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Blood Pressure Volume 31, 2022 - Issue 1
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Editorial

Single-pill combinations, hypertension control and clinical outcomes: potential, pitfalls and solutions

Brent M. Egana American Medical Association, Greenville, SC, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1470-5875
ORCID Icon,
Sverre E. Kjeldsenb Departments of Cardiology and Nephrology, University of Oslo, Ullevaal Hospital, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0003-2389-0272
ORCID Icon,
Krzysztof Narkiewiczc Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, PolandORCID Iconhttps://orcid.org/0000-0001-5949-5018
ORCID Icon,
Reinhold Kreutzd Charité – Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-4818-211X
ORCID Icon &
Michel Burniere Faculty of Biology and Medicine, University of Lausanne, Lausanne, SwitzerlandORCID Iconhttps://orcid.org/0000-0003-1283-8487
ORCID Icon
Pages 164-168 | Received 13 Jun 2022, Accepted 23 Jun 2022, Published online: 23 Jul 2022

References

  • Fuchs FD, Whelton PK. High blood pressure and cardiovascular disease. Hypertension. 2020;75(2):285–292.
  • Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol. 2020;16(4):223–227.
  • Frieden TR. The future of public health. N Engl J Med. 2015;373(18):1748–1754.
  • Feldman RD, Zou GZ, Vandervoort MK, et al. A simplified approach to the treatment of uncomplicated hypertension: a cluster randomized, controlled trial. Hypertension. 2009;53(4):646–653.
  • Egan BM, Bandyopadhyay D, Shaftman SR, et al. Initial monotherapy and combination therapy and hypertension control in the first year. Hypertension. 2012;59(6):1124–1131.
  • Rea F, Corrao G, Merlino L, et al. Initial antihypertensive treatment strategies and therapeutic inertia. Hypertension. 2018;72(4):846–853.
  • Mancia G, Rea F, Corrao G, et al. Two-drug combinations as first-step antihypertensive treatment. Circ Res. 2019;124(7):1113–1123.
  • Salam A, Kanukula R, Atkins E, et al. Efficacy and safety of dual combination therapy of blood pressure-lowering drugs as initial treatment for hypertension: a systematic review and Meta-analysis of randomized controlled trials. J Hypertension. 2019;37(9):1768–1774.
  • Tsioufis K, Kreutz R, Sykara G, et al. Impact of single-pill combination therapy on adherence, blood pressure control, and clinical outcomes: a rapid assessment of recent literature. J Hypertens. 2020;38(6):1016–1028.
  • Persu A, Lopez-Sublet M, Algharably EAE, et al. Starting antihypertensive drug treatment with combination therapy: controversies in hypertension - pro side of the argument. Hypertension. 2021;77(3):800–805.
  • Parati G, Kjeldsen S, Coca A, et al. Adherence to single-pill versus free-equivalent combination therapy in hypertension. Hypertension. 2021;77(2):692–705.
  • Law MR, Wald NJ, Morris JK, et al. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ. 2003;326(7404):1427.
  • Bellows BK, Ruiz-Negrón N, Bibbins-Domingo K, et al. Clinic-based strategies to reach United States million hearts 2022 blood pressure control goals. Circ Cardiovasc Qual Outcomes. 2019;12(6):e005624.
  • Webster R, Salam A, de Silva HA, for the TRIUMPH Study Group, et al. Fixed low-dose triple combination antihypertensive medications vs usual care for blood pressure control in patients with mild to moderate hypertension in Sri Lanka: a randomized clinical trial. JAMA. 2018;320(6):566–579.
  • Mariampillai JE, Eskås PA, Heimark S, et al. A case for less intensive blood pressure control: it matters to achieve target blood pressure early and sustained below 140/90 mmHg. Prog Cardiov Dis. 2016;59(3):209–218.
  • Williams B, Mancia G, Spiering W, et al. 2018 Practice guidelines for the management of arterial hypertension of the european society of cardiology and the european society of hypertension. Blood Press. 2018;27(6):314–340.
  • Egan BM, Yang J, Rakotz MK, et al. Self-reported antihypertensive medication class and relationship to treatment guidelines. Hypertension. 2022;79(2):338–348.
  • Verma AA, Khuu W, Tadrous M, et al. Fixed-dose combination antihypertensive medications, adherence, and clinical outcomes: a population-based retrospective cohort study. PLoS Med. 2018;15(6):e1002584.
  • Borghi C, Wang J, Rodionov AV, et al. Projecting the long-term benefits of single pill combination therapy for patients with hypertension in five countries. Int J Cardiol Cardiovasc Risk Prev. 2021;10:200102.
  • Bruyn E, Nguyen L, Schutte AE, et al. Implementing single-pill combination therapy for hypertension: a scoping review of key health system requirements in 30 low- and Middle-income countries. Glob Heart. 2022;17(1):6.
  • ClinCalc DrugStats Database. The top 300 drugs of 2019. https://clincalc.com/DrugStats/Top300Drugs.aspx#. (accessed 04 May 2022).
  • Berlowitz DR, Ash AS, Hickey EC, et al. Inadequate management of blood pressure in a hypertensive population. N Engl J Med. 1998;339(27):1957–1963.

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