How to measure retinal microperfusion in patients with arterial hypertension

References

• Zhou B, Bentham J, Di Cesare M, et al. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. Lancet. 2017;389:37–55.
   PubMed Web of Science ®Google Scholar
• Savarese G, Lund LH. Global public health burden of heart failure. Card Fail Rev. 2017;03:7.
   Google Scholar
• Kohara K, Hiwada K. End-organ damage in essential hypertension in the elderly. J Hum Hypertens. 1995;9:717–721.
   PubMed Web of Science ®Google Scholar
• Mancia G, Frattola A, Groppelli A, et al. Blood pressure reduction and end-organ damage in hypertension. J Hypertens Suppl. 1994;12:S35–S42.
   Google Scholar
• Perloff D. Retrospective and prospective research on hypertension-related end-organ damage. J Cardiovasc Pharmacol. 1994;24:S1–S5.
   PubMedGoogle Scholar
• Laurent S, Briet M, Boutouyrie P. Large and small artery cross-talk and recent morbidity-mortality trials in hypertension. Hypertension. 2009;54:388–392.
   PubMed Web of Science ®Google Scholar
• Schmieder RE. End organ damage in hypertension. Dtsch Arztebl Int. 2010;107:866–873.
   PubMed Web of Science ®Google Scholar
• Schiffrin EL, Hayoz D. How to assess vascular remodelling in small and medium-sized muscular arteries in humans. J Hypertens. 1997;15:571–584.
   PubMed Web of Science ®Google Scholar
• Rizzoni D, Agabiti Rosei C, De Ciuceis C, et al. New methods to study the microcirculation. Am J Hypertens. 2018;31:265–273.
   PubMed Web of Science ®Google Scholar
• Mancia G, Fagard R, Narkiewicz K, et al. 2013 Practice guidelines for the management of arterial hypertension of the European Society ofHypertension (ESH) and the European Society of Cardiology (ESC): ESH/ESCTask Force for the Management of Arterial Hypertension. J. Hypertens. 2013;31:1925–1938.
   PubMed Web of Science ®Google Scholar
• Lee WH, Park JH, Won Y, et al. Retinal microvascular change in hypertension as measured by optical coherence tomography angiography. Sci Rep. 2019;9:156.
   PubMed Web of Science ®Google Scholar
• Dąbrowska E, Harazny JM, Miszkowska-Nagórna E, et al. Lumen narrowing and increased wall to lumen ratio of retinal microcirculation are valuable biomarkers of hypertension-mediated cardiac damage. Blood Press. 2019. Forthcoming.
   PubMed Web of Science ®Google Scholar
• Dąbrowska E, Harazny JM, Miszkowska-Nagórna E, et al. Aortic stiffness is not only associated with structural but also functional parameters of retinal microcirculation. Microvasc Res. 2020;129:103974.
   PubMed Web of Science ®Google Scholar
• Dąbrowska EE, Harazny JM, Wolf J, et al. The eye – a window to cardiovascular diseases. Arter Hypertens. 2020;24:56–60.
   Web of Science ®Google Scholar
• Levin L, Nilsson S, Ver Hoeve J, et al. Adler’s physiology of the eye. 11th ed. Edinburg (UK): Elsevier Saunders; 2011.
   Google Scholar
• Wu DM, Kawamura H, Sakagami K, et al. Cholinergic regulation of pericyte-containing retinal microvessels. Am J Physiol Heart Circ Physiol. 2003;284:H2083–H2090.
   PubMed Web of Science ®Google Scholar
• Hardarson SH. Retinal oximetry. Acta Ophthalmol. 2013;91:1–47.
   PubMed Web of Science ®Google Scholar
• Michelson G, Scibor M. Intravascular oxygen saturation in retinal vessels in normal subjects and open-angle glaucoma subjects. Acta Ophthalmol Scand. 2006;84:289–295.
   PubMedGoogle Scholar
• Januszewicz A, Więcek A, Hoffman P, et al. Nadciśnienie tętnicze: współczesna diagnostyka i podstawy terapii. 1st ed. Cracow (Poland): Medycyna Praktyczna; 2014.
   Google Scholar
• Hughes AD, Falaschetti E, Witt N, et al. Association of retinopathy and retinal microvascular abnormalities with stroke and cerebrovascular disease. Stroke. 2016;47:2862–2864.
   PubMed Web of Science ®Google Scholar
• Yatsuya H, Folsom AR, Wong TY, et al.; ARIC Study Investigators. Retinal microvascular abnormalities and risk of lacunar stroke: Atherosclerosis Risk in Communities Study. Stroke. 2010;41:1349–1355.
   PubMed Web of Science ®Google Scholar
• Doubal FN, MacGillivray TJ, Patton N, et al. Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke. Neurology. 2010;74:1102–1107.
   PubMed Web of Science ®Google Scholar
• Baker ML, Hand PJ, Wang JJ, et al. Retinal signs and stroke: revisiting the link between the eye and brain. Stroke. 2008;39:1371–1379.
   PubMed Web of Science ®Google Scholar
• Wong TY, Klein R, Couper DJ, et al. Retinal microvascular abnormalities and incident stroke: The Atherosclerosis Risk in Communities Study. Lancet. 2001;358:1134–1140.
   PubMed Web of Science ®Google Scholar
• Liew G, Wang JJ. Retinal vascular signs: a window to the heart? Rev Española Cardiol English Ed. 2011;64:515–521.
   PubMed Web of Science ®Google Scholar
• Krill AE. Fluoreszenzangiographie der retina. Lehrbuch und atlas. Am J Ophthalmol. 1969;67:160–161.
   Google Scholar
• Hodge JV, Clemett RS. Improved method for fluorescence angiography of the retina. Am J Ophthalmol. 1966;61:1400–1404.
   PubMed Web of Science ®Google Scholar
• Jung F, Kiesewetter H, Körber N, et al. Quantification of characteristic blood-flow parameters in the vessels of the retina with a picture analysis system for video-fluorescence angiograms: initial findings. Graefes Arch Clin Exp Ophthalmol. 1983;221:133–136.
   PubMed Web of Science ®Google Scholar
• Wolf S, Jung F, Kiesewetter H, et al. Video fluorescein angiography: Method and clinical application. Graefes Arch Clin Exp Ophthalmol. 1989;227:145–151.
   PubMed Web of Science ®Google Scholar
• Wei X, Balne PK, Meissner KE, et al. Assessment of flow dynamics in retinal and choroidal microcirculation. Surv Ophthalmol. 2018;63:646–664.
   PubMed Web of Science ®Google Scholar
• Khoobehi B, Peyman GA. Fluorescent labeling of blood cells for evaluation of retinal and choroidal circulation. Ophthalmic Surg Lasers. 1999;30:140–145.
   PubMedGoogle Scholar
• Riva CE, Sinclair SH, Grunwald JE. Autoregulation of retinal circulation in response to decrease of perfusion pressure. Investig Ophthalmol Vis Sci. 1981;21:34–38.
   PubMed Web of Science ®Google Scholar
• Riva CE, Petrig B. Blue field entoptic phenomenon and blood velocity in the retinal capillaries. J Opt Soc Am. 1980;70:1234–1238.
   PubMed Web of Science ®Google Scholar
• Loebl M, Riva CE. Macular Circulation and the Flying Corpuscles Phenomenon. Ophthalmology. 1978;85:911–917.
   PubMed Web of Science ®Google Scholar
• Shinohara S, Mochizuki A, Yoshida H, et al. Laser Doppler velocimeter using the self-mixing effect of a semiconductor laser diode. Appl Opt. 1986;25:1417.
   PubMed Web of Science ®Google Scholar
• Riva CE, Feke GT, Eberli B, et al. Bidirectional LDV system for absolute measurement of blood speed in retinal vessels. Appl Opt. 1979;18:2301–2306.
   PubMed Web of Science ®Google Scholar
• Fujii H. Visualisation of retinal blood flow by laser speckle flow-graphy. Med Biol Eng Comput. 1994;32:302–304.
   PubMed Web of Science ®Google Scholar
• Riva CE, Harino S, Petrig BL, et al. Laser Doppler flowmetry in the optic nerve. Exp Eye Res. 1992;55:499–506.
   PubMed Web of Science ®Google Scholar
• Riva C, Cranstoun S, Grunwald J, et al. Local choroidal blood flow in the cat by laser Doppler flowmetry. Investig Ophthalmol Vis Sci. 1994;35:608–618.
   PubMed Web of Science ®Google Scholar
• Riva CE, Cranstoun SD, Grunwald JE, et al. Choroidal blood flow in the foveal region of the human ocular fundus. Investig Ophthalmol Vis Sci. 1994;35:4273–4281.
   PubMed Web of Science ®Google Scholar
• Bender D, Tweer S, Werdin F, et al. The acute impact of local cooling versus local heating on human skin microcirculation using laser Doppler flowmetry and tissue spectrophotometry. Burns. 2020;46:104–109.
   PubMed Web of Science ®Google Scholar
• Mowla A, Taimre T, Lim Y, et al. Concurrent reflectance confocal microscopy and laser Doppler flowmetry to improve skin cancer imaging: a monte carlo model and experimental validation. Sensors. 2016;16:1411.
   PubMed Web of Science ®Google Scholar
• Sommer B, Kreuzer M, Bischoff B, et al. Combined laser-Doppler flowmetry and spectrophotometry: feasibility study of a novel device for monitoring local cortical microcirculation during aneurysm surgery. J Neurol Surg A Cent Eur Neurosurg. 2016;78:1–11.
   PubMedGoogle Scholar
• Barry O, Wang Y, Wahl G. Determination of baseline alveolar mucosa perfusion parameters using laser Doppler flowmetry and tissue spectrophotometry in healthy adults. Acta Odontol Scand. 2020;78:31–37.
   PubMed Web of Science ®Google Scholar
• Ghouth N, Duggal MS, BaniHani A, et al. The diagnostic accuracy of laser Doppler flowmetry in assessing pulp blood flow in permanent teeth: a systematic review. Dent Traumatol. 2018;34:311–319.
   PubMed Web of Science ®Google Scholar
• Abdulhameed YA, Lancaster G, McClintock PVE, et al. On the suitability of laser-Doppler flowmetry for capturing microvascular blood flow dynamics from darkly pigmented skin. Physiol Meas. 2019;40:074005.
   PubMed Web of Science ®Google Scholar
• Rajan V, Varghese B, Van Leeuwen TG, et al. Review of methodological developments in laser Doppler flowmetry. Lasers Med Sci. 2009;24:269–283.
   PubMed Web of Science ®Google Scholar
• Michelson G, Schmauss B, Langhans MJ, et al. Principle, validity, and reliability of scanning laser Doppler flowmetry. J Glaucoma. 1996;5:99–105.
   PubMed Web of Science ®Google Scholar
• Michelson G, Welzenbach J, Pal I, et al. Automatic full field analysis of perfusion images gained by scanning laser Doppler flowmetry. Br J Ophthalmol. 1998;82:1294–1300.
   PubMed Web of Science ®Google Scholar
• Harazny JM, Ritt M, Baleanu D, et al. Increased wall:lumen ratio of retinal arterioles in male patients with a history of a cerebrovascular event. Hypertension. 2007;50:623–629.
   PubMed Web of Science ®Google Scholar
• Kreis AJ, Nguyen T, Rogers S, et al. Reliability of different image analysis methods for scanning laser Doppler flowmetry. Curr Eye Res. 2008;33:493–499.
   PubMed Web of Science ®Google Scholar
• Harazny JM, Raff U, Welzenbach J, et al. New software analyses increase the reliability of measurements of retinal arterioles morphology by scanning laser Doppler flowmetry in humans. J Hypertens. 2011;29:777–782.
   PubMed Web of Science ®Google Scholar
• Harazny JM, Ott C, Raff U, et al. First experience in analysing pulsatile retinal capillary flow and arteriolar structural parameters measured noninvasively in hypertensive patients. J Hypertens. 2014;32:2246–2252.
   PubMed Web of Science ®Google Scholar
• Schiffrin EL. Effect of antihypertensive treatment on small artery remodeling in hypertension. Can J Physiol Pharmacol. 2003;81:168–176.
   PubMed Web of Science ®Google Scholar
• Koch E, Rosenbaum D, Brolly A, et al. Morphometric analysis of small arteries in the human retina using adaptive optics imaging: relationship with blood pressure and focal vascular changes. J Hypertens. 2014;32:890–898.
   PubMed Web of Science ®Google Scholar
• Rosenbaum D, Kachenoura N, Koch E, et al. Relationships between retinal arteriole anatomy and aortic geometry and function and peripheral resistance in hypertensives. Hypertens Res. 2016;39:536–542.
   PubMed Web of Science ®Google Scholar
• Rosenbaum D, Mattina A, Koch E, et al. Effects of age, blood pressure and antihypertensive treatments on retinal arterioles remodeling assessed by adaptive optics. J Hypertens. 2016;34:1115–1122.
   PubMed Web of Science ®Google Scholar
• Rosenbaum D, Koch E, Girerd X, et al. Imagerie des artérioles rétiniennes par optique adaptative, faisabilité et reproductibilité. Ann Cardiol Angeiol (Paris). 2013;62:184–188.
   PubMedGoogle Scholar
• De Ciuceis C, Coschignano MA, Caletti S, et al. Reproducibility of the evaluation of the wall to lumen ratio of retinal arterioles with two different non-invasive approaches. J Hypertens. 2017;35:e153–e154.
   Web of Science ®Google Scholar
• Babcock HW. Adaptive optics revisited. Science. 1990;249:253–257.
   PubMed Web of Science ®Google Scholar
• Liang J, Williams DR, Miller DT. Supernormal vision and high-resolution retinal imaging through adaptive optics. J Opt Soc Am A Opt Image Sci Vis. 1997;14:2884–2892.
   PubMed Web of Science ®Google Scholar
• de Carlo TE, Romano A, Waheed NK, et al. A review of optical coherence tomography angiography (OCTA). Int J Retin Vitr. 2015;1:1–15.
   PubMedGoogle Scholar
• Yannuzzi NA, Gregori NZ, Roisman L, et al. Fluorescein angiography versus optical coherence tomography angiography in macular telangiectasia type i treated with bevacizumab therapy. Ophthalmic Surg Lasers Imaging Retina. 2017;48:263–266.
   PubMed Web of Science ®Google Scholar
• Kiyota N, Kunikata H, Shiga Y, et al. Relationship between laser speckle flowgraphy and optical coherence tomography angiography measurements of ocular microcirculation. Graefes Arch Clin Exp Ophthalmol. 2017;255:1633–1642.
   PubMed Web of Science ®Google Scholar
• Endersid C, Lang GE, Dreyhaupt J, et al. Quantity and quality of image artifacts in optical coherence tomography angiography. PLos One. 2019;14:e0210505.
   Google Scholar
• Holmen IC, Konda MS, Pak JW, et al. Prevalence and severity of artifacts in optical coherence tomographic angiograms. JAMA Ophthalmol. 2020;138:119–126.
   PubMed Web of Science ®Google Scholar
• Say EAT, Ferenczy S, Magrath GN, et al. Image quality and artifacts on optical coherence tomography angiography. Retina. 2017;37:1660–1673.
   PubMedGoogle Scholar
• Leitgeb RA, Werkmeister RM, Blatter C, et al. Doppler optical coherence tomography. Prog Retin Eye Res. 2014;41:26–43.
   PubMed Web of Science ®Google Scholar
• Wang Y, Bower BA, Izatt JA, et al. In vivo total retinal blood flow measurement by Fourier domain Doppler optical coherence tomography. J Biomed Opt. 2007;12:041215.
   PubMed Web of Science ®Google Scholar
• Sugiyama T, Araie M, Riva CE, et al. Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol. 2010;88:723–729.
   PubMed Web of Science ®Google Scholar
• Aizawa N, Nitta F, Kunikata H, et al. Laser speckle and hydrogen gas clearance measurements of optic nerve circulation in albino and pigmented rabbits with or without optic disc atrophy. Investig Ophthalmol Vis Sci. 2014;55:7991–7996.
   PubMed Web of Science ®Google Scholar
• Wang L, Cull GA, Piper C, et al. Anterior and posterior optic nerve head blood flow in nonhuman primate experimental glaucoma model measured by laser speckle imaging technique and microsphere method. Investig Ophthalmol Vis Sci. 2012;53:8303–8309.
   PubMed Web of Science ®Google Scholar
• Tsuda S, Kunikata H, Shimura M, et al. Pulse-waveform analysis of normal population using laser speckle flowgraphy. Curr Eye Res. 2014;39:1207–1215.
   PubMed Web of Science ®Google Scholar
• Luft N, Wozniak PA, Aschinger GC, et al. Ocular blood flow measurements in healthy White subjects using laser speckle flowgraphy. PLoS One. 2016;11:e0168190.
   PubMed Web of Science ®Google Scholar
• Shiba T, Takahashi M, Matsumoto T, et al. Pulse waveform analysis in ocular microcirculation by laser speckle flowgraphy in patients with left ventricular systolic and diastolic dysfunction. J Vasc Res. 2018;55:329–337.
   PubMed Web of Science ®Google Scholar
• Landa G, Rosen RB. New patterns of retinal collateral circulation are exposed by a retinal functional imager (RFI). Br J Ophthalmol. 2010;94:54–58.
   PubMed Web of Science ®Google Scholar
• Landa G, Jangi AA, Garcia PMT, et al. Initial report of quantification of retinal blood flow velocity in normal human subjects using the Retinal Functional Imager (RFI). Int Ophthalmol. 2012;32:211–215.
   PubMedGoogle Scholar
• Jiang H, DeBuc DC, Rundek T, et al. Automated segmentation and fractal analysis of high-resolution non-invasive capillary perfusion maps of the human retina. Microvasc Res. 2013;89:172–175.
   PubMed Web of Science ®Google Scholar
• Lopes De Faria JM, Duarte DA, Larico Chavez RF, et al. Reliability and validity of digital assessment of perifoveal capillary network measurement using high-resolution imaging. Br J Ophthalmol. 2014;98:726–729.
   PubMed Web of Science ®Google Scholar
• Landa G, Garcia PMT, Rosen RB. Correlation between Retina Blood Flow Velocity Assessed by Retinal Function Imager and Retina Thickness Estimated by Scanning Laser Ophthalmoscopy/Optical Coherence Tomography. Ophthalmologica. 2009;223:155–161.
   PubMed Web of Science ®Google Scholar
• Hickam JB, Frayser R, Ross JC. A study of retinal venous blood oxygen saturation in human subjects by photographic means. Circulation. 1963;27:375–385.
   PubMed Web of Science ®Google Scholar
• Hickam JB, Sieker HO, Frayser R. Studies of retinal circulation and A-V oxygen difference in man. Trans Am Clin Climatol Assoc. 1959;71:34–44.
   PubMedGoogle Scholar
• Stefánsson E, Olafsdottir OB, Eliasdottir TS, et al. Retinal oximetry: metabolic imaging for diseases of the retina and brain. Prog Retin Eye Res. 2019;70:1–22.
   PubMed Web of Science ®Google Scholar
• Linsenmeier RA, Zhang HF. Retinal oxygen: from animals to humans. Prog Retin Eye Res. 2017;58:115–151.
   PubMed Web of Science ®Google Scholar
• Told R, Boltz A, Schmetterer L, et al. Method comparison of two non-invasive dual-wavelength spectrophotometric retinal oximeters in healthy young subjects during normoxia. Acta Ophthalmol. 2018;96:e614–e618.
   PubMed Web of Science ®Google Scholar
• Geirsdottir A, Palsson O, Hardarson SH, et al. Retinal vessel oxygen saturation in healthy individuals. Investig Ophthalmol Vis Sci. 2012;53:5433–5442.
   PubMed Web of Science ®Google Scholar
• Man REK, Sasongko MB, Kawasaki R, et al. Associations of retinal oximetry in healthy young adults. Investig Ophthalmol Vis Sci. 2014;55:1763–1769.
   PubMed Web of Science ®Google Scholar
• O’Connell RA, Anderson AJ, Hosking SL, et al. Test-retest reliability of retinal oxygen saturation measurement. Optom Vis Sci. 2014;91:608–614.
   PubMed Web of Science ®Google Scholar
• Goharian I, Iverson SM, Ruiz RC, et al. Reproducibility of retinal oxygen saturation in normal and treated glaucomatous eyes. Br J Ophthalmol. 2015;99:318–322.
   Google Scholar
• Blondal R, Sturludottir MK, Hardarson SH, et al. Reliability of vessel diameter measurements with a retinal oximeter. Graefes Arch Clin Exp Ophthalmol. 2011;249:1311–1317.
   PubMed Web of Science ®Google Scholar
• Bek T, Stefánsson E, Hardarson SH. Retinal oxygen saturation is an independent risk factor for the severity of diabetic retinopathy. Br J Ophthalmol. 2019;103:1167–1172.
   PubMed Web of Science ®Google Scholar
• Eliasdottir TS. Retinal oximetry and systemic arterial oxygen levels. Acta Ophthalmol. 2018;96:1–44.
   PubMed Web of Science ®Google Scholar
• Shughoury A, Mathew S, Arciero J, et al. Retinal oximetry in glaucoma: investigations and findings reviewed. Acta Ophthalmol. 2020;98:559–571.
   PubMed Web of Science ®Google Scholar
• Stefánsson E, Olafsdottir OB, Einarsdottir AB, et al. Retinal oximetry discovers novel biomarkers in retinal and brain diseases. Investig Ophthalmol Vis Sci. 2017;58:BIO227–BIO233.
   PubMed Web of Science ®Google Scholar
• Michelson G, Harazny J. Relationship between ocular pulse pressures and retinal vessel velocities. Ophthalmology. 1997;104:664–671.
   PubMed Web of Science ®Google Scholar
• Lieb WE, Cohen SM, Merton DA, et al. Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol. 1991;109:527–531.
   PubMedGoogle Scholar
• Williamson TH, Harris A. Color Doppler ultrasound imaging of the eye and orbit. Surv Ophthalmol. 1996;40:255–267.
   PubMed Web of Science ®Google Scholar
• Wang JJ, Mitchell P, Leung H, et al. Hypertensive retinal vessel wall signs in a general older population: the Blue Mountains Eye Study. Hypertension. 2003;42:534–541.
   PubMed Web of Science ®Google Scholar
• Kan H, Stevens J, Heiss G, et al. Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study. Am J Clin Nutr. 2007;86:1626–1632.
   PubMed Web of Science ®Google Scholar
• Ikram MK, De Jong FJ, Vingerling JR, et al. Are retinal arteriolar or venular diameters associated with markers for cardiovascular disorders? The Rotterdam study. Investig Ophthalmol Vis Sci. 2004;45:2129–2134.
   PubMed Web of Science ®Google Scholar
• Polak K, Dorner G, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84:1285–1290.
   PubMed Web of Science ®Google Scholar
• Yip W, Tham YC, Hsu W, et al. Comparison of common retinal vessel caliber measurement software and a conversion algorithm. Transl Vis Sci Technol. 2016;5:11.
   PubMed Web of Science ®Google Scholar
• Aliahmad B, Kumar DK. Retinal image vasculature analysis software (RIVAS). In: Yang XS, Papa JP, editors. Bio-inspired computation and applications in image processing. Amsterdam (The Netherlands): Elsevier; 2016. p. 323–345.
   Google Scholar
• Kohler J, White RJ, Divani AA, et al. Comparison of IVAN and VAMPIRE: two free retinal vascular measurement software packages. Investig Ophthalmol Vis Sci. 2016;57:5959.
   Web of Science ®Google Scholar
• Vilser W, Nagel E, Lanzl I. Retinal vessel analysis – new possibilities. Biomed Tech (Berl). 2002;47 Suppl 1 Pt 2:682–685.
   PubMedGoogle Scholar
• Leung H, Wang JJ, Rochtchina E, et al. Computer-assisted retinal vessel measurement in an older population: correlation between right and left eyes. Clin Experiment Ophthalmol. 2003;31:326–330.
   PubMed Web of Science ®Google Scholar
• Muiesan ML, Salvetti M, Paini A, et al. Ocular fundus photography with a smartphone device in acute hypertension. J Hypertens. 2017;35:1660–1665.
   PubMed Web of Science ®Google Scholar
• Adam MK, Brady CJ, Flowers AM, et al. Quality and diagnostic utility of mydriatic smartphone photography: the smartphone ophthalmoscopy reliability trial. Ophthalmic Surg Lasers Imaging Retina. 2015;46:631–637.
   PubMed Web of Science ®Google Scholar
• Panwar N, Huang P, Lee J, et al. Fundus photography in the 21st century – a review of recent technological advances and their implications for worldwide healthcare. Telemed. e-Health. 2016;22:198–208.
   PubMed Web of Science ®Google Scholar
• Xu X, Ding W, Wang X, et al. Smartphone-based accurate analysis of retinal vasculature towards point-of-care diagnostics. Sci Rep. 2016;6:9.
   PubMed Web of Science ®Google Scholar
• Bongard O, Bounameaux H. Clinical investigation of skin microcirculation. Dermatology (Basel). 1993;186:6–11.
   PubMed Web of Science ®Google Scholar
• Neubauer-Geryk J, Hoffmann M, Wielicka M, et al. Current methods for the assessment of skin microcirculation: Part 1. Postepy Dermatol Alergol. 2019;36:247–254.
   PubMedGoogle Scholar
• Bonacci E, Santacroce N, D'Amico N, et al. Nail-fold capillaroscopy in the study of microcirculation in elderly hypertensive patients. Arch Gerontol Geriatr. 1996;22:79–83.
   PubMedGoogle Scholar
• Turner TA. Diagnostic thermography. Vet Clin North Am Equine Pract. 2001;17:95–114.
   PubMed Web of Science ®Google Scholar
• Harazny JM, Schmieder RE, Welzenbach J, et al. Local application of tropicamide 0.5% reduces retinal capillary blood flow. Blood Press. 2013;22:371–376.
   PubMed Web of Science ®Google Scholar
• Harazny J, Michelson G. Retinale zirkulation und lokale applikation von phenylephrin. 2004 [accessed 2020 Mar 24]. Available from: https://2006.archiv.dog.org/poster2.html
   Google Scholar
• Hohberger B, Müller M, Hosari S, et al. OCT-angiography: Mydriatic phenylephrine and tropicamide do not influence retinal microvasculature in macula and peripapillary region. PLoS One. 2019;14:e0221395.
   PubMed Web of Science ®Google Scholar
• Cheng J, Yu J, Jiang C, et al. Phenylephrine affects peripapillary retinal vasculature-an optic coherence tomography angiography study. Front Physiol. 2017;8:996.
   PubMed Web of Science ®Google Scholar
• Mayama C, Ishii K, Saeki T, et al. Effects of topical phenylephrine and tafluprost on optic nerve head circulation in monkeys with unilateral experimental glaucoma. Investig Ophthalmol Vis Sci. 2010;51:4117–4124.
   PubMed Web of Science ®Google Scholar
• Tsui E, Sehi M, Cheng RWF, et al. The impact of topical mydriatic ophthalmic solutions on retinal vascular reactivity and blood flow. Exp Eye Res. 2013;112:134–138.
   PubMed Web of Science ®Google Scholar
• Robinson F, Petrig BL, Sinclair SH, et al. Does topical phenylephrine, tropicamide, or proparacaine affect macular blood flow? Ophthalmology. 1985;92:1130–1132.
   PubMed Web of Science ®Google Scholar
• Takayama J, Mayama C, Mishima A, et al. Topical phenylephrine decreases blood velocity in the optic nerve head and increases resistive index in the retinal arteries. Eye (Lond). 2009;23:827–834.
   PubMed Web of Science ®Google Scholar
• Takayama J, Mishima A, Ishii K. Effects of topical phenylephrine on blood flow in the posterior segments of monkey and aged human eyes. Jpn J Ophthalmol. 2004;48:243–248.
   PubMed Web of Science ®Google Scholar
• Komar K, Stremplewski P, Motoczyńska M, et al. Multimodal instrument for high-sensitivity autofluorescence and spectral optical coherence tomography of the human eye fundus. Biomed Opt Express. 2013;4:2683–2695.
   PubMed Web of Science ®Google Scholar
• McDougall SR, Watson MG, Devlin AH, et al. A hybrid discrete-continuum mathematical model of pattern prediction in the developing retinal vasculature. Bull Math Biol. 2012;74:2272–2314.
   PubMed Web of Science ®Google Scholar
• Spaide RF. Volume-rendered optical coherence tomography of retinal vein occlusion pilot study. Am J Ophthalmol. 2016;165:133–144.
   PubMed Web of Science ®Google Scholar