Associations of urinary orosomucoid, N-acetyl-β-D-glucosaminidase, and albumin with blood pressure and hypertension after 7 years. The Tromsø Study

References

• GBD 2013 Risk Factors Collaborators, Forouzanfar MH, Alexander L, et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(10010):2287–2323.
   PubMed Web of Science ®Google Scholar
• Al-Makki A, DiPette D, Whelton PK, et al. Hypertension pharmacological treatment in adults: a World Health Organization guideline executive summary. Hypertension. 2022;79(1):293–301.
   PubMed Web of Science ®Google Scholar
• Zheng W, Mu J, Chu C, et al. Association of blood pressure trajectories in early life with subclinical renal damage in middle age. J Am Soc Nephrol. 2018;29(12):2835–2846.
   PubMed Web of Science ®Google Scholar
• Johnson RJ, Herrera-Acosta J, Schreiner GF, et al. Subtle acquired renal injury as a mechanism of salt-sensitive hypertension. N Engl J Med. 2002;346(12):913–923.
   PubMed Web of Science ®Google Scholar
• Chronic Kidney Disease Prognosis Consortium, Matsushita K, van der Velde M, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010;375(9731):2073–2081.
   PubMed Web of Science ®Google Scholar
• Williams B, Mancia G, Spiering W, et al. 2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH/ESC Task Force for the Management of Arterial Hypertension. J Hypertens. 2018;36(12):2284–2309.
   PubMed Web of Science ®Google Scholar
• Dyer AR, Greenland P, Elliott P, et al. Estimating laboratory precision of urinary albumin excretion and other urinary measures in the International Study on Macronutrients and Blood Pressure. Am J Epidemiol. 2004;160(3):287–294.
   PubMed Web of Science ®Google Scholar
• Chang AR, Kramer H, Wei G, et al. Effects of intensive blood pressure control in patients with and without albuminuria: post hoc analyses from SPRINT. Clin J Am Soc Nephrol. 2020;15(8):1121–1128.
   PubMed Web of Science ®Google Scholar
• Alharf AA, Cleland S, Webster J, et al. Microalbuminuria in subjects with hypertension attending specialist blood pressure clinics. J Hum Hypertens. 2016;30(9):527–533.
   PubMed Web of Science ®Google Scholar
• Gerstein HC, Mann JF, Yi Q, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA. 2001;286(4):421–426.
   PubMed Web of Science ®Google Scholar
• Fassett RG, Venuthurupalli SK, Gobe GC, et al. Biomarkers in chronic kidney disease: a review. Kidney Int. 2011;80(8):806–821.
   PubMed Web of Science ®Google Scholar
• Lousa I, Reis F, Beirao I, et al. New potential biomarkers for chronic kidney disease management-a review of the literature. Int J Mol Sci. 2020;22(1):43.
   PubMed Web of Science ®Google Scholar
• Fried LF, Lewis J. Albuminuria is not an appropriate therapeutic target in patients with CKD: the con view. Clin J Am Soc Nephrol. 2015;10(6):1089–1093.
   PubMed Web of Science ®Google Scholar
• Shlomai G, Grassi G, Grossman E, et al. Assessment of target organ damage in the evaluation and follow-up of hypertensive patients: where do we stand? J Clin Hypertens (Greenwich). 2013;15(10):742–742.
   PubMed Web of Science ®Google Scholar
• Taal MW. Progress in risk prediction for people with chronic kidney disease. Curr Opin Nephrol Hypertens. 2014;23(6):519–524.
   PubMed Web of Science ®Google Scholar
• Sorensson J, Matejka GL, Ohlson M, et al. Human endothelial cells produce orosomucoid, an important component of the capillary barrier. Am J Physiol. 1999;276(2):H530–H534.
   PubMedGoogle Scholar
• Clausen P, Jensen JS, Jensen G, et al. Elevated urinary albumin excretion is associated with impaired arterial dilatory capacity in clinically healthy subjects. Circulation. 2001;103(14):1869–1874.
   PubMed Web of Science ®Google Scholar
• Haraldsson BS, Johnsson EK, Rippe B. Glomerular permselectivity is dependent on adequate serum concentrations of orosomucoid. Kidney Int. 1992;41(2):310–316.
   PubMed Web of Science ®Google Scholar
• Haraldsson B, Rippe B. Orosomucoid as one of the serum components contributing to normal capillary permselectivity in rat skeletal muscle. Acta Physiol Scand. 1987;129(1):127–135.
   PubMedGoogle Scholar
• Gimbrone MA Jr, Garcia-Cardena G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ Res. 2016;118(4):620–636.
   PubMed Web of Science ®Google Scholar
• Dickson LE, Wagner MC, Sandoval RM, et al. The proximal tubule and albuminuria: really! J Am Soc Nephrol. 2014;25(3):443–453.
   PubMed Web of Science ®Google Scholar
• Suzuki M, Wiers K, Brooks EB, et al. Initial validation of a novel protein biomarker panel for active pediatric lupus nephritis. Pediatr Res. 2009;65(5):530–536.
   PubMed Web of Science ®Google Scholar
• Jiang H, Guan G, Zhang R, et al. Increased urinary excretion of orosomucoid is a risk predictor of diabetic nephropathy. Nephrology (Carlton). 2009;14(3):332–337.
   PubMed Web of Science ®Google Scholar
• Hultberg B, Ravnskov U. The excretion of N-acetyl-beta-glucosaminidase in glomerulonephritis. Clin Nephrol. 1981;15(1):33–38.
   PubMed Web of Science ®Google Scholar
• Bosomworth MP, Aparicio SR, Hay AW. Urine N-acetyl-beta-D-glucosaminidase–a marker of tubular damage? Nephrol Dial Transplant. 1999;14(3):620–626.
   PubMed Web of Science ®Google Scholar
• Solbu MD, Toft I, Lochen ML, et al. N-acetyl-beta-D-glucosaminidase does not enhance prediction of cardiovascular or all-cause mortality by albuminuria in a low-risk population. J Am Soc Nephrol. 2016;27(2):533–542.
   PubMed Web of Science ®Google Scholar
• Tylicki L, Manitius J, Lysiak-Szydlowska W, et al. Tubular injury: the first symptom of hypertensive kidney involvement? Med Sci Monit. 2003;9(4):CR135–CR141.
   PubMedGoogle Scholar
• Lee E, Lee YK, Kang HJ. Association between the urinary N-acetyl-beta-D-glucosaminidase/creatinine ratio and factors of the metabolic syndrome. Ann Clin Lab Sci. 2018;48(5):627–633.
   PubMed Web of Science ®Google Scholar
• Eggen AE, Mathiesen EB, Wilsgaard T, et al. The sixth survey of the Tromso Study (Tromso 6) in 2007–08: collaborative research in the interface between clinical medicine and epidemiology: study objectives, design, data collection procedures, and attendance in a multipurpose population-based health survey. Scand J Public Health. 2013;41(1):65–80.
   PubMed Web of Science ®Google Scholar
• https://uit.no/research/tromsostudy. The seventh survey of the Tromsø Study. Available from: https://uit.no/research/tromsostudy/project?pid=708909
   Google Scholar
• European Society of Hypertension-European Society of Cardiology Guidelines Commitee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens. 2003;21(6):1011–1053.
   PubMed Web of Science ®Google Scholar
• Ptinopoulou AG, Pikilidou MI, Lasaridis AN. The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review. Hypertens Res. 2013;36(2):91–101.
   PubMed Web of Science ®Google Scholar
• Vittinghus E. Preanalytical handling of stored urine samples, and measurement of beta 2-microglobulin, orosomucoid, albumin, transferrin and immunoglobulin G in urine by enzyme-linked immunosorbent assays (ELISA). Scand J Clin Lab Invest. 1990;50(8):843–849.
   PubMed Web of Science ®Google Scholar
• Tencer J, Thysell H, Andersson K, et al. Long-term stability of albumin, protein HC, immunoglobulin G, kappa- and lambda-chain-immunoreactivity, orosomucoid and alpha 1-antitrypsin in urine stored at −20 degrees C. Scand J Urol Nephrol. 1997;31(1):67–71.
   PubMed Web of Science ®Google Scholar
• Stevens LA, Coresh J, Schmid CH, et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kidney Dis. 2008;51(3):395–406.
   PubMed Web of Science ®Google Scholar
• Eriksen BO, Mathisen UD, Melsom T, et al. The role of cystatin C in improving GFR estimation in the general population. Am J Kidney Dis. 2012;59(1):32–40.
   PubMed Web of Science ®Google Scholar
• Kaufman RL. Comparing effects in dichotomous logistic regression: a variety of standardized coefficients. Soc Sci Q. 1996;77:90–109.
   Web of Science ®Google Scholar
• King JE. Standardized coefficients in logistic regression. Paper presented at: Annual meeting of the Southwest Educational Research Association; 2007 Feb 7–10; San Antonio, TX.
   Google Scholar
• Melsom T, Solbu MD, Schei J, et al. Mild albuminuria is a risk factor for faster GFR decline in the nondiabetic population. Kidney Int Rep. 2018;3(4):817–824.
   PubMed Web of Science ®Google Scholar
• Storhaug HM, Toft I, Norvik JV, et al. Uric acid is associated with microalbuminuria and decreased glomerular filtration rate in the general population during 7 and 13 years of follow-up: the Tromso study. BMC Nephrol. 2015;16:210.
   PubMed Web of Science ®Google Scholar
• Melsom T, Schei J, Stefansson VT, et al. Prediabetes and risk of glomerular hyperfiltration and albuminuria in the general nondiabetic population: a prospective cohort study. Am J Kidney Dis. 2016;67(6):841–850.
   PubMed Web of Science ®Google Scholar
• Nie L, Chu H, Liu C, et al. Linear regression with an independent variable subject to a detection limit. Epidemiology. 2010;21 Suppl 4:S17–S24.
   PubMedGoogle Scholar
• Kim SR, Lee YH, Lee SG, et al. The renal tubular damage marker urinary N-acetyl-beta-D-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes. Cardiovasc Diabetol. 2017;16(1):16.
   PubMedGoogle Scholar
• Engstrom G, Stavenow L, Hedblad B, et al. Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk. Arterioscler Thromb Vasc Biol. 2003;23(12):2247–2251.
   PubMed Web of Science ®Google Scholar
• Engstrom G, Lind P, Hedblad B, et al. Long-term effects of inflammation-sensitive plasma proteins and systolic blood pressure on incidence of stroke. Stroke. 2002;33(12):2744–2749.
   PubMed Web of Science ®Google Scholar
• Berntsson J, Ostling G, Persson M, et al. Orosomucoid, carotid plaque, and incidence of stroke. Stroke. 2016;47(7):1858–1863.
   PubMed Web of Science ®Google Scholar
• Jungbauer CG, Uecer E, Stadler S, et al. N-acteyl-ss-D-glucosaminidase and kidney injury molecule-1: New predictors for long-term progression of chronic kidney disease in patients with heart failure. Nephrology (Carlton). 2016;21(6):490–498.
   PubMed Web of Science ®Google Scholar
• Sun ZJ, Wang JW, Chang DY, et al. Unstably controlled systolic blood pressure trajectories are associated with markers for kidney damage in prediabetic population: results from the INDEED cohort study. J Transl Med. 2020;18(1):194.
   PubMed Web of Science ®Google Scholar
• Solbu MD, Norvik JV, Storhaug HM, et al. The association between adiponectin, serum uric acid and urinary markers of renal damage in the general population: cross-sectional data from the Tromso study. Kidney Blood Press Res. 2016;41(5):623–634.
   PubMed Web of Science ®Google Scholar
• Christiansen MS, Hommel E, Magid E, et al. Orosomucoid in urine is a powerful predictor of cardiovascular mortality in normoalbuminuric patients with type 2 diabetes at five years of follow-up. Diabetologia. 2005;48(2):386–393.
   PubMed Web of Science ®Google Scholar
• Fournier T, Medjoubi NN, Porquet D. Alpha-1-acid glycoprotein. Biochim Biophys Acta. 2000;1482(1–2):157–171.
   PubMed Web of Science ®Google Scholar
• Kremer JM, Wilting J, Janssen LH. Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev. 1988;40(1):1–47.
   PubMed Web of Science ®Google Scholar
• Israili ZH, Dayton PG. Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab Rev. 2001;33(2):161–235.
   PubMed Web of Science ®Google Scholar
• Logdberg L, Wester L. Immunocalins: a lipocalin subfamily that modulates immune and inflammatory responses. Biochim Biophys Acta. 2000;1482(1–2):284–297.
   PubMed Web of Science ®Google Scholar
• Hochepied T, Berger FG, Baumann H, et al. Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties. Cytokine Growth Factor Rev. 2003;14(1):25–34.
   PubMed Web of Science ®Google Scholar
• Svendstrup M, Christiansen MS, Magid E, et al. Increased orosomucoid in urine is an independent predictor of cardiovascular and all-cause mortality in patients with type 2 diabetes at 10 years of follow-up. J Diabetes Complications. 2013;27(6):570–575.
   PubMed Web of Science ®Google Scholar
• Christiansen MS, Hommel E, Magid E, et al. Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes. Diabetologia. 2002;45(1):115–120.
   PubMed Web of Science ®Google Scholar
• Christiansen MS, Iversen K, Larsen CT, et al. Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes. Scand J Clin Lab Invest. 2009;69(2):272–281.
   PubMed Web of Science ®Google Scholar
• Suzuki M, Ross GF, Wiers K, et al. Identification of a urinary proteomic signature for lupus nephritis in children. Pediatr Nephrol. 2007;22(12):2047–2057.
   PubMed Web of Science ®Google Scholar
• Sand KM, Bern M, Nilsen J, et al. Unraveling the interaction between FcRn and albumin: opportunities for design of albumin-based therapeutics. Front Immunol. 2014;5:682.
   PubMed Web of Science ®Google Scholar
• Comper WD, Russo LM, Vuchkova J. Are filtered plasma proteins processed in the same way by the kidney? J Theor Biol. 2016;410:18–24.
   PubMed Web of Science ®Google Scholar
• Andreassen RM, Kronborg JB, Schirmer H, et al. Urinary orosomucoid is associated with diastolic dysfunction and carotid arteriopathy in the general population. Cross-sectional data from the Tromso study. Scand Cardiovasc J. 2022;56(1):148–156.
   PubMed Web of Science ®Google Scholar
• Zhuo JL, Li XC. Proximal nephron. Compr Physiol. 2013;3(3):1079–1123.
   PubMed Web of Science ®Google Scholar
• Ascher SB, Scherzer R, Peralta CA, et al. Association of kidney function and early kidney injury with incident hypertension in HIV-infected women. Hypertension. 2017;69(2):304–313.
   PubMed Web of Science ®Google Scholar
• Agirbasli M, Radhakrishnamurthy B, Jiang X, et al. Urinary N-acetyl-beta-D-glucosaminidase changes in relation to age, sex, race, and diastolic and systolic blood pressure in a young adult biracial population. The Bogalusa Heart Study. Am J Hypertens. 1996;9(2):157–161.
   PubMed Web of Science ®Google Scholar
• Alderman MH, Melcher L, Drayer DE, et al. Increased excretion of urinary N-acetyl-beta-glucosaminidase in essential hypertension and its decline with antihypertensive therapy. N Engl J Med. 1983;309(20):1213–1217.
   PubMed Web of Science ®Google Scholar
• Opsahl JA, Abraham PA, Halstenson CE, et al. Correlation of office and ambulatory blood pressure measurements with urinary albumin and N-acetyl-beta-D-glucosaminidase excretions in essential hypertension. Am J Hypertens. 1988;1(3 Pt 3):117S–120S.
   PubMed Web of Science ®Google Scholar
• Nauta FL, Scheven L, Meijer E, et al. Glomerular and tubular damage markers in individuals with progressive albuminuria. Clin J Am Soc Nephrol. 2013;8(7):1106–1114.
   PubMed Web of Science ®Google Scholar
• Dyer AR, Greenland P, Elliott P, et al. Evaluation of measures of urinary albumin excretion in epidemiologic studies. Am J Epidemiol. 2004;160(11):1122–1131.
   PubMed Web of Science ®Google Scholar
• Vart P, Scheven L, Lambers Heerspink HJ, et al. Urine albumin-creatinine ratio versus albumin excretion for albuminuria staging: a prospective longitudinal cohort study. Am J Kidney Dis. 2016;67(1):70–78.
   PubMed Web of Science ®Google Scholar
• Tassi C, Mancuso F, Feligioni L, et al. Expression modes of urinary N-acetyl-beta-D-glucosaminidase in patients with chronic renal insufficiency. Clin Chim Acta. 2004;346(2):129–133.
   PubMed Web of Science ®Google Scholar
• Ellam TJ, El Nahas M. Proteinuria thresholds are irrational: a call for proteinuria indexing. Nephron Clin Pract. 2011;118(3):c217–c224.
   PubMedGoogle Scholar