood Pressure, Reduces Angiogenesis in Rat Models of Secondary Hypertension

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Pages 116-124 | Published online: 08 Jul 2009

  • Noon JP, Walker BR, Webb DJ, et al. Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure. J Clin Invest 1997; 99: 1873-9.
  • Ie Noble FA, Stassen FR, Hacking WJ, Struijker Boudier HA. Angiogenesis and hypertension. J Hypertens 1998; 16: 1563-72.
  • Hutchins PM, Darnell AE. Observation of a decreased number of small arterioles in spontaneously hypertensive rats. Circ Res 1974; 34 and 35:1-161-5.
  • Prewitt RL, Chen, II, Dowel 1 R. Development of microvascular rarefaction in the spontaneously hypertensive rat. Am J Physiol 1982; 243: H243-51.
  • Boegehold MA, Kotchen TA. Effect of dietary salt on the skeletal muscle microvasculature in Dahl rats. Hypertension 1990; 15: 420-6.
  • Boegehold MA. Microvascular changes associated with high salt intake and hypertension in Dahl rats. Int J Microcirc Clin Exp 1993; 12: 143-56.
  • Henrich HA, Romen W, Heimgartner W, Hartung E, Baumer F. Capillary rarefaction characteristic of the skeletal muscle of hypertensive patients. Klin Wochenschr 1988; 66: 54-60.
  • Boegehold MA, Johnson MD, Overbeck HW. Pressureindependent arteriolar rarefaction in hypertension. Am J Physiol 1991; 261: H83-7.
  • Battegay EJ. Angiogenesis: mechanistic insights, neovascular diseases, and therapeutic prospects. J Mol Med 1995; 73: 333-46.
  • Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HAJ. Microcirculation in hypertension. A new target for treatment? Circulation 2001; 104: 735-40
  • Folkman J, Shing Y. Angiogenesis. J Biol Chem 1992; 267: 10931-4.
  • GalIo O, Masini E, Morbidelli L, et al. Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer. J Natl Cancer Inst 1998; 90: 587-96.
  • Garcia-Cardena G, Folkman J. Is there a role for nitric oxide in tumor angiogenesis? J Natl Cancer Inst 1998; 90: 560-1.
  • Vakkala M, Kahlos K, Lakari E, Paakko P, Kinnula V, Soini Y. Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas. Clin Cancer Res 2000; 6: 2408-16.
  • Jadeski LC, LaIa PK. Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors. Am J Pathol 1999; 155: 1381-90.
  • Ziehe M, Morbidelli L, Choudhuri R, et al. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic flbroblast growth factorinduced angiogenesis. J Clin Invest 1997; 99: 2625-34.
  • Papapetropoulos A, Garcia-Cardena G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100: 3131-9.
  • Kroll J, Waltenberger J. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR). Biochem Biophys Res Commun 1998; 252: 743-6.
  • He H, Venema VJ, Gu X, Venema RC, Marrero MB, Caldwell RB. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J Biol Chem 1999; 274: 25130-5.
  • Radisavljevic Z, Avraham H, Avraham S. Vascular endothelial growth factor up-regulates ICAM-I expression via the phosphatidylinositol 3 OH-kinase/AKT/nitric oxide pathway and modulates migration of brain microvascular endothelial cells. J Biol Chem 2000; 275: 20770-4.
  • Dulak J, Jozkowicz A, Dembinska-Kiec A, et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vase Biol 2000; 20: 659-66.
  • Kimura H, Weisz A, Kurashima Y, et al. Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide. Blood 2000; 95: 189-97.
  • Sieber CC, Sumanovski LT, Stumm M, Van der Kooij M, Battegay E. In vivo angiogenesis in normal an portal hypertensive rats: role of basic fibroblast growth factor and nitric oxide. J Hepatol 2001; 34: 644-50
  • Sumanovski LT, Battegay E, Stumm M, van der Kooij M, Sieber CC. Increased angiogenesis in portal hypertensive rats: role of nitric oxide. Hepatology 1999; 29: 1044-9.
  • Meirelles Pereira LM, Mandarim-de-Lacerda CA. Effect of antihypertensive drugs on the myocardial microvessels in rats with nitric oxide blockade. Pathol Res Pract 2000; 196: 305-11.
  • Morbidelli L, Chang CH, Douglas JG, Granger HJ, Ledda F, Ziehe M. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am J Physiol 1996; 270: H411-5.
  • Dahl LK, Heine M, Tassinari L. Role of genetic factors in susceptibility to experimental hypertension due to chronic excess salt ingestion. Nature 1962; 194: 480-2
  • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-42.
  • Nathan C, Xie QW. Nitric oxide syntheses: roles, tolls, and controls. Cell 1994; 78: 915-8.
  • Schmidt HH, Walter U. NO at work. Cell 1994; 78:919-25.
  • Arnold F, West DC. Angiogenesis in wound healing. Pharmacol Ther 1991; 52: 407-22.
  • Albina JE, Mills CD, Henry WL, Jr., Caldwell MD. Temporal expression of different pathways of 1-arginine metabolism in healing wounds. J Immunol 1990; 144:3877-80.
  • Schaffer MR, Tantry U, Gross SS, Wasserburg HL, Barbul A. Nitric oxide regulates wound healing. J Surg Res 1996; 63: 237-40.
  • Bulgrin JP, Shabani M, Chakravrthy D, Smith DJ. Nitric oxide synthesis is suppressed in steroid-impaired and diabetic wounds. Wounds 1995; 7: 48-57.
  • Yamasaki K, Edington HD, McClosky C, et al. Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer. J Clin Invest 1998; 101:967-71.
  • Lee PC, Salyapongse AN, Bragdon GA, et al. Impaired wound healing and angiogenesis in eNOS-deficient mice. Am J Physiol 1999; 277: H1600-8.
  • Chen PY, Sanders PW. Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats. Hypertension 1993; 22: 812-8.
  • Patel A, Layne S, Watts D, Kirchner KA. L-Arginine administration normalizes pressure natriuresis in hypertensive Dahl rats. Hypertension 1993; 22: 863-9.
  • Hu L, Manning RD, Jr. Role of nitric oxide in regulation of long-term pressure-natriuresis relationship in Dahl rats. Am J Physiol 1995; 268: H2375-83.
  • Simchon S, Manger W, Blumberg G, Brensilver J, Cortell S. Impaired renal vasodilation and urinary cGMP excretion in Dahl salt-sensitive rats. Hypertension 1996; 27: 653-7.
  • Ni Z, Oveisi F, Vaziri ND. Nitric oxide synthase isotype expression in salt-sensitive and salt-resistant Dahl rats. Hypertension 1999; 34: 552-7.
  • Rudd MA, Trolliet M, Hope S, et al. Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition. Am J Physiol 1999; 277: H732-9.
  • Mattson DL, Higgins DJ. Influence of dietary sodium intake on renal medullary nitric oxide synthase. Hypertension 1996; 27: 688-92.
  • Barton M, Vos I, Shaw S, et al. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endotfaelial dysfunction and role of endotfaelin for vascular hypertrophy and Glomerulosclerosis. J Am Soc Nephrol 2000; 11: 835-45.
  • Deng AY. Is the nitric oxide system involved in genetic hypertension in Dahl rats? Kidney Int 1998; 53: 1501-11.
  • Rapp JP. Dahl salt-susceptible and salt-resistant rats. A review. Hypertension 1982; 4: 753-63.
  • Rapp JP, Dene H. Development and characteristics of inbred strains of Dahl salt-sensitive and salt-resistant rats. Hypertension 1985;7:340-9.

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