Changes in sympathetic nervous system activity after renal denervation: results from the randomised Oslo RDN study

References

• Grassi G, Mark A, Esler M. The sympathetic nervous system alterations in human hypertension. Circ Res. 2015;116(6):976–990.
   PubMed Web of Science ®Google Scholar
• Esler M, Jennings G, Biviano B, et al. Mechanism of elevated plasma noradrenaline in the course of essential hypertension. J Cardiovasc Pharmacol. 1986;8(Suppl 5):S39–S43.
   PubMed Web of Science ®Google Scholar
• Goldstein DS, Lake CR. Plasma norepinephrine and epinephrine levels in essential hypertension. Fed Proc. 1984;43(1):57–61.
   PubMedGoogle Scholar
• Townsend RR, Mahfoud F, Kandzari DE, et al. Catheter-based renal denervation in patients with uncontrolled hypertension in the absence of antihypertensive medications (SPYRAL HTN-OFF MED): a randomised, sham-controlled, proof-of-concept trial. Lancet. 2017;390(10108):2160–2170.
   PubMed Web of Science ®Google Scholar
• Kandzari DE, Bohm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet. 2018;391(10137):2346–2355.
   PubMed Web of Science ®Google Scholar
• Weber MA, Mahfoud F, Schmieder RE, et al. Renal denervation for treating hypertension: current scientific and clinical evidence. JACC Cardiovasc Interv. 2019;12(12):1095–1105.
   PubMed Web of Science ®Google Scholar
• Mahfoud F, Bohm M, Schmieder R, et al. Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry. Eur Heart J. 2019;40(42):3474–3482.
   PubMed Web of Science ®Google Scholar
• Bergland OU, Soraas CL, Larstorp ACK, et al. The randomised Oslo study of renal denervation vs. Antihypertensive drug adjustments: efficacy and safety through 7 years of follow-up. Blood Press. 2020:1–10. doi: 10.1080/08037051.2020.1828818.
   PubMed Web of Science ®Google Scholar
• Dorr O, Liebetrau C, Mollmann H, et al. Brain-derived neurotrophic factor as a marker for immediate assessment of the success of renal sympathetic denervation. J Am Coll Cardiol. 2015;65(11):1151–1153.
   PubMed Web of Science ®Google Scholar
• Hassellund SS, Flaa A, Sandvik L, et al. Long-term stability of cardiovascular and catecholamine responses to stress tests: an 18-year follow-up study. Hypertension. 2010;55(1):131–136.
   PubMed Web of Science ®Google Scholar
• Tsuji H, Larson MG, Venditti FJ, Jr, et al. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation. 1996;94(11):2850–2855.
   PubMed Web of Science ®Google Scholar
• Breuer HW, Skyschally A, Schulz R, et al. Heart rate variability and circulating catecholamine concentrations during steady state exercise in healthy volunteers. Br Heart J. 1993;70(2):144–149.
   PubMedGoogle Scholar
• Fadl Elmula FE, Hoffmann P, Larstorp AC, et al. Adjusted drug treatment is superior to renal sympathetic denervation in patients with true treatment-resistant hypertension. Hypertension. 2014;63(5):991–999.
   PubMed Web of Science ®Google Scholar
• Fadl Elmula FE, Hoffmann P, Fossum E, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension after witnessed intake of medication before qualifying ambulatory blood pressure. Hypertension. 2013;62(3):526–532.
   PubMed Web of Science ®Google Scholar
• Symplicity HTNI, Esler MD, Krum H, et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376(9756):1903–1909.
   PubMed Web of Science ®Google Scholar
• Goldstein DS. Catecholamines 101. Clin Auton Res. 2010;20(6):331–352.
   PubMed Web of Science ®Google Scholar
• Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996;93(5):1043–1065.
   PubMed Web of Science ®Google Scholar
• von Rosenberg W, Chanwimalueang T, Adjei T, et al. Resolving ambiguities in the LF/HF ratio: LF-HF scatter plots for the categorization of mental and physical stress from HRV. Front Physiol. 2017;8:360.
   PubMed Web of Science ®Google Scholar
• Mansia G, De Backer G, Dominiczak A, et al. ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Press. 2007;16(3):135–232.
   PubMed Web of Science ®Google Scholar
• Hines EA, Brown GE. Jr. Cold pressor test for measuring reactibility of blood pressure: data concerning 571 normal and hypertensive subjects. Amer Heart J. 1936;11(1):1–9.
   Google Scholar
• Zygmunt A, Stanczyk J. Methods of evaluation of autonomic nervous system function. Arch Med Sci. 2010;6(1):11–18.
   PubMed Web of Science ®Google Scholar
• Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther. 2003;305(3):800–811.
   PubMed Web of Science ®Google Scholar
• Abboud FM. The sympathetic system in hypertension. State-of-the-art review. Hypertension. 1982;4(3 Pt 2):208–225.
   PubMed Web of Science ®Google Scholar
• Grassi G, Bombelli M, Seravalle G, et al. Diurnal blood pressure variation and sympathetic activity. Hypertens Res. 2010;33(5):381–385.
   PubMed Web of Science ®Google Scholar
• Esler M, Jennings G, Lambert G, et al. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev. 1990;70(4):963–985.
   PubMed Web of Science ®Google Scholar
• Umetani K, Singer DH, McCraty R, et al. Twenty-four hour time domain heart rate variability and heart rate: relations to age and gender over nine decades. J Am Coll Cardiol. 1998;31(3):593–601.
   PubMed Web of Science ®Google Scholar
• Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017;5:258.
   PubMed Web of Science ®Google Scholar
• Sevre K, Lefrandt JD, Nordby G, et al. Autonomic function in hypertensive and normotensive subjects: the importance of gender. Hypertension. 2001;37(6):1351–1356.
   PubMed Web of Science ®Google Scholar
• Heathers JA. Everything Hertz: methodological issues in short-term frequency-domain HRV. Front Physiol. 2014;5:177.
   PubMed Web of Science ®Google Scholar
• Billman GE. Heart rate variability - a historical perspective. Front Physiol. 2011;2:86
   PubMed Web of Science ®Google Scholar
• Hoogerwaard AF, de Jong MR, Adiyaman A, et al. Renal sympathetic denervation induces changes in heart rate variability and is associated with a lower sympathetic tone. Clin Res Cardiol. 2019;108(1):22–30.
   PubMed Web of Science ®Google Scholar
• Grassi G. Sympathomodulatory effects of antihypertensive drug treatment. Am J Hypertens. 2016;29(6):665–675.
   PubMed Web of Science ®Google Scholar
• Burnier M, Egan BM. Adherence in hypertension. Circ Res. 2019;124(7):1124–1140.
   PubMed Web of Science ®Google Scholar
• Rognstad S, Soraas CL, Bergland OU, et al. Establishing serum reference ranges for antihypertensive drugs. Ther Drug Monit. 2020.doi: 10.1097/FTD.0000000000000806.
   PubMedGoogle Scholar
• Muller P, Flesch G, de Gasparo M, et al. Pharmacokinetics and pharmacodynamic effects of the angiotensin II antagonist valsartan at steady state in healthy, normotensive subjects. Eur J Clin Pharmacol. 1997;52(6):441–449.
   PubMed Web of Science ®Google Scholar
• Patel P, Gupta PK, White CM, et al. Screening for non-adherence to antihypertensive treatment as a part of the diagnostic pathway to renal denervation. J Hum Hypertens. 2016;30(6):368–373.
   PubMed Web of Science ®Google Scholar
• Sevre K, Rostrup M. Blood pressure and heart rate responses to cold pressor test in patients admitted to hospital due to chest pain. Blood Press. 1999;8(2):110–113.
   PubMed Web of Science ®Google Scholar